LOCUS       NM_144799               1678 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus LIM and cysteine-rich domains 1 (Lmcd1), mRNA.
ACCESSION   NM_144799
VERSION     NM_144799.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1678)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1678)
  AUTHORS   Bai,Y., Tian,M., He,P., Zhang,Y., Chen,J., Zhao,Z., Lan,J. and
            Zhang,B.
  TITLE     LMCD1 is involved in tubulointerstitial inflammation in the early
            phase of renal fibrosis by promoting NFATc1-mediated NLRP3
            activation
  JOURNAL   Int Immunopharmacol 121, 110362 (2023)
   PUBMED   37311356
  REMARK    GeneRIF: LMCD1 is involved in tubulointerstitial inflammation in
            the early phase of renal fibrosis by promoting NFATc1-mediated
            NLRP3 activation.
REFERENCE   3  (bases 1 to 1678)
  AUTHORS   Yu,R., Tian,M., He,P., Chen,J., Zhao,Z., Zhang,Y. and Zhang,B.
  TITLE     Suppression of LMCD1 ameliorates renal fibrosis by blocking the
            activation of ERK pathway
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1869 (4), 119200 (2022)
   PUBMED   34968577
  REMARK    GeneRIF: Suppression of LMCD1 ameliorates renal fibrosis by
            blocking the activation of ERK pathway.
REFERENCE   4  (bases 1 to 1678)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1678)
  AUTHORS   Xu,J., Liu,H., Lan,Y. and Jiang,R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1678)
  AUTHORS   Combes,A.N., Lesieur,E., Harley,V.R., Sinclair,A.H., Little,M.H.,
            Wilhelm,D. and Koopman,P.
  TITLE     Three-dimensional visualization of testis cord morphogenesis, a
            novel tubulogenic mechanism in development
  JOURNAL   Dev Dyn 238 (5), 1033-1041 (2009)
   PUBMED   19334288
REFERENCE   7  (bases 1 to 1678)
  AUTHORS   Crompton,L.A., Du Roure,C. and Rodriguez,T.A.
  TITLE     Early embryonic expression patterns of the mouse Flamingo and
            Prickle orthologues
  JOURNAL   Dev Dyn 236 (11), 3137-3143 (2007)
   PUBMED   17937400
REFERENCE   8  (bases 1 to 1678)
  AUTHORS   Rath,N., Wang,Z., Lu,M.M. and Morrisey,E.E.
  TITLE     LMCD1/Dyxin is a novel transcriptional cofactor that restricts
            GATA6 function by inhibiting DNA binding
  JOURNAL   Mol Cell Biol 25 (20), 8864-8873 (2005)
   PUBMED   16199866
  REMARK    GeneRIF: Expression of LMCD1/dyxin is remarkably similar to that of
            GATA6, with high-level expression observed in distal airway
            epithelium of the lung, vascular smooth muscle, and myocardium.
REFERENCE   9  (bases 1 to 1678)
  AUTHORS   Bekman,E. and Henrique,D.
  TITLE     Embryonic expression of three mouse genes with homology to the
            Drosophila melanogaster prickle gene
  JOURNAL   Mech Dev 119 Suppl 1, S77-S81 (2002)
   PUBMED   14516664
REFERENCE   10 (bases 1 to 1678)
  AUTHORS   Bespalova,I.N. and Burmeister,M.
  TITLE     Identification of a novel LIM domain gene, LMCD1, and chromosomal
            localization in human and mouse
  JOURNAL   Genomics 63 (1), 69-74 (2000)
   PUBMED   10662546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153822.13.
