LOCUS       NM_001081109            8193 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus lemur tyrosine kinase 2 (Lmtk2), mRNA.
ACCESSION   NM_001081109 XM_132499
VERSION     NM_001081109.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8193)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8193)
  AUTHORS   Bao,H. and Gao,M.
  TITLE     Overexpression of lemur tyrosine kinase-2 protects neurons from
            oxygen-glucose deprivation/reoxygenation-induced injury through
            reinforcement of Nrf2 signaling by modulating GSK-3beta
            phosphorylation
  JOURNAL   Biochem Biophys Res Commun 521 (4), 964-970 (2020)
   PUBMED   31722791
  REMARK    GeneRIF: LMTK2 overexpression alleviated oxygen-glucose
            deprivation/reoxygenation-induced neuronal apoptosis and oxidative
            damage by enhancing Nrf2/antioxidant response element antioxidant
            signaling via modulation of GSK-3beta phosphorylation.
REFERENCE   3  (bases 1 to 8193)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 8193)
  AUTHORS   McLachlan,S., Lee,S.M., Steele,T.M., Hawthorne,P.L., Zapala,M.A.,
            Eskin,E., Schork,N.J., Anderson,G.J. and Vulpe,C.D.
  TITLE     In silico QTL mapping of basal liver iron levels in inbred mouse
            strains
  JOURNAL   Physiol Genomics 43 (3), 136-147 (2011)
   PUBMED   21062905
REFERENCE   5  (bases 1 to 8193)
  AUTHORS   Tomomura,M., Morita,N., Yoshikawa,F., Konishi,A., Akiyama,H.,
            Furuichi,T. and Kamiguchi,H.
  TITLE     Structural and functional analysis of the apoptosis-associated
            tyrosine kinase (AATYK) family
  JOURNAL   Neuroscience 148 (2), 510-521 (2007)
   PUBMED   17651901
REFERENCE   6  (bases 1 to 8193)
  AUTHORS   Kawa,S., Ito,C., Toyama,Y., Maekawa,M., Tezuka,T., Nakamura,T.,
            Nakazawa,T., Yokoyama,K., Yoshida,N., Toshimori,K. and Yamamoto,T.
  TITLE     Azoospermia in mice with targeted disruption of the Brek/Lmtk2
            (brain-enriched kinase/lemur tyrosine kinase 2) gene
  JOURNAL   Proc Natl Acad Sci U S A 103 (51), 19344-19349 (2006)
   PUBMED   17158803
REFERENCE   7  (bases 1 to 8193)
  AUTHORS   Kawa,S., Fujimoto,J., Tezuka,T., Nakazawa,T. and Yamamoto,T.
  TITLE     Involvement of BREK, a serine/threonine kinase enriched in brain,
            in NGF signalling
  JOURNAL   Genes Cells 9 (3), 219-232 (2004)
   PUBMED   15005709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121845.3.
