LOCUS       NM_026719               5422 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LMBR1 domain containing 1 (Lmbrd1), transcript variant
            1, mRNA.
ACCESSION   NM_026719
VERSION     NM_026719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5422)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5422)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5422)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5422)
  AUTHORS   Mohammed,Y., Michaud,S.A., Petrosova,H., Yang,J., Ganguly,M.,
            Schibli,D., Flenniken,A.M., Nutter,L.M.J., Adissu,H.A.,
            Lloyd,K.C.K., McKerlie,C. and Borchers,C.H.
  TITLE     Proteotyping of knockout mouse strains reveals sex- and
            strain-specific signatures in blood plasma
  JOURNAL   NPJ Syst Biol Appl 7 (1), 25 (2021)
   PUBMED   34050187
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5422)
  AUTHORS   Kitai,K., Kawaguchi,K., Tomohiro,T., Morita,M., So,T. and
            Imanaka,T.
  TITLE     The lysosomal protein ABCD4 can transport vitamin B12 across
            liposomal membranes in vitro
  JOURNAL   J Biol Chem 296, 100654 (2021)
   PUBMED   33845046
REFERENCE   6  (bases 1 to 5422)
  AUTHORS   Dutchak,P.A., Laxman,S., Estill,S.J., Wang,C., Wang,Y., Wang,Y.,
            Bulut,G.B., Gao,J., Huang,L.J. and Tu,B.P.
  TITLE     Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1
            Inhibitor NPRL2
  JOURNAL   Cell Rep 12 (3), 371-379 (2015)
   PUBMED   26166573
REFERENCE   7  (bases 1 to 5422)
  AUTHORS   Tseng,L.T., Lin,C.L., Tzen,K.Y., Chang,S.C. and Chang,M.F.
  TITLE     LMBD1 protein serves as a specific adaptor for insulin receptor
            internalization
  JOURNAL   J Biol Chem 288 (45), 32424-32432 (2013)
   PUBMED   24078630
  REMARK    GeneRIF: LMBD1 plays an imperative role in mediating and regulating
            the endocytosis of the IR.
REFERENCE   8  (bases 1 to 5422)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   9  (bases 1 to 5422)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 5422)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY322390.1, BY291845.1, AK167080.1, AK032560.1, AK158982.1 and
            AI504365.1.
            
            On Jan 20, 2007 this sequence version replaced NM_026719.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.163000.1,
                                           SRR1660811.80724.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               BY322390.1         1-145
            146-469             BY291845.1         113-436
            470-2117            AK167080.1         289-1936
            2118-4423           AK032560.1         2417-4722
            4424-5332           AK158982.1         4260-5168
            5333-5422           AI504365.1         1-90                c
FEATURES             Location/Qualifiers
     source          1..5422
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 10.18 cM"
     gene            1..5422
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /note="LMBR1 domain containing 1"
                     /db_xref="GeneID:68421"
                     /db_xref="MGI:MGI:1915671"
     exon            1..273
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1827
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     probable lysosomal cobalamin transporter; protein N90b;
                     LMBR1 domain-containing protein 1; lysosomal cobalamin
                     transport escort protein LMBD1"
                     /codon_start=1
                     /product="lysosomal cobalamin transport escort protein
                     LMBD1 isoform 1"
                     /protein_id="NP_080995.2"
                     /db_xref="CCDS:CCDS35528.1"
                     /db_xref="GeneID:68421"
                     /db_xref="MGI:MGI:1915671"
                     /translation="MAAAAAELVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVST
                     VTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWADANVTVQIENTVLYGYYTLY
                     SVILFCVFFWIPFVYFYYEEKDEDDASKCTQIKTALKYTLGFVVICALLLLVGAFVPL
                     HLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPL
                     NLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLPARDRRALKQCEERLRTL
