LOCUS       NM_001005511            4882 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus lemur tyrosine kinase 3 (Lmtk3), transcript variant 2,
            mRNA.
ACCESSION   NM_001005511 XM_001002520
VERSION     NM_001005511.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4882)
  AUTHORS   Montrose,K., Kobayashi,S., Manabe,T. and Yamamoto,T.
  TITLE     Lmtk3-KO Mice Display a Range of Behavioral Abnormalities and Have
            an Impairment in GluA1 Trafficking
  JOURNAL   Neuroscience 414, 154-167 (2019)
   PUBMED   31310731
  REMARK    GeneRIF: Behavioral analysis of Lmtk3-KO mice revealed a number of
            abnormalities that have been linked to psychiatric disease such as
            hyper-sociability, PPI deficits and cognitive dysfunction. Further
            investigation revealed abnormalities in GluA1 trafficking after
            AMPA stimulation in Lmtk3-KO neurons, along with a reduction in
            GluA1 expression in the post-synaptic density.
REFERENCE   2  (bases 1 to 4882)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 4882)
  AUTHORS   Inoue,T., Hoshina,N., Nakazawa,T., Kiyama,Y., Kobayashi,S., Abe,T.,
            Yamamoto,T., Manabe,T. and Yamamoto,T.
  TITLE     LMTK3 deficiency causes pronounced locomotor hyperactivity and
            impairs endocytic trafficking
  JOURNAL   J Neurosci 34 (17), 5927-5937 (2014)
   PUBMED   24760852
  REMARK    GeneRIF: the dopamine metabolite levels and dopamine turnover rate
            are increased in the striata of Lmtk3(-/-) mice compared with
            controls. In addition, we found that LMTK3 is involved in the
            endocytic trafficking of N-methyl-d-aspartate receptors.
REFERENCE   4  (bases 1 to 4882)
  AUTHORS   Tomomura,M., Morita,N., Yoshikawa,F., Konishi,A., Akiyama,H.,
            Furuichi,T. and Kamiguchi,H.
  TITLE     Structural and functional analysis of the apoptosis-associated
            tyrosine kinase (AATYK) family
  JOURNAL   Neuroscience 148 (2), 510-521 (2007)
   PUBMED   17651901
REFERENCE   5  (bases 1 to 4882)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   6  (bases 1 to 4882)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167242.4 and AC149053.3.
            
            On Dec 13, 2019 this sequence version replaced NM_001005511.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094377.1, AB288873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC167242.4         184567-184640
            75-187              AC167242.4         186229-186341
            188-321             AC167242.4         187111-187244
            322-472             AC167242.4         187470-187620
            473-549             AC167242.4         188054-188130
            550-668             AC167242.4         188564-188682
            669-756             AC167242.4         191535-191622
            757-905             AC167242.4         191955-192103
            906-990             AC167242.4         192971-193055
            991-1112            AC167242.4         193137-193258
            1113-1262           AC167242.4         193351-193500
            1263-3700           AC167242.4         193784-196221
            3701-4095           AC167242.4         198859-199253
            4096-4231           AC167242.4         201096-201231
            4232-4369           AC167242.4         201572-201709
            4370-4882           AC149053.3         157562-158074       c
