LOCUS       NM_025681               3124 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus limb and CNS expressed 1 (Lix1), mRNA.
ACCESSION   NM_025681
VERSION     NM_025681.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3124)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3124)
  AUTHORS   Wakeling,E.N. and Fyfe,J.C.
  TITLE     Lix1 knockout mouse does not exhibit spinal muscular atrophy
            phenotype
  JOURNAL   J Hered 102 Suppl 1, S32-S39 (2011)
   PUBMED   21846745
  REMARK    GeneRIF: Lix1 knockout mouse does not exhibit spinal muscular
            atrophy phenotype.
REFERENCE   3  (bases 1 to 3124)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3124)
  AUTHORS   Dawe,C.E., Kooistra,M.K., Fairbridge,N.A., Pisio,A.C. and
            McDermid,H.E.
  TITLE     Role of chromatin remodeling gene Cecr2 in neurulation and inner
            ear development
  JOURNAL   Dev Dyn 240 (2), 372-383 (2011)
   PUBMED   21246654
REFERENCE   5  (bases 1 to 3124)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   6  (bases 1 to 3124)
  AUTHORS   Eng,S.R., Dykes,I.M., Lanier,J., Fedtsova,N. and Turner,E.E.
  TITLE     POU-domain factor Brn3a regulates both distinct and common programs
            of gene expression in the spinal and trigeminal sensory ganglia
  JOURNAL   Neural Dev 2, 3 (2007)
   PUBMED   17239249
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3124)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   8  (bases 1 to 3124)
  AUTHORS   Osipovich,A.B., Singh,A. and Ruley,H.E.
  TITLE     Post-entrapment genome engineering: first exon size does not affect
            the expression of fusion transcripts generated by gene entrapment
  JOURNAL   Genome Res 15 (3), 428-435 (2005)
   PUBMED   15741512
REFERENCE   9  (bases 1 to 3124)
  AUTHORS   Moeller,C., Yaylaoglu,M.B., Alvarez-Bolado,G., Thaller,C. and
            Eichele,G.
  TITLE     Murine Lix1, a novel marker for substantia nigra, cortical layer 5,
            and hindbrain structures
  JOURNAL   Brain Res Gene Expr Patterns 1 (3-4), 199-203 (2002)
   PUBMED   12638132
  REMARK    GeneRIF: This protein is a marker for substantia nigra, cerebral
            cortex and hindbrain development.
REFERENCE   10 (bases 1 to 3124)
  AUTHORS   Swindell,E.C., Moeller,C., Thaller,C. and Eichele,G.
  TITLE     Cloning and expression analysis of chicken Lix1, a founding member
            of a novel gene family
  JOURNAL   Mech Dev 109 (2), 405-408 (2001)
   PUBMED   11731258
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049574.1, BC052700.1 and BC063057.1.
            
            On Nov 25, 2006 this sequence version replaced NM_025681.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063057.1, BC052700.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1318              BC049574.1         15-1332
            1319-3093           BC052700.1         1119-2893
            3094-3124           BC063057.1         2886-2916
FEATURES             Location/Qualifiers
     source          1..3124
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 9.77 cM"
     gene            1..3124
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /note="limb and CNS expressed 1"
                     /db_xref="GeneID:66643"
                     /db_xref="MGI:MGI:1913893"
     exon            1..341
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1108
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /note="limb expression 1 homolog"
                     /codon_start=1
                     /product="protein limb expression 1 homolog"
                     /protein_id="NP_079957.2"
                     /db_xref="CCDS:CCDS37456.1"
                     /db_xref="GeneID:66643"
                     /db_xref="MGI:MGI:1913893"
                     /translation="MDRTLESLRHIIAQALPHRDPALVFKDLNVVSMLQEFWESKQQQ
                     KATFSSEGLVVYESMPSSGPPFVSYVTLPGGSCFGNFQCCLSRAEARRDAAKVALINS
                     LFNELPSRRITKEFIMESVQEAVASTRGTLDDADDPSTSVGAYHYMLESNMGKTMLEF
                     QELMTIFQLLHWNGSLKALRETKCSRQEVISYYSQYSLDEKMRSHMALDWIMKERESP
                     GILSQELRAALGQLEEARKAGQELRFYKEKKEILSLALTQIYSDPDPSSPSDDQLSLT
                     ALCGYH"
     exon            342..505
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            506..646
