LOCUS       NM_201529               6109 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus LIM domain only 7 (Lmo7), transcript variant 1, mRNA.
ACCESSION   NM_201529 XM_001472577 XM_001480973
VERSION     NM_201529.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6109)
  AUTHORS   Duan,S., Lou,X., Chen,S., Jiang,H., Chen,D., Yin,R., Li,M., Gou,Y.,
            Zhao,W., Sun,L. and Qian,F.
  TITLE     Macrophage LMO7 deficiency facilitates inflammatory injury via
            metabolic-epigenetic reprogramming
  JOURNAL   Acta Pharm Sin B 13 (12), 4785-4800 (2023)
   PUBMED   38045056
REFERENCE   2  (bases 1 to 6109)
  AUTHORS   Gomes,G., do Amaral,M.J., Bagri,K.M., Vasconcellos,L.M.,
            Almeida,M.D.S., Alvares,L.E. and Mermelstein,C.
  TITLE     New Findings on LMO7 Transcripts, Proteins and Regulatory Regions
            in Human and Vertebrate Model Organisms and the Intracellular
            Distribution in Skeletal Muscle Cells
  JOURNAL   Int J Mol Sci 22 (23), 12885 (2021)
   PUBMED   34884689
  REMARK    GeneRIF: New Findings on LMO7 Transcripts, Proteins and Regulatory
            Regions in Human and Vertebrate Model Organisms and the
            Intracellular Distribution in Skeletal Muscle Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6109)
  AUTHORS   Guerin,A., Roy,N.H., Kugler,E.M., Berry,L., Burkhardt,J.K.,
            Shin,J.B. and Striepen,B.
  TITLE     Cryptosporidium rhoptry effector protein ROP1 injected during
            invasion targets the host cytoskeletal modulator LMO7
  JOURNAL   Cell Host Microbe 29 (9), 1407-1420 (2021)
   PUBMED   34348092
REFERENCE   4  (bases 1 to 6109)
  AUTHORS   Chen,Z.K., Chen,D.Z., Cai,C., Jin,L.L., Xu,J., Tu,Y.L., Huang,X.Z.,
            Xu,J.L., Chen,M.Z., Xue,F.B., Lan,X.L., Wang,X.D., Ge,Y.L., -L
            Sun,H. and Chen,Y.P.
  TITLE     BMSCs attenuate hepatic fibrosis in autoimmune hepatitis through
            regulation of LMO7-AP1-TGFbeta signaling pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 25 (3), 1600-1611 (2021)
   PUBMED   33629329
  REMARK    GeneRIF: BMSCs attenuate hepatic fibrosis in autoimmune hepatitis
            through regulation of LMO7-AP1-TGFbeta signaling pathway.
REFERENCE   5  (bases 1 to 6109)
  AUTHORS   Du,T.T., Dewey,J.B., Wagner,E.L., Cui,R., Heo,J., Park,J.J.,
            Francis,S.P., Perez-Reyes,E., Guillot,S.J., Sherman,N.E., Xu,W.,
            Oghalai,J.S., Kachar,B. and Shin,J.B.
  TITLE     LMO7 deficiency reveals the significance of the cuticular plate for
            hearing function
  JOURNAL   Nat Commun 10 (1), 1117 (2019)
   PUBMED   30850599
  REMARK    GeneRIF: A hair cell protein called LIM only protein 7 (LMO7) is
            specifically localized in the cuticular plate and the cell
            junction. Lmo7 KO mice suffer multiple cuticular plate
            deficiencies, including reduced filamentous actin density and
            abnormal stereociliar rootlets. In addition to the cuticular plate
            defects, older Lmo7 KO mice develop abnormalities in inner hair
            cell stereocilia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6109)
  AUTHORS   Lu,J., Izvolsky,K.I., Qian,J. and Cardoso,W.V.
  TITLE     Identification of FGF10 targets in the embryonic lung epithelium
            during bud morphogenesis
  JOURNAL   J Biol Chem 280 (6), 4834-4841 (2005)
   PUBMED   15556938
REFERENCE   7  (bases 1 to 6109)
  AUTHORS   Jin,J., Cardozo,T., Lovering,R.C., Elledge,S.J., Pagano,M. and
            Harper,J.W.