            
            On May 19, 2018 this sequence version replaced NM_001081109.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB288872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-416               AC121845.3         159263-159678       c
            417-541             AC121845.3         130562-130686       c
            542-686             AC121845.3         125759-125903       c
            687-760             AC121845.3         116440-116513       c
            761-879             AC121845.3         112325-112443       c
            880-967             AC121845.3         111674-111761       c
            968-1101            AC121845.3         103045-103178       c
            1102-1186           AC121845.3         95349-95433         c
            1187-1308           AC121845.3         93620-93741         c
            1309-1458           AC121845.3         88153-88302         c
            1459-4327           AC121845.3         83562-86430         c
            4328-4460           AC121845.3         77170-77302         c
            4461-4700           AC121845.3         76618-76857         c
            4701-8193           AC121845.3         71831-75323         c
FEATURES             Location/Qualifiers
     source          1..8193
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.85 cM"
     gene            1..8193
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /note="lemur tyrosine kinase 2"
                     /db_xref="GeneID:231876"
                     /db_xref="MGI:MGI:3036247"
     exon            1..416
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..4729
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /EC_number="2.7.11.1"
                     /note="apoptosis-associated tyrosine kinase 2;
                     brain-enriched kinase"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LMTK2"
                     /protein_id="NP_001074578.1"
                     /db_xref="CCDS:CCDS39376.1"
                     /db_xref="GeneID:231876"
                     /db_xref="MGI:MGI:3036247"
                     /translation="MPGPPASPPPPMLLLLLLLTVGCARAAPLPQTGAGEVPVVEVPS
                     LFVILSVCSLLILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSIQSPA
                     EVFTLSVPNISLPAPSQFQASVEGLKSQVARHSLNYIQEIGSGWFGKVLLGETYTGTS
                     VARVIVKELKVSASPKEQDTFLKSGEPYYILQHPNVLQCVGQCVEAIPYLLVFEFCDL
                     GDLKAYLHNEQEHVRGDSQTMLLQRMACEIAAGLAAMHKLHFLHSDLALRNCYLTSDL
                     NVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSL
                     GVTLWELFNNAAQPYANLSDLDVLNQVIRERDMKLPKPQLEQPYSDRWYEVLQFCWLP
                     PDKRPAAEDVHRLLTYLRMQSQRDSEVDFEQQWTALKPDTNSRDASSSAAFPILDHFA
                     RDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDEQGRGHPDEALSYSSMFFPVEV
                     FENSLSDPGPGKQDDSGQEVPVRAPGVVPVFDAHNLSVGSDYYIQLEEKSSSNLGLDP
                     PALLTTEVDKLERAGAEEPRTEEDFFQSSAHPKEASSTEDSRATSIPGSPFNLFSDLD
                     KADDLPSHQKIFDLMELNGVQADFKPAILSSSLDDPKDTCQSDKEKPHKLLDQGPLCL
                     SESLLHQDHFDPLSVQELSENFLFLQEKNLLKGSLTTKEQVSDLQTELKNAGFTSALL
