LOCUS       NM_001013770            2854 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus lipase, member O3 (Lipo3), mRNA.
ACCESSION   NM_001013770 XM_001004986
VERSION     NM_001013770.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2854)
  AUTHORS   Kooistra MK, Leduc RY, Dawe CE, Fairbridge NA, Rasmussen J, Man JH,
            Bujold M, Juriloff D, King-Jones K and McDermid HE.
  TITLE     Strain-specific modifier genes of Cecr2-associated exencephaly in
            mice: genetic analysis and identification of differentially
            expressed candidate genes
  JOURNAL   Physiol Genomics 44 (1), 35-46 (2012)
   PUBMED   22045912
REFERENCE   2  (bases 1 to 2854)
  AUTHORS   Holmes RS, Cox LA and VandeBerg JL.
  TITLE     Comparative studies of mammalian acid lipases: Evidence for a new
            gene family in mouse and rat (Lipo)
  JOURNAL   Comp Biochem Physiol Part D Genomics Proteomics 5 (3), 217-226
            (2010)
   PUBMED   20598663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139790.1 and AI662771.1.
            
            On Apr 18, 2016 this sequence version replaced NM_001013770.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139790.1, AK170332.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2721              AK139790.1         2-2722
            2722-2854           AI662771.1         1-133               c
FEATURES             Location/Qualifiers
     source          1..2854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.18 cM"
     gene            1..2854
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /note="lipase, member O3"
                     /db_xref="GeneID:381236"
                     /db_xref="MGI:MGI:2147592"
     exon            1..421
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..564
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            565..670
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             572..1771
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /EC_number="3.1.1.3"
                     /note="lipase, member O1"
                     /codon_start=1
                     /product="lipase, member O3 precursor"
                     /protein_id="NP_001013792.2"
                     /db_xref="CCDS:CCDS37961.1"
                     /db_xref="GeneID:381236"
                     /db_xref="MGI:MGI:2147592"
                     /translation="MLWLLRTMCLIHVLGKIFCLFGPKKNPEAHMNVSEIIKHWDYPS
                     EEYEVVTDDGYILPINRIPHGKNNANSSAPKMVVFCQHGLLATPGAWVSNPPVNSLAF
                     ILADAGYDVWMGSSRGSTWAKKHVALNPDSKEFWDFSFDQMIKYDLPATINFILDKTG
                     QKQIYYIGHSQGTLLAIGAFATNQTLAEKIKLNILLAPIYSVQHSKGISHLASYLTPT
                     TIKLLFGEKEFFPTVVFSEVGACVCNINFFTAICAAIMGSMGGYSPDQLNKSRLDVYV
                     KLNLAGTSVKVLIHYNQVGRSGILQAYDWGSPSLNMQHYNQTTPPVYNVEDMKVPTAM
                     FTGLKDFLSDPEDVEILKPKIHNLTYLKTIPDFSHFDFILGLNARKEVSEEILTILRK
                     YEGDVQL"
     exon            671..788
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..987
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1097
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1234
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1378
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1450
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1522
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..2842
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2815..2820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
     polyA_site      2839
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
     polyA_site      2842
                     /gene="Lipo3"
