LOCUS       NM_008505               1646 bp    mRNA    linear   ROD 28-MAR-2023
DEFINITION  Mus musculus LIM domain only 2 (Lmo2), transcript variant 1, mRNA.
ACCESSION   NM_008505 XM_001001351
VERSION     NM_008505.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1646)
  AUTHORS   Abdulla HD, Alserihi R, Flensburg C, Abeysekera W, Luo MX, Gray
            DHD, Liu X, Smyth GK, Alexander WS, Majewski IJ and McCormack MP.
  TITLE     Overexpression of Lmo2 initiates T-lymphoblastic leukemia via
            impaired thymocyte competition
  JOURNAL   J Exp Med 220 (6) (2023)
   PUBMED   36920307
  REMARK    GeneRIF: Overexpression of Lmo2 initiates T-lymphoblastic leukemia
            via impaired thymocyte competition.
REFERENCE   2  (bases 1 to 1646)
  AUTHORS   Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR,
            Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O
            and Maynard C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   3  (bases 1 to 1646)
  AUTHORS   Yamada Y, Zhong Y, Miki S, Taura A and Rabbitts TH.
  TITLE     The transcription factor complex LMO2/TAL1 regulates branching and
            endothelial cell migration in sprouting angiogenesis
  JOURNAL   Sci Rep 12 (1), 7226 (2022)
   PUBMED   35508511
  REMARK    GeneRIF: The transcription factor complex LMO2/TAL1 regulates
            branching and endothelial cell migration in sprouting angiogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1646)
  AUTHORS   Hirano KI, Hosokawa H, Koizumi M, Endo Y, Yahata T, Ando K and
            Hozumi K.
  TITLE     LMO2 is essential to maintain the ability of progenitors to
            differentiate into T-cell lineage in mice
  JOURNAL   Elife 10, e68227 (2021)
   PUBMED   34382935
  REMARK    GeneRIF: LMO2 is essential to maintain the ability of progenitors
            to differentiate into T-cell lineage in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1646)
  AUTHORS   La Manno G, Siletti K, Furlan A, Gyllborg D, Vinsland E, Mossi
            Albiach A, Mattsson Langseth C, Khven I, Lederer AR, Dratva LM,
            Johnsson A, Nilsson M, Lonnerberg P and Linnarsson S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   6  (bases 1 to 1646)
  AUTHORS   Neale GA, Rehg JE and Goorha RM.
  TITLE     Ectopic expression of rhombotin-2 causes selective expansion of
            CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic
            mice
  JOURNAL   Blood 86 (8), 3060-3071 (1995)
   PUBMED   7579400
REFERENCE   7  (bases 1 to 1646)
  AUTHORS   Osada H, Grutz G, Axelson H, Forster A and Rabbitts TH.
  TITLE     Association of erythroid transcription factors: complexes involving
            the LIM protein RBTN2 and the zinc-finger protein GATA1
  JOURNAL   Proc Natl Acad Sci U S A 92 (21), 9585-9589 (1995)
   PUBMED   7568177
REFERENCE   8  (bases 1 to 1646)
  AUTHORS   Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey RP, Metcalf D
            and Begley CG.
  TITLE     Absence of yolk sac hematopoiesis from mice with a targeted
            disruption of the scl gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (15), 7075-7079 (1995)
   PUBMED   7624372
REFERENCE   9  (bases 1 to 1646)
  AUTHORS   Foroni L, Boehm T, White L, Forster A, Sherrington P, Liao XB,
            Brannan CI, Jenkins NA, Copeland NG and Rabbitts TH.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   10 (bases 1 to 1646)
  AUTHORS   Boehm T, Foroni L, Kaneko Y, Perutz MF and Rabbitts TH.
  TITLE     The rhombotin family of cysteine-rich LIM-domain oncogenes:
            distinct members are involved in T-cell translocations to human
            chromosomes 11p15 and 11p13
  JOURNAL   Proc Natl Acad Sci U S A 88 (10), 4367-4371 (1991)
   PUBMED   2034676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB864414.1, W76814.1, AK013416.1, BX523983.1 and AV361906.1.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_008505.5.
