LOCUS       NM_001172062            1742 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus lectin, mannose-binding, 1 (Lman1), transcript variant
            2, mRNA.
ACCESSION   NM_001172062
VERSION     NM_001172062.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Everett,L.A., Lin,Z., Friedman,A., Tang,V.T., Myers,G.,
            Balbin-Cuesta,G., King,R., Zhu,G., McGee,B. and Khoriaty,R.
  TITLE     LMAN1 serves as a cargo receptor for thrombopoietin
  JOURNAL   JCI Insight 9 (24), e175704 (2024)
   PUBMED   39499573
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Aure,M.H., Symonds,J.M., Villapudua,C.U., Dodge,J.T., Werner,S.,
            Knosp,W.M. and Hoffman,M.P.
  TITLE     FGFR2 is essential for salivary gland duct homeostasis and
            MAPK-dependent seromucous acinar cell differentiation
  JOURNAL   Nat Commun 14 (1), 6485 (2023)
   PUBMED   37838739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Everett,L.A., Khoriaty,R.N., Zhang,B. and Ginsburg,D.
  TITLE     Altered phenotype in LMAN1-deficient mice with low levels of
            residual LMAN1 expression
  JOURNAL   Blood Adv 4 (22), 5635-5643 (2020)
   PUBMED   33196840
  REMARK    GeneRIF: Altered phenotype in LMAN1-deficient mice with low levels
            of residual LMAN1 expression.
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Fu,Y.L., Zhang,B. and Mu,T.W.
  TITLE     LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors
  JOURNAL   Biochem Biophys Res Commun 511 (2), 356-362 (2019)
   PUBMED   30791981
  REMARK    GeneRIF: LMAN1 promotes the surface trafficking of endogenous
            gamma-aminobutyric acid type A receptors.
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Zhu,M., Zheng,C., Wei,W., Everett,L., Ginsburg,D. and Zhang,B.
  TITLE     Analysis of MCFD2- and LMAN1-deficient mice demonstrates distinct
            functions in vivo
  JOURNAL   Blood Adv 2 (9), 1014-1021 (2018)
   PUBMED   29735583
  REMARK    GeneRIF: MCFD2-deficient mice generated by gene targeting also
            demonstrate reduced plasma FV and FVIII, with levels lower than
            those in LMAN1-deficient mice, similar to previous observations in
            LMAN1- and MCDF2-deficient humans.
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Velloso,L.M., Svensson,K., Schneider,G., Pettersson,R.F. and
            Lindqvist,Y.
  TITLE     Crystal structure of the carbohydrate recognition domain of
            p58/ERGIC-53, a protein involved in glycoprotein export from the
            endoplasmic reticulum
  JOURNAL   J Biol Chem 277 (18), 15979-15984 (2002)
   PUBMED   11850423
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Nakajima,K., Takei,Y., Tanaka,Y., Nakagawa,T., Nakata,T., Noda,Y.,
            Setou,M. and Hirokawa,N.
  TITLE     Molecular motor KIF1C is not essential for mouse survival and
            motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum
            transport
  JOURNAL   Mol Cell Biol 22 (3), 866-873 (2002)
   PUBMED   11784862
REFERENCE   8  (bases 1 to 1742)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 1742)
  AUTHORS   Garver,W.S., Heidenreich,R.A., Erickson,R.P., Thomas,M.A. and
            Wilson,J.M.
  TITLE     Localization of the murine Niemann-Pick C1 protein to two distinct
            intracellular compartments
  JOURNAL   J Lipid Res 41 (5), 673-687 (2000)
   PUBMED   10787428
REFERENCE   10 (bases 1 to 1742)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY766745.1, AK011495.1 and AC152076.4.
