LOCUS       NM_001037918            1472 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus lipoyltransferase 1 (Lipt1), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001037918 XM_890305 XM_898917
VERSION     NM_001037918.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Solmonson,A., Faubert,B., Gu,W., Rao,A., Cowdin,M.A.,
            Menendez-Montes,I., Kelekar,S., Rogers,T.J., Pan,C., Guevara,G.,
            Tarangelo,A., Zacharias,L.G., Martin-Sandoval,M.S., Do,D.,
            Pachnis,P., Dumesnil,D., Mathews,T.P., Tasdogan,A., Pham,A.,
            Cai,L., Zhao,Z., Ni,M., Cleaver,O., Sadek,H.A., Morrison,S.J. and
            DeBerardinis,R.J.
  TITLE     Compartmentalized metabolism supports midgestation mammalian
            development
  JOURNAL   Nature 604 (7905), 349-353 (2022)
   PUBMED   35388219
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Ni,M., Solmonson,A., Pan,C., Yang,C., Li,D., Notzon,A., Cai,L.,
            Guevara,G., Zacharias,L.G., Faubert,B., Vu,H.S., Jiang,L., Ko,B.,
            Morales,N.M., Pei,J., Vale,G., Rakheja,D., Grishin,N.V.,
            McDonald,J.G., Gotway,G.K., McNutt,M.C., Pascual,J.M. and
            DeBerardinis,R.J.
  TITLE     Functional Assessment of Lipoyltransferase-1 Deficiency in Cells,
            Mice, and Humans
  JOURNAL   Cell Rep 27 (5), 1376-1386 (2019)
   PUBMED   31042466
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   Cao,X., Zhu,L., Song,X., Hu,Z. and Cronan,J.E.
  TITLE     Protein moonlighting elucidates the essential human pathway
            catalyzing lipoic acid assembly on its cognate enzymes
  JOURNAL   Proc Natl Acad Sci U S A 115 (30), E7063-E7072 (2018)
   PUBMED   29987032
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048005.1 and AC119189.8.
            
            [WARNING] On Jul 30, 2024 this sequence was replaced by
            NM_001037918.5.
            
            On Dec 9, 2019 this sequence version replaced NM_001037918.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019519.1, AK048005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-619               AK048005.1         15-633
            620-1472            AC119189.8         106897-107749       c
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 16.13 cM"
     gene            1..1472
                     /gene="Lipt1"
                     /gene_synonym="EG623661"
                     /note="lipoyltransferase 1"
                     /db_xref="GeneID:623661"
                     /db_xref="MGI:MGI:3645211"
     exon            1..107
                     /gene="Lipt1"
                     /gene_synonym="EG623661"
                     /inference="alignment:Splign:2.1.0"
     exon            108..1472
                     /gene="Lipt1"
                     /gene_synonym="EG623661"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1453..1458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lipt1"
                     /gene_synonym="EG623661"
                     /note="hexamer: ATTAAA"
     polyA_site      1472
                     /gene="Lipt1"
                     /gene_synonym="EG623661"
                     /note="major polyA site"
ORIGIN      
        1 actccccagc aactgcgtct agagggctga gtgttctggg ttccacgtgg gttgattgag
       61 ttttaatttg cagaaaaagc tgctgcgggc gcgaccggaa gtggcagcat gctaattcca
      121 ctttcaatga agaattgctt ccgattactt tgtcagcaca aggtcccagc agctggcttt
      181 aaaagcccac ccacacatgg gctcatttta cagtcgatct ccaatgatgt atatgaaaat
      241 ctggcttttg aagactggat ccacgaccac atacatctag aaggcaagcc gattcttttc
      301 ctttggagaa attctccttc tgtcgtcatc ggcaggcatc agaatccgtg gcaggaatgt
      361 aacctccatc tgatgagaca ggaaggaatc aaactggctc ggaggaagag tggaggagga
      421 gccgtgtacc acgacatggg taacatcaac ctcaccttct ttaccaccaa aaccaagtat
      481 gacagaatgg aaaatctgaa actaatcgtg agagctctga atgctgtcca accccagctg
      541 gatgtgcagc ctaccaaaaa gtttgacctg ctactcgacg ggcagtttaa aatctcagga
      601 accgcatcaa agatcggccg gactgccgcg taccaccact gcaccttgct atgcagcacc
      661 aaccggacag ctctgtcttc ttcgctgaag agcccgtact gcgggataaa gagcaacgcc
      721 actcccagca tcccttccgc tgtcaaaaac cttctggaaa gagattccac gctgacctgt
      781 gaagttctga tgagtgcggt ggctgcagag tacgcggcgc atcatcaagt tgatggtcac
      841 gtcaacctaa taaaccctgc agatgagacg atgttccctg gaataaaccg caaagtcaag
      901 gaactgcaaa gttgggagtg ggtatacggc aggactccca agtttaccgt ggacaccacg
      961 tttcatgtgc cgtatgagca ggcgcatttg gaaatccaag tgttcatgga tgtaaagaac
     1021 ggacgaatcg aaacctgcgc tattaaggca cccgatcact ggctgccgct ggaaataggt
     1081 gagaaattaa actcaagttt catcggcagc aaattctgcc ccgttgaaac caccctgcta
     1141 acgaatgtat tactgagaac atgtccaggc gaccatcact tacacagtaa atggtacatt
     1201 ctgtgtgaaa aaatcagggg gataatgtga ccctaacaac tttgtctaca ctggcagttt
     1261 tggtgagaaa aaaactttaa actacaattt gtcttatatc ttaacagaaa taggggtgtc
     1321 agtttgaacc tgtgttggtc ttgaggtggc ctgtccctaa tttcaactcc tcagcttttg
     1381 tcagactttg attgataatc tgttaagggt tttggcactt tcagggcctc gtcctcttcc
     1441 atttctcctc tcattaaact tcagagaaga aa
//