            
            On Nov 27, 2008 this sequence version replaced NM_008505.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057880.1, BG293022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               BB864414.1         4-262
            260-580             W76814.1           142-462
            581-1520            AK013416.1         612-1551
            1521-1589           BX523983.1         421-489
            1590-1646           AV361906.1         209-265
FEATURES             Location/Qualifiers
     source          1..1646
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.46 cM"
     gene            1..1646
                     /gene="Lmo2"
                     /gene_synonym="Rbtn-2; Rbtn2; Rhom-2; Ttg2"
                     /note="LIM domain only 2"
                     /db_xref="GeneID:16909"
                     /db_xref="MGI:MGI:102811"
     exon            1..426
                     /gene="Lmo2"
                     /gene_synonym="Rbtn-2; Rbtn2; Rhom-2; Ttg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..862
                     /gene="Lmo2"
                     /gene_synonym="Rbtn-2; Rbtn2; Rhom-2; Ttg2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rhombotin-2; LMO-2; LIM domain only protein 2;
                     cysteine-rich protein TTG-2; T-cell translocation protein
                     2; LIM only 2"
                     /codon_start=1
                     /product="rhombotin-2 isoform 1"
                     /protein_id="NP_032531.2"
                     /db_xref="CCDS:CCDS16482.2"
                     /db_xref="GeneID:16909"
                     /db_xref="MGI:MGI:102811"
                     /translation="MIRSLSLAFEGSAVTVLERGGASSPAERPSKRRRRSGGARAPEG
                     VRVQAASQPRATKGAPPPPGTPPPSPMSSAIERKSLDPSEEPVDEVLQIPPSLLTCGG
                     CQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQ
                     DGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDI
                     YEWTKINGII"
     exon            427..642
                     /gene="Lmo2"
                     /gene_synonym="Rbtn-2; Rbtn2; Rhom-2; Ttg2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..1646
                     /gene="Lmo2"
                     /gene_synonym="Rbtn-2; Rbtn2; Rhom-2; Ttg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagccggct actgcgcgcg atcgggaccg ggcggcggcg gcggcggctg tggtgacggc
       61 agcgggaccg ggatggaagg ttaagtcctg agcagcggca gctgtcgcag ccaccggagg
      121 gaggccgggc tgctccccgg ccccctgcct tggccgccgc gcgccgggca gctggatgat
      181 tcgctctctc tctttggcgt ttgaagggag cgcggtgact gtccttgagc gtggaggggc
      241 gagctcgcca gcggagcgac cgagcaagag gaggcgcagg agcggcggcg cccgagcacc
      301 cgagggggtc cgagtccagg cagctagcca gccacgcgcc acaaagggag cgcccccgcc
      361 gcccggcacg ccgcccccct ccccaatgtc ctcggccatc gaaaggaaga gcctggaccc
      421 gtctgaggaa cccgtggatg aggtgctgca gataccccca tccctgctga catgtggtgg
      481 ctgccagcag aacatagggg accgctactt cctgaaagcc atcgaccagt actggcatga
      541 ggattgcctc agctgtgacc tctgtgggtg tcggctggga gaggtgggga ggcgcctcta
      601 ctacaagctg ggacggaaat tgtgcaggag agactatctc aggctttttg gtcaggatgg
      661 tctctgtgca tcctgtgaca agcggatccg tgcctatgag atgacgatgc gggtgaaaga
      721 caaagtgtat cacctggagt gtttcaaatg cgccgcctgt cagaagcatt tctgtgtagg
      781 tgacagatac cttctcatca actccgacat agtgtgtgaa caagacatct acgagtggac
      841 caagatcaat gggatcatct aggccagagt cccaggcacc tgtggggagg tgttcagtga
      901 agacgccgtc tcggtgtggt cttcactctt aggctctttg ggaacctgag ggtgggtgag
      961 gcatttctta ggagattatg gactcttcct gggcactaac gacatagcaa tcacatgaca
     1021 taatgcaaag gctgagactt cagtgacaaa aaggaccagc ccttagagag aatttatggt
     1081 cacaggctag ccatagtaac tgacaagatt agtggaggaa atatttgggg accagcatgc
     1141 actgtgccat cctgataggc ttccccaggt aactatcgat tagatgtgac cttggtgttc
     1201 atggactaga gttgtgcaat taattttttc ctggctttgg taactaccct gttctagtca
     1261 cagtccttca cactaggaaa ggaaagagag aagaaatagt cactcttttt ttctttcttt
     1321 cttttttcct tggtcacctt cccgtggcct taagctctgg agccaaggga aactgcatgg
     1381 aggtacattt cagttgggaa tgaaatccac atctttcaac cagacaaata tttatagcga
     1441 tgttgatgaa tcactgtttt tagacacctt cattttgagg tgaggcgccc cacagattgt
     1501 ttctatacaa atgtaaatct taaaaaaaaa aggtcaaagt tgttcaacta ttttattatc
     1561 ttagattata tcaaagtatt tgttgtgtgt cattaaaaaa aaaactcgat tctgaagact
     1621 taataaaaat gacaagctga aatgca
//
