LOCUS       NM_001081157            2215 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus leiomodin 3 (fetal) (Lmod3), mRNA.
ACCESSION   NM_001081157 XM_149772
VERSION     NM_001081157.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Schultz,L.E., Colpan,M., Smith,G.E. Jr., Mayfield,R.M.,
            Larrinaga,T.M., Kostyukova,A.S. and Gregorio,C.C.
  TITLE     A nemaline myopathy-linked mutation inhibits the actin-regulatory
            functions of tropomodulin and leiomodin
  JOURNAL   Proc Natl Acad Sci U S A 120 (47), e2315820120 (2023)
   PUBMED   37956287
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Lin,F.H., Wang,A., Dai,W., Chen,S., Ding,Y. and Sun,L.V.
  TITLE     Lmod3 promotes myoblast differentiation and proliferation via the
            AKT and ERK pathways
  JOURNAL   Exp Cell Res 396 (2), 112297 (2020)
   PUBMED   32980291
  REMARK    GeneRIF: Lmod3 promotes myoblast differentiation and proliferation
            via the AKT and ERK pathways.
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Wu,T., Mu,Y., Bogomolovas,J., Fang,X., Veevers,J., Nowak,R.B.,
            Pappas,C.T., Gregorio,C.C., Evans,S.M., Fowler,V.M. and Chen,J.
  TITLE     HSPB7 is indispensable for heart development by modulating actin
            filament assembly
  JOURNAL   Proc Natl Acad Sci U S A 114 (45), 11956-11961 (2017)
   PUBMED   29078393
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Scheffer,D.I., Shen,J., Corey,D.P. and Chen,Z.Y.
  TITLE     Gene Expression by Mouse Inner Ear Hair Cells during Development
  JOURNAL   J Neurosci 35 (16), 6366-6380 (2015)
   PUBMED   25904789
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Cenik,B.K., Garg,A., McAnally,J.R., Shelton,J.M., Richardson,J.A.,
            Bassel-Duby,R., Olson,E.N. and Liu,N.
  TITLE     Severe myopathy in mice lacking the MEF2/SRF-dependent gene
            leiomodin-3
  JOURNAL   J Clin Invest 125 (4), 1569-1578 (2015)
   PUBMED   25774500
  REMARK    GeneRIF: LMOD3 deficiency in mice causes nemaline myopathy. In
            skeletal muscle, Lmod3 transcription was controlled by SRF and
            MEF2. LMOD3 and KLHL40 enhanced MRTF-SRF activity.
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Garg,A., O'Rourke,J., Long,C., Doering,J., Ravenscroft,G.,
            Bezprozvannaya,S., Nelson,B.R., Beetz,N., Li,L., Chen,S.,
            Laing,N.G., Grange,R.W., Bassel-Duby,R. and Olson,E.N.
  TITLE     KLHL40 deficiency destabilizes thin filament proteins and promotes
            nemaline myopathy
  JOURNAL   J Clin Invest 124 (8), 3529-3539 (2014)
   PUBMED   24960163
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Nanda,V. and Miano,J.M.
  TITLE     Leiomodin 1, a new serum response factor-dependent target gene
            expressed preferentially in differentiated smooth muscle cells
  JOURNAL   J Biol Chem 287 (4), 2459-2467 (2012)
   PUBMED   22157009
REFERENCE   10 (bases 1 to 2215)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155724.8.
            
            On Jun 3, 2018 this sequence version replaced NM_001081157.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030676.1, BC127157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AC155724.8         138336-138815       c
            481-1875            AC155724.8         133228-134622       c
            1876-2215           AC155724.8         124590-124929       c
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 44.92 cM"
     gene            1..2215
                     /gene="Lmod3"
                     /gene_synonym="5430424A14Rik"
                     /note="leiomodin 3 (fetal)"
                     /db_xref="GeneID:320502"
                     /db_xref="MGI:MGI:2444169"
     exon            1..480
                     /gene="Lmod3"
                     /gene_synonym="5430424A14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1902
                     /gene="Lmod3"
                     /gene_synonym="5430424A14Rik"
                     /codon_start=1
                     /product="leiomodin-3"
                     /protein_id="NP_001074626.1"