  TITLE     Systematic analysis and nomenclature of mammalian F-box proteins
  JOURNAL   Genes Dev 18 (21), 2573-2580 (2004)
   PUBMED   15520277
REFERENCE   8  (bases 1 to 6109)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   9  (bases 1 to 6109)
  AUTHORS   Semenova,E., Wang,X., Jablonski,M.M., Levorse,J. and Tilghman,S.M.
  TITLE     An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse
            chromosome 14 causes defects in viability, postnatal growth and
            degeneration of muscle and retina
  JOURNAL   Hum Mol Genet 12 (11), 1301-1312 (2003)
   PUBMED   12761045
REFERENCE   10 (bases 1 to 6109)
  AUTHORS   Kurihara,L.J., Semenova,E., Miller,W., Ingram,R.S., Guan,X.J. and
            Tilghman,S.M.
  TITLE     Candidate genes required for embryonic development: a comparative
            analysis of distal mouse chromosome 14 and human chromosome 13q22
  JOURNAL   Genomics 79 (2), 154-161 (2002)
   PUBMED   11829485
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025630.9, AC163658.2 and AC154477.2.
            
            On Sep 14, 2022 this sequence version replaced NM_201529.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF071857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               CT025630.9         174234-174524
            292-362             AC163658.2         66157-66227
            363-432             AC163658.2         79370-79439
            433-539             AC163658.2         112788-112894
            540-570             AC154477.2         147069-147099       c
            571-684             AC154477.2         145632-145745       c
            685-883             AC154477.2         141550-141748       c
            884-1136            AC154477.2         138137-138389       c
            1137-1418           AC154477.2         136979-137260       c
            1419-2138           AC154477.2         134895-135614       c
            2139-2168           AC154477.2         133845-133874       c
            2169-2286           AC154477.2         125967-126084       c
            2287-2429           AC154477.2         123852-123994       c
            2430-3003           AC154477.2         121907-122480       c
            3004-3309           AC154477.2         120182-120487       c
            3310-3424           AC154477.2         111671-111785       c
            3425-3586           AC154477.2         110391-110552       c
            3587-3693           AC154477.2         109205-109311       c
            3694-3754           AC154477.2         108214-108274       c
            3755-3811           AC154477.2         106807-106863       c
            3812-3837           AC154477.2         104895-104920       c
            3838-3942           AC154477.2         104507-104611       c
            3943-4035           AC154477.2         103847-103939       c
            4036-4478           AC154477.2         102900-103342       c
            4479-4544           AC154477.2         101997-102062       c
            4545-4597           AC154477.2         100402-100454       c
            4598-4811           AC154477.2         96242-96455         c
            4812-5087           AC154477.2         93100-93375         c
            5088-5196           AC154477.2         91271-91379         c