                     ESPQRGSESSELEFLENTLDFPLSQGDTRGQNEGAGVRRHSGTSPQASPALLTEEGSP
                     TAPTDPILKPEETKSFRDVRVPEDSICLELGPDPVTVGVEIPATDAKTLDGGNRPPDV
                     TCQSKEALSLTNRHPILVNDITAQGSVESCLPESRQDLQNEPFSEDPLSVSSLEKHSE
                     AAETLNQLNSKAAPEDAALASALSSDSTSQDSLLEDSLSTPIPTSEQSVETPDSLDSV
                     DVREALLESLGSHTPRKLLPPDKPADSGYETENLESPEWTLHPAPEGTADSDAAAAGD
                     SGHSSLPPNPVIVISDAGDGHRGAEGPPQSFTLGPQSSYRDSAYFSDNDSEPDKKPEE
                     VPGTSANALVLVKGQSPPESVVPEESSDVREGCLEAPQDKPDQSRVSTLQNSCHSELQ
                     ETLQPTPADASRESCPVNDEASSPLSLLNSEPSSCDDLDTQEDRPCTLASTGTNTNEL
                     LAYMSSTLDKSLPSHLESSKLKEPDIEGKYLGKLCVSGMLDLSEDGMDADEEDENSDD
                     SDEDLRAFNLHSLSSESEDDTEHPVPIIVSNDDGRHLRSLLKPSAAEAIEQLPEDWKK
                     EKKAVTFFDDVTVYLFDQETPTKELGHCGGEAHGPGPSSPAASSSSPYLGRCMNSESS
                     TDEEGGGFEWDDDFSPDPFMSKTTSLLGSKPSLQTSKYFSPPPPARSAEQSWPHVSPC
                     SRFSISPANIASFSLTHLTDSDIEQGGSSEDGDKD"
     exon            417..541
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            542..686
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            687..760
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            761..879
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..967
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1101
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1186
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1308
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1458
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..4327
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4460
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4461..4700
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     exon            4701..8193
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8162..8167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /note="hexamer: AATAAA"
     regulatory      8166..8171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /note="hexamer: AATATA"
     polyA_site      8183
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
     polyA_site      8189
                     /gene="Lmtk2"
                     /gene_synonym="2900041G10Rik; A330101P12Rik; aatyk2; BREK;
                     cprk; KPI-2; KPI2"
                     /note="major polyA site"
ORIGIN      
        1 gtcacatgac gcagcccatc atggcggcgg gagcgcggct gcctgggccc gcggctccgc
       61 aggctgggcg ccgttgctgc tgttgagggg cggcggcggc ggcggtggcg gcgctgacgg
      121 gcgggaagga tgatgctggc tccgaggcca gagcggcgga tgcagaccag gaacaaggtt
      181 gacgtttggc taaagagacg tgtgtcccga agcagccggc gccggtgtcg ctgaggcggc
      241 gcggagggct gaccgactga ctgaaggcgg cgacccgaga gccggccccg tgggggaccg
      301 cgcggtggac gagatgccgg ggccgccggc gtcgccgccg ccgccgatgc tcctgctgct
      361 cctgctcctg acggtcggct gtgcccgggc cgcgccactt ccgcaaacag gtgcagggga
      421 agtacctgtt gtagaagttc cctccttgtt tgtgatcctg tcggtgtgca gtttattgat
      481 actgatagtg ttaattgcaa actgtgtttc ctgctgtaag gacccagaaa tagactttaa
      541 ggaatttgaa gacaattttg atgatgagat agacttcacc ccaccagcag aagacacccc
      601 gtccatccag tccccagcag aggtcttcac gctctcagtg cccaacatct cacttccagc
