LOCUS       NM_053098               1967 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Mus musculus leiomodin 2 (cardiac) (Lmod2), mRNA.
ACCESSION   NM_053098 XM_132983
VERSION     NM_053098.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Larrinaga,T.M., Farman,G.P., Mayfield,R.M., Yuen,M.,
            Ahrens-Nicklas,R.C., Cooper,S.T., Pappas,C.T. and Gregorio,C.C.
  TITLE     Lmod2 is necessary for effective skeletal muscle contraction
  JOURNAL   Sci Adv 10 (11), eadk1890 (2024)
   PUBMED   38478604
  REMARK    GeneRIF: Lmod2 is necessary for effective skeletal muscle
            contraction.
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Kuwabara,Y., York,A.J., Lin,S.C., Sargent,M.A., Grimes,K.M.,
            Pirruccello,J.P. and Molkentin,J.D.
  TITLE     A human FLII gene variant alters sarcomeric actin thin filament
            length and predisposes to cardiomyopathy
  JOURNAL   Proc Natl Acad Sci U S A 120 (19), e2213696120 (2023)
   PUBMED   37126682
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   Ahrens-Nicklas,R.C., Pappas,C.T., Farman,G.P., Mayfield,R.M.,
            Larrinaga,T.M., Medne,L., Ritter,A., Krantz,I.D., Murali,C.,
            Lin,K.Y., Berger,J.H., Yum,S.W., Carreon,C.K. and Gregorio,C.C.
  TITLE     Disruption of cardiac thin filament assembly arising from a
            mutation in LMOD2: A novel mechanism of neonatal dilated
            cardiomyopathy
  JOURNAL   Sci Adv 5 (9), eaax2066 (2019)
   PUBMED   31517052
  REMARK    GeneRIF: Disruption of cardiac thin filament assembly arising from
            a mutation in LMOD2: A novel mechanism of neonatal dilated
            cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Pappas,C.T., Farman,G.P., Mayfield,R.M., Konhilas,J.P. and
            Gregorio,C.C.
  TITLE     Cardiac-specific knockout of Lmod2 results in a severe reduction in
            myofilament force production and rapid cardiac failure
  JOURNAL   J Mol Cell Cardiol 122, 88-97 (2018)
   PUBMED   30102883
  REMARK    GeneRIF: Loss of Lmod2 in adult mice results in a rapid loss of
            contractile force and cardiac failure. These results indicate that
            Lmod2 functions to maintain thin filament length and uniformity,
            which contributes to proper contractile force generation.
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   Chu,M., Novak,S.M., Cover,C., Wang,A.A., Chinyere,I.R.,
            Juneman,E.B., Zarnescu,D.C., Wong,P.K. and Gregorio,C.C.
  TITLE     Increased Cardiac Arrhythmogenesis Associated With Gap Junction
            Remodeling With Upregulation of RNA-Binding Protein FXR1
  JOURNAL   Circulation 137 (6), 605-618 (2018)
   PUBMED   29101288
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Pappas,C.T., Mayfield,R.M., Henderson,C., Jamilpour,N., Cover,C.,
            Hernandez,Z., Hutchinson,K.R., Chu,M., Nam,K.H., Valdez,J.M.,
            Wong,P.K., Granzier,H.L. and Gregorio,C.C.
  TITLE     Knockout of Lmod2 results in shorter thin filaments followed by
            dilated cardiomyopathy and juvenile lethality
  JOURNAL   Proc Natl Acad Sci U S A 112 (44), 13573-13578 (2015)
   PUBMED   26487682
  REMARK    GeneRIF: Data indicate that leiomodin 2 protein(Lmod2) functions to
            elongate actin filaments in the heart.
REFERENCE   7  (bases 1 to 1967)
  AUTHORS   Nanda,V. and Miano,J.M.
  TITLE     Leiomodin 1, a new serum response factor-dependent target gene
            expressed preferentially in differentiated smooth muscle cells
  JOURNAL   J Biol Chem 287 (4), 2459-2467 (2012)
   PUBMED   22157009
REFERENCE   8  (bases 1 to 1967)
  AUTHORS   Davie,J.K., Cho,J.H., Meadows,E., Flynn,J.M., Knapp,J.R. and
            Klein,W.H.
  TITLE     Target gene selectivity of the myogenic basic helix-loop-helix
            transcription factor myogenin in embryonic muscle
  JOURNAL   Dev Biol 311 (2), 650-664 (2007)
   PUBMED   17904117
REFERENCE   9  (bases 1 to 1967)
  AUTHORS   Ding,S., Wu,X., Li,G., Han,M., Zhuang,Y. and Xu,T.
  TITLE     Efficient transposition of the piggyBac (PB) transposon in
            mammalian cells and mice
  JOURNAL   Cell 122 (3), 473-483 (2005)
   PUBMED   16096065
REFERENCE   10 (bases 1 to 1967)
  AUTHORS   Conley,C.A., Fritz-Six,K.L., Almenar-Queralt,A. and Fowler,V.M.
  TITLE     Leiomodins: larger members of the tropomodulin (Tmod) gene family
  JOURNAL   Genomics 73 (2), 127-139 (2001)
   PUBMED   11318603
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK147141.1.
