LOCUS       NM_001159404            4413 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus LLGL1 scribble cell polarity complex component
            (Llgl1), transcript variant 3, mRNA.
ACCESSION   NM_001159404
VERSION     NM_001159404.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4413)
  AUTHORS   Hou,C., Zhang,A., Jin,Y., Ye,C., Li,R., Liu,Z. and Gao,J.
  TITLE     Role of LGL1 in cerebellar primordium of embryonic mice
  JOURNAL   Neuroreport 35 (6), 374-379 (2024)
   PUBMED   38526932
  REMARK    GeneRIF: Role of LGL1 in cerebellar primordium of embryonic mice.
REFERENCE   2  (bases 1 to 4413)
  AUTHORS   Eifert,T., Hsu,C.J., Becker,A.L., Graessle,S., Horne,A.,
            Bemmann,F., Zhang,Q., Heuser,M., Vasioukhin,V., Scholl,S.,
            Hochhaus,A., Siegerist,F., Endlich,N., Bullinger,L., Lane,S.W.,
            Haas,S., Schnoeder,T.M. and Heidel,F.H.
  TITLE     Cell fate determinant Llgl1 is required for propagation of acute
            myeloid leukemia
  JOURNAL   Leukemia 37 (10), 2027-2035 (2023)
   PUBMED   37587260
REFERENCE   3  (bases 1 to 4413)
  AUTHORS   Ma,R., Gong,D., You,H., Xu,C., Lu,Y., Bergers,G., Werb,Z.,
            Klein,O.D., Petritsch,C.K. and Lu,P.
  TITLE     LGL1 binds to Integrin beta1 and inhibits downstream signaling to
            promote epithelial branching in the mammary gland
  JOURNAL   Cell Rep 38 (7), 110375 (2022)
   PUBMED   35172155
  REMARK    GeneRIF: LGL1 binds to Integrin beta1 and inhibits downstream
            signaling to promote epithelial branching in the mammary gland.
REFERENCE   4  (bases 1 to 4413)
  AUTHORS   Zhang,Y., Yuan,P., Ma,X., Deng,Q., Gao,J., Yang,J., Zhang,T.,
            Zhang,C. and Zhang,W.
  TITLE     Deletion of Smooth Muscle Lethal Giant Larvae 1 Promotes Neointimal
            Hyperplasia in Mice
  JOURNAL   Front Pharmacol 13, 834296 (2022)
   PUBMED   35140622
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4413)
  AUTHORS   Amberg,N. and Hippenmeyer,S.
  TITLE     Genetic mosaic dissection of candidate genes in mice using mosaic
            analysis with double markers
  JOURNAL   STAR Protoc 2 (4), 100939 (2021)
   PUBMED   34825212
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4413)
  AUTHORS   Wakabayashi,Y., Kikkawa,Y., Matsumoto,Y., Shinbo,T., Kosugi,S.,
            Chou,D., Furuya,M., Jishage,K., Noda,T., Yonekawa,H. and
            Kominami,R.
  TITLE     Genetic and physical delineation of the region of the mouse
            deafness mutation shaker-2
  JOURNAL   Biochem Biophys Res Commun 234 (1), 107-110 (1997)
   PUBMED   9168970
REFERENCE   7  (bases 1 to 4413)
  AUTHORS   Koyama,K., Fukushima,Y., Inazawa,J., Tomotsune,D., Takahashi,N. and
            Nakamura,Y.
  TITLE     The human homologue of the murine Llglh gene (LLGL) maps within the
            Smith-Magenis syndrome region in 17p11.2
  JOURNAL   Cytogenet Cell Genet 72 (1), 78-82 (1996)
   PUBMED   8565641
REFERENCE   8  (bases 1 to 4413)
  AUTHORS   Strand,D., Unger,S., Corvi,R., Hartenstein,K., Schenkel,H.,
            Kalmes,A., Merdes,G., Neumann,B., Krieg-Schneider,F., Coy,J.F. et
            al.
  TITLE     A human homologue of the Drosophila tumour suppressor gene l(2)gl
            maps to 17p11.2-12 and codes for a cytoskeletal protein that
            associates with nonmuscle myosin II heavy chain
  JOURNAL   Oncogene 11 (2), 291-301 (1995)
   PUBMED   7542763
REFERENCE   9  (bases 1 to 4413)
  AUTHORS   Kuwabara,K., Takahashi,Y., Tomotsune,D., Takahashi,N. and
            Kominami,R.