            
            Transcript Variant: This variant (2) differs in the 3' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011495.1, AK151949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BY766745.1         1-15
            16-1736             AK011495.1         2-1722
            1737-1742           AC152076.4         52659-52664
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.08 cM"
     gene            1..1742
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /note="lectin, mannose-binding, 1"
                     /db_xref="GeneID:70361"
                     /db_xref="MGI:MGI:1917611"
     exon            1..262
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1578
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /note="protein ERGIC-53; ER-Golgi intermediate compartment
                     53 kDa protein"
                     /codon_start=1
                     /product="protein ERGIC-53 precursor"
                     /protein_id="NP_001165533.1"
                     /db_xref="CCDS:CCDS29313.1"
                     /db_xref="GeneID:70361"
                     /db_xref="MGI:MGI:1917611"
                     /translation="MAVSRRRVPQAGARSFFCALLLSFSQFTGSDGTGGDAAAPGAAG
                     TQAELPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSADQIRIAPSLKSQRGSVW
                     TKAKAAFENWEVEVTFRVTGRGRIGADGLAIWYTENQGLDGPVFGSADTWNGVGIFFD
                     SFDNDGKKNNPAIVVIGNNGQINYDHQNDGATQALASCQRDFRNKPYPVRAKITYYQK
                     TLTVMINNGFTPDKNDYEFCAKVENMVIPTQGHFGISAATGGLADDHDVLSFLTFQLT
                     EPGKEPPTAEKDISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPADDIFESI
                     GDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISRRGAGTPGQPGQV
                     SQQELDTVVKSQQEILRQVNEVKNSMSETVRLVSGIQHPGSAGVYETTQHFMDIKEHL
                     HVVKRDIDSLAQRSMPSNEKPKCPDLPPFPSCLSTIHFVIFVVVQTVLFVGYIMYRTQ
                     QEAAAKKFF"
     exon            263..417
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            418..525
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            526..587
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            588..687
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            688..811
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            812..870
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1003
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1197
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1268
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1419
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..1541
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1742
                     /gene="Lman1"
                     /gene_synonym="2610020P13Rik; C730041J05; ERGIC53; F5F8D;
                     gp58; MCFD1; MR60; P58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctctgcg tcccagaatc caagatggcg gtgtccaggc ggagggttcc ccaggctgga
       61 gcgcggtcgt tcttctgcgc cctgctgctg tctttcagcc aattcaccgg gagcgacggc
      121 acgggaggcg acgctgcggc tcccggcgcc gcgggcaccc aggccgagtt gccacaccgc
      181 cgtttcgagt acaaatacag ctttaagggg ccgcatctgg tgcagagcga tgggaccgtg
      241 cccttttggg cccacgcggg gaatgctatt ccaagtgcag atcagattcg aatagcgccg
      301 tcattaaaaa gccaaagagg ttccgtgtgg accaaagcaa aagcagcctt cgagaactgg
      361 gaagtggaag tgacattccg agtgaccgga agaggtcgaa ttggagccga tggcttagca
      421 atttggtata cagaaaatca aggcttggac ggccctgtgt ttggatcagc tgatacgtgg
      481 aatggtgttg gaatattttt tgattctttt gacaatgatg gaaagaaaaa taatcctgct
      541 atagtagtta taggcaacaa tggacaaatc aattatgacc atcaaaatga tggtgccact
      601 caagctttag cgagttgtca gagggacttt cgtaataaac cctatcctgt ccgggcaaag
      661 attacgtatt accagaagac actgacagtc atgatcaata atggctttac accagataaa
      721 aatgattatg aattctgtgc caaagtggaa aacatggtta tccccacaca aggtcatttt
      781 gggatatcag cggcaacagg gggacttgca gatgaccacg acgttctttc tttcctgact
      841 ttccaactga ccgagcctgg aaaagagcca cctacagcag aaaaagacat ttcagaaaaa
      901 gaaaaggaaa agtatcaaga ggagtttgag cacttccagc aagaattaga caagaagaag
      961 gaggaattcc agaagggcca ccctgacctc caggggcagc cagcggatga catcttcgag
     1021 agcataggcg atcgggagct gagacaggtg tttgaaggac agaatcgtat tcatctggag
     1081 atcaagcagc tgaaccggca gctggatatg attcttgatg aacagaggag gtacgtctcg
     1141 tccctgacag aggagatctc caggagagga gcaggaaccc cgggacagcc tgggcaggtc
     1201 tctcagcagg aactggacac cgttgtgaag agccagcagg agattctgag acaagtgaat
     1261 gaggtgaaga actccatgag tgaaactgtg cggctggtga gtggcatcca gcacccgggc
     1321 tcagcaggcg tctacgagac aactcagcac ttcatggaca tcaaggaaca cctgcacgtg
     1381 gtgaagagag atatcgacag cctcgcacag cgcagcatgc catctaatga aaaaccaaaa
     1441 tgcccagacc taccaccatt cccgtcgtgt ctatccacga tccactttgt gatatttgta
     1501 gtggtgcaga cagtgttgtt cgttggctat atcatgtaca ggactcagca agaagcagct
     1561 gccaaaaaat tcttttgacc ttcattttcc tatatgtaca tcatgtatgt atgtgcaaat
     1621 gttgtctttt tgagggaatt tagtatttaa attgcttcat agtctaagtt attaaatttt
     1681 gtatgaaata actcttgaaa acattcactt ttcagtaaaa aataaatgtt aaagacaacc
     1741 ac
//