                     RKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGI
                     DSGFIIFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWI
                     RLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDA
                     HKGNSTLAVPKRCDADAPKDQCTVTRTYIFLHKFWFFSAAYYFGNWAFLVVFLIGLIV
                     SCCKGKKSVIEGVDEDSDLSDDEPSAYSA"
     exon            274..450
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            451..511
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            512..609
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..677
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..766
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..840
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..966
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1119
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1184
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1287
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1392
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1542
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1621
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1713
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..5392
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /note="hexamer: ATTAAA"
     polyA_site      2123
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /note="major polyA site"
     regulatory      5363..5368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /note="hexamer: ATTAAA"
     polyA_site      5392
                     /gene="Lmbrd1"
                     /gene_synonym="0910001K20Rik; LMBD1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgacgtca cggtgcgtcg ggtgcgcccc gcctcggctc ggctggtcgc caggggacgc
       61 tcgcgggccg ggtctccttg gcaaccctcc gctctgcccc tccgcccctt taacctttag
      121 gctgcgcagt tccgggtccc tcttcgttcc gtcccgtccc gtcccgtgcc ttccctcccc
      181 acccctttgg gcttatccgg accggaagcg aagatggcgg cggcggcggc cgagctggtg
      241 atcggctggt gcatcttcgg cctcttgctc ctggctattt tggccttttg ctgggtctac
      301 gttcggaagt accagagtca gcgggaaagt gaggtcgtct ccactgtgac agccattttt
      361 tcactggctg ttgctctgat cacatcagca ctgctgccgg tggatatatt tttggtttct
      421 tacatgaaaa atcaaaatgg cacattcaag gactgggctg acgccaatgt caccgtacag
      481 attgagaata ccgttctgta tggctactat actctgtatt ctgtcattct cttctgtgtg
      541 ttcttctgga tcccgtttgt gtacttctac tacgaagaga aggatgagga cgacgccagc
      601 aaatgcaccc aaattaaaac ggcgctcaag tacactttgg gatttgttgt gatctgcgct
      661 ctgctgcttc tcgttggtgc ctttgtgcct ctgcatctgc ccaacaacaa caactcaaca
      721 gagtgggaaa aggtgaagct cctgtttgaa gaccttggaa ctggtcaagg cctggcagct
      781 ctgtcctttt ccatcagctc tctgaccttg attgggatgc tggcggccat aacctacaca
      841 gcgtacggca tgtcggcatt acctttaaac ctaatcaaag gcactagaag cactgcctac
      901 gagcgcctgg agaacacgga ggacatcgag gaagtggagc agcacattca gacgattcga
      961 tccaagagca aagatggtcg acctttgcca gcgagggata gacgtgcctt aaagcaatgt
     1021 gaagaaagac taagaacgct taggaaaaga gagcggcact tggaattcat tgaaaacagc
     1081 tggtggacga aattttgtgg tgccctgcgc cccctgaaga tcatttgggg aatatttttc
     1141 atcctcgttg cgttgctgtt tgtaatttct ctcttcctgt caaatttgga taaagctctt
     1201 cattcagcag gaatagattc gggtttcatc atcttcggaa ctaacctgag caatccactg
     1261 aacatgcttt tgccgttgtt acaaacagtg ttccctcttg attacattct tataacaatt
     1321 attattatgt actttatttt tacttcgatg gcaggaattc gaaacattgg catttggttc
     1381 ttttggatta ggttatataa aatcagaaga gggcgaacca ggcctcaggc actcttattt
     1441 ctctgcatga tcctcctgct cattgtcctt cataccagct acatgatcta cagtctcgcg
     1501 cctcagtacg tgatgtacgg aagccagaat tacttaatag agagcaatat aacttctgat
     1561 gcccataaag gcaattcaac cctcgctgtg ccaaaaagat gtgacgcaga tgcccctaaa
     1621 gatcagtgta ctgttacccg aacatacatt ttcctccaca agttctggtt cttcagtgct
     1681 gcatactatt ttggtaactg ggcctttctc gtggtgttct tgatcggatt aattgtatcc
     1741 tgctgtaaag ggaagaagtc agtcatagaa ggagtggatg aagattcgga cttaagtgat
     1801 gatgagccgt ctgcctactc tgcgtgaacg gccttctgtc ctaagggctt aatgaagctg
     1861 gctgaatatc tattatgcgt tttcaaaagt ttaaagtaac attaaaatga actgtctagc
     1921 tttcatcaaa aatgagagca tggccattaa aaagtactat attttttatg tttcctgaag
     1981 tagcattatt gtatcataga ttaacattta aaattgctat aatactgtgt aaatacagag