            5197-5299           AC154477.2         89879-89981         c
            5300-6109           AC154477.2         87846-88655         c
FEATURES             Location/Qualifiers
     source          1..6109
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 50.9 cM"
     gene            1..6109
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /note="LIM domain only 7"
                     /db_xref="GeneID:380928"
                     /db_xref="MGI:MGI:1353586"
     exon            1..291
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..5322
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="LIM domain only protein 7 isoform 1"
                     /protein_id="NP_963287.2"
                     /db_xref="CCDS:CCDS37001.1"
                     /db_xref="GeneID:380928"
                     /db_xref="MGI:MGI:1353586"
                     /translation="MEGMEDAEADCSVAFAEAQRWVEAVTEKNFETTDFRASLENGVL
                     LCDLINKLKPGVVKKINRLSTPIAGLDNINVFLRACEQIGLKEAQLFHPGDLQDLSNR
                     VTVKQEETDRRLKNVLITLYWLGRKAQSNPYYNGPYLNLKAFETLLGQALTKALEDSS
                     CLKRSGRDSGYGDIWCPDRGEFPAPPGSHRREDSFESLDSLGSRSLTSCSSDFTLRVG
                     KEGCESDIDWEFTFKMQDYNKDDMSYRRISAIEPKSALPFNRFLPNKSKQPSYVPAPL
                     RKKRPDKHEDNRRSWASPVYTETDGTFSSTQRRTWGPKMETWHTVQETSTSSWCVEEE
                     EEKLTRMPNIVKDDLYVRKLSPVMPSPGSSFDQFLPKCWTPEDMNWKKIKRETYKPWY
                     KEFQGFSQFLLLQALQTYSDDILSSETSVKLDPTSGPRLITRRKNRSPAPGYRAHDLE
                     LPALDPDLENDDFFVRKTGAFHANPCVLRAFEDFRSFSEPDDAVERDIILQCREGELV
                     LPDLEKDDMIVRRIPAQKKEVPLSGAPDRYQPVPFPEPWTLPPEIQAKFLSVLERTRP
                     PKEQSSGCRVLVPSYRQKKDDMLARKIQSWKLGTAVPPISFKPGPCSEADLQKWEAIW
                     EASRLRHRKRLMVERLFQKIYGENGSKSMSDVSAEDVQNLRQVRYEEMQKIKSQLKEQ
                     DQKWQDDLAKWKNRRKSYTSDLQKKKEEREEIEKQALEKSDRSSKTFREMLQDRESRG
                     STVTSWRRTYSSDDILDDGVLPPTVTLSETSYQSERLEDEARAHPAEMPKEDSTTFAN
                     REDSVVAETQLASHSPEEQRLAPSPSEEPRQASGSSAEPHQAPLLSTEPRRTPLPSEE
                     PHQASLSSTLQRPSSLSSQQSWSTRAESTRISASLPRSYQRTDTARLTSVVTARPFGT
                     SSRGISSLPRSYTMDDGWKYNGDVEVVKREQLDLGRATGPKPDSSHFISGSASEKEVI
                     ATEDVASLSSPTLPSSSLSHDRAVSSKATFSSMSGLDSVSDSGEGRGSPLREVSRSLD
                     QFSDMRVSINQTPGNKPVFGFTIKWDISGIFVASVEQGSPAEFSQLQVDDEILAINNT
                     KFSYKDTKKWEEVMANAQETGNLVMDVRRYGKSGSSETKWIDTTSGIYNSDKSSSLSV
                     TTDFSESLQSPYTESKEVNGIHEESNPFDSKASESISLKNLKRRSQFFEQGSSDSVAP
                     DLPVPTLSAPSRWAWDQEEERRRQERWQKEQDRLLQEKYQREQEKLREEWQRAQQEAE
                     RENSKYLDEELMVLNSNSISLTSREPVAATWEATWSEGSKSLDSEGTRAGEEDRGQLE
                     DDAVYEDQSQKLQELEQEKKRKEQEAQEEERRKQREAQAWAEAEAKAWAEAQARAEAE
                     AKARAEAQARAEAEAQKRAEAQKLQAERERETSVKIYQYRRPIDSYDLPKREDDTSGM
                     LPTDRSKSRSTTELNDPLIEKNGSSKYSERIGATSFSHRSSKKDQAPSEAELERQQIL
                     QEMRKRTSLHNDNSWIRQRSASVNKEPICLPGIMRRGESLDNLDSQRPGSWRQSPWHS
                     QPAGVYASSSVQDFSRPPPQLLSTSNRAYMRNPSSAVPPPAGSVKTSPGSPSPRSHSP
                     SMSQSGSQLRNRSVSGKRVCSYCNNILGKGAAMIIETLGLSYHLHCFKCVSCGCDLGG
                     SSSGAEVRIRNHQLYCNDCYLRFKSGRPTAM"
     exon            292..362
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            363..432
