LOCUS       NP_001002011             665 aa            linear   ROD 11-MAR-2025
DEFINITION  prelamin-A/C isoform A precursor [Mus musculus].
ACCESSION   NP_001002011
VERSION     NP_001002011.2
DBSOURCE    REFSEQ: accession NM_001002011.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 665)
  AUTHORS   Ferraioli,S., Sarigol,F., Prakash,C., Filipczak,D., Foisner,R. and
            Naetar,N.
  TITLE     LAP2alpha facilitates myogenic gene expression by preventing
            nucleoplasmic lamin A/C from spreading to active chromatin regions
  JOURNAL   Nucleic Acids Res 52 (19), 11500-11518 (2024)
   PUBMED   39228367
  REMARK    GeneRIF: LAP2alpha facilitates myogenic gene expression by
            preventing nucleoplasmic lamin A/C from spreading to active
            chromatin regions.
REFERENCE   2  (residues 1 to 665)
  AUTHORS   Herrero-Fernandez,B., Ortega-Zapero,M., Gomez-Bris,R., Saez,A.,
            Iborra,S., Zorita,V., Quintas,A., Vazquez,E., Dopazo,A.,
            Sanchez-Madrid,F., Arribas,S.M. and Gonzalez-Granado,J.M.
  TITLE     Role of lamin A/C on dendritic cell function in antiviral immunity
  JOURNAL   Cell Mol Life Sci 81 (1), 400 (2024)
   PUBMED   39264480
  REMARK    GeneRIF: Role of lamin A/C on dendritic cell function in antiviral
            immunity.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 665)
  AUTHORS   Sahu,S.K., Reddy,P., Lu,J., Shao,Y., Wang,C., Tsuji,M.,
            Delicado,E.N., Rodriguez Esteban,C. and Belmonte,J.C.I.
  TITLE     Targeted partial reprogramming of age-associated cell states
            improves markers of health in mouse models of aging
  JOURNAL   Sci Transl Med 16 (764), eadg1777 (2024)
   PUBMED   39259812
REFERENCE   4  (residues 1 to 665)
  AUTHORS   Jahn,D., Schramm,S., Benavente,R. and Alsheimer,M.
  TITLE     Dynamic properties of meiosis-specific lamin C2 and its impact on
            nuclear envelope integrity
  JOURNAL   Nucleus 1 (3), 273-283 (2010)
   PUBMED   21327075
  REMARK    GeneRIF: lamin C2 as a 'natural lamin deletion mutant' that confers
            unique properties to the nuclear envelope which would be essential
            for dynamic telomere repositioning during meiotic prophase I
REFERENCE   5  (residues 1 to 665)
  AUTHORS   Sullivan,T., Escalante-Alcalde,D., Bhatt,H., Anver,M., Bhat,N.,
            Nagashima,K., Stewart,C.L. and Burke,B.
  TITLE     Loss of A-type lamin expression compromises nuclear envelope
            integrity leading to muscular dystrophy
  JOURNAL   J Cell Biol 147 (5), 913-920 (1999)
   PUBMED   10579712
REFERENCE   6  (residues 1 to 665)
  AUTHORS   Eggert,M., Radomski,N., Tripier,D., Traub,P. and Jost,E.
  TITLE     Identification of phosphorylation sites on murine nuclear lamin C
            by RP-HPLC and microsequencing
  JOURNAL   FEBS Lett 292 (1-2), 205-209 (1991)
   PUBMED   1959608
REFERENCE   7  (residues 1 to 665)
  AUTHORS   Weber,K., Plessmann,U. and Traub,P.
  TITLE     Maturation of nuclear lamin A involves a specific carboxy-terminal
            trimming, which removes the polyisoprenylation site from the
            precursor; implications for the structure of the nuclear lamina
  JOURNAL   FEBS Lett 257 (2), 411-414 (1989)
   PUBMED   2583287
REFERENCE   8  (residues 1 to 665)
  AUTHORS   Riedel,W. and Werner,D.
  TITLE     Nucleotide sequence of the full-length mouse lamin C cDNA and its
            deduced amino-acid sequence
  JOURNAL   Biochim Biophys Acta 1008 (1), 119-122 (1989)
   PUBMED   2719959
REFERENCE   9  (residues 1 to 665)
  AUTHORS   Rober,R.A., Weber,K. and Osborn,M.
  TITLE     Differential timing of nuclear lamin A/C expression in the various
            organs of the mouse embryo and the young animal: a developmental
            study
  JOURNAL   Development 105 (2), 365-378 (1989)
   PUBMED   2680424
REFERENCE   10 (residues 1 to 665)
  AUTHORS   Houliston,E., Guilly,M.N., Courvalin,J.C. and Maro,B.
  TITLE     Expression of nuclear lamins during mouse preimplantation
            development
  JOURNAL   Development 102 (2), 271-278 (1988)
   PUBMED   3046911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC145168.5, AK147150.1,
            AK004619.2 and AW047412.1.
            
            On Dec 11, 2007 this sequence version replaced NP_001002011.1.