      661 tccatcccag ttccaggctt ctgtggaagg tttgaagtct caagtcgccc gccacagtct
      721 caactacata caggagatcg ggagtggctg gtttggaaag gtcctcctgg gagagactta
      781 cacaggcacc agcgtcgcga gagtcatagt gaaggagtta aaagtcagtg caagccccaa
      841 ggagcaggac actttcctga agagtggaga gccttactac atcctccagc atccaaatgt
      901 cctccagtgt gtggggcagt gtgtggaagc catcccctac cttctggtgt ttgagttctg
      961 cgacctgggt gacctgaagg cttacctgca caatgagcaa gaacacgtgc ggggtgattc
     1021 acagaccatg ctgctacaga ggatggcgtg tgagattgcc gcagggctgg cagccatgca
     1081 caagctgcac tttctgcaca gtgatctggc cctgcggaat tgttatctca cctccgactt
     1141 aaatgtcaaa gtgggtgact atggaatagg cttcagcaga tacaaggagg attacattga
     1201 gacagatgac aagaaagttt tccccctgag atggactgct ccagaattag tgaccagctt
     1261 tcaagacaga ctcttgactg cagatcagac taaatacagt aatatctggt ccttaggtgt
     1321 aacactttgg gaactcttca acaatgctgc tcagccgtat gcaaaccttt ctgacctgga
     1381 tgtcctcaat caagtcattc gggagaggga catgaagctc ccaaagccgc agctggagca
     1441 gccgtactcg gatagatggt acgaagtgct gcagttctgc tggctgcctc ctgacaagag
     1501 gccagccgca gaagacgtgc accgtctgct aacttacctg aggatgcaga gccagcggga
     1561 ctcggaggtc gactttgaac agcagtggac tgctctcaag cccgacacca acagcaggga
     1621 cgcatccagc agcgctgcct tccccatcct tgaccacttc gcccgggacc ggctgggtcg
     1681 ggagatggag gaggtcctca cggtgacgga gaccagccag ggcctgagct ttgagtatgt
     1741 gtgggaggct gccaagcacg accattttga tgagcagggc cggggccacc cagatgaagc
     1801 cctgtcttac tccagcatgt tcttcccagt ggaggtgttt gagaattcgc tttcagatcc
     1861 tggccctggc aagcaagatg acagtggcca ggaggtgccc gtgagggccc ctggggtggt
     1921 tcctgtgttt gatgcacaca acctctctgt tggaagtgac tactacatcc agctggagga
     1981 gaaaagcagc agcaatctgg gactggaccc ccctgcactg ctcacaactg aagtagataa
     2041 gctagagagg gctggggctg aggaacccag gacagaagag gatttcttcc agagcagtgc
     2101 tcaccccaaa gaagccagct ctaccgagga ctcacgtgct accagcatcc ctgggagccc
     2161 tttcaaccta tttagtgacc ttgacaaagc agatgacctg cccagtcacc aaaaaatatt
     2221 tgatctaatg gaactaaatg gagttcaagc tgactttaag ccagccatct tgagttcaag
     2281 cctggatgac cccaaggaca cctgccagtc tgacaaagaa aagccccata agctcttgga
     2341 ccagggccct ctgtgcttat cagaaagcct tttgcaccaa gatcactttg atccactgag
     2401 tgtccaagaa ttgtcagaaa actttttatt tcttcaggag aaaaatctac tgaaaggctc
     2461 tctgactacc aaggagcaag tgagcgacct tcaaacagaa ctcaagaatg caggttttac
     2521 ctcagcactg ttggagtcac cccagagagg ctctgaaagt tctgaacttg agttcctgga
     2581 aaatacacta gactttcctt tgtcacaggg agacacgcgt ggacagaatg aaggtgcagg
     2641 tgtcaggcgt cacagtggta cctcaccaca ggcctcccca gccttgctca cagaagaagg
     2701 atctcctact gcccccacag acccaattct gaagccagaa gaaaccaaat cctttagaga
     2761 tgtcagagtc cccgaggact ccatctgctt ggagctaggc cccgaccccg tgactgttgg
     2821 agttgaaatt cctgctactg atgccaaaac cctcgatggg ggcaacagac ccccagacgt
     2881 cacttgccaa agcaaggagg ccttgagtct aaccaacaga caccccatcc ttgtgaatga
     2941 tattactgct cagggtagcg tggagagttg tcttccagaa tcgagacagg atttacaaaa
     3001 tgagccattt tcagaagacc ctcttagtgt cagctcactg gagaaacact cggaagctgc
     3061 ggagacttta aaccagctta actctaaggc tgccccggag gatgcagcct tggcgtctgc
     3121 cctctcctcg gattctacca gccaagatag cctcttagaa gacagtttgt caacacccat
