LOCUS       NM_145438               3557 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus LLGL2 scribble cell polarity complex component
            (Llgl2), transcript variant 1, mRNA.
ACCESSION   NM_145438
VERSION     NM_145438.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3557)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3557)
  AUTHORS   Fernandez-Guerrero,M., Zdral,S., Castilla-Ibeas,A.,
            Lopez-Delisle,L., Duboule,D. and Ros,M.A.
  TITLE     Time-sequenced transcriptomes of developing distal mouse limb buds:
            A comparative tissue layer analysis
  JOURNAL   Dev Dyn 251 (9), 1550-1575 (2022)
   PUBMED   34254395
REFERENCE   3  (bases 1 to 3557)
  AUTHORS   Kharfallah,F., Guyot,M.C., El Hassan,A.R., Allache,R., Merello,E.,
            De Marco,P., Di Cristo,G., Capra,V. and Kibar,Z.
  TITLE     Scribble1 plays an important role in the pathogenesis of neural
            tube defects through its mediating effect of Par-3 and Vangl1/2
            localization
  JOURNAL   Hum Mol Genet 26 (12), 2307-2320 (2017)
   PUBMED   28369449
REFERENCE   4  (bases 1 to 3557)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3557)
  AUTHORS   Bell,S.M., Zhang,L., Xu,Y., Besnard,V., Wert,S.E., Shroyer,N. and
            Whitsett,J.A.
  TITLE     Kruppel-like factor 5 controls villus formation and initiation of
            cytodifferentiation in the embryonic intestinal epithelium
  JOURNAL   Dev Biol 375 (2), 128-139 (2013)
   PUBMED   23266329
REFERENCE   6  (bases 1 to 3557)
  AUTHORS   Dahan,I., Yearim,A., Touboul,Y. and Ravid,S.
  TITLE     The tumor suppressor Lgl1 regulates NMII-A cellular distribution
            and focal adhesion morphology to optimize cell migration
  JOURNAL   Mol Biol Cell 23 (4), 591-601 (2012)
   PUBMED   22219375
REFERENCE   7  (bases 1 to 3557)
  AUTHORS   Sripathy,S., Lee,M. and Vasioukhin,V.
  TITLE     Mammalian Llgl2 is necessary for proper branching morphogenesis
            during placental development
  JOURNAL   Mol Cell Biol 31 (14), 2920-2933 (2011)
   PUBMED   21606200
  REMARK    GeneRIF: Data suggest that mammalian Llgl2 is required for proper
            polarized invasion of trophoblasts and efficient branching
            morphogenesis during placental development, but, unlike its
            Drosophila ortholog, it does not function as a canonical tumor
            suppressor gene.
REFERENCE   8  (bases 1 to 3557)
  AUTHORS   Weimer,J.M., Yokota,Y., Stanco,A., Stumpo,D.J., Blackshear,P.J. and
            Anton,E.S.
  TITLE     MARCKS modulates radial progenitor placement, proliferation and
            organization in the developing cerebral cortex
  JOURNAL   Development 136 (17), 2965-2975 (2009)
   PUBMED   19666823
REFERENCE   9  (bases 1 to 3557)
  AUTHORS   Klezovitch,O., Fernandez,T.E., Tapscott,S.J. and Vasioukhin,V.
  TITLE     Loss of cell polarity causes severe brain dysplasia in Lgl1
            knockout mice
  JOURNAL   Genes Dev 18 (5), 559-571 (2004)
   PUBMED   15037549
REFERENCE   10 (bases 1 to 3557)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY200843.1, AK167536.1, AK078901.1 and BE982097.1.
            
            On Apr 11, 2007 this sequence version replaced NM_145438.1.