  TITLE     mgl-1, a mouse homologue of the Drosophila tumor-suppressor gene
            l(2)gl, maps to chromosome 11
  JOURNAL   Genomics 20 (2), 337-338 (1994)
   PUBMED   8020994
REFERENCE   10 (bases 1 to 4413)
  AUTHORS   Tomotsune,D., Shoji,H., Wakamatsu,Y., Kondoh,H. and Takahashi,N.
  TITLE     A mouse homologue of the Drosophila tumour-suppressor gene l(2)gl
            controlled by Hox-C8 in vivo
  JOURNAL   Nature 365 (6441), 69-72 (1993)
   PUBMED   8103190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596215.7.
            
            On Mar 11, 2020 this sequence version replaced NM_001159404.1.
            
            Transcript Variant: This variant (3) uses an alternate splice
            pattern in the 3' coding region and an alternate splice site in the
            central coding region, compared to variant 1. The resulting isoform
            (3) has a shorter and distinct C-terminus and lacks an internal two
            aa segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159412.1, BC050913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AL596215.7         186771-187012       c
            243-340             AL596215.7         183831-183928       c
            341-422             AL596215.7         181962-182043       c
            423-553             AL596215.7         181731-181861       c
            554-709             AL596215.7         180590-180745       c
            710-872             AL596215.7         180357-180519       c
            873-1008            AL596215.7         180139-180274       c
            1009-1063           AL596215.7         179906-179960       c
            1064-1218           AL596215.7         179599-179753       c
            1219-1442           AL596215.7         179300-179523       c
            1443-1510           AL596215.7         179064-179131       c
            1511-1664           AL596215.7         178015-178168       c
            1665-1769           AL596215.7         177819-177923       c
            1770-2062           AL596215.7         176985-177277       c
            2063-2210           AL596215.7         176584-176731       c
            2211-2364           AL596215.7         176272-176425       c
            2365-2660           AL596215.7         175081-175376       c
            2661-2925           AL596215.7         174448-174712       c
            2926-3040           AL596215.7         174219-174333       c
            3041-3147           AL596215.7         173984-174090       c
            3148-4413           AL596215.7         172526-173791       c
FEATURES             Location/Qualifiers
     source          1..4413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.81 cM"
     gene            1..4413
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /note="LLGL1 scribble cell polarity complex component"
                     /db_xref="GeneID:16897"
                     /db_xref="MGI:MGI:102682"
     exon            1..242
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..3272
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     lethal(2) giant larvae protein homolog 1; LLGL; mlgl;
                     mgl-1; lethal giant larvae homolog 1"
                     /codon_start=1
                     /product="lethal(2) giant larvae protein homolog 1 isoform
                     3"
                     /protein_id="NP_001152876.1"
                     /db_xref="CCDS:CCDS48813.1"
                     /db_xref="GeneID:16897"
                     /db_xref="MGI:MGI:102682"
                     /translation="MMKFRFRRQGADPQREKLKQELFAFHKTVEHGFPNQPSALAFDP
                     ELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAATVTQMHFLPGQGRLLTLLDDSSLHLW
                     EIIHHNGCAHLEEGLSFHPPSRPSFDNASFPASLTRVTVVLLVAGNTAALGTESGSIF
                     FLDVATLALLEGQTLSPDVVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGL
                     LVIWSQATQSVDNVFLGNQQLESLCWGRDGSSIISSHSDGSYAIWSTDTGSPPTLQPT
                     VVTTPYGPFPCKAINKILWRSCESGDHFIIFSGGMPRASYGDRHCVSVLRAETLVTLD