FEATURES             Location/Qualifiers
     source          1..4882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.5 cM"
     gene            1..4882
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /note="lemur tyrosine kinase 3"
                     /db_xref="GeneID:381983"
                     /db_xref="MGI:MGI:3039582"
     exon            1..74
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            75..187
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..4386
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase LMTK3;
                     apoptosis-associated tyrosine kinase 3"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK3 precursor"
                     /protein_id="NP_001005511.2"
                     /db_xref="CCDS:CCDS39961.1"
                     /db_xref="GeneID:381983"
                     /db_xref="MGI:MGI:3039582"
                     /translation="MPAPGALILLAAVSASGCLASPAHPDGFALSRAPLAPPYAVVLI
                     SCSGLLAFIFLLLTCLCCKRGDVRFKEFENPEGEDCSGEYTPPAEETSSSQSLPDVYI
                     LPLAEVSLPMPAPQPPHSDISTPLGLSRQHLSYLQEIGSGWFGKVILGEVFSDYSPAQ
                     VVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIMEFCQLGDL
                     KRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTS
                     DLTVRIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVW
                     SLGVTLWELFEFGAQPYRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCW
                     RPPAQRPSASDLQLQLTYLLSERPPRPPPPPPPPRDGPFPWPWPPSHSAPRPGTLSSQ
                     FPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRGGGAPPWQPASAPPAPHT
                     NPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPLDPGVPG
                     PQAPQTPSEVPQLVSETWASPLFPAPRPFPAQSSGSGGFLLSGWDPEGRGAGETLAGD
                     PAEVLGEQGTAPWAEEEEEESSPGEDSSSLGGGPSRRGPLPCPLCSREGPCSCLPLER
                     GDAVAGWGDHPALGCPHPPEDDSSLRAERGSLADLPLVPPTSAPLEFLDPLMGAAAPQ
                     YPGRGPPPAPPPPPPPPRASAEPAASPDPPSALASPGSGLSSPGPKPGDSGYETETPF
                     SPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGSQEKPTFVVQVST
                     EQLLMSLREDVTKNLLGDKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLVSRKKVP
                     SRSLPVNGVTVLENGKPGVPDMKEKVAENGLESPEKEERALVNGEPMSPEAGEKVLAN
                     GVLMSPKSEEKVAENGVLRLPRNTERPPEIGPRRVPGPWEKTPETGGLAPETLLDRAP
                     APCEAALPQNGLEMAPGQLGPAPKSGNPDPGTEWRVHESGGAPRAPGAGKLDLGSGGR
                     ALGGVGTAPAGGPASAVDAKAGWVDNSRPLPPPPQPLGAQQRRPEPVPLKARPEVAQE
                     EEPGVPDNRLGGDMAPSVDEDPLKPERKGPEMPRLFLDLGPPQGNSEQIKAKLSRLSL
                     ALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEDEEAA
                     GSRDPGRTREAPVPVVVSSADGDTVRPLRGLLKSPRAADEPEDSELERKRKMVSFHGD
                     VTVYLFDQETPTNELSVQGTPEGDTEPSTPPAPPTPPHPTTPGDGFPNSDSGFGGSFE
                     WAEDFPLLPPPGPPLCFSRFSVSPALETPGPPARAPDARPAGPVEN"
     exon            188..321
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            322..472
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            473..549
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            550..668
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..756
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            757..905
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            906..990
