LOCUS       NM_019980               2240 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus LPS-induced TN factor (Litaf), mRNA.
ACCESSION   NM_019980
VERSION     NM_019980.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2240)
  AUTHORS   Li,W.J., Zhou,W.P., Li,X.Y., Jiang,X.L., Deng,Y.C., Shen,J.,
            Xie,H., Tan,G., Huang,L. and Zhang,H.
  TITLE     LITAF Promotes Atherosclerotic Plaque Formation by Stimulating the
            NF-kappaB Inflammatory Pathway
  JOURNAL   Curr Med Sci 43 (6), 1201-1205 (2023)
   PUBMED   37848750
  REMARK    GeneRIF: LITAF Promotes Atherosclerotic Plaque Formation by
            Stimulating the NF-kappaB Inflammatory Pathway.
REFERENCE   2  (bases 1 to 2240)
  AUTHORS   Song,J., Liu,Y., Wan,J., Zhao,G.N., Wang,J.C., Dai,Z., Hu,S.,
            Yang,L., Liu,Z., Fu,Y., Dong,E. and Tang,Y.D.
  TITLE     SIMPLE Is an Endosomal Regulator That Protects Against NAFLD by
            Targeting the Lysosomal Degradation of EGFR
  JOURNAL   Hepatology 74 (6), 3091-3109 (2021)
   PUBMED   34320238
  REMARK    GeneRIF: SIMPLE Is an Endosomal Regulator That Protects Against
            NAFLD by Targeting the Lysosomal Degradation of EGFR.
REFERENCE   3  (bases 1 to 2240)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2240)
  AUTHORS   Xiang,M., Yang,F., Zhou,Y., Li,W., Zou,Y., Ye,P., Zhu,L., Wang,P.X.
            and Chen,M.
  TITLE     LITAF acts as a novel regulator for pathological cardiac
            hypertrophy
  JOURNAL   J Mol Cell Cardiol 156, 82-94 (2021)
   PUBMED   33823186
  REMARK    GeneRIF: LITAF acts as a novel regulator for pathological cardiac
            hypertrophy.
REFERENCE   5  (bases 1 to 2240)
  AUTHORS   Liu,J., Zuo,Z., Sastalla,I., Liu,C., Jang,J.Y., Sekine,Y., Li,Y.,
            Pirooznia,M., Leppla,S.H., Finkel,T. and Liu,S.
  TITLE     Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the
            Bacillus cereus Hemolysin BL Toxin Host Receptors
  JOURNAL   Cell Host Microbe 28 (3), 402-410 (2020)
   PUBMED   32544461
  REMARK    GeneRIF: Sequential CRISPR-Based Screens Identify LITAF and CDIP1
            as the Bacillus cereus Hemolysin BL Toxin Host Receptors.
REFERENCE   6  (bases 1 to 2240)
  AUTHORS   Jin,C., Fu,W.X., Xie,L.P., Qian,X.P. and Chen,W.F.
  TITLE     SDF-1alpha production is negatively regulated by mouse estrogen
            enhanced transcript in a mouse thymus epithelial cell line
  JOURNAL   Cell Immunol 223 (1), 26-34 (2003)
   PUBMED   12914755
REFERENCE   7  (bases 1 to 2240)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 2240)
  AUTHORS   Xie,L.P., Fu,W.X., Jin,C., Dong,X.Y. and Chen,W.F.
  TITLE     Negative regulation of monocyte chemoattractant protein-1 gene
            expression by a mouse estrogen-enhanced transcript
  JOURNAL   Eur J Immunol 32 (10), 2837-2846 (2002)
   PUBMED   12355436
REFERENCE   9  (bases 1 to 2240)
  AUTHORS   Moriwaki,Y., Begum,N.A., Kobayashi,M., Matsumoto,M., Toyoshima,K.
            and Seya,T.
  TITLE     Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall
            complex induce a novel lysosomal membrane protein, SIMPLE, that
            bridges the missing link between lipopolysaccharide and
            p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1
  JOURNAL   J Biol Chem 276 (25), 23065-23076 (2001)
   PUBMED   11274176
REFERENCE   10 (bases 1 to 2240)
  AUTHORS   Jolliffe,C.N., Harvey,K.F., Haines,B.P., Parasivam,G. and Kumar,S.
  TITLE     Identification of multiple proteins expressed in murine embryos as
            binding partners for the WW domains of the ubiquitin-protein ligase
            Nedd4
  JOURNAL   Biochem J 351 Pt 3 (Pt 3), 557-565 (2000)
   PUBMED   11042109
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076162.1 and BX637242.1.