                     FTSRVIDFFTVHSTQPEDECDNPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSS
                     AITCSAHVANVPSKLWARIVSAGEQQSPQPASSALSWPITGGRNLAQEPSQRGLLLTG
                     HEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAVEDDWPPFRKVGCFDPY
                     SDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSEVPAEHAVSVANVDLLQDREGFT
                     WKGHERLNPHTGLLPWPAGFQPRMLIQCLPPAAVTAVTLHAEWSLVAFGTSHGFGLFD
                     YQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRTPAASS
                     KLQEANAQLAEQTCPHDLEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDATHHGP
                     TMWAGTNSGSVFAYALEVPAATAGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDGR
                     GRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRV
                     RKVALATFASVMSEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDISGIASC
                     VFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWPQNATQPRLQESPKLSQANG
                     TRDIILAPESCEGSPSSAHSKRADTMEPPEAALSPVSIDSAASGDTMLDTTGDVTVEY
                     VKDFLG"
     exon            243..340
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            341..422
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            423..553
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..709
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..872
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1008
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1063
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1218
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1442
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1510
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1664
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1769
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..2062
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2210
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2364
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2365..2660
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2925
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2926..3040
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3147
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..4413
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4385..4390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /note="hexamer: AATAAA"
     polyA_site      4413
                     /gene="Llgl1"
                     /gene_synonym="Lgl1; Llglh; Mgl1"
                     /note="major polyA site"
ORIGIN      
        1 attgtctggc gagcaagggg cggcacggca cggcgggcac gctcacgtcg tgggtcgggc
       61 gggcgtccgt ggcgtcccgc gcctccgtgc aggccccgcc ccgcgcctca ggaccggcgg
      121 ggccgggcgc atcccgcggc ggtggcggag gcgggcgcaa gatgatgaag tttcggttcc
      181 ggcggcaggg cgccgacccg cagcgcgaga agcttaagca ggagctcttc gccttccaca
      241 agactgtgga gcatggcttc cccaatcagc ccagcgcctt ggccttcgat cctgagctcc
      301 gcatcatggc catcggcacc agatctgggg ccgtcaagat ctatggtgca cccggagtgg
      361 aatttacagg cctacatcgg gacgcagcca ccgtcaccca gatgcatttc ctccctggtc
      421 agggccgcct cctgaccctg ctagatgaca gcagcttgca tctctgggag atcatccatc
      481 ataatggctg cgcccacctg gaggaaggcc tcagcttcca cccacccagc agacccagtt
      541 ttgacaatgc cagtttccct gccagtctaa cacgtgtcac tgtggtcctg ctcgtagctg
      601 gcaatacagc agccctggga actgagagtg gtagcatatt cttcctggat gtagccaccc
      661 tggcactgct ggaggggcag actctcagcc cagatgtggt tctgcgcagt gtgccagatg
      721 attaccggtg tggaaaggcc ttgggccctg tggagtcact ccagggacat ctgcaagacc
      781 ccagcaagat cctcataggc tacagtcggg gtttactggt catctggagc caggccacac
      841 agtctgtgga caacgttttc ctaggtaacc agcagctgga gagcctgtgt tggggccgtg
      901 atggcagcag cattatcagc tcacacagtg atggcagcta tgccatctgg tccacagaca
      961 ctggcagccc cccaacgctg cagcccactg tagtgaccac accctacggc cccttcccct
     1021 gcaaggccat caacaagatt ctgtggcgga gctgtgagtc aggagaccac tttatcatct
     1081 tcagtggtgg catgcctcga gccagctatg gtgaccgcca ctgtgtgagt gtactgcgag
     1141 cagagacact ggtgaccctg gacttcacct ctcgtgtcat tgacttcttc acggtgcaca