     3181 ccccacctca gagcagtctg tggagacgcc agactccctg gattcagtgg atgtccgtga
     3241 agcattgcta gagtccctag gctcccacac ccctcggaaa ctcttgcctc ccgataagcc
     3301 tgccgacagc ggctatgaga cggagaacct ggaatctcct gagtggaccc tgcaccctgc
     3361 acccgaaggc actgctgact cagacgcagc tgcagcaggt gacagtggcc acagcagttt
     3421 gcctcccaac ccggtcattg tcatctcgga tgcaggcgat ggccacagag gtgctgaagg
     3481 tcctcctcag agcttcacac ttggccccca gagttcatat cgagactctg catacttctc
     3541 agacaatgac tcggagccag ataaaaagcc cgaggaggtc ccaggaacat ctgccaatgc
     3601 cctggtgttg gtaaagggcc agtccccacc tgagtcagtt gtcccagaag aaagctctga
     3661 tgtcagagaa ggctgcctgg aagccccaca ggacaagcca gatcaaagtc gggtgtctac
     3721 tttgcagaat tcttgtcact cagaactaca agaaacattg cagcccacac cagctgatgc
     3781 ttccagagag tcctgtcctg tgaacgacga ggccagcagc cccttgagtt tgttgaattc
     3841 agaacctagc agctgcgatg acctggacac acaggaagat cgcccatgca ccctggcctc
     3901 cacaggtaca aataccaatg aactccttgc atacatgagt tccacactgg ataaatcttt
     3961 gcccagccac ttggagagct ccaagctgaa ggagccagac attgaaggga aataccttgg
     4021 caaactttgt gtgtctggga tgctggacct ctcggaggat gggatggatg ccgatgagga
     4081 ggatgagaac agcgacgact cggacgagga ccttcgagcc ttcaacttgc acagcctaag
     4141 ctctgagtct gaagacgaca cggagcaccc tgtgcccatc attgtcagta acgatgatgg
     4201 taggcacctg cggagtttgc tgaaaccctc agctgccgag gccattgagc agctgccgga
     4261 agactggaag aaggaaaaga aggcagtgac atttttcgat gatgtcaccg tttatctgtt
     4321 tgaccaggaa acccccacca aagagctggg gcactgcggg ggagaagcac atggccctgg
     4381 gcccagcagc ccagcagcgt cctcaagttc cccctaccta gggaggtgca tgaattccga
     4441 aagttccacg gatgaagaag gcggaggctt tgaatgggac gatgacttct ccccggaccc
     4501 tttcatgtca aagacaacaa gccttctggg ttccaagcct tctcttcaaa cctccaaata
     4561 cttctctcct cccccaccgg ccaggagcgc agagcagagc tggccgcacg tgtccccctg
     4621 ctcccggttc tccatctctc ctgccaacat tgccagcttc tctctcacac acctcacgga
     4681 ctcagacatt gaacaaggag gcagcagtga agacggagac aaggactagt tggctgtaga
     4741 cactctccca gccagcagcg ctcctgcttg tccacctgag caacgcaatc cactccatgc
     4801 tgactggcac cagacagtga gcggctcagg agtgatggaa agcggggcca ccacgccagg
     4861 aagcaactcc ctctgcagcg ctcgtctgcc cgctcgcctg ggctgctcct gcactcgtgc
     4921 tgggcatcct gccgaagtgg ccacactgcc acactgctct ggctcacgag tattggagga
     4981 cctgagcacc tcaggccgtg ggtctgtgtg gggtgtgtgg gtgtggatgt ctgcctcgcc
     5041 acaggtgcca cagaggggca ggcgcaccag gggagggagt gctcacaagt gagccatatt
     5101 tattgtcttt aggaaatcac taattgctct ttgactgcac tgtgggtgag tgttctgagc
     5161 tcccaatatt gtacagcatc gtaaattatc caaggaagat atggcaggcc aagctggtgc
     5221 tgaccgctgg tttgattttc ttttttgttt ttgtttttgt ctctgtctcc ttgggtgtct
     5281 gctctgcatg gcactgtaaa gcttcggtat tttgagtgtt cttctttctt agacccaccc
     5341 gcgggaaccg ttcacaggta ccctccctcg ggcccttttg attctgggag ttaggttgtg
     5401 ttttatgttc ttagaggaca tatttttgat gaggccaaaa ctgctgttct gtttcgttga
     5461 ttgcatcgag catgtttcta tataaggtgg gtactctgag cagcctgccc tgcctctcgt
     5521 gctttgaaat tcttttggta gaaatccctg aagaggtgca cccatcactc agtgcccagg
     5581 gtccttttct ggcgagatga ggccatgcac cacttgctca gcacagaggc cagcttgcgg
     5641 gagctctgcg tctcaggcag gtgggacctc tgagacactg gtccccacag agctgtaagt
