LOCUS       NM_010723               1704 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus LIM domain only 4 (Lmo4), transcript variant 1, mRNA.
ACCESSION   NM_010723
VERSION     NM_010723.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1704)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   2  (bases 1 to 1704)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   3  (bases 1 to 1704)
  AUTHORS   Sinclair-Wilson,A., Lawrence,A., Ferezou,I., Cartonnet,H.,
            Mailhes,C., Garel,S. and Lokmane,L.
  TITLE     Plasticity of thalamocortical axons is regulated by serotonin
            levels modulated by preterm birth
  JOURNAL   Proc Natl Acad Sci U S A 120 (33), e2301644120 (2023)
   PUBMED   37549297
REFERENCE   4  (bases 1 to 1704)
  AUTHORS   Felske,T., Tocco,C., Peron,S., Harb,K., Alfano,C., Galante,C.,
            Berninger,B. and Studer,M.
  TITLE     Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming
            of upper layer cortical neurons and cortical glia towards
            deep-layer neuron identities
  JOURNAL   PLoS Biol 21 (8), e3002237 (2023)
   PUBMED   37552690
  REMARK    GeneRIF: Lmo4 synergizes with Fezf2 to promote direct in vivo
            reprogramming of upper layer cortical neurons and cortical glia
            towards deep-layer neuron identities.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1704)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1704)
  AUTHORS   Grutz,G., Forster,A. and Rabbitts,T.H.
  TITLE     Identification of the LMO4 gene encoding an interaction partner of
            the LIM-binding protein LDB1/NLI1: a candidate for displacement by
            LMO proteins in T cell acute leukaemia
  JOURNAL   Oncogene 17 (21), 2799-2803 (1998)
   PUBMED   9840944
REFERENCE   7  (bases 1 to 1704)
  AUTHORS   Jain,M.K., Kashiki,S., Hsieh,C.M., Layne,M.D., Yet,S.F.,
            Sibinga,N.E., Chin,M.T., Feinberg,M.W., Woo,I., Maas,R.L., Haber,E.
            and Lee,M.E.
  TITLE     Embryonic expression suggests an important role for CRP2/SmLIM in
            the developing cardiovascular system
  JOURNAL   Circ Res 83 (10), 980-985 (1998)
   PUBMED   9815145
REFERENCE   8  (bases 1 to 1704)
  AUTHORS   Kenny,D.A., Jurata,L.W., Saga,Y. and Gill,G.N.
  TITLE     Identification and characterization of LMO4, an LMO gene with a
            novel pattern of expression during embryogenesis
  JOURNAL   Proc Natl Acad Sci U S A 95 (19), 11257-11262 (1998)
   PUBMED   9736723
REFERENCE   9  (bases 1 to 1704)
  AUTHORS   Baumeister,A., Arber,S. and Caroni,P.
  TITLE     Accumulation of muscle ankyrin repeat protein transcript reveals
            local activation of primary myotube endcompartments during muscle
            morphogenesis
  JOURNAL   J Cell Biol 139 (5), 1231-1242 (1997)
   PUBMED   9382869
REFERENCE   10 (bases 1 to 1704)
  AUTHORS   Rout,U.K., Krawetz,S.A. and Armant,D.R.
  TITLE     Ethanol-induced intracellular calcium mobilization rapidly alters
            gene expression in the mouse blastocyst
  JOURNAL   Cell Calcium 22 (6), 463-474 (1997)
   PUBMED   9502196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123883.10 and AK080534.1.
