LOCUS       NM_010721               2871 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus lamin B1 (Lmnb1), mRNA.
ACCESSION   NM_010721 XM_993305
VERSION     NM_010721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Dias,A.P., Rehmani,T., Salih,M. and Tuana,B.
  TITLE     Tail-anchored membrane protein SLMAP3 is essential for targeting
            centrosomal proteins to the nuclear envelope in skeletal myogenesis
  JOURNAL   Open Biol 14 (10), 240094 (2024)
   PUBMED   39378988
REFERENCE   2  (bases 1 to 2871)
  AUTHORS   Zhang,Y., Kang,H.R., Jun,Y., Kang,H., Bang,G., Ma,R., Ju,S.,
            Yoon,D.E., Kim,Y., Kim,K., Kim,J.Y. and Han,K.
  TITLE     Neurodevelopmental disorder-associated CYFIP2 regulates
            membraneless organelles and eIF2alpha phosphorylation via protein
            interactors and actin cytoskeleton
  JOURNAL   Hum Mol Genet 33 (19), 1671-1687 (2024)
   PUBMED   38981622
REFERENCE   3  (bases 1 to 2871)
  AUTHORS   Hayakawa-Yano,Y., Furukawa,T., Matsuo,T., Ogasawara,T., Nogami,M.,
            Yokoyama,K., Yugami,M., Shinozaki,M., Nakamoto,C., Sakimura,K.,
            Koyama,A., Ogi,K., Onodera,O., Takebayashi,H., Okano,H. and Yano,M.
  TITLE     Qki5 safeguards spinal motor neuron function by defining the motor
            neuron-specific transcriptome via pre-mRNA processing
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2401531121 (2024)
   PUBMED   39226364
REFERENCE   4  (bases 1 to 2871)
  AUTHORS   Chen,X., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Wu,H. and
            Qi,Y.
  TITLE     SENP3-regulated Nodal signaling plays a potential role in cardiac
            left-right asymmetry development
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133294 (2024)
   PUBMED   38925188
REFERENCE   5  (bases 1 to 2871)
  AUTHORS   Huang,F., Wang,Y., Lv,X. and Huang,C.
  TITLE     WTAP-mediated N6-methyladenosine modification promotes the
            inflammation, mitochondrial damage and ferroptosis of kidney
            tubular epithelial cells in acute kidney injury by regulating LMNB1
            expression and activating NF-kappaB and JAK2/STAT3 pathways
  JOURNAL   J Bioenerg Biomembr 56 (3), 285-296 (2024)
   PUBMED   38517565
  REMARK    GeneRIF: WTAP-mediated N6-methyladenosine modification promotes the
            inflammation, mitochondrial damage and ferroptosis of kidney
            tubular epithelial cells in acute kidney injury by regulating LMNB1
            expression and activating NF-kappaB and JAK2/STAT3 pathways.
REFERENCE   6  (bases 1 to 2871)
  AUTHORS   Justice,M.J., Gilbert,D.J., Kinzler,K.W., Vogelstein,B.,
            Buchberg,A.M., Ceci,J.D., Matsuda,Y., Chapman,V.M., Patriotis,C.,
            Makris,A. et al.
  TITLE     A molecular genetic linkage map of mouse chromosome 18 reveals
            extensive linkage conservation with human chromosomes 5 and 18
  JOURNAL   Genomics 13 (4), 1281-1288 (1992)
   PUBMED   1354644
REFERENCE   7  (bases 1 to 2871)
  AUTHORS   Hoger,T.H., Zatloukal,K., Waizenegger,I. and Krohne,G.
  TITLE     Characterization of a second highly conserved B-type lamin present
            in cells previously thought to contain only a single B-type lamin
  JOURNAL   Chromosoma 99 (6), 379-390 (1990)
   PUBMED   2102682
  REMARK    Erratum:[Chromosoma. 1990 Dec;100(1):67-9. doi:
            10.1007/BF00337604.. PMID: 2102440]
REFERENCE   8  (bases 1 to 2871)
  AUTHORS   Rober,R.A., Weber,K. and Osborn,M.