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            433..539
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            540..570
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            571..684
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            685..883
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1136
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1418
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..2138
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2168
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2286
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2429
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..3003
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3309
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3424
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3425..3586
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3693
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3694..3754
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3755..3811
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3812..3837
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..3942
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            3943..4035
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            4036..4478
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..4544
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            4545..4597
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4811
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            4812..5087
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            5088..5196
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            5197..5299
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     exon            5300..6109
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6071..6076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /note="hexamer: AATAAA"
     polyA_site      6109
                     /gene="Lmo7"
                     /gene_synonym="FBXO20; Gm914; mKIAA0858"
                     /note="major polyA site"
ORIGIN      
        1 cttctgcaca ccgcttccag ttgcctcttc acctcctcct gctccagtca ggctgaactt
       61 gagccgattt ctagagtttg gagaaagcaa ctcctgcaaa ttcttctagg ttcctgaact
      121 caaactgcac gtcgctacaa agggcggggg acgcgtggcg tgggagctct gggtcccggc
      181 gcgcacccac tgagctgctc ctctccctct cttgccctag acatggaagg gatggaggac
      241 gccgaggccg attgctctgt tgcattcgca gaggctcaga gatgggtgga ggctgtaact
      301 gagaagaatt ttgaaacaac ggattttcga gcctctctag aaaatggtgt tctgttgtgc
      361 gacttgatta ataagctcaa acctggcgtc gttaagaaga tcaatagact gtctacccca
      421 atagcaggtt tggataacat aaatgttttt ttgagagctt gtgaacagat tggattgaaa
      481 gaagcccagc tttttcatcc gggggatcta caggacttat caaaccgagt caccgtcaag
      541 caagaagaga ctgacaggag actgaaaaat gttttgataa ctttgtactg gctgggaaga
      601 aaagcacaaa gtaaccccta ctataatggt ccctatctca atttgaaagc ttttgagact
      661 cttttagggc aagctttgac taaggcactt gaagattcca gctgcctgaa aagaagtggc
      721 cgggacagtg gctacgggga catctggtgt cctgacagag gagaatttcc tgcccctcca
      781 ggtagccaca gaagggaaga ttcctttgag agcttggact cgctggggtc cagatctctg
      841 accagctgtt cctcagactt cactctgaga gttgggaagg aaggttgcga aagtgacatc