     1201 gcacacagcc agaggatgag tgtgacaacc cccaggcctt agccgtgctt ctggaggagg
     1261 agctggtggt gctggacctg cagacaccag gctggccagc tgtgcccgcc ccttacctgg
     1321 ccccactgca ttcgtcagct atcacctgct ctgcccatgt tgccaatgtc cccagcaagc
     1381 tgtgggcccg cattgtaagt gctggtgagc agcagagccc acagcctgcc tccagtgcct
     1441 tgagttggcc cattaccggg ggccggaact tggcccagga accctcgcag cgtgggctgc
     1501 tgctcactgg ccatgaggat ggcactgtgc ggttctggga cgcctctggt gtggcgctaa
     1561 ggccactcta caaactgagc acagctggcc tcttccagac ggactgtgaa catgctgaca
     1621 gcctggccca ggctgtggag gatgactggc cgcccttccg caaggtgggc tgctttgatc
     1681 cctacagtga tgacccccgg ctaggaatcc agaaggttgc gctttgcaag tacacagccc
     1741 agatggtggt agctggcact gcaggccagg tgctggtgct ggagctcagt gaggtcccag
     1801 cagagcatgc cgtcagtgtg gccaacgtgg atcttcttca ggatcgcgag ggcttcacgt
     1861 ggaagggtca cgagcggctg aacccacaca cggggctgct gccgtggcct gccggattcc
     1921 agccccgcat gctgatacag tgcctcccac ccgccgctgt cactgctgtc acactccatg
     1981 ctgagtggag cctcgtggcc tttggtacca gtcatggctt tggccttttt gactaccagc
     2041 gcaagagccc tgtgctggct aggtgcaccc ttcaccccaa tgattctttg gccatggagg
     2101 ggccactgtc acgggtgaag tccctcaaga agtcactgag acagtcattc cggcgaatcc
     2161 gcaagagccg tgtctcaggc aaaaaacgga ctcctgctgc cagtagcaag ttgcaggagg
     2221 ccaatgccca gctggccgag cagacctgcc cacacgacct ggagatgaca cccgtgcagc
     2281 gccgcattga gcctcggtct gctgacgact cgctctccgg tgttgtacgc tgcctctact
     2341 ttgctgacac gttccttcga gatgcgaccc accacgggcc caccatgtgg gcgggcacca
     2401 actcgggctc tgtgttcgcc tatgcgctgg aggttccagc agccacagca ggcggagaga
     2461 agcggcctga gcaggcagtg gaggcggtgc tgggcaagga ggtgcagcta atgcaccgag
     2521 cacctgtggt ggccattgct gtgctggatg gtcgtggccg gccactgcct gagccctatg
     2581 aggcttcccg ggacctggcc caggcgccag acatgcaagg cggccatgct gtgctcattg
     2641 catctgagga acaattcaag gtgttcacac tacccaaggt gagtgctaag actaaattca
     2701 agcttacagc ccatgaaggc tgtcgtgtgc ggaaggtagc cctggctaca tttgccagcg
     2761 tgatgtctga ggactatgcc gagacctgcc ttgcctgcct caccaacctg ggtgatgtcc
     2821 acgtcttctc ggtgcctggc ctgaggcctc aggtgcacta ctcctgtatc cggaaggagg
     2881 acatcagtgg catcgcttcc tgtgtcttca cacgtcacgg ccagggcttt tacttgattt
     2941 ctccatcgga atttgagcgc ttctcactga gtgctcgcaa catcacagaa ccactatgtt
     3001 ctctggatat aagctggccc caaaatgcca cccagcccag gcttcaagag tcacccaagc
     3061 tgagccaggc taatgggacc agagacatca ttctggcccc agagagctgc gaaggaagcc
     3121 ctagctctgc ccacagcaag cgagctgata ccatggaacc acccgaggcc gctctctcgc
     3181 ctgtgtccat tgattcagct gctagtgggg ataccatgct ggacacaaca ggggatgtca
     3241 ccgtggaata tgtgaaggat tttctggggt gaggccagct gctctcccaa gccgccatcc
     3301 ccagggcaac taggggtctt cttaccccag cccttctgat tactgccctc cccagctctc
     3361 ctgaggactc tgagaagaac ctgcggaacc tggaggcaga tgatgcttgt cgggcctaca
     3421 cccttctgat taaatgaggt gctgtggggc agcctggcct taccacacag cagctgccat
     3481 ccctcactcc agctggaacc ctgcaggctt ctctaatggt gtcattcctc gaagcctagc
     3541 tgccttcctc tggctgtcag gcatagggga tccacagtca tgaaagggcc tggcctggca
     3601 gcactgaaat cctgtgcatt tagaaggcca cctctgaccc tgtgggtgta ggagttgatg
     3661 cttatccagt ccacagagcc catttcacag gagagtcact gaggctgata ggtcctgcct
     3721 attgagccag cacatggacc ttatgtgccc ctaccgtatc ttgctatgga cccagcctag
     3781 ctggagactg gagctctctg gaccttagta gctagtgcct ctgcagccta cattgggcat
     3841 agataactaa ccataccctc ttctacttgg taccctccta gctccccagc aagcccatct
     3901 tgggccatca ctgaaagggg ctgcctaccc cgcaggcagg catgacctgg gtttgctccc
     3961 cttagtcgtc accatctgtc ggtcttgcct tgccccttaa cacggacccg ctgactgatg
     4021 ctgggccctg aacacatccc agcctcaagc tcagccggag gggtgcgagc atccttttgc
     4081 actccatact gtacttcctt tctcctcaag cagagtattt ttctaacgcc tggactgagc
     4141 tggccagtca tttctaaagc agttttggta cttgctcctg gcctgtgtgt attgtgtgct
     4201 cctgtgacta gagactgctg ggcgtcatga ctgaagtcag tcagaggtgt gtgtgtgcgt
     4261 gtgtgtgcac gtgtgtgtgc ggcagtgagg atgggcttcc ctgtagatgc caccttcggc
     4321 ttttctgtct ttttttaaaa actagttgtt ttaatattaa aagtactgat tttttaatat
     4381 tgaaaataaa agcatttaat atcttttaaa cta
//