  TITLE     Differential timing of nuclear lamin A/C expression in the various
            organs of the mouse embryo and the young animal: a developmental
            study
  JOURNAL   Development 105 (2), 365-378 (1989)
   PUBMED   2680424
REFERENCE   9  (bases 1 to 2871)
  AUTHORS   Hoger,T.H., Krohne,G. and Franke,W.W.
  TITLE     Amino acid sequence and molecular characterization of murine lamin
            B as deduced from cDNA clones
  JOURNAL   Eur J Cell Biol 47 (2), 283-290 (1988)
   PUBMED   3243285
REFERENCE   10 (bases 1 to 2871)
  AUTHORS   Houliston,E., Guilly,M.N., Courvalin,J.C. and Maro,B.
  TITLE     Expression of nuclear lamins during mouse preimplantation
            development
  JOURNAL   Development 102 (2), 271-278 (1988)
   PUBMED   3046911
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132252.1 and BC052729.1.
            
            On May 15, 2008 this sequence version replaced NM_010721.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132252.1, X16705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AK132252.1         1-51
            52-2871             BC052729.1         1-2820
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 30.84 cM"
     gene            1..2871
                     /gene="Lmnb1"
                     /note="lamin B1"
                     /db_xref="GeneID:16906"
                     /db_xref="MGI:MGI:96795"
     exon            1..662
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..2067
                     /gene="Lmnb1"
                     /codon_start=1
                     /product="lamin-B1"
                     /protein_id="NP_034851.2"
                     /db_xref="CCDS:CCDS29261.1"
                     /db_xref="GeneID:16906"
                     /db_xref="MGI:MGI:96795"
                     /translation="MATATPVQQQRAGSRASAPATPLSPTRLSRLQEKEELRELNDRL
                     AVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERA
                     KLQIELGKFKAEHDQLLLNYAKKESDLSGAQIKLREYEAALNSKDAALATALGDKKSL
                     EGDLEDLKDQIAQLEASLSAAKKQLADETLLKVDLENRCQSLTEDLEFRKNMYEEEIN
                     ETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENA
                     RLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDMLAKERD
                     NSRRMLSDREREMAEIRDQMQQQLSDYEQLLDVKLALDMEISAYRKLLEGEEERLKLS
                     PSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDV
                     DGKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTVWAANAGVTA
                     SPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPEEEEEEEEEPIGVA
                     VEEERFHQQGAPRASNKSCAIM"
     exon            663..819
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..945
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1116
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1242
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1463
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1689
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1794
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1914
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2025
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2843
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2820..2825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmnb1"
                     /note="hexamer: AATAAA"
     polyA_site      2843
                     /gene="Lmnb1"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcctct cgccgccctc ctcctcggcc cgcccgccgc tctgagcagc ccgagaggaa
