LOCUS       NM_001002011            3189 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus lamin A (Lmna), transcript variant 1, mRNA.
ACCESSION   NM_001002011
VERSION     NM_001002011.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3189)
  AUTHORS   Ferraioli,S., Sarigol,F., Prakash,C., Filipczak,D., Foisner,R. and
            Naetar,N.
  TITLE     LAP2alpha facilitates myogenic gene expression by preventing
            nucleoplasmic lamin A/C from spreading to active chromatin regions
  JOURNAL   Nucleic Acids Res 52 (19), 11500-11518 (2024)
   PUBMED   39228367
  REMARK    GeneRIF: LAP2alpha facilitates myogenic gene expression by
            preventing nucleoplasmic lamin A/C from spreading to active
            chromatin regions.
REFERENCE   2  (bases 1 to 3189)
  AUTHORS   Herrero-Fernandez,B., Ortega-Zapero,M., Gomez-Bris,R., Saez,A.,
            Iborra,S., Zorita,V., Quintas,A., Vazquez,E., Dopazo,A.,
            Sanchez-Madrid,F., Arribas,S.M. and Gonzalez-Granado,J.M.
  TITLE     Role of lamin A/C on dendritic cell function in antiviral immunity
  JOURNAL   Cell Mol Life Sci 81 (1), 400 (2024)
   PUBMED   39264480
  REMARK    GeneRIF: Role of lamin A/C on dendritic cell function in antiviral
            immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3189)
  AUTHORS   Sahu,S.K., Reddy,P., Lu,J., Shao,Y., Wang,C., Tsuji,M.,
            Delicado,E.N., Rodriguez Esteban,C. and Belmonte,J.C.I.
  TITLE     Targeted partial reprogramming of age-associated cell states
            improves markers of health in mouse models of aging
  JOURNAL   Sci Transl Med 16 (764), eadg1777 (2024)
   PUBMED   39259812
REFERENCE   4  (bases 1 to 3189)
  AUTHORS   Jahn,D., Schramm,S., Benavente,R. and Alsheimer,M.
  TITLE     Dynamic properties of meiosis-specific lamin C2 and its impact on
            nuclear envelope integrity
  JOURNAL   Nucleus 1 (3), 273-283 (2010)
   PUBMED   21327075
  REMARK    GeneRIF: lamin C2 as a 'natural lamin deletion mutant' that confers
            unique properties to the nuclear envelope which would be essential
            for dynamic telomere repositioning during meiotic prophase I
REFERENCE   5  (bases 1 to 3189)
  AUTHORS   Sullivan,T., Escalante-Alcalde,D., Bhatt,H., Anver,M., Bhat,N.,
            Nagashima,K., Stewart,C.L. and Burke,B.
  TITLE     Loss of A-type lamin expression compromises nuclear envelope
            integrity leading to muscular dystrophy
  JOURNAL   J Cell Biol 147 (5), 913-920 (1999)
   PUBMED   10579712
REFERENCE   6  (bases 1 to 3189)
  AUTHORS   Eggert,M., Radomski,N., Tripier,D., Traub,P. and Jost,E.
  TITLE     Identification of phosphorylation sites on murine nuclear lamin C
            by RP-HPLC and microsequencing
  JOURNAL   FEBS Lett 292 (1-2), 205-209 (1991)
   PUBMED   1959608
REFERENCE   7  (bases 1 to 3189)
  AUTHORS   Weber,K., Plessmann,U. and Traub,P.
  TITLE     Maturation of nuclear lamin A involves a specific carboxy-terminal
            trimming, which removes the polyisoprenylation site from the
            precursor; implications for the structure of the nuclear lamina
  JOURNAL   FEBS Lett 257 (2), 411-414 (1989)
   PUBMED   2583287
REFERENCE   8  (bases 1 to 3189)
  AUTHORS   Riedel,W. and Werner,D.
  TITLE     Nucleotide sequence of the full-length mouse lamin C cDNA and its
            deduced amino-acid sequence
  JOURNAL   Biochim Biophys Acta 1008 (1), 119-122 (1989)
   PUBMED   2719959
REFERENCE   9  (bases 1 to 3189)
  AUTHORS   Rober,R.A., Weber,K. and Osborn,M.
  TITLE     Differential timing of nuclear lamin A/C expression in the various
            organs of the mouse embryo and the young animal: a developmental
            study
  JOURNAL   Development 105 (2), 365-378 (1989)
   PUBMED   2680424
REFERENCE   10 (bases 1 to 3189)
  AUTHORS   Houliston,E., Guilly,M.N., Courvalin,J.C. and Maro,B.
