LOCUS       NM_057173               1298 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus LIM domain only 1 (Lmo1), transcript variant 1, mRNA.
ACCESSION   NM_057173
VERSION     NM_057173.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1298)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   2  (bases 1 to 1298)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1298)
  AUTHORS   Biswas,S., Chan,C.S., Rubenstein,J.L.R. and Gan,L.
  TITLE     The transcription regulator Lmo3 is required for the development of
            medial ganglionic eminence derived neurons in the external globus
            pallidus
  JOURNAL   Dev Biol 503, 10-24 (2023)
   PUBMED   37532091
REFERENCE   4  (bases 1 to 1298)
  AUTHORS   Cheffer,A., Garcia-Miralles,M., Maier,E., Akol,I., Franz,H.,
            Srinivasan,V.S.V. and Vogel,T.
  TITLE     DOT1L deletion impairs the development of cortical
            parvalbumin-expressing interneurons
  JOURNAL   Cereb Cortex 33 (19), 10272-10285 (2023)
   PUBMED   37566909
REFERENCE   5  (bases 1 to 1298)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1298)
  AUTHORS   McGuire,E.A., Rintoul,C.E., Sclar,G.M. and Korsmeyer,S.J.
  TITLE     Thymic overexpression of Ttg-1 in transgenic mice results in T-cell
            acute lymphoblastic leukemia/lymphoma
  JOURNAL   Mol Cell Biol 12 (9), 4186-4196 (1992)
   PUBMED   1508213
REFERENCE   7  (bases 1 to 1298)
  AUTHORS   Foroni,L., Boehm,T., White,L., Forster,A., Sherrington,P.,
            Liao,X.B., Brannan,C.I., Jenkins,N.A., Copeland,N.G. and
            Rabbitts,T.H.
  TITLE     The rhombotin gene family encode related LIM-domain proteins whose
            differing expression suggests multiple roles in mouse development
  JOURNAL   J Mol Biol 226 (3), 747-761 (1992)
   PUBMED   1507224
REFERENCE   8  (bases 1 to 1298)
  AUTHORS   Boehm,T., Gonzalez-Sarmiento,R., Kennedy,M. and Rabbitts,T.H.
  TITLE     A simple technique for generating probes for RNA in situ
            hybridization: an adjunct to genome mapping exemplified by the
            RAG-1/RAG-2 gene cluster
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3927-3931 (1991)
   PUBMED   2023940
REFERENCE   9  (bases 1 to 1298)
  AUTHORS   McGuire,E.A., Davis,A.R. and Korsmeyer,S.J.
  TITLE     T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein
            normally expressed in neural lineage cells
  JOURNAL   Blood 77 (3), 599-606 (1991)
   PUBMED   1703797
REFERENCE   10 (bases 1 to 1298)
  AUTHORS   Freyd,G., Kim,S.K. and Horvitz,H.R.
  TITLE     Novel cysteine-rich motif and homeodomain in the product of the
            Caenorhabditis elegans cell lineage gene lin-11
  JOURNAL   Nature 344 (6269), 876-879 (1990)
   PUBMED   1970421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147221.4.
            
            On Mar 14, 2022 this sequence version replaced NM_057173.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053074.1, SRR7345562.2729803.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               AC147221.4         163072-163621
            551-764             AC147221.4         189935-190148
            765-890             AC147221.4         192897-193022
            891-1298            AC147221.4         194628-195035
FEATURES             Location/Qualifiers
     source          1..1298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.21 cM"
     gene            1..1298
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /note="LIM domain only 1"
                     /db_xref="GeneID:109594"
                     /db_xref="MGI:MGI:102812"
     exon            1..550
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..996
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rhombotin-1; LIM domain only protein 1; cysteine-rich
                     protein TTG-1; T-cell translocation protein 1; LIM only 1"
                     /codon_start=1
                     /product="rhombotin-1 isoform 1"
                     /protein_id="NP_476514.1"
                     /db_xref="CCDS:CCDS40080.1"
                     /db_xref="GeneID:109594"
                     /db_xref="MGI:MGI:102812"
                     /translation="MMVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYW
                     HEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVM
                     RARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQVDYEEGHLNGTFESQVQ"
     exon            551..764
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..890
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1298
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /note="hexamer: ATTAAA"
     polyA_site      1298
                     /gene="Lmo1"
                     /gene_synonym="Rbtn-1; Rbtn1; Ttg1"
                     /note="major polyA site"
ORIGIN      
        1 atacattgag ggagaaaggc agcgggagac ggccgccgag attcccccat ctctttgaat
       61 ataatttcag attgagattc agattaaatc cgaggggaaa acactttatg aggctgaaag
      121 ctgtgtcgtt gccagagcca gggttatgag ctatcaaatg caattacatt aagacagatt
      181 atactgggca aattgagcca tttagaaggt gagaatcaaa gaaacggctc tgatcctctc
      241 ttcccccttc tctctccctc tccctctctc tctttctctc taaattgcag ttcgtagttc
      301 cttgcaattc tgaggcacaa aagtaggtga gactgctttt gtatctgcga agtgcttcac
      361 tcctgaatgt aattctagct gagtgcaatc taggttaaga gccggacaag cgggtaatta
      421 gagcccgctt gctgccggag gaccggctgc ccagccgaag cgcgcccgga gtcggcgccc
      481 ttttcccggc cgagccgagc agcggctgga cacggagcgc ccgagatgat ggtgctggac
      541 aaggaggacg gtgtgccgat gctctccgtc caacctaagg ggaaacagaa gggctgcgca
      601 ggctgcaacc gcaagatcaa ggaccggtac ctgctgaagg cactggacaa gtactggcat
      661 gaggactgcc tcaagtgtgc ctgctgtgac tgtcgcctgg gcgaggtggg ctccactctc
      721 tacaccaagg ccaacctcat cctgtgccgg cgtgactacc tgaggctttt tggcaccaca
      781 ggaaactgtg ctgcctgcag caagctgatc ccagcttttg agatggtgat gcgggcccga
      841 gacaatgtgt atcaccttga ctgcttcgcc tgccagctct gcaatcagag attttgcgtg
      901 ggagacaaat tcttcctgaa gaacaacatg atcttgtgcc aggtggacta tgaggagggg
      961 catctcaatg gcacctttga atcccaggtt cagtaacgcc caccatctgg cctccaggtc
     1021 catctgtccg tctgcccacc tgtccacctg cctggcaggc cggccagcca ctctgcctgc
     1081 gcgggctggc cagccgctgt cctacaagtt agaacttcat cctcgatggg aaggtggctg
     1141 ttctccacca ccactgccca tctctgtggg acccctcctg gggccaggct cagcctgtac
     1201 agtctgtctt ctgtatataa atgggaacat ttattttatg agaaatgtaa tgcgatttta
     1261 ttactggcgt ggattaaact tatgaatgtt tccgggga
//
