LOCUS       NM_026010               1235 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus lipoyl(octanoyl) transferase 2 (putative) (Lipt2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026010 XM_905399
VERSION     NM_026010.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1235)
  AUTHORS   Cao,X., Zhu,L., Song,X., Hu,Z. and Cronan,J.E.
  TITLE     Protein moonlighting elucidates the essential human pathway
            catalyzing lipoic acid assembly on its cognate enzymes
  JOURNAL   Proc Natl Acad Sci U S A 115 (30), E7063-E7072 (2018)
   PUBMED   29987032
REFERENCE   2  (bases 1 to 1235)
  AUTHORS   Habarou,F., Hamel,Y., Haack,T.B., Feichtinger,R.G., Lebigot,E.,
            Marquardt,I., Busiah,K., Laroche,C., Madrange,M., Grisel,C.,
            Pontoizeau,C., Eisermann,M., Boutron,A., Chretien,D.,
            Chadefaux-Vekemans,B., Barouki,R., Bole-Feysot,C., Nitschke,P.,
            Goudin,N., Boddaert,N., Nemazanyy,I., Delahodde,A., Kolker,S.,
            Rodenburg,R.J., Korenke,G.C., Meitinger,T., Strom,T.M.,
            Prokisch,H., Rotig,A., Ottolenghi,C., Mayr,J.A. and de Lonlay,P.
  TITLE     Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation
            Defect Associated with Severe Neonatal Encephalopathy
  JOURNAL   Am J Hum Genet 101 (2), 283-290 (2017)
   PUBMED   28757203
REFERENCE   3  (bases 1 to 1235)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC115472.1, AK008917.1 and BE648757.1.
            
            On May 7, 2009 this sequence version replaced NM_026010.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011925.1, AK013127.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-826               BC115472.1         1-826
            827-1200            AK008917.1         808-1181
            1201-1235           BE648757.1         1-35                c
FEATURES             Location/Qualifiers
     source          1..1235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.33 cM"
     gene            1..1235
                     /gene="Lipt2"
                     /gene_synonym="2610209A20Rik"
                     /note="lipoyl(octanoyl) transferase 2 (putative)"
                     /db_xref="GeneID:67164"
                     /db_xref="MGI:MGI:1914414"
     exon            1..471
                     /gene="Lipt2"
                     /gene_synonym="2610209A20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..701
                     /gene="Lipt2"
                     /gene_synonym="2610209A20Rik"
                     /EC_number="2.3.1.181"
                     /note="putative octanoyltransferase, mitochondrial;
                     putative lipoyltransferase 2, mitochondrial;
                     lipoate-protein ligase B; lipoyl/octanoyl transferase;
                     octanoyl-[acyl-carrier-protein]-protein
                     N-octanoyltransferase"
                     /codon_start=1
                     /product="octanoyl-[acyl-carrier-protein]:protein
                     N-octanoyltransferase LIPT2, mitochondrial"
                     /protein_id="NP_080286.2"
                     /db_xref="CCDS:CCDS21494.1"
                     /db_xref="GeneID:67164"
                     /db_xref="MGI:MGI:1914414"
                     /translation="MSLPVVRLVWLGRVHYSELLALQEHWLRRLQADPRPGTLSGTKA
                     GVLLVCEPAGPVYTGGLRGGLTPEETTRLRALGAEVRATGRGGLATFHGPGQLLCHPV
                     LDLRLLGLRLRTHVAALEACAVRLCELRGLQGARARPPPYTGVWLGERKICAIGVRCG
                     RHITSHGLALNCSTDLTWFEHIVPCGLVGTGVTSLSEALQRLVTVDEVMPSFLVAFKE
                     TFKCTLISEDSPS"
     exon            472..1229
                     /gene="Lipt2"
                     /gene_synonym="2610209A20Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgatgtc gctgcctgtg gtccggctcg tttggcttgg tcgggtgcac tactcggagc
       61 tgctggcgtt gcaggagcat tggctacggc ggctacaggc agaccctcgc cctgggaccc
      121 tgtcggggac caaagcgggt gtgctcttgg tctgcgagcc agcggggccc gtatacacgg
      181 gcgggctacg cggtggcctg acacccgagg agactacgcg gctgagggcc ttgggcgccg
      241 aggtgcgcgc caccggccgc ggcggcctgg ccactttcca cggcccgggc cagttgctct
      301 gccacccggt gcttgacttg cggctcctag gcctgcgcct gcgcacccac gtggcggcgc
      361 tggaggcgtg cgccgtgcga ctgtgcgaac ttcggggcct gcagggcgcc cgcgcgcggc
      421 cgccgcccta cactggcgtc tggctggggg agcgcaagat ctgcgcgatc ggagtccgct
      481 gtggaagaca catcacgtcc cacggcttgg ctctgaactg ttcaaccgac ctcacatggt
      541 ttgagcacat tgtgccttgt ggactggttg gaactggagt cacttccctg agtgaggcgc
      601 ttcaaagact tgtcactgtg gatgaagtaa tgccatcatt ccttgtggca ttcaaggaga
      661 ctttcaagtg cacgttaatc tctgaggaca gccccagctg aaggacattc attcacctta
      721 tccttgggat gatggttcta caatagaaag cttctagtct gactgagtcc ccagaactac
      781 tctgattcac tgaccatgac aggccctgag caattgctag tctgactgag tccccagaac
      841 tactctgatt cactgaccat gacaggccct gagcaattgc tccctgtatc tcctcaccta
      901 cctcagacga cattatgaaa atactatgaa aagtcacagg ctacctaaag catccccatg
      961 accattaaca cctgttaatg gagacactcc agtgttatta tcaactgcca tttcctaatt
     1021 acttgctact ttttcagtgc taacagcaat tgtatcagtt gtatctaaca gcagttttga
     1081 ctcttaggtt ttttgagttc tgtgggaacc aaatctctgt gaggcccagg gaagtgataa
     1141 agttactctt ctcaggagac ctgggtcttt cttcagtaaa ggagaaagcc tcttcaaaaa
     1201 aataaaataa aatagttttg cctttctgga aaaaa
//