            
            On Jun 16, 2009 this sequence version replaced NM_010723.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010278.1, AK159590.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               AC123883.10        103252-103604       c
            354-1184            AK080534.1         2-832
            1185-1704           AC123883.10        86879-87398         c
FEATURES             Location/Qualifiers
     source          1..1704
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 68.61 cM"
     gene            1..1704
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /note="LIM domain only 4"
                     /db_xref="GeneID:16911"
                     /db_xref="MGI:MGI:109360"
     exon            1..436
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /inference="alignment:Splign:2.1.0"
     exon            437..675
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..937
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /note="LMO-4; breast tumor autoantigen; LIM domain only
                     protein 4; ethanol induced 4"
                     /codon_start=1
                     /product="LIM domain transcription factor LMO4"
                     /protein_id="NP_034853.1"
                     /db_xref="CCDS:CCDS51085.1"
                     /db_xref="GeneID:16911"
                     /db_xref="MGI:MGI:109360"
                     /translation="MVNPGSSSQPPPVTAGSLSWKRCAGCGGKIADRFLLYAMDSYWH
                     SRCLKCSCCQAQLGDIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMR
                     AQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLP
                     DQKVC"
     exon            676..772
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /inference="alignment:Splign:2.1.0"
     exon            773..928
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1704
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1457..1462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /note="hexamer: AATACA"
     polyA_site      1475
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /note="major polyA site"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /note="hexamer: AATAAA"
     polyA_site      1695
                     /gene="Lmo4"
                     /gene_synonym="A730077C12Rik; Crp3; Etohi4"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggagg agcgcgggcg cggcgggggc gggggcgcgt acaaagtgaa gccacattgc
       61 caaacttgca gccgcgattg cagcagtggc tgctgctgcg ccgcgcgggc ccggccgagg
      121 gagcctgcag ctgctcgcgc gcagccgggg gctgaggacc gggaccctcg ggctgagact
      181 tgacacttct tcgccgggcc gcctgccact tagcgtgggg ctccctctac ccgccccaga
      241 gccacgcgat taaaaaaaaa aaaaaaaaaa aaagcagccc ttagccccct cctccccttt
      301 cctgcttctg cgagaactcc ctccctccct ccagctccgc cagccccagc gcccctgccc
      361 tggaagccga gcggctccgc tcgcatttcg ccgccgccgc cgcctctcgc agtgttgcaa
      421 tataggggag aagcagacca tggtgaatcc gggcagcagc tcgcagccgc ccccggtgac
      481 ggccggctcc ctctcctgga agcgctgcgc aggctgcggg ggcaagatcg cggaccgctt
      541 tctgctctat gccatggaca gctactggca tagccgctgc ctcaagtgct cctgctgcca
      601 ggcgcagctg ggcgacattg gcacgtcctg ttacaccaag agcggcatga tcctttgcag
      661 aaatgactac attaggttat ttgggaatag cggtgcttgc agtgcctgtg gacagtcgat
      721 tcctgcaagt gagctcgtca tgagggccca aggcaacgtg tatcatctca agtgtttcac
      781 atgttctacc tgccggaatc gcctggtccc gggagatcgg tttcactaca tcaatggcag
      841 tttattttgt gaacatgata gacccacagc cctcatcaat ggccatttga attcacttca
      901 gagcaatcca ctactgccag accagaaggt ctgctgagag gtcagagtaa tgcagaatgc
      961 gtgccttcat ctcagaattg ctcatcccag gtggatccca tgtgtctgca gtagaccagt
     1021 cacctttgta gccagcacca tgccatcgcg ccccctttag tcttgagtac ccttcctgca
     1081 tttattggtg tattaaaatg actgaatatg aacattaagg actccatgaa cctgggctaa
     1141 tgggagatgg tagcgaggat gaaaaaagat ccaccgaagg acatctaggg gggagggtgc
     1201 ttgggggggg gagggaaatg actaatgaag ctaattaaac gaagcatcac caatctgctt
     1261 tctaccctca ttaacaatta gcagggcccc ggccagagtg tgagccctgt tttactttaa
     1321 caacattctg tttgctcttt gtatatttaa gtgttgtaat gaaatgtgtt tcaatcaacc
     1381 tgaacatgag ttaaaaggaa agagatgtgg cttttgtgat aattctatca caaacacttt
     1441 tattgtatct ctgtaaaata caatgtatgt atgcatgtga gtgttcttgt cctgatgttg
     1501 ctccgcccat gacaaaggtt aaaaaaaaaa aaagaaaaga agaaaaaaaa atgaggctca
     1561 tagccgctac tatgtagaaa tcccccctac ttctaatttg ctgaatgaag aaaaaaatct
     1621 tttatttgtg atattttcag agacatttgc tctagtatgg tgtatttaaa taataaaaac
     1681 ttaaaagaaa aaatattcaa caga
//
