LOCUS       NM_029098               2136 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus limb region 1 like (Lmbr1l), transcript variant 1,
            mRNA.
ACCESSION   NM_029098
VERSION     NM_029098.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2136)
  AUTHORS   Liu,W., Jiang,X., Li,X., Sun,K., Yang,Y., Yang,M., Li,S. and Zhu,X.
  TITLE     LMBR1L regulates the proliferation and migration of endothelial
            cells through Norrin/beta-catenin signaling
  JOURNAL   J Cell Sci 135 (6) (2022)
   PUBMED   35146515
  REMARK    GeneRIF: LMBR1L regulates the proliferation and migration of
            endothelial cells through Norrin/beta-catenin signaling.
REFERENCE   2  (bases 1 to 2136)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2136)
  AUTHORS   Choi,J.H., Zhong,X., McAlpine,W., Liao,T.C., Zhang,D., Fang,B.,
            Russell,J., Ludwig,S., Nair-Gill,E., Zhang,Z., Wang,K.W.,
            Misawa,T., Zhan,X., Choi,M., Wang,T., Li,X., Tang,M., Sun,Q.,
            Yu,L., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073040
  REMARK    GeneRIF: LMBR1L has an essential function during lymphopoiesis and
            lymphoid activation, acting as a negative regulator of the
            Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 2136)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161165.5.
            
            On Mar 23, 2023 this sequence version replaced NM_029098.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023397.1, AK030589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC161165.5         127199-127412       c
            215-299             AC161165.5         124486-124570       c
            300-333             AC161165.5         122906-122939       c
            334-473             AC161165.5         121747-121886       c
            474-577             AC161165.5         121493-121596       c
            578-704             AC161165.5         120845-120971       c
            705-773             AC161165.5         118737-118805       c
            774-838             AC161165.5         118552-118616       c
            839-911             AC161165.5         118198-118270       c
            912-995             AC161165.5         118025-118108       c
            996-1072            AC161165.5         117869-117945       c
            1073-1150           AC161165.5         117243-117320       c
            1151-1224           AC161165.5         116886-116959       c
            1225-1315           AC161165.5         115593-115683       c
            1316-1382           AC161165.5         115265-115331       c
            1383-1544           AC161165.5         114014-114175       c
            1545-2136           AC161165.5         113266-113857       c
FEATURES             Location/Qualifiers
     source          1..2136
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 55.1 cM"
     gene            1..2136
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /note="limb region 1 like"
                     /db_xref="GeneID:74775"
                     /db_xref="MGI:MGI:1289247"
     exon            1..214
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1612
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lipocalin-interacting membrane receptor; protein LMBR1L;
                     uteroglobin receptor; lipocalin-1-interacting membrane
                     receptor"
                     /codon_start=1
                     /product="protein LMBR1L isoform 1"
                     /protein_id="NP_083374.1"
                     /db_xref="CCDS:CCDS27811.1"
                     /db_xref="GeneID:74775"
                     /db_xref="MGI:MGI:1289247"
                     /translation="MEAADYEVLSVREQLFHDRVRECIISILLFATLYILCHIFLTRF
                     KKPAEFTTVDDEDATVNKIALELCTFTLAVALGAVLLLPFSIISNEVLLSLPRNYYIQ
                     WLNGSLIHGLWNLVFLFSNLSLVFLMPFAYFFTESEGFAGSRKGVLGRVYETVVMLIL
                     LTLLVLGMVWVASAIVDNDKASRESLYDFWEYYLPYLYSCISFLGVLLLLVCTPLGLA
                     RMFSVTGKLLVKPRLLEDLEEQLNCSAFEEAALTRRICNPTSCWLPLDMELLHRQVLA
                     LQAQRVLLEKRRKASAWQRNLGYPLAMLCLLVLTGLSVLIVAVHILELLIDEAAMPRG