     2041 tttccaggtt tgtgagggaa tgtttgtgga aattttcttt attgtaaaat agtgttaaat
     2101 ttattaaaat cttacacaat atacattccc tttgttgctt ttaagaaaca taagaagtca
     2161 ctttgtcttg tgccttaggg tctctggaat aatgtgaaac ttttaagtag cttccgctga
     2221 ttggctaaac aatgtctcag tattgcttgt gggtaagcat aactcatggg cagcttgctt
     2281 tcaattctgc ccataacata atgagtctaa ctcaagtaga gttcgtgaaa aagtgttaaa
     2341 ctgcctaaaa ccacaagact ctaagatgtg ttccaggtgg cagtgttcag atcttaatcc
     2401 atggagtacc tctacaagaa tatgtagata aaatttgttt tatagaaggc tttgaaactt
     2461 ggaaggtcat aaatggaaat gtcaagaatg aatgctgaag actgagctta ctaagcgtgg
     2521 taggtcacgt gacagcatac tcagctgctt ctcatgtaaa ggatttggaa acctgtgaaa
     2581 gaaaatgaaa gttgtgtgac ttaacagagt tttctgactg cgttctgggc agtgaaaata
     2641 aaggcttaat tcgctaatgt cagctaggac ttattcaaaa gtatttaccg ggatgcttga
     2701 agtaaaagat ctgtatggct caggagaaga cctaagagtt aactcgtctg cccctgaatc
     2761 ttcggcccaa gttctgactg tacttgctgc tctgattgat tccctgcctc acctgagaag
     2821 cttctagaac ctgctaggag acttggcttc tgttcccact cttatgtgat tcaccgggat
     2881 gccgatccct tctgctccta gttcacgttt tgggggtgtg ggtcagtccc ttggcctccc
     2941 cctgcatccc gaccctgtac tcttgcttgt ctgtaagctc cgttactgct tcagttgcaa
     3001 cactaagcct ctctgctgtt tgtttatagc aaaaggcctg gcctgtcagt attaggctcc
     3061 catattgtgc ccaccaaaaa tcaagaccgc cttatatatg aagcccatca tgaagttgtg
     3121 ttggtttttt tctgcctatc ttttctttac tctgtcctct cttctatcta cttggtgcca
     3181 cttaccctgt tagaatatat ccttccaaag tcacatgttg aagtcctcac tctagctgga
     3241 gaaatggctc agcagttaag agcactggct gctcttcaga ggtcctgaat tcaaatgcca
     3301 gcaaccactt gtgatgggat atgatgccat tttatggtgt ttctaaagtc agggcactca
     3361 tatatataaa ataaataaat ttaaacaaag aaaggtaatc taggtaagat taggccgttg
     3421 agtggatccc tcctagagat gtctgggctc tgcaggcagc ttggggacga agtcatggaa
     3481 ggacacagaa aaaggcaatc tataagccaa agaaagagac ctctagaagc cagctctgcc
     3541 agcactttgc ctgtcaacat ctggcttcca tagctgttgg ataatacatt ttcacttgac
     3601 aacccattga gtccatggtg tttgccattg agccaaggca actaactaac acacgctgcc
     3661 tcctaaactt cctcactacc tgtgcttcca agtcctgact cctctcagct ttttcttgac
     3721 atttaaaaca gaaatggaat tagttcattg cttcgctgtg aaaggctttc acttatttta
     3781 aaatgaaacc cgtaagcccc tgcatggtat ttaaggccgt tctgatgttt tatttgcttg
     3841 cagggctctt ggccatttcc tctgtattta catgagtgat tcctcatagc cgtacttgaa
     3901 tggttccttc tgcatacttg aatgcccagg cagcctttcc cctaaggaaa ttctttatca
     3961 acccttgggc ttggggttat gttgctcctc taagggctgg aggagagaag atgctggctc
     4021 ttggctgttt gtgtggacca tgacaggaca gcggatggtg actgactgct tccatgtgca
     4081 cctgcacatt gcaaaggttt tctgactttg ttcttgggaa ccagaataac tcgtagagaa
     4141 tactcgtaga ataacatgta gagagtacta ataggtgaat ttgctaattt gaagctataa
     4201 acatgtctac attggttaag cctacataaa ctatactttt atcaaagtat caggaggcat
     4261 atatatcttt tgagactttt tttgctatct aataagttta gaaatatcct aattattcta
     4321 tatacttacg ataggatttt tttttgttag accaacttct tagcttacca tggtactctt
     4381 tattgtttaa acaagaaaat tttaaatata tattttgctc ctttcatttc ctgagtgtta
     4441 agaagcctac tttattcaaa tgctactttg tccccctttt ggtgtaatga aatgtgttgg
     4501 actttatatt tccataaagc tgacttctaa gtgtcacgac ttcgactaat gaacagcttc
     4561 tctcctttga agtcttcaca gaaatgccta aattagagat cattcagagc attggctttc
     4621 caaagactga gggccctcat gtcccatgtc gacttcaaag tgatcaattt atgtagccat
     4681 gaatcggaaa tgagaagcct ggaaccagct tctagccagc tcagggctgc tgcagcaaag
     4741 gaagtttaaa aaggaaacaa aacaacaaca acaacaacaa aacccttact gtgcaggtaa
     4801 aaaactggtt aggagctcca aggagaaaaa aaaaataaag tagcaatgtt ttcatgaacc
     4861 tacaagatag atcagcagtg gctcggggcg tggtggcacg cctttaatcc cagcacttgg
     4921 gaggcagagg caggtgaatt tctgagttca aggccagcct ggtctacaga gtgagttcca
     4981 ggacagccag ggctacacag agaaaccctg tcccgaaaaa actaaaaaaa aaaaaaaaaa
     5041 aaaaaaaaaa gatcagtagg tagtttgcac acaggccttc ccatctgagt cccatctcag
     5101 tctcccaagg agaacaggcc agagagacct ggatctcaga ggacccagag agaacaagct
     5161 cctgagactg gtccctgacc tgcctatgcc tgcactccca catatgcagc ataaactaat
     5221 agtgttttct ggtgtactac taaggtctta tgaatgttac atatttaaag taatgtactg
     5281 atttagaaac aatctacaga cacagcacac ttgatgttgg ccactttgtc atctttctgt
     5341 cactatgaca aaacaaaatc atattaaaag gaactttggt tcccaaatgc aaaaaaaaaa
     5401 aaaaaaaaaa aaaaaaaaaa aa
//