            
            Summary: This gene encodes a protein that is a member of the lamin
            family. Nuclear lamins, intermediate filament-like proteins, are
            the major components of the nuclear lamina, a protein meshwork
            associated with the inner nuclear membrane. This meshwork is
            thought to maintain the integrity of the nuclear envelope,
            participate in chromatin organization, and regulate gene
            transcription. Vertebrate lamins consist of two types, A and B.
            This protein is an A-type and is proposed to be developmentally
            regulated. In mouse deficiency of this gene is associated with
            muscular dystrophy. Mouse lines with different mutations in this
            gene serve as pathophysiological models for several human
            laminopathies. In humans, mutations in this gene lead to several
            diseases: Emery-Dreifuss muscular dystrophy, familial partial
            lipodystrophy, limb girdle muscular dystrophy, dilated
            cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford
            progeria syndrome. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004619.2, AK147150.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..665
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.84 cM"
     Protein         1..665
                     /product="prelamin-A/C isoform A precursor"
                     /note="prelamin-A/C; lamin-A/C; lamin C"
                     /calculated_mol_wt=74107
     mat_peptide     1..662
                     /product="Prelamin-A/C. /id=PRO_0000398837"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
                     /calculated_mol_wt=73906
     mat_peptide     1..647
                     /product="Lamin-A/C. /id=PRO_0000063811"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
                     /calculated_mol_wt=72347
     Region          1..130
                     /region_name="Interaction with MLIP.
                     /evidence=ECO:0000250|UniProtKB:P02545"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          1..33
                     /region_name="Head"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          1..25
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            18
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            19
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            22
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          30..386
                     /region_name="Filament"
                     /note="Intermediate filament protein; pfam00038"
                     /db_xref="CDD:459643"
     Site            32
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          34..70
                     /region_name="Coil 1A"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            51
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            66
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          71..80
                     /region_name="Linker 1"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            71
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            78
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          81..218
                     /region_name="Coil 1B"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            97
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            107
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            108
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            114
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            123
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            135
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            144
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            155
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            171
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            180
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            201
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            208
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            212
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          219..242
                     /region_name="Linker 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            233
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          243..383
                     /region_name="Coil 2"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            260
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            265
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            266
                     /site_type="other"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            270
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            277
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            301
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            307
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            311
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            316
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            325
                     /site_type="other"
                     /note="Stutter. /evidence=ECO:0000305; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            330
                     /site_type="other"
                     /note="Heptad change of phase; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            341
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          384..665
                     /region_name="Tail"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Region          384..442
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19131326,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            392
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; Phosphoserine, by
                     CDK1. /evidence=ECO:0000269|PubMed:1959608,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            395
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            398
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            403
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            404
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            406
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            407
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:1959608; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            414
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            416
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          417..422
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            417
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            420
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            423
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            426
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            429
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            431
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          434..541
                     /region_name="LTD"
                     /note="Lamin Tail Domain; pfam00932"
                     /db_xref="CDD:460003"
     Site            450
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060,
                     ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            457
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            458
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            460
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            463
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            486
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000269|PubMed:31576060; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            496
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            500
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            505
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            510
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P48679; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            533
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            546
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            548
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Region          553..577
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48678.2)"
     Site            570
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            572
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            573
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            613
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            614
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            617
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            620
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            626
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            629
                     /site_type="glycosylation"
                     /note="O-linked (GlcNAc) serine.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            629
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            633
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            637
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            647..648
                     /site_type="cleavage"
                     /note="Cleavage, by endoprotease.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            653
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     Site            662
                     /site_type="methylation"
                     /note="Cysteine methyl ester.
                     /evidence=ECO:0000250|UniProtKB:P02545; propagated from
                     UniProtKB/Swiss-Prot (P48678.2)"
     CDS             1..665
                     /gene="Lmna"
                     /gene_synonym="Dhe"
                     /coded_by="NM_001002011.3:250..2247"
                     /note="isoform A precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS38482.1"
                     /db_xref="GeneID:16905"
                     /db_xref="MGI:MGI:96794"
ORIGIN      
        1 metpsqrrat rsgaqasstp lsptritrlq ekedlqelnd rlavyidrvr sletenaglr
       61 lriteseevv srevsgikaa yeaelgdark tldsvakera rlqlelskvr eefkelkarn
      121 tkkegdllaa qarlkdleal lnskeaalst alsekrtleg elhdlrgqva kleaalgeak
      181 kqlqdemlrr vdaenrlqtl keeldfqkni yseelretkr rhetrlveid ngkqrefesr
      241 ladalqelra qhedqveqyk kelektysak ldnarqsaer nsnlvgaahe elqqsririd
      301 slsaqlsqlq kqlaakeakl rdledslare rdtsrrllae keremaemra rmqqqldeyq
      361 elldiklald meihayrkll egeeerlrls psptsqrsrg rasshssqsq gggsvtkkrk
      421 lessesrssf sqhartsgrv aveevdeegk fvrlrnksne dqsmgnwqir rqngddplmt
      481 yrfppkftlk agqvvtiwas gagathsppt dlvwkaqntw gcgsslrtal instgeevam
      541 rklvrsltmv ednedddedg eellhhhrgs hcsgsgdpae ynlrsrtvlc gtcgqpadka
      601 aggagaqvgg sissgssass vtvtrsfrsv ggsgggsfgd nlvtrsyllg nssprsqssq
      661 ncsim
//