                     MQDAALGQASFSKLGSFGAIIQVVLIFYLMVSSVVGFYSSPLFGSLRPRWHDTSMTQI
                     IGNCVCLLVLSSALPVFSRTLGLTRFDLLGDFGRFNWLGNFYIVFLYNAAFAGLTTLC
                     LVKTFTAAVRAELIRAFGLDRLPLPVSGFPRASRKKQHQ"
     exon            215..299
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            300..333
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            334..473
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            474..577
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            578..704
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            705..773
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            774..838
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            839..911
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            912..995
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1072
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1150
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1224
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1315
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1382
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1544
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..2136
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2097..2102
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /note="hexamer: AATAAA"
     polyA_site      2136
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /note="major polyA site"
ORIGIN      
        1 agattacctt gagtttccgt cacgggcagc gaggagaggc gcttaggctg ggtccgggtg
       61 cttggcgggc ggcggcggcc tcatccccgc tcgtcctccc cgggcccgga gacacccccg
      121 ccccagtcat gctgagcaga gtatggaagc agctgactac gaagtgctat ccgtgcgaga
      181 acagctgttc cacgacaggg tccgcgagtg catcatctca atacttctgt ttgcaacact
      241 ctacatcctc tgccatatct tcctgacccg cttcaagaag cctgctgagt tcaccacagt
      301 ggatgatgaa gatgccacag ttaacaagat tgcgctggag ctgtgcacct ttaccctggc
      361 ggtcgccctg ggcgccgtct tactcctgcc cttctccatc atcagcaacg aggtgctgct
      421 ctcgttgcca cgcaactact acatccagtg gctcaatggc tccctcatcc atggtctgtg
      481 gaacctcgtt ttcctcttct ccaatctgtc cctcgtcttc cttatgccct ttgcatattt
      541 cttcacagag tctgaaggct ttgctggctc cagaaagggt gtcctgggcc gggtctacga
      601 gacagtggtg atgttgatcc tcctcacgct gcttgtgctg ggcatggtgt gggtggcatc
      661 cgccattgta gacaatgaca aggccagcag ggagtcgctc tacgacttct gggagtacta
      721 cctcccctat ctctactcct gtatctcctt cctcggagtt ctgctgcttc tggtgtgcac
      781 tccactaggt ctcgcccgca tgttctctgt cactgggaag ttgctggtca agccccggct
      841 actggaagac ctggaggaac agctgaactg ctcagccttt gaggaggcag ctctgactcg
      901 aagaatctgc aatcccacct cctgctggct gccactggac atggaactgc tgcatagaca
      961 ggtcctggct ctgcaggcac agagggtcct cttggaaaag cgtcggaagg cgtcagcctg
     1021 gcaacggaac ctgggctacc ctctggccat gctgtgcttg ctggtgctga cgggcctgtc
     1081 tgtcctcatc gtggctgtcc acatcctgga gctgcttatt gacgaggctg ccatgccacg
     1141 gggcatgcag gatgctgccc taggccaggc ctccttctcc aaactgggat cctttggcgc
     1201 catcatccag gttgtgctga tattttacct gatggtgtcc tcagtggtgg gtttctacag
     1261 ctctccactc tttggaagcc tgaggcctag gtggcatgac acatcgatga cacagatcat
     1321 tgggaactgt gtctgcctcc tggtcctcag ctcagcactt cctgtcttct ctagaactct
     1381 tggcctgaca cgctttgacc tgctgggtga ctttggacgc ttcaactggc taggcaattt
     1441 ctacatcgtg ttcctctaca acgcagcctt tgctggcctc accacactct gtctggtgaa
     1501 gaccttcacg gcagctgtga gggcagagct gatccgagcc tttgggctgg acagactgcc
     1561 actgcctgtc tctgggtttc cccgggcttc taggaagaag cagcatcaat gacctccagc
     1621 tgggggctga gaaggagaga actgggcagt gcctaggcct ggcggtgagc cccagggggc
     1681 tgcacctcag gacctggaac ctgagagtag gtgacagagg ggacggacca tctgcactgt
     1741 tgcttaatct gagccagagt ttgggacccg gctggcctcc tgccttttca gatgtagctg
     1801 tggcctgagc atccatctgg tggagctggg ggactcgctc tagttcctgg acccaaatac
     1861 gtttacacat ctatctgcct caatcctgtt ccaggccatg cctgaagcca tgtttacatg
     1921 atttgatgtg caatagggtg ggtgggactt ggggggactg ggccaggggt aggttctgga
     1981 gacaggtctt ccttgcctct ggcccagaag agccgaagca ctgtgctatc ctgtggaggg
     2041 ctttggacca ctggagagac caagggtgct gggaggaggc ggctgcaccc acgagcaata
     2101 aaattgatcc cagggttttc ttggttcttt tgtaaa
//
