LOCUS       NM_001356307            3640 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus LIM domain only 3 (Lmo3), transcript variant 6, mRNA.
ACCESSION   NM_001356307 XM_006505339
VERSION     NM_001356307.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3640)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   2  (bases 1 to 3640)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
  REMARK    GeneRIF: The transcription regulator Lmo3 is required for the
            development of medial ganglionic eminence derived neurons in the
            external globus pallidus.
REFERENCE   3  (bases 1 to 3640)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   4  (bases 1 to 3640)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   5  (bases 1 to 3640)
  AUTHORS   Wagner,G., Fenzl,A., Lindroos-Christensen,J., Einwallner,E.,
            Husa,J., Witzeneder,N., Rauscher,S., Groger,M., Derdak,S., Mohr,T.,
            Sutterluty,H., Klinglmuller,F., Wolkerstorfer,S., Fondi,M.,
            Hoermann,G., Cao,L., Wagner,O., Kiefer,F.W., Esterbauer,H. and
            Bilban,M.
  TITLE     LMO3 reprograms visceral adipocyte metabolism during obesity
  JOURNAL   J Mol Med (Berl) 99 (8), 1151-1171 (2021)
   PUBMED   34018016
  REMARK    GeneRIF: LMO3 reprograms visceral adipocyte metabolism during
            obesity.
REFERENCE   6  (bases 1 to 3640)
  AUTHORS   Parganas,E., Wang,D., Stravopodis,D., Topham,D.J., Marine,J.C.,
            Teglund,S., Vanin,E.F., Bodner,S., Colamonici,O.R., van
            Deursen,J.M., Grosveld,G. and Ihle,J.N.
  TITLE     Jak2 is essential for signaling through a variety of cytokine
            receptors
  JOURNAL   Cell 93 (3), 385-395 (1998)
   PUBMED   9590173
REFERENCE   7  (bases 1 to 3640)
  AUTHORS   Isomoto,S., Horio,Y., Matsumoto,S., Kondo,C., Yamada,M.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Kurachi,Y.
  TITLE     Sur2 and Kcnj8 genes are tightly linked on the distal region of
            mouse chromosome 6
  JOURNAL   Mamm Genome 8 (10), 790-791 (1997)
   PUBMED   9321483
REFERENCE   8  (bases 1 to 3640)
  AUTHORS   Hinks,G.L., Shah,B., French,S.J., Campos,L.S., Staley,K., Hughes,J.
            and Sofroniew,M.V.
  TITLE     Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse
            hippocampus and other forebrain regions: differential regulation by
            seizure activity
  JOURNAL   J Neurosci 17 (14), 5549-5559 (1997)
   PUBMED   9204936
REFERENCE   9  (bases 1 to 3640)
  AUTHORS   Nagasawa,M., Sakimura,K., Mori,K.J., Bedell,M.A., Copeland,N.G.,
            Jenkins,N.A. and Mishina,M.
  TITLE     Gene structure and chromosomal localization of the mouse NMDA
            receptor channel subunits
  JOURNAL   Brain Res Mol Brain Res 36 (1), 1-11 (1996)
   PUBMED   9011744
REFERENCE   10 (bases 1 to 3640)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121968.3 and AC125215.4.