            
            Transcript Variant: This variant (1) is the predominant transcript
            and encodes a shorter isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY033650.1, BC037226.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BY200843.1         2-30
            30-2521             AK167536.1         2-2493
            2522-3515           AK078901.1         253-1246
            3516-3557           BE982097.1         1-42                c
FEATURES             Location/Qualifiers
     source          1..3557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..3557
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /note="LLGL2 scribble cell polarity complex component"
                     /db_xref="GeneID:217325"
                     /db_xref="MGI:MGI:1918843"
     exon            1..120
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            121..226
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..3235
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lethal(2) giant larvae protein homolog 2; lethal giant
                     larvae-like protein 2; LLGL scribble cell polarity complex
                     component 2"
                     /codon_start=1
                     /product="LLGL scribble cell polarity complex component 2
                     isoform 1"
                     /protein_id="NP_663413.2"
                     /db_xref="CCDS:CCDS25649.1"
                     /db_xref="GeneID:217325"
                     /db_xref="MGI:MGI:1918843"
                     /translation="MRRFLRTGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSL
                     RILAIGTRSGAVKLYGAPGVEFMGLHKENNAVLQIHFLPGQCQLVTLLDDNSLHLWSL
                     KVKGGVSELQEEESFTLRGPPGAAPSATQVTEILPHSSGELLYLGTESGNVFVVQLPG
                     FRTLHDRTICSDEVLQWLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDL
                     QGSRALSHFLSSQQLENASWQRDGCLIVTCHSDGSHCQWPVSSDTQNPEPLRSSIPYG
                     PFPCKAITKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVID
                     FTVLSEADPAAAFDDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCSHH
                     VSNIPLKLWERIIAAGSRQNSHFSTMEWPIDGGTSLAPPPPQRDLLLTGHEDGTVRFW
                     DASGVCLRLLYKLSTVRVFLTDTDPSENLIAQGEDEWPPLRKVGSFDPYSDDPRLGIQ
                     KIFLCKYSGYLAVAGTAGQVLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAA
                     RPGPVCFEAGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFV
                     KCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSSHKRRPGGPTGEAQAQAVN
                     IKAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTN
                     GGTVYAFSLRVPPAERRTDEPVRAEQAKEIQLMHRAPVVGILVLDGHNVPLPEPLEVA
                     HDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVGVAHFGSC
                     RAEDYGEHHLAVLTNLGDIQVVSMPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYL
                     ISPSEFERFSLSTKWLVEPRCLVDSTKAKKHNRPSNGNGTGLKMTSSGHVRNSKSQSD
                     GDEKKPGPVMEHALLNDAWVLKEIQSTLEGDRRSYGNWHPHRVAVGCRLSNGEAE"
     exon            227..324
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            325..406
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..522
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            523..681
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            682..844
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..977
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1032
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1187
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1405
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1473
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1627
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1732
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..2025
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2026..2176
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2333
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2450
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2617
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2882
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2883..3045
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3074
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3075..3122
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3165
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3227
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3542
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3496..3501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /note="hexamer: AGTAAA"
     regulatory      3513..3518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
