LOCUS       NP_001343236             156 aa            linear   ROD 07-DEC-2024
DEFINITION  LIM domain only protein 3 isoform 2 [Mus musculus].
ACCESSION   NP_001343236 XP_006505402
VERSION     NP_001343236.1
DBSOURCE    REFSEQ: accession NM_001356307.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 156)
  AUTHORS   Deska-Gauthier,D., Borowska-Fielding,J., Jones,C., Zhang,H.,
            MacKay,C.S., Michail,R., Bennett,L.A., Bikoff,J.B. and Zhang,Y.
  TITLE     Embryonic temporal-spatial delineation of excitatory spinal V3
            interneuron diversity
  JOURNAL   Cell Rep 43 (1), 113635 (2024)
   PUBMED   38160393
REFERENCE   2  (residues 1 to 156)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
  REMARK    GeneRIF: The transcription regulator Lmo3 is required for the
            development of medial ganglionic eminence derived neurons in the
            external globus pallidus.
REFERENCE   3  (residues 1 to 156)
  AUTHORS   Su-Feher,L., Rubin,A.N., Silberberg,S.N., Catta-Preta,R., Lim,K.J.,
            Ypsilanti,A.R., Zdilar,I., McGinnis,C.S., McKinsey,G.L.,
            Rubino,T.E. Jr., Hawrylycz,M.J., Thompson,C., Gartner,Z.J.,
            Puelles,L., Zeng,H., Rubenstein,J.L.R. and Nord,A.S.
  TITLE     Single cell enhancer activity distinguishes GABAergic and
            cholinergic lineages in embryonic mouse basal ganglia
  JOURNAL   Proc Natl Acad Sci U S A 119 (15), e2108760119 (2022)
   PUBMED   35377797
REFERENCE   4  (residues 1 to 156)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   5  (residues 1 to 156)
  AUTHORS   Wagner,G., Fenzl,A., Lindroos-Christensen,J., Einwallner,E.,
            Husa,J., Witzeneder,N., Rauscher,S., Groger,M., Derdak,S., Mohr,T.,
            Sutterluty,H., Klinglmuller,F., Wolkerstorfer,S., Fondi,M.,
            Hoermann,G., Cao,L., Wagner,O., Kiefer,F.W., Esterbauer,H. and
            Bilban,M.
  TITLE     LMO3 reprograms visceral adipocyte metabolism during obesity
  JOURNAL   J Mol Med (Berl) 99 (8), 1151-1171 (2021)
   PUBMED   34018016
  REMARK    GeneRIF: LMO3 reprograms visceral adipocyte metabolism during
            obesity.
REFERENCE   6  (residues 1 to 156)
  AUTHORS   Parganas,E., Wang,D., Stravopodis,D., Topham,D.J., Marine,J.C.,
            Teglund,S., Vanin,E.F., Bodner,S., Colamonici,O.R., van
            Deursen,J.M., Grosveld,G. and Ihle,J.N.
  TITLE     Jak2 is essential for signaling through a variety of cytokine
            receptors
  JOURNAL   Cell 93 (3), 385-395 (1998)
   PUBMED   9590173
REFERENCE   7  (residues 1 to 156)
  AUTHORS   Isomoto,S., Horio,Y., Matsumoto,S., Kondo,C., Yamada,M.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Kurachi,Y.
  TITLE     Sur2 and Kcnj8 genes are tightly linked on the distal region of
            mouse chromosome 6
  JOURNAL   Mamm Genome 8 (10), 790-791 (1997)
   PUBMED   9321483
REFERENCE   8  (residues 1 to 156)
  AUTHORS   Hinks,G.L., Shah,B., French,S.J., Campos,L.S., Staley,K., Hughes,J.
            and Sofroniew,M.V.
  TITLE     Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse
            hippocampus and other forebrain regions: differential regulation by
            seizure activity
  JOURNAL   J Neurosci 17 (14), 5549-5559 (1997)
   PUBMED   9204936
REFERENCE   9  (residues 1 to 156)
  AUTHORS   Nagasawa,M., Sakimura,K., Mori,K.J., Bedell,M.A., Copeland,N.G.,
            Jenkins,N.A. and Mishina,M.
  TITLE     Gene structure and chromosomal localization of the mouse NMDA
            receptor channel subunits
  JOURNAL   Brain Res Mol Brain Res 36 (1), 1-11 (1996)
   PUBMED   9011744
REFERENCE   10 (residues 1 to 156)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121968.3 and AC125215.4.
            
            On Sep 28, 2017 this sequence version replaced XP_006505402.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363660.2425455.1,
                                           ERR3363658.4646766.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..156
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 69.02 cM"
     Protein         1..156
                     /product="LIM domain only protein 3 isoform 2"
                     /note="LIM domain only protein 3; neuronal-specific
                     transcription factor DAT1; LIM only 3"
                     /calculated_mol_wt=17768
     Region          24..78
                     /region_name="LIM1_LMO1_LMO3"
                     /note="The first LIM domain of LMO1 and LMO3 (LIM domain
                     only protein 1 and 3); cd09388"
                     /db_xref="CDD:188774"
     Site            order(24,27,45,48,51,54,74,77)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188774"
     Region          88..142
                     /region_name="LIM2_LMO1_LMO3"
                     /note="The second LIM domain of LMO1 and LMO3 (LIM domain
                     only protein 1 and 3); cd09389"
                     /db_xref="CDD:188775"
     Site            order(88,91,110,113,116,119,138,141)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188775"
     CDS             1..156
                     /gene="Lmo3"
                     /gene_synonym="Lmo-3; Rbtn-3; Rbtn3"
                     /coded_by="NM_001356307.2:146..616"
                     /note="isoform 2 is encoded by transcript variant 6"
                     /db_xref="CCDS:CCDS90132.1"
                     /db_xref="GeneID:109593"
                     /db_xref="MGI:MGI:102810"
ORIGIN      
        1 mqkqeksfgi qmlsvqpdtk pkgcagcnrk ikdryllkal dkywhedclk caccdcrlge
       61 vgstlytkan lilcrrdylr lfgvtgncaa csklipafem vmrakdnvyh ldcfacqlcn
      121 qrfcvgdkff lknnmilcqt dyeeglmkeg yapqvr
//
