LOCUS       NM_027340               1502 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus lipase, family member N (Lipn), mRNA.
ACCESSION   NM_027340 XM_355173 XM_900789 XM_917142 XM_924712 XM_972704
            XM_972783
VERSION     NM_027340.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1502)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1502)
  AUTHORS   Aibara,D., Matsuo,K. and Matsusue,K.
  TITLE     Lipase family member N is a novel target gene for
            CCAAT/enhancer-binding protein alpha in type 2 diabetic model mouse
            liver
  JOURNAL   Endocr J 69 (5), 567-575 (2022)
   PUBMED   35082200
  REMARK    GeneRIF: Lipase family member N is a novel target gene for
            CCAAT/enhancer-binding protein alpha in type 2 diabetic model mouse
            liver.
REFERENCE   3  (bases 1 to 1502)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1502)
  AUTHORS   Pichery,M., Huchenq,A., Sandhoff,R., Severino-Freire,M.,
            Zaafouri,S., Opalka,L., Levade,T., Soldan,V., Bertrand-Michel,J.,
            Lhuillier,E., Serre,G., Maruani,A., Mazereeuw-Hautier,J. and
            Jonca,N.
  TITLE     PNPLA1 defects in patients with autosomal recessive congenital
            ichthyosis and KO mice sustain PNPLA1 irreplaceable function in
            epidermal omega-O-acylceramide synthesis and skin permeability
            barrier
  JOURNAL   Hum Mol Genet 26 (10), 1787-1800 (2017)
   PUBMED   28369476
REFERENCE   5  (bases 1 to 1502)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1502)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK154333.1.
            
            On Apr 6, 2007 this sequence version replaced NM_027340.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1502              AK154333.1         2-1503
FEATURES             Location/Qualifiers
     source          1..1502
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.32 cM"
     gene            1..1502
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /note="lipase, family member N"
                     /db_xref="GeneID:70166"
                     /db_xref="MGI:MGI:1917416"
     exon            1..228
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            229..344
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1433
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /EC_number="3.1.1.13"
                     /EC_number="3.1.1.3"
                     /note="lipase member N; lipase-like abhydrolase
                     domain-containing protein 4; lipase-like, ab-hydrolase
                     domain containing 4"
                     /codon_start=1
                     /product="lipase member N precursor"
                     /protein_id="NP_081616.1"
                     /db_xref="CCDS:CCDS37962.1"
                     /db_xref="GeneID:70166"
                     /db_xref="MGI:MGI:1917416"
                     /translation="MPMMWLFLTTACLIPGTLSAGGFLDFENKVNPEVWMNASEIIMY
                     NGYPSEEYDVTTADGYILAINRIPHGRAQTGQTGPRPVVYMQHALFADNAYWLENFAN
                     GSLGFILADAGYDVWMGNSRGNTWSRRHKTLSANEEKFWAFSFNEMAKYDLPGIIDFI
                     VNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPVISFKYPTSVFTNLF
                     LLPKSIIKLVFGTKGVLLEDKNARMSFITFCNQKLLQPLCSEFMSLWAGFNKKNMNMS
                     RLDVYMAHAPTGSSIQNMLHIKQLYRSDEFRAYDWGSEAENMNHYNQSYPPLYDLTAM
                     KVPTAIWAGGHDVLVTPQDVARILPQITNLRYFKQFPDWNHFDFVWGLDAPQRLYSKI
                     ISLMKEYF"
     exon            345..462
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            463..661
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            662..771
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            772..908
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1055
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1127
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1199
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1502
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctagcttc taactgtcac tgcagccaag gcttcagcca aagcttcaga ctgatgtcaa
       61 aagcaaaagt tcggaagtcc tctgggcagg tgacgctcac ctaacgaggt aagaatggag
      121 attcatccca accaggagac agataagagt ggacatcagg tgcagtgggg ctgtctgcat
      181 gcccttccta gacctgttac ctgttggctc tgtgaccttg ggcagatcgc atgcctatga
      241 tgtggctatt tttaacaacg gcttgtttga tacctggaac cttaagcgct ggtggattct
      301 tggattttga aaataaagta aatcctgaag tgtggatgaa tgctagtgaa ataatcatgt
      361 acaacggcta ccccagtgaa gagtatgacg tcaccaccgc agatgggtac attctcgcca
      421 tcaacagaat tccccatggg agagcacaga ctgggcagac aggaccccgg cctgttgtat
      481 atatgcaaca tgccttgttt gcagacaatg cctactggct tgagaatttt gccaatggaa
      541 gcctagggtt catactagca gatgcaggtt atgatgtgtg gatgggaaac agtcgaggaa
      601 acacttggtc aagaagacac aaaactctct cagcaaatga agagaaattc tgggctttta
      661 gcttcaatga aatggccaaa tatgacctcc cagggataat agatttcatt gtgaataaaa
      721 caggtcagga gaagttgtac ttcattggac attcactcgg cactacaata ggatttgtag
      781 ccttttccac catgcctgaa ctggcgcaaa gaatcaaaat gaattttgcc ttgggtcctg
      841 tgatctcatt caaatatcct acaagcgttt ttaccaattt gtttctactt ccaaaatcca
      901 taatcaagct tgtgtttggc accaaaggtg tccttttaga agataagaat gcaaggatgt
      961 catttatcac attctgcaac caaaagctac tccaaccatt gtgtagtgaa tttatgtcct
     1021 tgtgggctgg attcaacaaa aaaaatatga atatgagtcg actggatgtg tacatggccc
     1081 acgctcccac aggatcatca attcagaaca tgctgcacat aaagcagctt taccgatctg
     1141 atgaattcag agcttatgac tggggaagtg aagctgaaaa tatgaatcac tacaaccaga
     1201 gttaccctcc cttgtatgac ctgacggcca tgaaggtacc cactgccatt tgggctggtg
     1261 gacacgatgt gctcgtaact cctcaagatg tagccaggat acttccccaa attacaaatc
     1321 tacgctactt caagcaattt ccagattgga accattttga ttttgtctgg ggccttgatg
     1381 cccctcaaag actgtacagt aaaatcataa gtttgatgaa agaatacttc taaatacagt
     1441 ccatcaattt ttcagtcaaa ctttgcttcc aggcccatga gaggctttag gaaaacccct
     1501 gg
//