     5701 gagaagagca gtttgtccac tctgggtgct gctgagggag ctgtttggga agaagccatc
     5761 cctggccata gcccccagga tacagccagc ccctgtagct gcaagtagca gggcagagac
     5821 cccagcaggg cctccagcag ccctcatggc ccctttcctg taccaagcac ccagctctcc
     5881 tcttgttctg aaagggattt cacatcttca gcgtagcttc agtacatcat cggaggagtc
     5941 tgctgtccct aacacagagg gagacctcgc tttcctaccc caagcaagta ttggtggcca
     6001 tggcagcgtg gcgaagccat gctgggcggg agctgcacct gctggcgtgg ctcttctcac
     6061 tgagctcctc gccccaaata tcccggtgct gcccctgctg tccaggctcc agtgtgacaa
     6121 tgggttgagt ctccaggccc tggccaggac atcctgctat caatcagaag gacttggact
     6181 ctcctgcaga gtgcaagtgt gggtgtcggt gtgagttcac ctaacaaatc atgaccttta
     6241 tcatcaactc tgattcgatc catgcgtttt ttttatacta agcaataact ttacgatcaa
     6301 cagaagaaat tttaaaacag agtctccttt tcccatcctt ggtgcagact gtgcctgcct
     6361 ggactccgta gaaagcactg gattttgtga catgtatatt aaaaacaggg catttcaaag
     6421 taattttgcc aaaattgtca taactgaatt tttgctgtgt ggactttctg attttttttt
     6481 aattattttt ttacctctat ctaccagctt tagttgagaa agaaaggagg tgtaattata
     6541 ataagttttt tttgtttttt tttttcaaat tacaggtttc agaagttgag attcactgat
     6601 tacagtcagg tggatccata tgtgtagcct cctttcgcag ccagcctggg atagagttac
     6661 tgacatttga gggctggcca tctttcacca tgctgagggg attttaacaa tacaattccc
     6721 gtttatattt atatctatat tgttctcatg gtaaattgcc aaaataaaag cattttatat
     6781 attgagttgg ggtgggggtg ggatagatct tctgtgtcgt tgcatggaag ggaagacttt
     6841 gtataacacg catcaacaca tcctccccaa atctcaagca atagacagaa atctcagtag
     6901 actaaactcc agcccatttt ttaaatgtga gcatgtgctt tgccatccag tgtgggtttt
     6961 gttttggttt aggttttgtt ttttgttttt caagataggg tttctctgtg tagccctggc
     7021 tgttctggaa cttgctgtat agtccaggct ggcctcaaac tcagagatcc acctgcctct
     7081 gccccctgat gctgccacca tacccagctg gttttatctt ttaatgataa cttaggtgcc
     7141 cttggtgggc tttccaaacc tggttactca acgttagcag tgaagcgagc cggtggtgac
     7201 tgtggctgga atgtggtggg cttggtgact tttctttctg ccctcccttg agtgctcacc
     7261 ctccacctac cagactggaa gctgacttta agtcctctaa taaaaataat gagccctcca
     7321 agtccctctt gatagcttct atttgttaga agatgaccta agtcagaaaa aagtagttcc
     7381 cccttcctga gagactctgt ctgggccaga agccattcat tgaaaggttg cgatggcaac
     7441 cagcctccag ccatgcaggc ctgtttttag agagatgggt ctctctgagg aggtctgtct
     7501 ccctgctgta caatgccttt taaaccttcc cctttttcca tacttcccat agggcatttg
     7561 tagaattagt gacccactgc atgtctgtcc ccaaggccgg gaaaagagac aggcagctcc
     7621 tcagcctgag aacgccgccg atgcgaccaa gtgtcaggct ctatgtgcca tgcttcagag
     7681 tgcccacctt gagagaagcc accttgtagt cagagtgagc agacacagtt acgtcaaaca
     7741 tacatctcaa tatttcttaa gaagcaaacg ggggcaccag tcttggcttt taggaagctc
     7801 tgtttaactt acacataagt tcttaagatg tgttggcagt attgcgtcac ccacggccgt
     7861 cccgggggct gaacgtgtgg cgtttggtta ctgaagcctg ctcaggcgaa gctgggtctt
     7921 gtgcatgttc ccactgtttc atcctgtcct cgccagggat ctgggtggga cagtcacacc
     7981 cacggcctgc tacccaccag gttgtactta acgcaatcag aaggggttca tggcaatata
     8041 acagttaatg aacttggagt ttaaattgtg tacattttta aattgtaaga tttttactgt
     8101 atattgaagc ttagtgtgat tcaataaatt gcttgtaatt taaaaactat ttaatattca
     8161 aaataaatat agttatatat ttataataat ctc
//