                     /db_xref="CCDS:CCDS39576.1"
                     /db_xref="GeneID:320502"
                     /db_xref="MGI:MGI:2444169"
                     /translation="MSGHSRNSEQEDTLSEELDEDELLANLSPEELKELQSEMEVMAP
                     DPHLPVGMIQKDQTDKAPTGNFNHKSLVDYMYLQKASRRMLEDERVPVSFVQSEKNTQ
                     NQREVGDKGIKNMPQFLKEKLNSEILAKKRESNGSNNVQEAEDDDEDEEEEEEDDEDE
                     EEEEEDEEDDEGEEDEDGEQANREKNDAKEQIHNNPGTYQQLATKTAHEQKDTSETKE
                     KGEKKIAKLDPKKLALDTSFLKVSARPSGNQTDLDGSLRRVRQNDPDMKELNLNNIEN
                     IPKEMLLDFVNAMKKNKHIKTFSLANVGADESVAFALANMLRENRSVTTLNIESNFIT
                     GKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEISRLLKANTTLLKMGYHFELPG
                     PRMVVTNLLTRNQDKRRQKRQEEQQQQQLKEQRKLIAMLENGLGLPPGMWERLGGPMP
                     DPRMQEFFQPASGRPLDAQEVPFGSRKEMIKNPPQPPQCKTDPDSFRVVKLKRIQRKS
                     RMPEAREAQEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSNVAYLKPVQL
                     PKELE"
     exon            481..1875
                     /gene="Lmod3"
                     /gene_synonym="5430424A14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2215
                     /gene="Lmod3"
                     /gene_synonym="5430424A14Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcactccc agcagctcaa ccaacaccat tgagtgagaa aatctctcaa gggtgggttg
       61 gcctaagata tttgttaatt agaagacact gaggtgtttg catactgatt ccttctttaa
      121 aatatatcat attggattat ttcttctttt ctggtgatct agaaacagat agaaaaaaag
      181 taaactatgt cggggcacag caggaattcg gagcaagaag acacccttag tgaggagctc
      241 gatgaagacg aactcctagc caacttatcc cctgaagagc tgaaggaact gcagtcagag
      301 atggaagtca tggcccctga cccccacctt cctgtgggga tgatccaaaa ggatcaaaca
      361 gacaaggcac ccacaggaaa cttcaaccat aagtctctcg ttgattacat gtatttgcaa
      421 aaggcgtcta gacgcatgct ggaagatgaa cgagttcctg tcagttttgt gcagtctgag
      481 aaaaacactc aaaaccagcg tgaagtagga gacaagggca ttaaaaacat gccccagttt
      541 ttaaaagaaa agctcaatag tgaaatcctt gcaaaaaaaa gagaatcaaa tgggagcaac
      601 aatgtacaag aagcagaaga tgatgatgaa gatgaagagg aggaggagga agatgacgaa
      661 gatgaagagg aggaggaaga agatgaagag gatgatgaag gggaagagga tgaagatggt
      721 gaacaagcca acagagaaaa aaatgacgca aaagaacaaa tccacaacaa tccgggcacc
      781 taccagcaac tggctactaa aacagcgcac gagcaaaaag acacatcaga gaccaaagaa
      841 aaaggtgaga agaaaatagc caaattagac cctaagaagt tagctctaga taccagtttt
      901 ctgaaggtaa gtgcgaggcc ctcagggaac cagacagacc tggacgggag cttgagacga
      961 gtgagacaga acgaccccga catgaaggaa ctcaacctga acaacattga aaatatccct
     1021 aaagaaatgt tgctggactt cgtcaatgcc atgaagaaaa acaaacacat caaaaccttc
     1081 agtttagcca acgtcggtgc tgatgagagc gtagcgtttg ccctggccaa catgctgcgg
     1141 gaaaacagga gcgtcaccac cctcaatatt gagtccaact tcatcactgg gaagggcatc
     1201 gtggccatca tgaggtgcct ccagttcaat gaaacgctaa ctgaacttcg gtttcacaac
     1261 cagagacata tgctaggtca ccacgccgag atggaaatat ccaggcttct gaaggccaac
     1321 accactctgt tgaagatggg ctaccatttc gagcttccgg gtcccagaat ggtggtaacg
     1381 aatctgctta ccaggaacca ggataaacgg aggcagaaac gacaggagga acagcagcag
     1441 cagcaactta aagagcagag aaagctgata gctatgttgg agaatgggtt ggggctgccc
     1501 cctgggatgt gggagaggtt gggaggaccc atgcccgacc ccagaatgca ggagttcttc
     1561 cagcctgcat ctgggcggcc cctcgatgct caggaagtcc cctttggttc aagaaaggaa
     1621 atgatcaaaa atccgcccca gcctccacag tgcaagacgg accctgactc cttcagggtg
     1681 gtgaagctga agagaattca gcgcaaatct cgaatgccgg aagccagaga ggcacaggag
     1741 aaaaccaacc tcaaagatgt aatcaaaacg ctcaagccag tgccgagaaa taggccgccc
     1801 ccgctggtgg aaatcactcc cagagaccag ctcttgaatg acatccgaca cagcaatgtc
     1861 gcctacctta aacctgtgca actgccaaag gagctggagt aagatgagca gagtcaccta
     1921 gaacagcaag ctcagagctg gaggccattt cacgaacagt gcaggcgacg gacctggggc
     1981 cgtggctcca gccaggctga ggatggtttg ggctgtgaga agacacaggc ccaagagaaa
     2041 agggaaggat gcagaacacc catgttcaca gacaacacgt tcttcttctc agagtttgac
     2101 tgccttgcct gaaaattgta gcgttgtgct tctagaagca gaagctaacc tcgtttggta
     2161 aaccctttac tattgttttc ttctagtgag tgacaataaa tatgaaggaa gtgtt
//