  TITLE     Expression of nuclear lamins during mouse preimplantation
            development
  JOURNAL   Development 102 (2), 271-278 (1988)
   PUBMED   3046911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145168.5, AK147150.1,
            AK004619.2 and AW047412.1.
            
            On May 7, 2013 this sequence version replaced NM_001002011.2.
            
            Summary: This gene encodes a protein that is a member of the lamin
            family. Nuclear lamins, intermediate filament-like proteins, are
            the major components of the nuclear lamina, a protein meshwork
            associated with the inner nuclear membrane. This meshwork is
            thought to maintain the integrity of the nuclear envelope,
            participate in chromatin organization, and regulate gene
            transcription. Vertebrate lamins consist of two types, A and B.
            This protein is an A-type and is proposed to be developmentally
            regulated. In mouse deficiency of this gene is associated with
            muscular dystrophy. Mouse lines with different mutations in this
            gene serve as pathophysiological models for several human
            laminopathies. In humans, mutations in this gene lead to several
            diseases: Emery-Dreifuss muscular dystrophy, familial partial
            lipodystrophy, limb girdle muscular dystrophy, dilated
            cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford
            progeria syndrome. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004619.2, AK147150.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC145168.5         69395-69439         c
            46-2387             AK147150.1         2-2343
            2388-2475           AK004619.2         2341-2428
            2476-3167           AK147150.1         2432-3123
            3168-3189           AW047412.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.84 cM"
     gene            1..3189
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /note="lamin A"
                     /db_xref="GeneID:16905"
                     /db_xref="MGI:MGI:96794"
     exon            1..605
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2247
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /note="isoform A precursor is encoded by transcript
                     variant 1; prelamin-A/C; lamin-A/C; lamin C"
                     /codon_start=1
                     /product="prelamin-A/C isoform A precursor"
                     /protein_id="NP_001002011.2"
                     /db_xref="CCDS:CCDS38482.1"
                     /db_xref="GeneID:16905"
                     /db_xref="MGI:MGI:96794"
                     /translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
                     YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
                     QLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEG
                     ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRET
                     KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
                     SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
                     RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
                     PTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGK
                     FVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSP
                     PTDLVWKAQNTWGCGSSLRTALINSTGEEVAMRKLVRSLTMVEDNEDDDEDGEELLHH
                     HRGSHCSGSGDPAEYNLRSRTVLCGTCGQPADKAAGGAGAQVGGSISSGSSASSVTVT
                     RSFRSVGGSGGGSFGDNLVTRSYLLGNSSPRSQSSQNCSIM"
     exon            606..762
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            763..888
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1059
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1185
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1406
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1629
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1737
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1857
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1953
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2220
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..3173