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            647..742
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            743..820
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            821..3102
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3093
                     /gene="Lix1"
                     /gene_synonym="5730466L18Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttaaca gaacgaagcc atgggaacca gcctgtcagc cagcctttca ggctaattag
       61 ctcagcatac aacaaagata agtgagcctg agaggagggc cctgagggtc tttagattct
      121 gggaaatgtc tgattggcag atgttaaaag ggattcttta gtaatccact gcatcaatga
      181 gctgcacaaa ttcagtccag agctgcaaga attcaggcat gaggagactg tgcaggaggc
      241 ttgcacaggc agactcgaga tggacagaac cttggaatct ctgaggcaca tcattgccca
      301 agccttgcct cacagagacc cggctttggt cttcaaagac ttgaatgttg tgtcaatgtt
      361 acaggaattt tgggaaagca agcagcagca gaaagccacc ttctccagtg agggactggt
      421 ggtctatgag tcaatgcctt cctctgggcc tccctttgtg agctatgtga ctctccctgg
      481 agggagctgc tttggcaact ttcagtgctg cttaagtaga gctgaggcca ggcgggatgc
      541 tgctaaagtg gcgctcatca actctctctt caatgagcta ccctcccgaa ggatcaccaa
      601 ggagttcatc atggagagtg ttcaggaagc agtagcctcc accaggggca cgttagatga
      661 tgcggatgac ccaagcacaa gtgtgggagc ctatcactac atgctggagt caaacatggg
      721 gaagactatg ctggagtttc aggaactaat gaccattttc caactactgc actggaatgg
      781 aagcctgaaa gccctccgtg aaacaaagtg ctctcgacag gaagtcatct cctactattc
      841 ccaatattct ttagatgaaa agatgcgtag ccacatggcc ctggactgga ttatgaagga
      901 gcgtgaatca ccaggaattc tctctcaaga gctgcgtgca gccctagggc agctggagga
      961 agccaggaag gctggacaag aactacgatt ttacaaagaa aaaaaagaaa tcctgagctt
     1021 ggccctgact cagatctata gtgaccctga cccttcctca cccagtgatg accagctaag
     1081 cctcacggct ctgtgtggct atcattagca aggccaggtg gcaggtttcc tgaggacgtt
     1141 cacatcagga atctacctga cagaagttgt tagagatttt agcatgatag tcagtacctg
     1201 aaggctgtac tgctcctaca cagtctgttc acagaatggg aggctagggt tgactgatcc
     1261 cgatcccaac ttcctacttc atgtatgttt tcaaccattc ccttagggat tctacttcag
     1321 aataaaaaga aagacaacaa aattacttta gaaagcattc ttcagggttt gatctaatct
     1381 aaaaaaccta gttgatatgt gccttgctaa attgtatgca ttgcttcaca caacagtcca
     1441 gtagagcagt cttggagaaa acagcagcca ggactaggga aaggatcatg ataacttctt
     1501 tttttctttt tttttggggg ggcacagttt ctctgtgtag ccctggctgt cctggaactt
     1561 gtctttagat caggctggcc ttgaactcag agctctgctt ctgagtacta ggattaacta
     1621 catctaccac aaccacctgg cctataacaa tgttttaaat acttaagagt aaataaatag
     1681 tacagatgat ttaaaaaaaa tgtacaacac tcagcatgtt ttgaaccctc ctgaaaatta
     1741 ctgtatcctc attatatatt ttgaaattag ctttaataac aaacactatc acatatactt
     1801 ctcagacagg atgaaattaa gtacataact gccctattcc aatgtcctaa aaaggtgatg
     1861 gtgtgtagtg ttagatgatt tcattttaaa atgatatttt tttaaaaatc atatcacttc
     1921 ccataatgag gctaaatgtt ctaaggaaaa aaaaacttta gatttttgta atcttgagaa
     1981 ggagttagga tttgtgtgtg tgttgaataa atttttaagt gaagaaattt ctatttcatt
     2041 ttttttttta caaacttttt atcatttcaa attcagcaca tttccccatg ttggctggga
     2101 tctttacgtg cagtgcatgt ttactgtgtt tggcaatgtc cacctcagaa gattgatatc
     2161 tgattagatg caagaacagt gcttgcgtgg gtcaagcttc tcctctcttt tataattatg
     2221 acactgtaca aattctctga actgaaaatt acgtagacta tttttccttg gaatattctc
     2281 agaaacttca gcaaaagcaa caaaggttat ggccatggct ggccctatct aatagcaaat
     2341 caacttcagc cagggcattg tgccaaccga gtatcacaca tgtctgtaac actggcacag
     2401 aggaacctaa gagagggaca agacaaacac gcacgcttgt tcttaacact gcactgtaga
     2461 aagggacaag aataaaggag tctctaagaa gatggagcca tgaaggtggt gcttgttgtt
     2521 gctatgaact ccctgaaaat tgaataaaaa gccacagact atctcatagc aatatataat
     2581 aatttcataa aacatatggc cctgccccaa aatttatgga ttagcccaga gcatcattga
     2641 cccttagttt gaagctcaca attttaaaag catacatagt tttacacttc atatgagaga
     2701 tctagtaacc catagaccat atattttttt cttttctttt ctttcttttt tttttttttt
     2761 ccgagacagg gtttctctgt gtagccctgg ctgtcctgga actcactctg tagaccagac
     2821 tggcctcgaa ctcagaaatc tgcctgcctc tgcctcccaa gtgctgggat taaaggcgtg
     2881 cgccaccact gcctggccat agaccatatt tttaagatta ctaccattac tctgaaatca
     2941 agaattgtat tgtttggggc atgatggttt aatttttata aaaatcaaaa tgcaccttgt
     3001 tgttatggag aaagaaatta agacaaacta gacactaaac tttggcaact gtaccagaac
     3061 attacagatt taataaaatc attgttcctt caatattctg aaaaaaaaaa aaaaaaaaaa
     3121 aaaa
//
