LOCUS       NP_083900                574 aa            linear   ROD 05-MAY-2025
DEFINITION  lipase maturation factor 1 [Mus musculus].
ACCESSION   NP_083900
VERSION     NP_083900.3
DBSOURCE    REFSEQ: accession NM_029624.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 574)
  AUTHORS   Sha,H., Sun,S., Francisco,A.B., Ehrhardt,N., Xue,Z., Liu,L.,
            Lawrence,P., Mattijssen,F., Guber,R.D., Panhwar,M.S., Brenna,J.T.,
            Shi,H., Xue,B., Kersten,S., Bensadoun,A., Peterfy,M., Long,Q. and
            Qi,L.
  TITLE     The ER-associated degradation adaptor protein Sel1L regulates LPL
            secretion and lipid metabolism
  JOURNAL   Cell Metab 20 (3), 458-470 (2014)
   PUBMED   25066055
REFERENCE   2  (residues 1 to 574)
  AUTHORS   Mao,H.Z., Ehrhardt,N., Bedoya,C., Gomez,J.A., DeZwaan-McCabe,D.,
            Mungrue,I.N., Kaufman,R.J., Rutkowski,D.T. and Peterfy,M.
  TITLE     Lipase maturation factor 1 (lmf1) is induced by endoplasmic
            reticulum stress through activating transcription factor 6alpha
            (Atf6alpha) signaling
  JOURNAL   J Biol Chem 289 (35), 24417-24427 (2014)
   PUBMED   25035425
  REMARK    GeneRIF: determined the alpha-synuclein-binding domain of beta-III
            tubulin and demonstrated that a short fragment containing this
            domain can suppress alpha-synuclein accumulation in the primary
            cultured cells
REFERENCE   3  (residues 1 to 574)
  AUTHORS   Ehrhardt,N., Bedoya,C. and Peterfy,M.
  TITLE     Embryonic viability, lipase deficiency, hypertriglyceridemia and
            neonatal lethality in a novel LMF1-deficient mouse model
  JOURNAL   Nutr Metab (Lond) 11, 37 (2014)
   PUBMED   25302068
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 574)
  AUTHORS   Hosseini,M., Ehrhardt,N., Weissglas-Volkov,D., Lai,C.M., Mao,H.Z.,
            Liao,J.L., Nikkola,E., Bensadoun,A., Taskinen,M.R., Doolittle,M.H.,
            Pajukanta,P. and Peterfy,M.
  TITLE     Transgenic expression and genetic variation of Lmf1 affect LPL
            activity in mice and humans
  JOURNAL   Arterioscler Thromb Vasc Biol 32 (5), 1204-1210 (2012)
   PUBMED   22345169
  REMARK    GeneRIF: variation in Lmf1 expression is a posttranslational
            determinant of LPL activity.
REFERENCE   5  (residues 1 to 574)
  AUTHORS   Yin,F., Doolittle,M.H. and Peterfy,M.
  TITLE     A quantitative assay measuring the function of lipase maturation
            factor 1
  JOURNAL   J Lipid Res 50 (11), 2265-2269 (2009)
   PUBMED   19471043
  REMARK    GeneRIF: Results show that cotransfection of LPL with wild-type
            Lmf1 restores its ability to support normal lipase maturation.
REFERENCE   6  (residues 1 to 574)
  AUTHORS   Ebersole,T., Lai,F. and Artzt,K.
  TITLE     New molecular markers for the distal end of the t-complex and their
            relationships to mutations affecting mouse development
  JOURNAL   Genetics 131 (1), 175-182 (1992)
   PUBMED   1350556
REFERENCE   7  (residues 1 to 574)
  AUTHORS   Lai,F. and Artzt,K.
  TITLE     Map positions of four dinucleotide repeats in the mouse t complex
  JOURNAL   Mamm Genome 3 (8), 476-477 (1992)
   PUBMED   1643311
REFERENCE   8  (residues 1 to 574)
  AUTHORS   Oka,K., Nakano,T., Tkalcevic,G.T., Scow,R.O. and Brown,W.V.
  TITLE     Molecular cloning of mouse hepatic triacylglycerol lipase: gene
            expression in combined lipase-deficient (cld/cld) mice
  JOURNAL   Biochim Biophys Acta 1089 (1), 13-20 (1991)
   PUBMED   2025643
REFERENCE   9  (residues 1 to 574)
  AUTHORS   Davis,R.C., Ben-Zeev,O., Martin,D. and Doolittle,M.H.
  TITLE     Combined lipase deficiency in the mouse. Evidence of impaired
            lipase processing and secretion
  JOURNAL   J Biol Chem 265 (29), 17960-17966 (1990)
   PUBMED   2211673
REFERENCE   10 (residues 1 to 574)
  AUTHORS   Oka,K., Yuan,J.G., Senda,M., Masibay,A.S., Qasba,P.K., Masuno,H.,
            Scow,R.O., Paterniti,J.R. Jr. and Brown,W.V.
  TITLE     Expression of lipoprotein lipase gene in combined lipase deficiency
  JOURNAL   Biochim Biophys Acta 1008 (3), 351-354 (1989)
   PUBMED   2474325
  REMARK    Erratum:[Biochim Biophys Acta 1989 Nov 2;1009(2):199. Oasba PK
            [corrected to Qasba PK]]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154418.2 and AC134908.5.
            
            On Jul 31, 2009 this sequence version replaced NP_083900.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010312.1, AK154622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..574
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.7 cM"
     Protein         1..574
                     /product="lipase maturation factor 1"
                     /note="transmembrane protein 112"
                     /calculated_mol_wt=65747
     Region          1..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1)"
     Site            50..72
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1)"
     Site            128..151
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1)"
     Region          169..547
                     /region_name="LMF1"
                     /note="Lipase maturation factor; pfam06762"
                     /db_xref="CDD:462004"
     Site            208..221
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1)"
     Site            293..321
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1)"
     Site            368..388
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U3R4.1)"
     CDS             1..574
                     /gene="Lmf1"
                     /gene_synonym="2400010G15Rik; cld; Tmem112"
                     /coded_by="NM_029624.5:14..1738"
                     /db_xref="CCDS:CCDS37502.2"
                     /db_xref="GeneID:76483"
                     /db_xref="MGI:MGI:1923733"
ORIGIN      
        1 mrpdslvmaa pegslrkrkv ggaehspasq pslardpads parlhtgtfw ltrivllral
       61 afiyfvaflv afnqnkalig drgllpckly lknvqeyfqg stgwaawtya ptimwlldws
      121 dmnfnldlia llglgissfv lvtgcanmil mtalwalyms lvnvgqiwys fgwesqllet
      181 gflgiflspl wtlsrlpknt ptsqivlwgf rwlifrimlg aglikvrgdk cwldltcmdf
      241 hyetqpvpnp iayylhrspw wfhrfetlsn hfvellvpff lflgrrmril hgvlqilfqv
      301 iliisgnlsf lnwltivpsl acfddaalgf lfpsgpqglk kqvleiqred tqrvqpkprd
      361 rgclvrqvvn islgilvawl svpvvinlls srqimntsfn plrivntyga fgsvtkerte
      421 vilqgtvspn asapdavwed yefkckpgdp wrqpclispy hyrldwlmwf aafqtyeqne
      481 wilhlagkll agdsealall avnpfegrtp prwirgehyr ykfslpggqh atqgkwwirk
      541 rigpyfpplr ledlkeyfkt rewplpepps rhtr
//