       61 acaaagtgct gcgggcggga gactcgcgtc cgccgcgcac agccgtctgc gtctcccggc
      121 tgccctggcc tcttcccgcg cgcgtctgcg agtgtgcgtg tacactcaca aagggcgtct
      181 ggcgggcgat cgcggccctc ccgcttcgct ctttgtgcgg tagccccgcc gccaccgcca
      241 gcccaggtcc gctcgatcct caccggcctg tggtttgtac cttcggtccc gccgcccgcc
      301 atggcgaccg cgacccccgt gcagcagcag cgggcgggca gccgcgccag cgcccccgcc
      361 acgccgctca gccccacgcg cctgtcgcgc ctgcaggaga aagaggagct gcgggagctc
      421 aacgaccgcc tggctgtgta catcgataag gtgcgcagcc tggagacgga gaacagcgcg
      481 ctgcagctgc aggtgaccga gcgcgaggag gtgcgcggcc gcgagctcac cggcctcaag
      541 gctctctacg agaccgagct ggccgacgca cgccgcgctc tggacgacac ggcccgcgag
      601 cgcgccaagc tccagatcga gctgggcaag ttcaaggccg agcacgacca gctgctgctc
      661 aattatgcca agaaggaatc tgatctcagt ggagcccaga tcaagcttcg agagtatgag
      721 gcggcactaa actctaagga tgcggcgctg gctactgccc taggggacaa aaagagttta
      781 gagggagact tggaggatct gaaagatcag attgcccagc tagaagcatc cttatctgcc
      841 gccaaaaagc agttagcaga tgaaacttta cttaaagtgg atttggagaa tcgctgtcag
      901 agccttactg aggacttgga gtttcgtaaa aatatgtatg aagaggagat caatgagaca
      961 aggaggaagc atgagacccg cttggtggaa gtggactctg ggcgtcagat tgagtatgag
     1021 tacaagctgg ctcaagccct gcatgagatg cgggagcagc acgacgcgca ggtgaggctg
     1081 tacaaggaag agctggagca gacctaccac gccaagcttg agaatgccag actctcctca
     1141 gagatgaaca cttccactgt caacagtgcc cgggaagagc tgatggagag ccggatgagg
     1201 atcgagagcc tctcctcaca gctctctaac ctgcagaaag agtctagagc gtgtttggaa
     1261 aggatccagg aattggagga catgcttgct aaggagagag acaactcgcg ccgcatgctg
     1321 tctgacagag agagagagat ggcggagatc agggaccaga tgcagcagca gctgagtgat
     1381 tatgagcagc tgctggacgt gaagctggcc ctggacatgg agatcagcgc ctacaggaag
     1441 ctcctggaag gcgaagaaga gcggttaaag ctctctccaa gcccttcttc ccgggtgacc
     1501 gtgtccagag cgtcctccag tcgcagtgtg cgcaccacca gaggaaagcg gaagagagtt
     1561 gatgtggagg agtcggaggc gagcagcagt gttagcattt cccactctgc ctcagccacg
     1621 gggaacgtgt gcattgaaga gatagatgtt gatgggaagt ttattcgctt gaagaacact
     1681 tctgagcagg atcaaccaat gggaggctgg gagatgatca gaaaaattgg agacacatca
     1741 gtcagttaca aatatacctc aagatatgtg ctgaaggctg gccagactgt cacagtgtgg
     1801 gctgcaaatg ctggcgtcac agccagccct ccaactgacc tcatctggaa gaaccagaac
     1861 tcttggggta ctggtgaaga tgtgaaggtt atattgaaga attctcaggg agaggaggtt
     1921 gctcagagaa gcacagtctt caagaccacc atacccgagg aggaggagga ggaggaggag
     1981 gagcccatcg gagtggctgt ggaggaggag cgtttccacc agcagggagc cccaagagca
     2041 tccaataaaa gctgtgccat tatgtgaact tgtcaagaca tggtcgatct tcctcaagct
     2101 agaagcatgg agtcctgtat acagtgcaga gccttctcag aagcacatga tatttttgta
     2161 tttcctttat gtgaattttt aagctgcgaa tctgatggcc ttaatttcct ttttgacact
     2221 gaaagttttg taaaagaaat cctatccata cacgttgtaa gatgtgaatt attgacactg
     2281 agctaactgt actgtttgga aaggggccct caagtttttg gcatttttct ttcctttttg
     2341 tatgtgtgta tgtaattttt tttttttaag ttcttttaag gggggacaag gagggtaaga
     2401 aaaccactgc gtgtccgggc ataattgaag cttgctctcc ctagatgggt ggtctgctct
     2461 cggtccttct ctgctctcta taaaatggtg ctgtgcggga gggagggggg aagtttttca
     2521 atatatgaac ttttgtatgg aatttttttg taataagtga tcaaggttac aaattttttt
     2581 tttaaataga aaagagaaga aaaacgttgt aagaaggcaa tattaatcta gtcaccatgt
     2641 acgcactctg gatggaggtt ctacagagct gttgattggt caactacttc tcttacattg
     2701 ttgactcatg aggggagcgg gcaggcgggg tgagggtggg ggaaggcttt ctcttcaaat
     2761 tcgctagttg agtttttaag atagtgtaac atgcttacat ttcttatccg acattaacaa
     2821 ataaaacgct gttttcctat taaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