            
            On Aug 26, 2022 this sequence version replaced NM_001356307.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2425455.1,
                                           ERR3363658.4646766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AC121968.3         33533-33702         c
            171-384             AC121968.3         28728-28941         c
            385-510             AC125215.4         199494-199619       c
            511-3640            AC125215.4         185212-188341       c
FEATURES             Location/Qualifiers
     source          1..3640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 69.02 cM"
     gene            1..3640
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /note="LIM domain only 3"
                     /db_xref="GeneID:109593"
                     /db_xref="MGI:MGI:102810"
     exon            1..170
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..616
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /note="isoform 2 is encoded by transcript variant 6; LIM
                     domain only protein 3; neuronal-specific transcription
                     factor DAT1; LIM only 3"
                     /codon_start=1
                     /product="LIM domain only protein 3 isoform 2"
                     /protein_id="NP_001343236.1"
                     /db_xref="CCDS:CCDS90132.1"
                     /db_xref="GeneID:109593"
                     /db_xref="MGI:MGI:102810"
                     /translation="MQKQEKSFGIQMLSVQPDTKPKGCAGCNRKIKDRYLLKALDKYW
                     HEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGVTGNCAACSKLIPAFEMVM
                     RAKDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQTDYEEGLMKEGYAPQVR"
     exon            171..384
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            385..510
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            511..3640
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3620..3625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /note="hexamer: AATAAA"
     polyA_site      3640
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /note="major polyA site"
ORIGIN      
        1 acaatagtgg atcctgggcc ctgcatgctg ctcaccagat ccacgcttgg gccccagatc
       61 cgagtgattc ccttttctac tctctgcctc cgggcttggt gctccatgcg aagctgcagc
      121 gactcaggca cgcctcagtc aactcatgca gaaacaagag aaaagttttg gcatacaaat
      181 gctctcagtt cagccagaca ccaagccaaa aggttgtgct ggctgcaacc gaaaaatcaa
      241 ggaccggtat ctcctaaagg cactggacaa atactggcat gaggactgcc tgaagtgtgc
      301 ctgctgcgac tgccgtttgg gagaggtggg ctccaccttg tacacgaagg ctaaccttat
      361 cctttgtcgc agagactatc tgaggctgtt tggtgtaacg ggaaactgcg ctgcctgtag
      421 caagctcatc cctgcctttg agatggtgat gcgtgccaag gataatgtgt accacctgga
      481 ctgctttgcc tgtcagcttt gcaatcagag attttgtgtc ggagacaaat ttttcttaaa
      541 gaacaatatg attctttgcc agacagacta cgaggaaggc ctcatgaaag aaggctatgc
      601 accccaggtc cgctgagccc gcagcagcgt ctccccaaca atgcaaagca ctacatcctt
      661 ttatcttttt tgctcacgtg tatataagaa tcaatcgaca caggaacctg ctgaataggg
      721 tagcggtagg tgagcaggat ggccatgtgg aggagaaggt ggactgcatc tgtatgtagt
      781 gaaattgccc ccgttcaaga gttgaatgtt cattattaaa gagagaagta atgtatatat
      841 tgctggattt ttttgcctgc cattcgtttt tttgtgtcac ttggcatgag atgtttattt
      901 tggactattg tatataatgt attgtaaatc caaagcacaa atgtaataca gttttattgt
