LOCUS       NP_081616                400 aa            linear   ROD 28-APR-2025
DEFINITION  lipase member N precursor [Mus musculus].
ACCESSION   NP_081616 XP_355173 XP_905882 XP_922235 XP_929805 XP_977798
            XP_977877
VERSION     NP_081616.1
DBSOURCE    REFSEQ: accession NM_027340.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 400)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 400)
  AUTHORS   Aibara,D., Matsuo,K. and Matsusue,K.
  TITLE     Lipase family member N is a novel target gene for
            CCAAT/enhancer-binding protein alpha in type 2 diabetic model mouse
            liver
  JOURNAL   Endocr J 69 (5), 567-575 (2022)
   PUBMED   35082200
  REMARK    GeneRIF: Lipase family member N is a novel target gene for
            CCAAT/enhancer-binding protein alpha in type 2 diabetic model mouse
            liver.
REFERENCE   3  (residues 1 to 400)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 400)
  AUTHORS   Pichery,M., Huchenq,A., Sandhoff,R., Severino-Freire,M.,
            Zaafouri,S., Opalka,L., Levade,T., Soldan,V., Bertrand-Michel,J.,
            Lhuillier,E., Serre,G., Maruani,A., Mazereeuw-Hautier,J. and
            Jonca,N.
  TITLE     PNPLA1 defects in patients with autosomal recessive congenital
            ichthyosis and KO mice sustain PNPLA1 irreplaceable function in
            epidermal omega-O-acylceramide synthesis and skin permeability
            barrier
  JOURNAL   Hum Mol Genet 26 (10), 1787-1800 (2017)
   PUBMED   28369476
REFERENCE   5  (residues 1 to 400)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (residues 1 to 400)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK154333.1.
            
            On or before Jan 30, 2007 this sequence version replaced
            XP_355173.3, XP_905882.1, XP_922235.1, XP_929805.1, XP_977877.1,
            XP_977798.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154333.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..400
                     /organism="Mus musculus"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.32 cM"
     Protein         1..400
                     /product="lipase member N precursor"
                     /EC_number="3.1.1.13"
                     /EC_number="3.1.1.3"
                     /note="lipase member N; lipase-like abhydrolase
                     domain-containing protein 4; lipase-like, ab-hydrolase
                     domain containing 4"
                     /calculated_mol_wt=43635
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2127
     mat_peptide     20..400
                     /product="Lipase member N. /id=PRO_0000286832"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3U4B4.1)"
                     /calculated_mol_wt=43635
     Region          39..397
                     /region_name="PLN02872"
                     /note="triacylglycerol lipase"
                     /db_xref="CDD:215470"
     Site            274
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q3U4B4.1)"
     CDS             1..400
                     /gene="Lipn"
                     /gene_synonym="2210418G03Rik; Lipl4"
                     /coded_by="NM_027340.2:231..1433"
                     /db_xref="CCDS:CCDS37962.1"
                     /db_xref="GeneID:70166"
                     /db_xref="MGI:MGI:1917416"
ORIGIN      
        1 mpmmwlfltt aclipgtlsa ggfldfenkv npevwmnase iimyngypse eydvttadgy
       61 ilainriphg raqtgqtgpr pvvymqhalf adnaywlenf angslgfila dagydvwmgn
      121 srgntwsrrh ktlsaneekf wafsfnemak ydlpgiidfi vnktgqekly fighslgtti
      181 gfvafstmpe laqrikmnfa lgpvisfkyp tsvftnlfll pksiiklvfg tkgvlledkn
      241 armsfitfcn qkllqplcse fmslwagfnk knmnmsrldv ymahaptgss iqnmlhikql
      301 yrsdefrayd wgseaenmnh ynqsypplyd ltamkvptai wagghdvlvt pqdvarilpq
      361 itnlryfkqf pdwnhfdfvw gldapqrlys kiislmkeyf
//
