LOCUS       NM_053106               3942 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus leiomodin 1 (smooth muscle) (Lmod1), mRNA.
ACCESSION   NM_053106
VERSION     NM_053106.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3942)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3942)
  AUTHORS   Dong,K., Shen,J., He,X., Hu,G., Wang,L., Osman,I., Bunting,K.M.,
            Dixon-Melvin,R., Zheng,Z., Xin,H., Xiang,M., Vazdarjanova,A.,
            Fulton,D.J.R. and Zhou,J.
  TITLE     CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific
            LncRNA That Maintains Contractile Phenotype by Binding Myocardin
  JOURNAL   Circulation 144 (23), 1856-1875 (2021)
   PUBMED   34694145
REFERENCE   3  (bases 1 to 3942)
  AUTHORS   Wen,T., Liu,J., He,X., Dong,K., Hu,G., Yu,L., Yin,Q., Osman,I.,
            Peng,J., Zheng,Z., Xin,H., Fulton,D., Du,Q., Zhang,W. and Zhou,J.
  TITLE     Transcription factor TEAD1 is essential for vascular development by
            promoting vascular smooth muscle differentiation
  JOURNAL   Cell Death Differ 26 (12), 2790-2806 (2019)
   PUBMED   31024075
REFERENCE   4  (bases 1 to 3942)
  AUTHORS   Halim,D., Wilson,M.P., Oliver,D., Brosens,E., Verheij,J.B., Han,Y.,
            Nanda,V., Lyu,Q., Doukas,M., Stoop,H., Brouwer,R.W., van
            IJcken,W.F., Slivano,O.J., Burns,A.J., Christie,C.K., de Mesy
            Bentley,K.L., Brooks,A.S., Tibboel,D., Xu,S., Jin,Z.G.,
            Djuwantono,T., Yan,W., Alves,M.M., Hofstra,R.M. and Miano,J.M.
  TITLE     Loss of LMOD1 impairs smooth muscle cytocontractility and causes
            megacystis microcolon intestinal hypoperistalsis syndrome in humans
            and mice
  JOURNAL   Proc Natl Acad Sci U S A 114 (13), E2739-E2747 (2017)
   PUBMED   28292896
  REMARK    GeneRIF: Loss of LMOD1 results in a reduction of filamentous actin,
            elongated cytoskeletal dense bodies, and impaired intestinal smooth
            muscle contractility.
REFERENCE   5  (bases 1 to 3942)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   6  (bases 1 to 3942)
  AUTHORS   Scheffer,D.I., Shen,J., Corey,D.P. and Chen,Z.Y.
  TITLE     Gene Expression by Mouse Inner Ear Hair Cells during Development
  JOURNAL   J Neurosci 35 (16), 6366-6380 (2015)
   PUBMED   25904789
REFERENCE   7  (bases 1 to 3942)
  AUTHORS   Nanda,V. and Miano,J.M.
  TITLE     Leiomodin 1, a new serum response factor-dependent target gene
            expressed preferentially in differentiated smooth muscle cells
  JOURNAL   J Biol Chem 287 (4), 2459-2467 (2012)
   PUBMED   22157009
  REMARK    GeneRIF: Lmod1 is a new SMC-restricted SRF/MYOCD target gene.
REFERENCE   8  (bases 1 to 3942)
  AUTHORS   Yoon,H., Lee,D.J., Kim,M.H. and Bok,J.
  TITLE     Identification of genes concordantly expressed with Atoh1 during
            inner ear development
  JOURNAL   Anat Cell Biol 44 (1), 69-78 (2011)
   PUBMED   21519551
REFERENCE   9  (bases 1 to 3942)
  AUTHORS   Conley,C.A., Fritz-Six,K.L., Almenar-Queralt,A. and Fowler,V.M.
  TITLE     Leiomodins: larger members of the tropomodulin (Tmod) gene family
  JOURNAL   Genomics 73 (2), 127-139 (2001)
   PUBMED   11318603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079173.1 and AC016814.14.