                     /gene_synonym="Lipo1"
ORIGIN      
        1 ggctttgctg ctgactcctc tcactcactt cagtcatcct caagaggcca actggcggtg
       61 acttcctgat ttatcctcca ggggacgatg ggattggggc tcgcccagta agtaagctgc
      121 tcggtggagg cctgggcaga acgtcccctg ggcctcagtc acccctgcgg ggttctccgc
      181 gctctcagga gcagacgtcc cgcgcagggc accgccctgc ctgacccagg cggggacaca
      241 gtggtagagt gggacggcga ggctccgcgc ctctgtcagc ggcctagctg aaggcccgcc
      301 gccatgtccc gggtactggt tgtgggcgcc gggctaaccg gaagtctgtg tgccgcgctg
      361 ctgaggaagg aaacaaccgc ccccctgtac ctcggcctgt gagacaaggg tggggacaca
      421 gtttttatga ggaactgtta gctcatggaa ttttgaagcc tctgacatcc cccattgaag
      481 gaatgaaagg gaaggaagga gattgcaact ttgtggcacc tcaaggattt tcttcagtta
      541 tcaagtacta cttgaaaaaa tcaggtttaa aatgctctgg ctgctgagaa caatgtgcct
      601 tattcatgta cttggtaaaa tattttgttt atttggacca aagaagaatc ctgaagctca
      661 catgaatgtt agcgagatta ttaaacactg ggattatcca agcgaagaat atgaggttgt
      721 gactgatgat ggttacattc ttccaattaa ccgaattcct catgggaaga acaatgctaa
      781 tagttcagcc ccaaagatgg tagtattttg tcagcatggc ttgcttgcaa cacctggtgc
      841 atgggtttcc aatccgcctg tcaacagcct ggccttcatc ctagcagatg ctgggtatga
      901 tgtgtggatg ggaagcagca gaggaagtac ctgggcaaag aaacacgtgg ccctcaaccc
      961 agattctaaa gaattctggg attttagttt tgatcaaatg ataaaatatg accttccagc
     1021 taccattaat ttcattctgg ataaaacagg acaaaagcag atttactaca ttggccattc
     1081 tcaaggaacc cttcttgcta ttggggcatt tgcaacaaat caaacactgg cagaaaagat
     1141 taaactcaac attttattgg ctccaattta tagtgttcaa cattccaaag gtatttcgca
     1201 ccttgcgtct tacctcactc caacgactat caagctcctc tttggtgaaa aagaattttt
     1261 tcctaccgta gttttcagtg aggtgggtgc atgtgtttgc aatattaact tcttcactgc
     1321 tatatgtgct gctatcatgg gatcgatggg tggatattct ccagaccagt taaataagag
     1381 ccgccttgat gtgtatgtaa agctcaatct agcaggaaca tcagtaaaag ttcttataca
     1441 ttataatcag gtaggaagaa gtggtatact tcaggcttat gattggggaa gtccatctct
     1501 gaatatgcaa cactacaatc agactactcc tcctgtatac aatgtggaag acatgaaggt
     1561 tccaactgcc atgtttactg gtttaaaaga ttttttgtct gacccagaag atgttgaaat
     1621 tttgaaaccc aaaatccaca acctcacata ccttaagact attcctgatt ttagccattt
     1681 tgattttata ctgggattaa atgctaggaa agaagtttct gaggaaattt taacaattct
     1741 taggaaatat gaaggtgatg ttcagcttta gctttttgca tgattttaaa cctttttgaa
     1801 agtctcttgt tcttataagt gcaaatattt tcttgcttgg cattttatct ccttaattat
     1861 ctttgatttt taagcagctg tttcatttgt tgaatcattt gttttagtga aaactatgac
     1921 catcaaggga atgtgtcatc ttgtgattgc tttttaagta atctaagtgt attttttaaa
     1981 aaattgctcc ctaagaaaag acctccattt aatttacagt gatgaaatcc taaaatacta
     2041 ataaaggaag aggcctggcc catactgtgc tatcacacat gatgctatct gaagaaaaga
     2101 tcataaaagc ttcataaatt cgaacccagg ctcaagaagg acagtcaatc ttgttgctca
     2161 gattccacaa gtattagtca ctagtctcat tgcaaacctc ccctgtcaca ccacctgtgt
     2221 gaaccaagca ctgtttgaga aagtcactta tgtcagtgtt ctctgaattg agagaacaat
     2281 aattatgtaa aatgatctga gttgttgaaa ataacccaca agaatgatca ttcattgaag
     2341 cccctgaata gggtattttg aattctcctt gtaacagaaa ttgaatacaa aatcaaacat
     2401 gcaattataa ttttattatt aaagtttaac ctatttaggt gttcaaagca taaagtaatt
     2461 attatgtgca cagtttggac aatataaaga ataactatgg ccagtctcaa atacattttt
     2521 cttacaatct tttacatgat aataaagaaa tgtagatgtg tgattacgtg tgtgaacaca
     2581 tacacatgtg ataagttcct tttattccaa gtttgtgtag aacattcact tgattaaatc
     2641 aaagtctaat gactttgtaa attaagtgac tttataatca aagtccagtg gcttctgtga
     2701 gtagccttta cccatctatt gatgttccca tgattactgt ctttgtccat ttatgggatg
     2761 ttgtattact ttattggctt ggaatatgac aaatcttccc tgtactattt ctggaataaa
     2821 gccaacttat taatgttaag caaaaaaaaa aaaa
//