            
            On Apr 5, 2007 this sequence version replaced NM_053098.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147141.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1967              AK147141.1         2-1968
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 11.28 cM"
     gene            1..1967
                     /gene="Lmod2"
                     /gene_synonym="C-Lmod"
                     /note="leiomodin 2 (cardiac)"
                     /db_xref="GeneID:93677"
                     /db_xref="MGI:MGI:2135672"
     exon            1..385
                     /gene="Lmod2"
                     /gene_synonym="C-Lmod"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1765
                     /gene="Lmod2"
                     /gene_synonym="C-Lmod"
                     /note="cardiac leiomodin"
                     /codon_start=1
                     /product="leiomodin-2"
                     /protein_id="NP_444328.1"
                     /db_xref="CCDS:CCDS19944.1"
                     /db_xref="GeneID:93677"
                     /db_xref="MGI:MGI:2135672"
                     /translation="MSTFGYRRGLSKYESIDEDELLASLSPEELKELERELEDIEPDR
                     NLPVGLRQKSLTEKTPTGNFSREALMAYWEKESQKLLEKERLGECGKVAEEDKEESEE
                     ELIFTESNSEVSEEVCTEDEEESQEEEEDSEEEEDSEEEEETTEATKHINGTVSYNSV
                     NTDNSKPKTFKSQIENINLTNGNSGRTQRNSESPAAIHPCGNPTVIEDALEKIRNNDP
                     DTTEVNLNNIENITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEH
                     ITSVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTT
                     LLRLGYHFELPGPRMSMTSILTRNMDKQRQKRMQEQKQQEGHDGGAALRTKVWQRGTP
                     GSSPYASPRQSPWSSPKVSKKVHTGRSRPPSPVAPPPPPPPPPLPPHMLPPPPPPPAP
                     PLPEKKLITRNIAEVIKQQESAQRALQNGQRKKKGKKVKKQPNNILKEIKNSLRSVQE
                     KKMEDSSRPSTPQRSVHENLMEAIRGSSIRQLRRVEVPEALR"
     exon            386..1738
                     /gene="Lmod2"
                     /gene_synonym="C-Lmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1967
                     /gene="Lmod2"
                     /gene_synonym="C-Lmod"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1967
                     /gene="Lmod2"
                     /gene_synonym="C-Lmod"
                     /note="putative"
ORIGIN      
        1 cagctgctga ccagcccgac cagcctgacg ctcgctcgcc tccctgtctg cctctgcttg
       61 ccttgaatgc ctggttcttt aagctcttgg ggagtctgac aaggccggga ccatgtctac
      121 gtttggctac agaaggggac ttagtaaata tgaatccatt gatgaggatg aacttctggc
      181 ctccctctca cctgaagagc tgaaggagct tgagagggag ctggaagaca ttgaacctga
      241 ccgaaacctt cctgtggggc taaggcaaaa gagtctgaca gagaaaaccc caacaggaaa
      301 cttcagccga gaggcgctga tggcgtattg ggaaaaggag tcccaaaaac ttttggagaa
      361 ggaacggctg ggggaatgtg gaaaggttgc agaagaagac aaggaagaga gtgaagagga
      421 actaattttc acagagagca acagcgaagt ctctgaggag gtgtgtacag aagatgagga
      481 agagtctcag gaggaagaag aggatagcga ggaagaagag gacagtgagg aagaggaaga
      541 gacaacagaa gccacaaaac atattaatgg aactgtaagc tacaatagtg ttaatactga
      601 taactctaag ccaaagacat ttaaaagcca aatagaaaat ataaatttaa ccaacggcaa
      661 cagtggaaga acacagagga actccgagtc accagccgcc attcaccctt gtggaaatcc
      721 cactgttatt gaggatgctc tggaaaagat tagaaacaat gaccctgata cgacagaagt
      781 taatctgaac aatatagaga acatcaccac ccagacctta tcccgatttg ctgaagctct
      841 caaggagaac acagtggtga agacgttcag cctggccaac acgcacgctg atgacgccgc
      901 ggcgattgcc attgcagaca tgctcaaggt taacgagcac attaccagcg taaacgtgga
      961 gtccaacttc atcactggca aggggatcct ggccatcatg agagccctgc agcacaacac
     1021 ggtgctcacg gagctgcgct tccacaacca gcggcacatc atgggctctc aggtggagat
     1081 ggaaattgtc aagctgctca aagagaatac cacgctgctg aggctgggct accattttga
     1141 gctcccagga ccaagaatga gtatgacgag tattttaaca aggaatatgg ataaacagag
     1201 gcaaaaacgc atgcaggagc aaaaacagca agaggggcac gatggaggag ctgctcttag
     1261 gaccaaagtc tggcaaagag ggacacctgg ctcttctcca tatgcatctc cgagacagtc
     1321 tccctggtca tctcccaaag tctccaagaa agtccacact gggaggagca gacctccatc
     1381 tcctgtggcc ccgcctccac cccctccccc tcctcctctt cctccccaca tgctgcctcc
     1441 tccccctcct ccccctgctc ctccactccc agagaaaaag ctcatcacca gaaacattgc
     1501 agaagtcatt aaacaacagg aaagtgccca gcgcgcccta caaaatggac agcgaaagaa
     1561 aaaagggaaa aaggttaaga aacaaccaaa caatatccta aaggaaatta agaattctct
     1621 gaggtcagtg caagagaaga aaatggaaga cagctcccga ccctctaccc cacagagatc
     1681 agttcatgag aacctcatgg aagccattcg ggggagcagt ataagacagc tacggagggt
     1741 ggaagttccc gaagctctga gatagaccga tctgtagaag aggacctgga actgtttagt
     1801 ggtgtaatcc gaggtgcatt gtgagctgtt cccaaaatgc cttctttaat ttggaatatt
     1861 tcccaacttc aaagatagtg tcactctgga attccaaagg gaattctaag atgcaatgag
     1921 catgtttctt ctgtaaatat gaaaataaac tttttttttt atgtcct
//
