LOCUS       NP_083374                489 aa            linear   ROD 01-MAY-2025
DEFINITION  protein LMBR1L isoform 1 [Mus musculus].
ACCESSION   NP_083374
VERSION     NP_083374.1
DBSOURCE    REFSEQ: accession NM_029098.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 489)
  AUTHORS   Liu,W., Jiang,X., Li,X., Sun,K., Yang,Y., Yang,M., Li,S. and Zhu,X.
  TITLE     LMBR1L regulates the proliferation and migration of endothelial
            cells through Norrin/beta-catenin signaling
  JOURNAL   J Cell Sci 135 (6) (2022)
   PUBMED   35146515
  REMARK    GeneRIF: LMBR1L regulates the proliferation and migration of
            endothelial cells through Norrin/beta-catenin signaling.
REFERENCE   2  (residues 1 to 489)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 489)
  AUTHORS   Choi,J.H., Zhong,X., McAlpine,W., Liao,T.C., Zhang,D., Fang,B.,
            Russell,J., Ludwig,S., Nair-Gill,E., Zhang,Z., Wang,K.W.,
            Misawa,T., Zhan,X., Choi,M., Wang,T., Li,X., Tang,M., Sun,Q.,
            Yu,L., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling
  JOURNAL   Science 364 (6440) (2019)
   PUBMED   31073040
  REMARK    GeneRIF: LMBR1L has an essential function during lymphopoiesis and
            lymphoid activation, acting as a negative regulator of the
            Wnt/beta-catenin pathway.
REFERENCE   4  (residues 1 to 489)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161165.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023397.1, AK030589.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..489
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 55.1 cM"
     Protein         1..489
                     /product="protein LMBR1L isoform 1"
                     /note="lipocalin-interacting membrane receptor; protein
                     LMBR1L; uteroglobin receptor; lipocalin-1-interacting
                     membrane receptor"
                     /calculated_mol_wt=54827
     Region          1..76
                     /region_name="LCN1-binding.
                     /evidence=ECO:0000250|UniProtKB:Q6UX01"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Region          1..59
                     /region_name="Interaction with LGB.
                     /evidence=ECO:0000250|UniProtKB:Q6UX01"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            22..42
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Region          24..452
                     /region_name="LMBR1"
                     /note="LMBR1-like membrane protein; pfam04791"
                     /db_xref="CDD:461429"
     Site            67..87
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            115..135
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            155..175
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            197..217
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            306..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            351..371
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            389..409
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     Site            432..452
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D1E5.1)"
     CDS             1..489
                     /gene="Lmbr1l"
                     /gene_synonym="1110013E13Rik; D15Ertd735e; Limr"
                     /coded_by="NM_029098.4:143..1612"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS27811.1"
                     /db_xref="GeneID:74775"
                     /db_xref="MGI:MGI:1289247"
ORIGIN      
        1 meaadyevls vreqlfhdrv reciisillf atlyilchif ltrfkkpaef ttvddedatv
       61 nkialelctf tlavalgavl llpfsiisne vllslprnyy iqwlngslih glwnlvflfs
      121 nlslvflmpf ayfftesegf agsrkgvlgr vyetvvmlil ltllvlgmvw vasaivdndk
      181 asreslydfw eyylpylysc isflgvllll vctplglarm fsvtgkllvk prlledleeq
      241 lncsafeeaa ltrricnpts cwlpldmell hrqvlalqaq rvllekrrka sawqrnlgyp
      301 lamlcllvlt glsvlivavh ilellideaa mprgmqdaal gqasfsklgs fgaiiqvvli
      361 fylmvssvvg fyssplfgsl rprwhdtsmt qiigncvcll vlssalpvfs rtlgltrfdl
      421 lgdfgrfnwl gnfyivflyn aafaglttlc lvktftaavr aelirafgld rlplpvsgfp
      481 rasrkkqhq
//