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3150..3155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /note="hexamer: AATACA"
     polyA_site      3173
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /note="major polyA site"
ORIGIN      
        1 gtagaggagg gcctattaga gcctctgcct ggctgtcagt gactcagtgt tcgcgggaac
       61 gctgcctcag cctcaacacc agccaaccca gatcccgagg tgcgccagcg cccagcccag
      121 atctccacgc ctgccaggag cgagcttcgc cggctcgctg tccccctgag cagcctctgt
      181 ccttctgtcc aagtcccgcg cccttctcgg gacccctgcc cagcgggcag cactgtcacc
      241 ctgccggcca tggagacccc gtcacagcgg cgcgccaccc gcagtggggc gcaggccagc
      301 tctaccccac tgtcgcccac tcggatcacc cggctgcagg agaaggagga cctgcaggag
      361 ctcaatgacc gcctggccgt gtacatcgat cgcgtgcgtt ccctggagac cgagaacgcg
      421 gggctgcgcc ttcgcatcac tgagtctgaa gaggtggtca gccgagaggt gtccggcatc
      481 aaggcggcct acgaggccga gctgggggat gcccgcaaga cccttgattc tgtggccaag
      541 gagcgcgccc gcctccagct agagctgagc aaagtgcgtg aggagttcaa ggagctgaag
      601 gctcgcaaca ccaagaagga gggggacttg ttggctgcgc aggcccggct caaggacctc
      661 gaggctcttc tcaactccaa ggaagctgcc ctgagcactg ctctcagtga gaagcgcaca
      721 ttggagggcg agctccatga cctgcggggg caggtagcca agcttgaggc ggccctggga
      781 gaggctaaga agcagcttca ggatgagatg ctgaggcgag tggatgctga gaacaggcta
      841 cagacgctga aggaggagct tgacttccag aagaacattt acagcgagga actgcgtgag
      901 accaagcgcc ggcatgagac gcggcttgtg gagatcgata acgggaagca gcgagagttt
      961 gagagccggc tggcagatgc cctgcaggag ctgcgggctc agcatgagga ccaggtggaa
     1021 cagtataaga aggagctaga aaagacatac tccgccaagc tggataatgc caggcagtct
     1081 gctgagagga acagcaacct cgtgggggct gcccatgagg aactgcagca gtctcgaatc
     1141 cgcattgaca gcctctcggc ccagctcagc cagctccaaa agcagttggc agccaaggag
     1201 gcaaagctgc gtgacctgga ggactcgctg gcccgtgagc gcgataccag ccggcgcctg
     1261 ctggctgaga aagagcgaga gatggcggag atgcgggcga ggatgcagca gcagctggac
     1321 gagtaccagg agctgctgga catcaagctg gccctggaca tggagatcca tgcctatcga
     1381 aagctgctgg agggcgagga ggagaggctg cgcctgtccc ccagccctac ctcgcagcgc
     1441 agccgtggcc gcgcctcctc ccactcatcc cagtctcagg gtggaggcag cgtcaccaaa
     1501 aagcgcaagc tggagtcttc cgagagccgg agcagcttct cgcagcatgc tcgcactagc
     1561 gggcgtgtgg cggtagagga agtcgatgaa gagggaaagt tcgtgcggct gcgcaacaag
     1621 tccaacgagg accagtccat gggcaactgg cagatcaggc gtcagaatgg tgacgatcct
     1681 ttgatgacct atcgcttccc accgaagttc accctaaagg ctgggcaggt ggtgacgatc
     1741 tgggcttcag gagctggggc cacccatagc ccccctactg acttggtgtg gaaggcgcag
     1801 aacacctggg gctgtgggag cagccttcgc accgctctca tcaactccac tggagaagaa
     1861 gtggccatgc gcaagctggt gcgctcactg accatggttg aggacaatga ggatgacgac
     1921 gaggatggag aagagctcct ccatcaccac cgtggttccc actgcagcgg ctcgggggac
     1981 cccgctgagt acaacctgcg ctcacgcacc gtgctgtgcg ggacgtgtgg gcagcctgct
     2041 gacaaggctg ccggtggagc gggagcccag gtgggcggat ccatctcctc tggctcttct
     2101 gcctccagtg tcacagtcac tcgaagcttc cgcagtgtgg ggggcagtgg gggtggcagc
     2161 ttcggggaca acctagtcac ccgctcctac ctcctgggca actccagtcc ccggagccag
     2221 agctcccaga actgcagcat catgtaatct gggacctgcc aggcagggct gggggcagag
     2281 gccacctgct cccccctcac cacatgccac ctcctgtctg ctccttagga gagcaggcct
     2341 gaagccaaag aaaaatttat cccctgcctt tggttttttt tttttttctt ctattttttt
     2401 tttctttttc taagagaagt tattttctac agtggtttta tactgaagga aaaactcaag
     2461 caaaaaaaaa aaaaatcttt atctcaatcc taagtccttc ccctttcttt ccttgtatct
     2521 gccttaaaac caaagggctt ctctaggagc ccagggaaag gactgctttt tatagagtct
     2581 agatttttgt cctgctgcct tggctttacc ctcatcccag gaccctgtga caatggtgcc
     2641 tgagaggcag gcatggagtt ctcttcacca gcctcctcca acagctggcc cactgccacg
     2701 ccagctgcag agaaatgggg cgcagagagg atgactgaga aggtcaagcc cctccccggc
     2761 actacacgag gccgaggctc ctctgcctgc cttaccttct tcctgccctt ccctagcctg
     2821 gggcgagtgg attcccagag gcaaatctgc cgtgcttgct ttttctatat tttatttaga
     2881 caagagatgg gaatgacggg gaaggagaag ggaagatcag tttgagccta ccttttccca
     2941 gcttctgagc ctggtgggct ctgtctcaat gatggagggc aatgtcaagt gggatacagg
     3001 gaagagtggg ggacgaaggc tcccagagat ggggagaacc tgctggggct ggtgagaagt
     3061 ctagaggtgc ggcgattggt ggctacagca aacactaagg aacccttcac cccatttccc
     3121 atctgcacct ctgctctccc ctccaaatca atacactagt tgtttccatc ccaaaaaaaa
     3181 aaaaaaaaa
//