      901 gattgggaat ttacattcaa aatgcaggat tacaacaaag atgatatgtc ctaccgaagg
      961 atttcagcca ttgagccaaa gtcagctctc ccgttcaatc gtttcttgcc gaacaaaagc
     1021 aagcagccgt cctatgtgcc agcacctttg aggaagaaga ggccagacaa acacgaggat
     1081 aacaggagga gctgggcaag cccggtctac acagaaacag acggaacatt ttcaagtacc
     1141 cagaggagaa cctggggtcc caagatggag acctggcaca cagtccaaga aacttccacc
     1201 tcttcttggt gtgtagaaga ggaagaggaa aagctcacgc gcatgcccaa cattgtgaag
     1261 gatgatctgt atgtgcggaa gcttagcccc gtcatgccaa gtccagggag ctcttttgat
     1321 cagttccttc ccaaatgttg gactccagaa gatatgaact ggaaaaaaat taaaagagag
     1381 acttataagc catggtataa ggaatttcag ggattcagtc agtttttatt gcttcaggcc
     1441 ctccaaacct actctgatga catcttgtcc tcggaaacaa gtgtcaaact cgatcctacc
     1501 tctggcccca ggctcataac tcgcaggaag aatcgctctc ccgcaccagg ctatcgagcc
     1561 catgaccttg agctgccagc cctagatccc gacttagaaa atgatgattt ctttgtcaga
     1621 aaaacagggg ctttccatgc aaatccgtgt gtccttcgag cctttgaaga ctttagaagt
     1681 ttctcggagc cagacgatgc cgtggaacga gatataattt tgcagtgtcg ggaaggtgaa
     1741 ctcgtacttc cagatttaga aaaggatgat atgattgtcc gcaggattcc agctcagaag
     1801 aaagaagtgc ccctttctgg ggccccggat aggtaccagc cagtcccttt ccctgaaccc
     1861 tggaccctac ctccagaaat ccaagcgaag tttctctctg tgctcgaaag gacacgccca
     1921 cccaaagaac aaagcagcgg ctgtagagtg ttagtccctt cctatcgaca gaagaaagac
     1981 gacatgttgg ctcgcaagat ccagtcttgg aagctgggga ctgctgtacc tcccatcagt
     2041 ttcaagcctg gcccctgcag cgaggccgac ctgcagaagt gggaggccat ctgggaggcc
     2101 agcaggctta ggcacaggaa gcggctgatg gttgagagac tctttcaaaa gatctatggt
     2161 gagaatggga gcaagtccat gagcgatgtc agcgcagagg atgttcagaa cctgcgtcag
     2221 gtgcgctacg aggagatgca gaaaataaaa tcccagctga aagaacaaga tcagaaatgg
     2281 caggatgacc ttgcaaaatg gaaaaaccgc cggaagagtt acacttcaga tctgcagaag
     2341 aaaaaggaag agagggaaga gattgagaag caggcactgg agaagtctga ccgcagctcc
     2401 aagacattta gggaaatgct gcaggacagg gaatctcgag gttctacagt tacgtcttgg
     2461 aggaggacct attcctctga tgacatcctc gatgatggag tgctccctcc tacagtgact
     2521 ctgtcagaaa ctagttacca gagcgagaga ctagaagatg aggcaagagc gcatcctgct
     2581 gagatgccca aagaagattc cacaacattt gcaaatagag aggacagtgt agtagctgag
     2641 actcagcttg cttctcacag tcctgaagag caacgtctgg ccccttctcc ttctgaggaa
     2701 ccgcgccagg cctctggatc ttctgcagaa ccgcaccagg ccccgttgct gtccacagaa
     2761 ccacgccgga cccctttgcc ttccgaggaa ccacaccagg cctctctatc ttctacacta
     2821 cagcgtccat cctcactctc ttctcagcag tcatggagta caagagcaga gtccactcgg
     2881 atttcagctt ctctccctag aagttaccag agaaccgata cagccaggtt aacatctgtg
     2941 gtcacagcga gaccttttgg cacatcttca aggggaatct cctcactgcc cagatcctac
     3001 acgatggatg atggctggaa atacaacgga gatgttgaag ttgtcaagag agagcaactc
     3061 gatttgggca gagccactgg cccgaagcct gactccagcc actttatttc gggctcagcc
     3121 agtgagaagg aggtcatagc cacagaagat gtggcaagct tgtcctctcc cacactccct
     3181 tcctcatctc tctcccacga ccgggcagtc tcttccaaag ccacgttctc atcaatgtct
     3241 ggtttggatt cagtgtctga ctctggagaa ggaagaggct caccattgag ggaagtttcc
     3301 aggtccctgg atcagttcag cgatatgaga gtcagcataa accagacgcc cgggaacaaa
     3361 cctgtctttg ggtttacgat aaaatgggat atttctggga tcttcgtagc atcagtcgaa
     3421 caaggtagcc cagcagaatt ttctcagctg caggtagatg atgaaattct tgccatcaat