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1112
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1262
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..3700
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            3701..4095
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4231
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4369
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     exon            4370..4882
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4882
                     /gene="Lmtk3"
                     /gene_synonym="aatyk3"
                     /note="major polyA site"
ORIGIN      
        1 attgagggga cgagtcgcag gtattcctgg accatggaga catcctcgcc gagggcggca
       61 gtccgcgctt ccggccgccg attcctccac ctcccttcca tcctggacaa gatgcctgca
      121 cccggcgcac tcatcctcct ggcggccgtc tccgcctccg gctgcctggc gtccccagcg
      181 cacccggatg gattcgctct gagccgggcc cctttggctc cgccctacgc tgtggtcctc
      241 atttcctgtt cgggtctgct ggccttcatc tttctcctcc ttacctgtct gtgttgcaaa
      301 cggggtgatg ttcgtttcaa ggagtttgag aacccggaag gggaggactg ctctggggag
      361 tacacccccc ctgcggagga gacctcctcc tcacagtcgc tgcctgatgt ctatattctg
      421 ccgctggcag aggtctcact gccaatgcct gccccgcagc ctccacactc agacatcagc
      481 acccccctgg gcctgagccg ccagcacctc agctacctgc aggagattgg cagcggctgg
      541 tttgggaagg tgatcctcgg ggaggttttc tcagactact cgccagccca ggtggtggtg
      601 aaggaactcc gggctagtgc cgggcccctg gaacagcgca agttcatctc cgaggctcag
      661 ccctacagga gcctgcagca tcccaacgtc ctccagtgcc tgggcgtctg tgtggagacc
      721 ttgcccttcc tgttgatcat ggagttctgc cagctggggg acctgaagcg ataccttcgg
      781 gcccagcggc cacctgaagg catgtcccct gaacttcccc ctcgagacct tcggacactg
      841 cagaggatgg gtctagagat tgcccgagga ctggcacacc tgcactctca caactatgtg
      901 cacagcgatc tggcgctgcg caactgcctg ctaacttcag acctgactgt gcgtattgga
      961 gactatgggc tggcgcacag caactacaag gaagactact acctgacacc cgagcgccta
     1021 tgggtgccgc tgcgctgggc agcgcccgag ctgctgggcg agctgcacgg cagcttcgtg
     1081 ctggtagatc aaagccggga gagtaatgtc tggtccctgg gggtgacact ctgggagcta
     1141 ttcgagttcg gggcacagcc ctatcgtcac ctatcggatg aggaggtcct ggcctttgtt
     1201 gtccgccagc agcacgtgaa gctggcccgg cccaggctca agctgcccta cgctgactat
     1261 tggtatgaca ttttgcagtc ttgctggcgg ccgccagccc agcgcccctc agcttctgat
     1321 ctccagctgc agctcactta cctgctgtct gagcggcccc ccaggccccc tcctccacca
     1381 ccccctcccc gagatgggcc cttcccctgg ccctggcccc cctcgcatag tgcgccgcgc
     1441 ccagggaccc tgtcctccca gttccccctt ctggatggct tccccggggc tgaccctgat
     1501 gatgtactca cagtcaccga gagcagccgt ggcctcaacc ttgagtgcct gtgggagaag
     1561 gcccgccgtg gggcaggccg gggtgggggt gcacctccct ggcaacccgc ttctgcgcct
     1621 cctgcgcccc ataccaatcc atccaatccc ttctatgagg cgctgtccac ccctagcgtg
     1681 cttccggtca tcagcgcacg cagtccctcg gtgagcagcg agtactatat ccgcctggag
     1741 gagcacggtt ctccaccaga gcccctcttc cccaacgact gggacccgct ggacccagga
     1801 gtacccggtc cccaggcccc ccagactccc tccgaggtcc ctcagctggt gtccgagacc
     1861 tgggcttccc ccctcttccc cgcgccccga cccttcccgg cccagtcctc gggatcaggt
     1921 ggtttcctgc tgagcggctg ggaccccgag ggccggggcg caggagagac cctggcagga
     1981 gatcctgccg aggtgcttgg ggaacagggt accgcaccct gggccgaaga ggaggaggaa
     2041 gagagctccc caggcgagga cagcagcagc cttggagggg gacccagccg caggggaccc
     2101 ctcccctgtc ccttgtgcag ccgcgagggt ccctgctcct gtctgccatt ggagcggggg