            
            On Mar 31, 2007 this sequence version replaced NM_053106.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079173.1, AK133276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1473              AK079173.1         2-1474
            1474-1958           AC016814.14        111996-112480
            1959-3238           AK079173.1         1960-3239
            3239-3942           AK079173.1         3241-3944
FEATURES             Location/Qualifiers
     source          1..3942
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.51 cM"
     gene            1..3942
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /note="leiomodin 1 (smooth muscle)"
                     /db_xref="GeneID:93689"
                     /db_xref="MGI:MGI:2135671"
     exon            1..458
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1985
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /codon_start=1
                     /product="leiomodin-1"
                     /protein_id="NP_444336.2"
                     /db_xref="CCDS:CCDS35718.1"
                     /db_xref="GeneID:93689"
                     /db_xref="MGI:MGI:2135671"
                     /translation="MSKVAKYRRQVSEDPDIDSLLSTLSPEEMEELEKELDVVDPDGS
                     IPVGLRQRNQTDKQPSGSFNREAMLNFCEKESKKLIQREMSVDESKQVGRKTDAKNGE
                     EKDSDASRKAPGPRQDSDLGKEPKKGVLKKSFSRDREEADGRGGEKPKEEKVIRGIDK
                     GRVRAAVDRKESGKDGREERAAAARKEEEKTGSVKNAGLSRDKDKKKEEVKEPSKKEE
                     VKLTAESRNTVGRREDGRLKESSKENKKPEDEGIGSGGRDWRKEDEKVKKEENQPDKE
                     VREESKTKAPEKQAPSCPNKPSDGQARAEEEAAPSIFDEPLEKVKNNDPEMTEVNVNN
                     SDCITNEILVRFTEALEFNTVVKVFALANTRADDHVAFAIAIMLKANKTITSLNLDSN
                     HITGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFE
                     LAGPRMTVTNLLSRNMDKQRQKRLQEQKQAQEASGEKKDRLEVPKVGALAKGSPKPSP
                     QPSPKPAPKNSPKKAGVPAAPPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQE
                     KNSRDQLLAAIRSSNLKQLKKVEVPKLLQ"
     exon            459..1958
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..3942
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2683..2688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /note="hexamer: AATATA"
     polyA_site      2707
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /note="major polyA site"
ORIGIN      
        1 actagcaggg aggctgctgt gtcccccgga gcacctgtag tacagcaggg cccaaagagc
       61 tgcagtgctc acctagctgg ggctttgcgc tcaaacccac tcaataccaa caggaaccag
      121 ggctcccgtc ccttccctgc ctactaccac cagcaagccc accacacttg gtaggagcag
      181 ctgctcactt tgccaagatg tccaaagtag ctaagtaccg gcggcaggtg agtgaagacc
      241 ccgacatcga tagcctgctg tccaccctct cccctgaaga gatggaggag ctggagaagg
      301 aactagatgt ggtggaccca gacgggagca tcccggtggg gctgcggcag aggaatcaaa
      361 cggacaaaca gccctcgggc tcattcaacc gggaagccat gctcaacttc tgtgaaaagg
      421 agagcaagaa actcatccag agagagatgt ctgtggatga aagcaagcaa gtggggagga
      481 agacagatgc caagaatgga gaggagaagg acagcgatgc cagcagaaag gccccaggcc
      541 ccagacagga ctcagacctg ggcaaggagc cgaagaaggg cgttttaaag aaaagcttct
      601 ccagggatcg agaggaggcc gatggcagag ggggtgagaa gcccaaggag gagaaggtca
      661 tcagaggtat tgataaaggc agggtcaggg ctgcggtgga caggaaggag tctgggaagg
      721 atggcagaga agagagggca gccgctgcaa ggaaggagga agaaaagaca gggagtgtca
      781 agaacgcagg tctgagcaga gacaaagaca agaagaaaga agaggtgaag gagcccagca
      841 agaaagagga ggtgaaactg acagcagaga gcagaaacac agtcgggaga cgggaggacg
      901 ggaggctgaa agagtcaagc aaggagaaca agaaaccaga ggatgagggc ataggttctg
      961 ggggcagaga ctggagaaaa gaggatgaaa aagttaagaa ggaagaaaac caacctgaca