            
            On Aug 13, 2022 this sequence version replaced NM_144799.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159946.1, BC019124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC153822.13        142203-142367
            166-254             AC153822.13        173444-173532
            255-510             AC153822.13        178881-179136
            511-846             AC153822.13        183971-184306
            847-1062            AC153822.13        197058-197273
            1063-1678           AC153822.13        198203-198818
FEATURES             Location/Qualifiers
     source          1..1678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.14 cM"
     gene            1..1678
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /note="LIM and cysteine-rich domains 1"
                     /db_xref="GeneID:30937"
                     /db_xref="MGI:MGI:1353635"
     exon            1..165
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1221
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /codon_start=1
                     /product="LIM and cysteine-rich domains protein 1"
                     /protein_id="NP_659048.1"
                     /db_xref="CCDS:CCDS20403.1"
                     /db_xref="GeneID:30937"
                     /db_xref="MGI:MGI:1353635"
                     /translation="MAKVAKDLNPGVQKMSLGQQQSARGVACLRCKGMCSGFEPHSWR
                     KICKSCKCSQEEHCLSSDLDDDRKIGRLLMDSKYATLTARVKGGDGIRIYKRNRMIMT
                     NPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKERQPVTGTEGALYRRRQLMHQ
                     LPIYDQDPSRCRGLVENELKAMEEFVKHYKSEALGVGEVALPGQGGLPKEENKTQEKP
                     EGTETTAPTTNGSLGDPSKEVEYVCELCKGAAPVDSPVVYADRAGYSKQWHPTCFQCI
                     KCSEPLVDLIYFWKDGAPWCGRHYCESVRPRCSGCDEIIFSEDYQRVEDLAWHRKHFI
                     CEGCEQLLSGRAYIVTKGQLLCPTCSKSKRS"
     exon            166..254
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            255..510
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            511..846
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1062
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1678
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1651..1656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /note="hexamer: AATAAA"
     polyA_site      1678
                     /gene="Lmcd1"
                     /gene_synonym="dyxin"
                     /note="major polyA site"
ORIGIN      
        1 acagagccgc cggctgcaca caggcaaagg aacctgaact tggccattca gcagcgctgt
       61 ccaggctgcg cgctccctct ggcccctgcc tgagaagcca ggtgctgttt ctgcaccgcc
      121 aggatggcaa aagtggctaa ggacctcaac cctggagtgc aaaagatgtc cttgggccag
      181 cagcagtccg caagaggagt ggcttgtctg cggtgcaagg gaatgtgctc cggcttcgag
      241 cctcactcgt ggaggaaaat atgcaagtct tgtaaatgca gccaggagga gcactgccta
      301 agctctgacc tggacgatga tcggaaaatt gggcgcctgc tgatggactc caagtatgcc
      361 actctcaccg ccagggtgaa aggcggagac ggcatccgca tctataagag gaaccgcatg
      421 atcatgacca accccatcgc caccggcaaa gaccccacct ttgacactat cacctacgag
      481 tgggctcccc caggagtcac ccagaaactg ggcctgcagt acatggaact catccccaag
      541 gagaggcagc ctgtgacagg cactgagggt gccctctacc gccgacgcca gctcatgcat
      601 cagctcccta tctatgacca ggacccctct cgatgccgtg gacttgtgga gaatgagctg
      661 aaagctatgg aggagttcgt caagcactac aagagcgagg cccttggggt gggcgaggtg
      721 gccctcccag ggcagggagg cttgcccaag gaagaaaaca agacacagga aaagccagag
      781 ggcacagaga ccactgcccc aaccaccaat ggcagcctgg gtgatccatc caaagaagtg
      841 gaatacgtct gtgagctctg caagggagca gccccagttg acagccctgt ggtctacgct
      901 gacagggctg gatacagcaa acagtggcac cccacgtgct ttcagtgtat caagtgctca
      961 gagccactgg tggacctcat ctacttctgg aaggatggtg caccctggtg tggccgccac
     1021 tactgtgaga gtgtgcggcc ccggtgctca ggctgtgatg agatcatctt ctcagaagac
     1081 taccagcgtg tggaagacct ggcctggcat cggaagcact tcatttgcga gggctgtgag
     1141 cagctgctga gcggccgtgc gtacatcgtc accaagggtc agctcctgtg ccccacatgc
     1201 agcaagtcaa aacgctcctg aaaggctgcc cgcccacagc cagcagagtc tatcggatcc
     1261 caccaggaga ctgaagccat cctatggggc ggatgccacg gccagcaagc agtgcatatt
     1321 ctaggttgag cagtggtaga tcttagaggg tcagtagttt caaaaacaga ggtattctaa
     1381 gaagtcttag aatggattta ttgtttccta gctgcaacca actaaagaca cactggtatc
     1441 ctgccaggga gccctaggag aaatttccca gaatgcattt ctgagggatc caatcaagaa
     1501 gtagatgtag gatatgcttt tttttttctc tcgtggacat gggatctctc cagggggcag
     1561 gatgagattc tcaactccca tttgtttgcc tctttctcaa gtggaatctg aatcttcaat
     1621 aaacaatgtt tttggcatga taaacatatc aataaaaggt ttatgaattt cacacaca
//
