LOCUS       NP_444336                595 aa            linear   ROD 30-APR-2024
DEFINITION  leiomodin-1 [Mus musculus].
ACCESSION   NP_444336
VERSION     NP_444336.2
DBSOURCE    REFSEQ: accession NM_053106.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 595)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 595)
  AUTHORS   Dong,K., Shen,J., He,X., Hu,G., Wang,L., Osman,I., Bunting,K.M.,
            Dixon-Melvin,R., Zheng,Z., Xin,H., Xiang,M., Vazdarjanova,A.,
            Fulton,D.J.R. and Zhou,J.
  TITLE     CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific
            LncRNA That Maintains Contractile Phenotype by Binding Myocardin
  JOURNAL   Circulation 144 (23), 1856-1875 (2021)
   PUBMED   34694145
REFERENCE   3  (residues 1 to 595)
  AUTHORS   Wen,T., Liu,J., He,X., Dong,K., Hu,G., Yu,L., Yin,Q., Osman,I.,
            Peng,J., Zheng,Z., Xin,H., Fulton,D., Du,Q., Zhang,W. and Zhou,J.
  TITLE     Transcription factor TEAD1 is essential for vascular development by
            promoting vascular smooth muscle differentiation
  JOURNAL   Cell Death Differ 26 (12), 2790-2806 (2019)
   PUBMED   31024075
REFERENCE   4  (residues 1 to 595)
  AUTHORS   Halim,D., Wilson,M.P., Oliver,D., Brosens,E., Verheij,J.B., Han,Y.,
            Nanda,V., Lyu,Q., Doukas,M., Stoop,H., Brouwer,R.W., van
            IJcken,W.F., Slivano,O.J., Burns,A.J., Christie,C.K., de Mesy
            Bentley,K.L., Brooks,A.S., Tibboel,D., Xu,S., Jin,Z.G.,
            Djuwantono,T., Yan,W., Alves,M.M., Hofstra,R.M. and Miano,J.M.
  TITLE     Loss of LMOD1 impairs smooth muscle cytocontractility and causes
            megacystis microcolon intestinal hypoperistalsis syndrome in humans
            and mice
  JOURNAL   Proc Natl Acad Sci U S A 114 (13), E2739-E2747 (2017)
   PUBMED   28292896
  REMARK    GeneRIF: Loss of LMOD1 results in a reduction of filamentous actin,
            elongated cytoskeletal dense bodies, and impaired intestinal smooth
            muscle contractility.
REFERENCE   5  (residues 1 to 595)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   6  (residues 1 to 595)
  AUTHORS   Scheffer,D.I., Shen,J., Corey,D.P. and Chen,Z.Y.
  TITLE     Gene Expression by Mouse Inner Ear Hair Cells during Development
  JOURNAL   J Neurosci 35 (16), 6366-6380 (2015)
   PUBMED   25904789
REFERENCE   7  (residues 1 to 595)
  AUTHORS   Nanda,V. and Miano,J.M.
  TITLE     Leiomodin 1, a new serum response factor-dependent target gene
            expressed preferentially in differentiated smooth muscle cells
  JOURNAL   J Biol Chem 287 (4), 2459-2467 (2012)
   PUBMED   22157009
  REMARK    GeneRIF: Lmod1 is a new SMC-restricted SRF/MYOCD target gene.
REFERENCE   8  (residues 1 to 595)
  AUTHORS   Yoon,H., Lee,D.J., Kim,M.H. and Bok,J.
  TITLE     Identification of genes concordantly expressed with Atoh1 during
            inner ear development
  JOURNAL   Anat Cell Biol 44 (1), 69-78 (2011)
   PUBMED   21519551
REFERENCE   9  (residues 1 to 595)
  AUTHORS   Conley,C.A., Fritz-Six,K.L., Almenar-Queralt,A. and Fowler,V.M.
  TITLE     Leiomodins: larger members of the tropomodulin (Tmod) gene family
  JOURNAL   Genomics 73 (2), 127-139 (2001)
   PUBMED   11318603
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079173.1 and AC016814.14.
            
            On Mar 31, 2007 this sequence version replaced NP_444336.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079173.1, AK133276.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 58.51 cM"
     Protein         1..595
                     /product="leiomodin-1"
                     /calculated_mol_wt=66137
     Region          1..69
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A0A0G2K0D3; propagated
                     from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Region          13..>95
                     /region_name="Tropomodulin"
                     /note="pfam03250"
                     /db_xref="CDD:460862"
     Region          81..322
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Site            85
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A0A0G2K0D3; propagated
                     from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Site            135
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A0A0G2K0D3; propagated
                     from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Region          165..288
                     /region_name="8 X approximate tandem repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Region          <335..>445
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          467..568
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Region          503..522
                     /region_name="5 X 4 AA approximate tandem repeats"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     Site            550
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:A0A0G2K0D3; propagated
                     from UniProtKB/Swiss-Prot (Q8BVA4.1)"
     CDS             1..595
                     /gene="Lmod1"
                     /gene_synonym="9530015K06Rik; SM-Lmod"
                     /coded_by="NM_053106.2:198..1985"
                     /db_xref="CCDS:CCDS35718.1"
                     /db_xref="GeneID:93689"
                     /db_xref="MGI:MGI:2135671"
ORIGIN      
        1 mskvakyrrq vsedpdidsl lstlspeeme elekeldvvd pdgsipvglr qrnqtdkqps
       61 gsfnreamln fcekeskkli qremsvdesk qvgrktdakn geekdsdasr kapgprqdsd
      121 lgkepkkgvl kksfsrdree adgrggekpk eekvirgidk grvraavdrk esgkdgreer
      181 aaaarkeeek tgsvknagls rdkdkkkeev kepskkeevk ltaesrntvg rredgrlkes
      241 skenkkpede gigsggrdwr kedekvkkee nqpdkevree sktkapekqa pscpnkpsdg
      301 qaraeeeaap sifdeplekv knndpemtev nvnnsdcitn eilvrfteal efntvvkvfa
      361 lantraddhv afaiaimlka nktitslnld snhitgkgil aifrallqnn tltelrfhnq
      421 rhicggktem eiakllkent tllklgyhfe lagprmtvtn llsrnmdkqr qkrlqeqkqa
      481 qeasgekkdr levpkvgala kgspkpspqp spkpapknsp kkagvpaapp ppppplappl
      541 imenlknsls patqrkmgdk vlpaqeknsr dqllaairss nlkqlkkvev pkllq
//