            
            On Apr 14, 2009 this sequence version replaced NM_019980.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078708.1, AK076162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2228              AK076162.1         3-2230
            2229-2240           BX637242.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2240
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 6.28 cM"
     gene            1..2240
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /note="LPS-induced TN factor"
                     /db_xref="GeneID:56722"
                     /db_xref="MGI:MGI:1929512"
     exon            1..76
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..301
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..567
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /note="mEET; LITAF-like protein; LPS-induced TNF-alpha
                     factor homolog; estrogen-enhanced transcript protein;
                     Nedd4 WW domain-binding protein 3"
                     /codon_start=1
                     /product="lipopolysaccharide-induced tumor necrosis
                     factor-alpha factor homolog"
                     /protein_id="NP_064364.1"
                     /db_xref="CCDS:CCDS27958.1"
                     /db_xref="GeneID:56722"
                     /db_xref="MGI:MGI:1929512"
                     /translation="MSAPGPYQAAAGPSVVPTAPPTYEETVGVNSYYPTPPAPMPGPA
                     TGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPVSFYDRPVQMCCPSCSKM
                     IVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKR
                     L"
     exon            302..458
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..2237
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1971..1976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /note="hexamer: AATAAA"
     polyA_site      1996
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
     polyA_site      2019
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /note="major polyA site"
     regulatory      2218..2223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
                     /note="hexamer: AATAAA"
     polyA_site      2237
                     /gene="Litaf"
                     /gene_synonym="3222402J11Rik; N4WBP3; TBX1"
ORIGIN      
        1 tgcctccccg gagccctccc ggcccgcgcg cgcggccaga gcagacctcc cggctcgact
       61 ggcggcgcgg gcagcggtaa aatgtcggct ccaggacctt accaagcagc tgcaggccct
      121 tcagtagtgc ccaccgcacc cccaacctat gaagaaacag tgggtgtcaa cagttactac
      181 ccaacgcccc cagcacctat gccgggacca gccacagggc tcattacagg cccagatggg
      241 aagggaatga atccaccttc gtactacacc cagcctgtgc ctgtccccaa cgccaacgca
      301 attgccgtgc agaccgttta tgtgcagcag cctgtctcct tctatgaccg ccccgtccag
      361 atgtgctgtc cttcctgcag caagatgatc gtgacccagc tgtcctacaa tgcgggagcc
      421 ctcacctggc tctcctgtgg cagtctgtgt ctgctgggat gcgttgctgg ctgctgcttc
      481 atcccgttct gcgtagacgc cctacaggat gtggaccact actgccccaa ctgcaaagcg
      541 ctcctgggca cctacaagcg cttgtaggac ttggccagcc cgccactgca gaggtagtag
      601 acaattgcta ccagaagtca cctgaccctt gcccagccag aagagcttga tgtcatctct
      661 tcgtgggctc catcttcgtg tcttttaggg ggtgggaaag gtaggaagag taacaagcct
      721 ccaagcccag aaactgctgc tggagttgtg ccctgcacat gcgaagacgt ggaccttggg
      781 tgttgtctca agggtttcct gcctgctcat gttaccccac taactgtgat tgttacccca
      841 tttgcatctc ctctgctgat ttgccattgg tgccagtctc aaaccccgaa gccacgattt
      901 gccttatttt tcactgtttg gcttgatcta ttcccatccc tgagacagag cctgccttaa
      961 agactggttt tgtaatgaca gacgtctctg gcactcagaa tcactttaat ttcatagagt
     1021 tgggtttttt atttttgttt ttttttttcc caagtgcaca gaagggctgc tcacacccac
     1081 cagacacata cagataaggt cacaagtact aaataaaagg ctcacattcc ttcctgtctc
     1141 agctcctggc ctgtgaaggg tctcctttct catacagttt ctgggaactc cctttgttca
     1201 taaacacaga tgaaagttac ttggcaggga gacatttcta gaataacttt tgtaatcacg
     1261 atacaccatt tctccatttg ctggtgtgtt tttagttggt tctgttttag tttttcacat
     1321 tcagtccagc ttgttggcca ggccagcctc gaactcctag gggatcctca gtcttcggct
     1381 ctcagacatg cagggcccta gctgtgtgcc tctacaccca ctgggccttt tgttctgttt
     1441 ttctttgaca gagaaacaaa caggtaattt cattgcctgc ctatgtaggt ttggtgtagt
     1501 tttgaaagcc ttgtctctgt ggggtctctt tgagggagtt gggggacctc tatttgagcc
     1561 ctgcttcagt gccgagagat tgggagtgga actccctgaa acatgatttc agtttttaga
     1621 gatgaccttc tgtggtacgg tcatcatggt ctccaacatc accagaccaa gtagaaggat
     1681 gtcaaagaca aattcagggc tctttctagg gtgaccactc tgccgtgtat aatattgtcc
     1741 cagtctggcc agctttctag gaggccctgg ctccatccta agtctacaca ggatctgctg
     1801 caaataacag tgtacggagt caacctgacc cggaacagaa gtctgcatgc tggttaagat
     1861 gcagcctagc cattgcctga gctgttcata caatgatccg gaagtgctag ccattatttt
     1921 tgcagtgaat tatggatacc atacatgact ttgatatctg cttttaaaca aataaaatct
     1981 ttgatcactc agtgaacaat ccagttcacc ttttatgaag aaaggccttg tgttgtgttt
     2041 ccaggcattg cccgaagaat cttaagttgc tctgttacac tagaaaatcc ttcctgaccc
     2101 acacctcagg cttcagctgc agcaagatga ctgttgctaa cgagttgcgt tcgaaggttt
     2161 ggctgtcggg agcccttagt cgtcatcaat ggcagcaagc cacggctttc aagttttaat
     2221 aaaatgccaa gaaggaaaaa
//