     2161 gacgctgtgg ccggctgggg ggaccaccct gcccttggtt gtccccaccc cccagaggac
     2221 gactcttcct tgcgtgcaga gcggggctcc ttggccgacc tgcctctggt cccccctacc
     2281 tcagcccctc tcgagtttct ggaccccctt atgggggccg cagcgcccca gtaccccggg
     2341 cgggggccac ctcccgctcc cccccctcca ccgccccctc cccgggcctc cgcggaaccg
     2401 gccgcgtccc ccgacccccc gtcggccctg gccagtccag gctccggcct atcgtctccg
     2461 ggccccaagc cgggggacag cggctacgag accgagaccc ctttttcccc cgagggagcc
     2521 ttcccaggtg ggggggcggc cgaggaggaa ggggtccctc ggccacgggc tccccccgag
     2581 ccacccgacc caggagcgcc ccggccaccc ccagacccgg gtcccctccc actcccaggg
     2641 tcccaggaga agccaacctt tgtagttcag gtgagcaccg agcagctgct gatgtcccta
     2701 cgggaggatg tgacaaagaa cctcctaggg gacaaggggt cgacacccgg ggagacagga
     2761 cccaggaagg cggggagaag ccccgcgaac agagagaagg gcccaggccc gaacagggac
     2821 ctgacatccc tggtcagcag gaagaaagtc cccagcagga gccttccagt gaacggggtg
     2881 acagtgttgg agaacgggaa gccaggagtc ccggacatga aggagaaggt ggcggagaat
     2941 ggcctggaat ctccggagaa agaagagaga gccctggtga atggggagcc gatgtcccca
     3001 gaggccgggg agaaggtgct ggcgaatggg gttctgatgt ccccaaagag cgaggagaag
     3061 gtggcagaga atggggtcct gaggctgccc aggaacacgg agaggccacc agagattgga
     3121 cctcggagag tcccagggcc ctgggagaag acgcccgaga ctgggggtct agctcccgag
     3181 accctgctgg atcgagcccc tgcgccctgc gaggcagcct tgccccagaa cggcttggag
     3241 atggcccctg gccagcttgg cccagccccc aagagcggga acccagaccc cgggaccgag
     3301 tggagagtcc acgagagtgg gggggcaccg agagcccccg gggctgggaa gctggacctc
     3361 gggagtgggg gccgagccct ggggggcgtg gggacggccc ccgccggcgg ccccgcaagc
     3421 gccgtggacg caaaggccgg atgggtagac aactcgagac cactgccacc tccgccacag
     3481 ccactggggg cccaacagag gaggccggag ccagtgcccc tgaaagccag gccggaggtg
     3541 gcccaagagg aagagccagg ggtcccagac aacaggctcg gcggagacat ggcccccagc
     3601 gtagacgagg accccctcaa gccggagagg aagggccccg agatgccacg cttgttcctg
     3661 gacttgggac cacctcaggg gaacagcgag cagatcaaag ccaaactctc ccggctctcg
     3721 ctggcgctcc caccgctcac gctcacgccg ttcccgggcc cgggcccgcg gcggccacct
     3781 tgggagggcg cggacgcagg ggcagctggc ggggaggccg gcggggcggg ggcgccgggg
     3841 ccagcggagg aggacgggga ggacgaggac gaggacgagg aggacgagga ggcagcgggc
     3901 tctcgggatc ccgggaggac gcgggaagcc ccagtgcccg tcgtggtgag cagcgccgac
     3961 ggggacacgg tccgcccgct gcgggggctg ctcaagtctc cacgcgcggc cgacgagcca
     4021 gaggacagcg agctggagag gaagcgcaag atggtctcct tccacgggga cgtgaccgtc
     4081 tacctcttcg accaggagac tccaaccaac gagttgagcg tccagggcac ccccgagggg
     4141 gacacggagc catcaactcc cccagcgccc ccgacgcctc cccaccccac caccccagga
     4201 gatgggtttc ccaacagcga cagcggcttt ggcggcagtt tcgagtgggc ggaggatttc
     4261 cccctcctcc ccccgccagg cccccccctg tgcttctccc gcttctccgt ctcacctgca
     4321 ctggagaccc cggggcctcc cgcccgggct cccgacgccc ggcccgcagg ccccgtggag
     4381 aactgactcc ccaaagaccc agcccctttg catcccaaga agagggcttg cgagcagaat
     4441 cttgtgtgga cgatggagcc attgcccctg acactgacac agcctctggg gaggtgcctg
     4501 aggctgggcc ctccctctcc tccaccatgt gccaaacagg aggcccaggc cctccaccca
     4561 gccccccaga tgagtcccct gatccccctg acccccccga cccccttgga gccacatgag
     4621 gcaggaagcc ccatcgctgg acagccacac gtcttggaac tgaactgaac cgaactcttt
     4681 tgggcccaga gccccctggc acagcagagg tctctcctgg ccccatgagg gccactggct
     4741 tcaggaacct ggcccccccc ccccatcttg cgtctcccct tcccccaagc ctggcccctg
     4801 gagggggcct ctgattcaaa ccttcgcgtg acattttcac attatttaaa aaaaaaagac
     4861 aaaaacaact tttggaggaa aa
//