                     /note="major polyA site"
     polyA_site      3542
                     /gene="Llgl2"
                     /gene_synonym="9130006H11Rik; Llglh2"
ORIGIN      
        1 ggtgagcagg aagcagacgg ccgccctgca gcccgtgggc cggagcaggg aacccgagtg
       61 gtgggtgacg gccgctgagg gacgccgagg cctcgggcag ggcccggccc gcgattgcag
      121 gtctgttgtg ggggccacaa actaaagcaa gatgaggcgg ttcctgagaa ctggacatga
      181 ccctgcccgg gagaggctga agcgggatct gttccagttt aacaagacag tggagcatgg
      241 cttcccacac cagcccagcg cccttggcta tagcccttcg ctgcgcatcc tggccatcgg
      301 aacccgctct ggagctgtca agctatatgg cgcccccggg gtagagttca tgggccttca
      361 caaggagaac aacgcagtgc tgcagatcca cttcctgcct ggtcagtgtc agctggtcac
      421 tctgctggat gacaatagcc tgcacctgtg gagcctgaag gtcaagggcg gggtgtcaga
      481 gctgcaggaa gaagagagct tcacattgcg tggcccccca ggggctgccc ccagtgccac
      541 gcaggtcact gagattctac ctcactcttc cggagaactg ctctacctgg gcaccgagag
      601 cggcaacgtg tttgtggtgc agctcccggg gttccgcacg ctgcacgaca ggaccatctg
      661 ttcagatgag gtgctgcaat ggttgccaga ggaggctcgc caccggcgag tgtttgagat
      721 ggtggaggct ctgcaggagc accctcgaga ccccaaccaa atcctcattg gctacagccg
      781 aggcctcgtc gtcatctggg accttcaggg cagccgagcg ctcagtcatt tcctcagcag
      841 ccagcaactg gagaatgcca gctggcagcg ggatggctgc ctgattgtca cctgccactc
      901 cgacggcagc cactgccagt ggcccgtctc cagtgacacc cagaacccag aacctctgcg
      961 cagctctata ccttacggtc cctttccttg caaagctata acgaaaatct tctggctcac
     1021 caccaggcaa gggttgccct tcaccatctt ccagggcggt atgccacggg ccagctatgg
     1081 ggaccgccac tgcatctcag tggtccacaa cggccagcag acggccttcg acttcacctc
     1141 ccgtgtcatt gacttcactg ttctctcaga ggctgaccct gcggctgcct ttgatgaccc
     1201 ctacgccctg gtggtgctag ccgaggagga actggtagtc attgacctgc agacacccgg
     1261 ctggccacca gtccagctgc cctacctggc ttccttgcac tgttccgcta tcacctgctc
     1321 ccaccacgtc tccaacatcc ccctgaagct atgggaacgc atcatcgccg cgggcagccg
     1381 ccagaactca cacttctcca ccatggagtg gcccatagat ggtggcacca gcctggcccc
     1441 accgccaccc cagagggacc tgctgctcac agggcacgag gacggcacgg tgcggttctg
     1501 ggacgcctcc ggtgtgtgct tacgtctgct ctacaaactg agcactgtga gggtgttcct
     1561 cacagacacg gaccccagcg agaacctcat tgcccagggt gaggacgagt ggcccccact
     1621 ccgcaaggtg ggctcctttg atccctacag cgatgatccg cggctaggca tccagaagat
     1681 tttcctctgc aaatacagcg gctacctggc tgtggcaggc acggcagggc aggtgctggt
     1741 gctggagttg aacgatgagg cggccgagca tgctgtggag caggtggagg ctgacctgct
     1801 gcaggaccag gagggttacc gctggaaggg gcacgagcgc ctcgccgccc gcccggggcc
     1861 cgtgtgcttt gaggcgggat ttcagccctt tgtactggtg cagtgccagc ccccagctgt
     1921 ggtcacctcc ttggctctgc actccgagtg gcggcttgtg gcctttggca ccagccatgg
     1981 tttcggcctc ttcgatcacc agcaacggcg gcaggtcttt gtcaagtgca cacttcaccc
     2041 cagtgaccag ctggccttgg agggccctct gtctcgagta aagtccctca agaagtctct
     2101 acgtcagtca ttccgtcgga tgcgtcgcag cagagtgtcc agtcataaac ggcggcctgg
     2161 tggccccaca ggcgaggcgc aggcccaggc tgtgaatatc aaggctgagc ggacgggcct
     2221 gcagaacatg gagttggcgc ccgtgcaacg gaagattgag gctcgctccg cggaggactc
     2281 cttcactggc tttgtccgga ccctctattt cgctgatacc tacctgaggg acagttcccg
     2341 ccactgtccc tccctgtggg ctggcaccaa cggaggcacc gtctacgcct tttccctgcg
     2401 cgtgcctcct gcagaaagaa gaacagatga acctgtccgg gcagagcagg ccaaggagat
     2461 ccagctgatg catcgcgcgc ctgtggtggg catcctggtg ctcgacggac acaacgtgcc
     2521 cctccccgag cccctggaag tcgcccatga cctgtcgaag agcccagaca tgcaagggag
     2581 ccaccaattg cttgtggtgt cggaggagca attcaaggta ttcacactgc ccaaggtgag
     2641 cgccaaactg aagctgaagc tgacggccct ggagggctca cgggtgcggc gagtcggtgt
     2701 cgcccacttt ggcagctgca gggctgagga ctatggggag caccacctgg cagtgctcac
     2761 caacttgggt gacatccagg tggtctcaat gcccctgctc aagccccagg tgcggtacag
     2821 ctgcatccgc cgggaggacg tcagcggcat agcttcctgt gtcttcacca aatatggcca
     2881 aggtttctat ctgatatcac cttcggagtt cgagcgcttt tctctctcca ccaagtggct
     2941 ggttgaaccc cggtgtttgg tggattcaac caaagccaag aagcacaacc ggcccagcaa
     3001 tggcaatggc acaggcctca aaatgacctc ctcaggccac gtcaggaact caaagagcca
     3061 aagtgatgga gatgagaaga agccgggccc agtgatggag cacgcgctgc tcaatgacgc
     3121 ctgggtccta aaggaaatcc agagcacgct ggagggggac cggaggagct atggcaattg
     3181 gcatcctcac cgcgtggctg tgggttgcag gctcagcaat ggagaagcag aatgactggg
     3241 acagcaccca ggctgtggga tgatcacaca ctactgaggg ccttgccagc ccaagccggg
     3301 ccaggggctg ccagtgccct ggccaccttc ctgttgctgc tcctggcctc aggagagggg
     3361 agctcccacc ggggccgccc ctcctgggcc ctgtctgtct gtctgtcctg acccttttac
     3421 caatgttgca cagtttttat ttccaccctc ttttgtagtg ggctgggttt taaattataa
     3481 attttaacca cctcaagtaa aactgagttt ttaataaaca ccttgtttcg tcttcacttt
     3541 aaaaaaaaaa aaaaaaa
//