     1021 aagaagtcag ggaagagagc aagaccaaag ccccggagaa acaggcgccc agttgcccca
     1081 acaagccctc tgatgggcaa gccagagcag aagaggaagc agctcccagc atatttgatg
     1141 aacctctgga gaaagtgaag aacaacgacc cagagatgac agaggtgaac gtcaacaact
     1201 cagactgcat caccaacgag atcctggtcc gcttcacaga ggccctggag ttcaacactg
     1261 tggtgaaggt gtttgccttg gccaatactc gggctgacga ccatgtggcc tttgcaattg
     1321 ctatcatgtt aaaggccaat aagaccatca ccagcctcaa cctggactcc aatcacatca
     1381 ctggcaaagg catcctggcc atcttccggg ccctcctcca gaacaacact ctgacagagc
     1441 tgcgctttca caaccagagg cacatctgtg ggggcaagac tgagatggag atcgccaagc
     1501 tgctcaagga gaacaccacc ttgctcaagc tgggctacca ttttgagctg gcaggacccc
     1561 ggatgactgt caccaatctg ctcagccgaa acatggacaa gcagcgacag aaacggctgc
     1621 aagagcaaaa gcaggcccag gaagccagtg gagagaagaa ggaccggctg gaggtaccca
     1681 aggtcggggc tctggccaag ggctccccca aaccttcacc ccagccatct ccaaagcctg
     1741 ctccaaagaa ctcacccaag aaagcaggtg ttccagcagc cccgcctccc cctccccctc
     1801 ccctggcccc gccccttatc atggagaacc taaagaactc actctcacca gctacccaga
     1861 ggaagatggg agacaaagtg ctccctgccc aggagaagaa ctcgcgtgac cagctcctgg
     1921 ctgccatccg ttctagcaac cttaagcagc tgaagaaggt agaggtgccc aagctacttc
     1981 aataggacag gcagccgggc attggtacca atgccatgac tgcccagact cttgtcccag
     2041 ggctacacag acccccacca ccccaccctg gctgagctgt tgcagctgtc cctgtccacc
     2101 atgggagagc atgagacctg gaccacgctc gagggaggac acctcatctc ttctcccttt
     2161 ccttttcttg tctctgaggc ccttcaaaaa ttgctttgaa acctggagct gaagtgtccg
     2221 gacaagagga gtcctttaag cacgtcacag agaagatggc actgcccaga gcccatgtag
     2281 caggcatgct gccaaaggct tatgatgcag aaaagatgtc tcccagggac cacatttgga
     2341 ccccagcctc actgtcccca gggccaggat tcaggtctct gaggagccct tgggcaaagt
     2401 tgctgggcca gtggcactct atgggacagt ggtagaggct ggaggggatg aaagtccaaa
     2461 ggcaaagtag gagggcagag gatactacaa accctccacc tgatatgcct gggcagcagg
     2521 catggttgga cagtgcctga gagagggtag gctccagatg ggagtagaaa gacagacaga
     2581 cagcagctgg acctgaaggg ttgatgccaa agcagacatt ttcttcacat cacctgctgc
     2641 tgtataaata gctatatatc tgtttttcca taagattttg ataatatata caaaccttta
     2701 gcttcaagtg gctatacctc accttttttc atgttaatgg tcctaatgtt cccaatggtc
     2761 ccaggttccc taaaaggcct cccaaagctc agggtccctg gcaagccatt caaggtgaca
     2821 gtagacatca tccctagagt ccgtgtacca ctacagaaag ggcagtctgg ggggaagctt
     2881 gaattcttga gacaaccttg tgacctggtg ttccaggtct gttcctcagc cagtctctct
     2941 gcctcgtatc tgtgcccaga actgttctca ggggctgaga gtcacacagg gccccgggat
     3001 ggctatatta ggcacgttca ggaatgatca ttccgtgact cttcctactg taggctcagg
     3061 gccagctctt cacagcagtt acaggcgaag gaaggcagag tgagtcagag tgactcaggg
     3121 aaggacagct cctgcaccca gtgtgactta gggccagagg tacctctcca cccccagcat
     3181 cccctgctgg aggcagagcc accacagcca tcaccggggg tacatggaat actgtcccaa
     3241 ctagggatga aactcagagt caggttccac gcccagcaca gaggccctgt tttccatccc
     3301 cggcacgatt tctttctgat ttactgccct gacggtaact gtgccaccat gaaactgcca
     3361 ccttggttct gggtcacaga caggtgctct gcctttttgt ttctcttttt gtttcttttt
     3421 ttctttttct tcagttagca gagagcaaag ccattggaat atgggtgggg tcccacctcc
     3481 ctaaggaagt agggtagctg ttatagggtc tggctcaaat cagagagggc taactcatat
     3541 cccagggtac actctgatcc cattccttcc caacccgtct atctactgct caagtaatgg
     3601 gctggcccag gggaggagag ataccagcgc tggttcccag atcgcaaaga gtatgctttg
     3661 gagtcaagcc catgagcttt catctgatgg tgcagggcac tagctagatg cttaagggtg
     3721 cttctgctta tcttccaact ctgtgatgtg gaagccaatc gcctcgatgt tttgcagata
     3781 gagttaatca gctgcacgtg ggtacatgac gaataagagg tagggctgag gtcttaactc
     3841 ctctctgctg ctgaaaaaac ggaccagtga tagtttttca caatgacatt ggaagccaaa
     3901 tggaactagt tttacatata taaatatata atttcctctt tt
//