     3481 aacaccaagt tttcatataa ggatacaaaa aagtgggagg aagttatggc aaacgcccaa
     3541 gaaactggaa acttagtgat ggacgtccgg cgttacggaa agtctggttc atctgaaaca
     3601 aagtggatcg atacaacatc aggaatttac aactcagaca agtcttcaag tttatcagtc
     3661 acaactgatt tctctgaaag ccttcagagt ccttatactg aatccaaaga agtcaatgga
     3721 attcacgagg aaagtaaccc ctttgattca aaagcatcag aatccatttc tttgaaaaat
     3781 ttaaaaaggc gatcacaatt ttttgaacaa ggaagctcgg attctgtggc ccccgatctt
     3841 ccagttccaa ccctcagtgc cccgagtcgc tgggcttggg atcaagagga ggagagacgg
     3901 aggcaggagc ggtggcagaa agagcaagat cgcctattgc aggaaaaata ccagcgtgag
     3961 caggagaagc tgagggagga gtggcagaga gcccaacagg aggcggagag agagaattcc
     4021 aagtacctgg atgaggagct gatggtccta aattccaaca gcatttctct gacctcccgg
     4081 gagcctgtgg ccgccacctg ggaagccacg tggagtgaag ggtccaagtc tctggacagc
     4141 gaaggcaccc gagcgggaga ggaggacagg ggacagctgg aagacgatgc tgtgtatgag
     4201 gaccaaagtc agaagctgca ggaacttgag caggagaaga aacggaagga gcaagaggct
     4261 caggaagagg agcgccgcaa gcagcgggag gcccaggcct gggcagaggc agaagctaag
     4321 gcttgggcgg aggcccaggc tcgggcagag gcagaagcta aggctcgggc ggaggcccag
     4381 gcccgggcag aggctgaggc tcaaaaacga gctgaagctc agaagctcca ggcagagagg
     4441 gaacgtgaaa cgtccgtcaa aatataccag taccgaaggc ccattgattc ctacgaccta
     4501 ccaaagagag aagacgacac ttcagggatg cttccaactg acaggagtaa atcaagatct
     4561 actacggaac taaatgaccc cctcatagag aaaaatggaa gcagcaaata ttcagagaga
     4621 attggggcca ctagcttttc acataggagt tctaagaagg atcaagcccc ctcagaagca
     4681 gagttggaga gacagcaaat ccttcaggaa atgaggaaga gaacatctct ccacaatgac
     4741 aacagctgga tccgacagcg cagcgccagt gtgaacaagg agcccatctg cctgcctggg
     4801 atcatgagga gaggggagtc tctggacaat ctggattccc agcggccggg ttcttggagg
     4861 cagtcccctt ggcacagcca gcctgccggg gtctatgcgt cttcctctgt ccaggacttc
     4921 agtcgccccc cacctcagct gttgtctaca tcaaaccgtg cctacatgcg gaacccatcc
     4981 tctgcggtgc cacctccagc cggctctgtg aagacctccc cagggtctcc ctctccacgc
     5041 agccattccc cttccatgtc acagtcaggc tctcagctac ggaataggtc agtgagtggg
     5101 aagcgtgtgt gctcctactg taataacatt ctgggcaaag gagccgccat gatcatcgag
     5161 accctgggtc tttcttatca tttacattgt tttaagtgtg tctcctgtgg gtgtgacctc
     5221 ggaggctctt cctcaggagc tgaagtcaga atccgaaacc accaactcta ctgcaatgac
     5281 tgctatctcc gattcaaatc tggacggcca accgccatgt gatgtaaacc cccattcgaa
     5341 agcgctgttg cagatagaag aggaggcgct tgtcactgat gcagagctat aaaaaaaaaa
     5401 atgctggatg gttttttccc ctcttttttt tttttaaagg aataatcatt gcctcgttaa
     5461 atgacatagg aacactgtgg tgttggtagg acctgtattt ttgttgttta tttataagaa
     5521 ggtaattatg tgtgtgtgtg tggggggggg aggagtgcag tattgacctt ttaaattcag
     5581 catcctaaaa gcacaagtgg aaaagaaaac taaacaaagc tcaagaactt aaaatccttc
     5641 tcatactcat atgattaatg atctcgtttg actctctagt ggtttttcga agaaggtatt
     5701 ttattttaat tttttaagtt cttaaacatt atttgaaata gttaatataa atgtgtaact
     5761 gtgtttgttt attataatgt attctaagtt aatgtggatc catatgaaaa atttcactta
     5821 aatccactca taaatttgct tcttttgtgg ttttctttac acggaaataa tccaattgaa
     5881 aaataatttt gcctctctgt aatgttttat tggtttgagg agggcactca attttcttta
     5941 caaggactgt tgatgctaag caaatgccag gagagggctg tttactttca gtaatgaaaa
     6001 atatccatgg cttgtatacc agtgatttcc tccagaaaca cgtgagctct tctgttccgc
     6061 tgcctttgta aataaacttg gtgatgcatt taaggaatgc tttttaaaa
//