      961 gttaccattt gtgtttggtt tgcttctttg tattgttgca tttagtacaa tcagtgtttc
     1021 aacttactgt acatttatgc tttctgtgtc tgccagctat tttcagcgag ctgtaccttt
     1081 ctagtaagaa ttgaagagca aacctccaca atgacacaca gatgaagcaa gactatcgac
     1141 gttagaaagg caaaaataag caagtaaaca aacaaaaaag cagttagtga catctgcttc
     1201 ttacggctac aacagcttgg tgtagcgccg cgttcttgtc ataaccccct attttcaggg
     1261 ggctaaagat cagctttaaa aaatgataac gatttcagct taaagcactt tcgttttatg
     1321 ccaacgtgaa aagtgccatt cttaaaatga ctttaaagct tagtgacgtc ctccaatgtc
     1381 ctttaccgag ctccttacca tcactattag atttattcta cttttgtttt tccagccaca
     1441 cgccctattt gaactagtgc ctttgggtag catgtgaaca acttccaaag ggttattcta
     1501 aatgagaacg gtattacccc agtcacgaca taatttaaaa gttttcaact tcttgtgtaa
     1561 atgttgtcca gatttctccc taggagatga gggctttgtg tccgtggtta atgagctgat
     1621 ggcccggaac aggcttgagg gtgcgtctcc tgaagtcggg atgctgccca ctgaaattct
     1681 gatggctgag tcgccctggg atctgctcac agccttggaa ctgtctgtac agaaaccgag
     1741 aagagaagta gagagattgg taaaaagttg agagctgctt ggtgatgatg tatttcgcct
     1801 gccatttact ttaatcttta aaacactttg aatttgctgt cacacttcct cggtccctcc
     1861 tgatcactgc catcttccaa ctcagattat gtaacacttg ggctaaaatc tatccccttt
     1921 attattatta ttattattat tattattatt tcattttgtt ttttaatggt gtttccccct
     1981 tatttaaatg atagctgatg aagaagaatg ttctagaaac agaaactgtg ggaaatgatt
     2041 acttaaattg caattaagga aataaaacca agaatacagc ttcctcttct gctcacactc
     2101 tgttcatttt gcattgtgca gtgagaccac tttgcaaacc cactccatac agacacagtg
     2161 taccgtattt gctcccaaga aaagtcaaca ctgcggtttt acttagtttg ttctccattg
     2221 ttgtacagga aatatctccc actgttactt gtattaacca tttccccagc cagtgtccct
     2281 gttacagatg gtgattaaat gccatcccga cattcttggt ctggggccaa aatctaatct
     2341 gaaatcggtg ctggtgtggc tttgagtcat ttcgaagcat gagtttatta ggagaacata
     2401 tgaggatctt aatgtcacct tttgcagaaa caaaaggttc tgtaaaaatt gaataataag
     2461 catattttgt aaatgcctca ttgtgaagaa tgtgaaactc ccacatgccc aaattcgagg
     2521 tagaatgaag aattgcaaag ctgtcctctt gtggtccgca agacgatcct cactgctctc
     2581 tcagccccac aaacttgctt tgtgattagc tatgacagta aaatacacaa aacaaaacct
     2641 ggaagagaga agatacagag ggcgggtgtg ggggagatgc aagcaagaag tagtttctaa
     2701 tacacagccc tgctagttcc tgctaatagt tatttaaggt tttacataaa gtctgtctac
     2761 atatttttca aatgatcctc agtttttccc atcaaaatga gttttcagat tgtctctgac
     2821 aggtcaaaac gtgtgtcggt ggaaacaaac ttttctcagt ttctgaaagc tcttcagcta
     2881 tccttgcctt gcccaaacca aacaggatct acattgcttt ggcttaattt ggggggaaat
     2941 tgttcacctg gattaaaagc taaagcctta atcttttttg attatcttta atctccatga
     3001 aattgtgaac caagaaaagg ggtaattttc cagctgtaag gtgtttccca gctacttggc
     3061 cacagttagt agcatttttt tttgacatga agcattaagt tagttttgct gagaactcgg
     3121 ggcccctgat tttgcctcaa ttcttctctt tgtgttgtgc agcccttgtg tcatggtatc
     3181 tgatgctgtg gtcagacgcc tgccacagtt ttgatttctc aggctgggga agttgtcctc
     3241 ctagcatctc tgcaggctac ttctgacgag gggccagtca acccccatcc caccagcttg
     3301 ctcagcttaa gggacgacca acgtttgtga cttcactttc atcttgctta ataaagatct
     3361 ggactctttt attattatta ttttttgttt aatttggatt catgtttaca atcaatcact
     3421 gttgattgcg cttaactggc aaagacgaag gtggtctgaa gaaagcatgt gctgtccaca
     3481 ggaaaatgca accttatgtc cctctctaaa cccaaatccc aacaagcctg aggaagccat
     3541 agcagctgct cctttccctg agactgctgg agattcctga aggaggaggc tctctgccat
     3601 tgtacttatg tgagaaataa ataaaattgt ccgaaatgaa
//
