LOCUS       NM_001083894            3811 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lipase, member H (Liph), transcript variant 1, mRNA.
ACCESSION   NM_001083894
VERSION     NM_001083894.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3811)
  AUTHORS   Shirokova,V., Biggs,L.C., Jussila,M., Ohyama,T., Groves,A.K. and
            Mikkola,M.L.
  TITLE     Foxi3 Deficiency Compromises Hair Follicle Stem Cell Specification
            and Activation
  JOURNAL   Stem Cells 34 (7), 1896-1908 (2016)
   PUBMED   26992132
REFERENCE   2  (bases 1 to 3811)
  AUTHORS   Grisanti,L., Rezza,A., Clavel,C., Sennett,R. and Rendl,M.
  TITLE     Enpp2/Autotaxin in dermal papilla precursors is dispensable for
            hair follicle morphogenesis
  JOURNAL   J Invest Dermatol 133 (10), 2332-2339 (2013)
   PUBMED   23677168
  REMARK    GeneRIF: We finally isolate control and Enpp2-null dermal pipilla
            precursors and identify the expression and upregulation of LIPH, an
            alternative LPA-producing enzyme, suggesting that this gene could
            functionally compensate for the absence of Enpp2.
REFERENCE   3  (bases 1 to 3811)
  AUTHORS   Furuta,D., Yamane,M., Tsujiuchi,T., Moriyama,R. and Fukushima,N.
  TITLE     Lysophosphatidic acid induces neurite branch formation through LPA3
  JOURNAL   Mol Cell Neurosci 50 (1), 21-34 (2012)
   PUBMED   22465231
REFERENCE   4  (bases 1 to 3811)
  AUTHORS   Inoue,A., Arima,N., Ishiguro,J., Prestwich,G.D., Arai,H. and
            Aoki,J.
  TITLE     LPA-producing enzyme PA-PLAalpha regulates hair follicle
            development by modulating EGFR signalling
  JOURNAL   EMBO J 30 (20), 4248-4260 (2011)
   PUBMED   21857648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3811)
  AUTHORS   Srivastava,A.K., Mohan,S., Masinde,G.L., Yu,H. and Baylink,D.J.
  TITLE     Identification of quantitative trait loci that regulate obesity and
            serum lipid levels in MRL/MpJ x SJL/J inbred mice
  JOURNAL   J Lipid Res 47 (1), 123-133 (2006)
   PUBMED   16254318
REFERENCE   6  (bases 1 to 3811)
  AUTHORS   Wen,X.Y., Stewart,A.K., Skaug,J., Wei,E. and Tsui,L.C.
  TITLE     Murine phosphatidylserine-specific phospholipase A1 (Ps-pla1) maps
            to chromosome 16 but is distinct from the lpd (lipid defect) locus
  JOURNAL   Mamm Genome 12 (2), 129-132 (2001)
   PUBMED   11210182
REFERENCE   7  (bases 1 to 3811)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   8  (bases 1 to 3811)
  AUTHORS   Yang,A., Kaghad,M., Wang,Y., Gillett,E., Fleming,M.D., Dotsch,V.,
            Andrews,N.C., Caput,D. and McKeon,F.
  TITLE     p63, a p53 homolog at 3q27-29, encodes multiple products with
            transactivating, death-inducing, and dominant-negative activities
  JOURNAL   Mol Cell 2 (3), 305-316 (1998)
   PUBMED   9774969
REFERENCE   9  (bases 1 to 3811)
  AUTHORS   Wen,X.Y., Bryce,D.M. and Breitman,M.L.
  TITLE     Characterization of lpd (lipid defect): a novel mutation on mouse
            chromosome 16 associated with a defect in triglyceride metabolism
  JOURNAL   Hum Mol Genet 7 (4), 743-750 (1998)
   PUBMED   9499429
REFERENCE   10 (bases 1 to 3811)
  AUTHORS   Kalcheva,I., Elliott,R.W., Dalziel,M. and Lau,J.T.
  TITLE     The gene encoding beta-galactoside alpha2,6-sialyltransferase maps
            to mouse chromosome 16
  JOURNAL   Mamm Genome 8 (8), 619-620 (1997)
   PUBMED   9250875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY118220.1, AK162492.1, AK134352.1 and BQ032777.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134352.1, AK162492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BY118220.1         2-35
            35-2711             AK162492.1         1-2677
            2712-3791           AK134352.1         2671-3750
            3792-3811           BQ032777.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..3811
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.95 cM"
     gene            1..3811
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /note="lipase, member H"
                     /db_xref="GeneID:239759"
                     /db_xref="MGI:MGI:2388029"
     exon            1..222
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1529
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /EC_number="2.7.11.30"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lipase H"
                     /codon_start=1
                     /product="lipase member H isoform 1 precursor"
                     /protein_id="NP_001077363.1"
                     /db_xref="CCDS:CCDS37296.1"
                     /db_xref="GeneID:239759"
                     /db_xref="MGI:MGI:2388029"
                     /translation="MLRLCFFISFMCLVKSDTDETCPSFTRLSFHSAVVGTGLSVRLM
                     LYTQRDQTCAQIINSTALGSLNVTKKTTFIIHGFRPTGSPPVWIEELVQSLISVQEMN
                     VVVVDWNRGATTVIYPHASSKTRQVASILKEFIDQMLVKGASLDNIYMIGVSLGAHIA
                     GFVGESYEGKLGRVTGLDPAGPLFNGRPPEERLDPSDALFVDVIHSDTDALGYKEALG
                     HIDFYPNGGLDQPGCPKTIFGGIKYFKCDHQMSVYLYLASLQNNCSITAYPCDSYRDY
                     RNGKCVSCGAGQIVPCPRVGYYADSWKEYLWDRDPPMTKAFFDTAETKPYCMYHYFVD
                     IVSWNKSVRRGFITIKLRGEDGNITESKIDHEPSAFEKYHQVSLLARFNRDLDKVAEI
                     SLLFSTGSVVGPKYKLRVLQMKLRSLAHPDRPHLCRYDLVLMENVETSFQPILCSQQQ
                     M"
     exon            223..590
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            591..699
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            700..801
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            802..891
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1059
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1155
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1267
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1441
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..3802
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2086
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /note="major polyA site"
     regulatory      2615..2620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /note="hexamer: AATGAA"
     polyA_site      2638
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /note="major polyA site"
     regulatory      3120..3125
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /note="hexamer: GATAAA"
     polyA_site      3143
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /note="major polyA site"
     polyA_site      3341
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
     regulatory      3779..3784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
                     /note="hexamer: AATAAA"
     polyA_site      3798
                     /gene="Liph"
                     /gene_synonym="C130037N08Rik; D16Wsu119e; H06; lpd1; lpd2;
                     Lpdlr; mPA-PLA1; P3; PLA1B"
ORIGIN      
        1 gacaggacta acagggccac agagcctccc tcggggactt cctgttgtca cggactcact
       61 cgcttcgaga aagccagact tcagggtggg acgcgggaac gcgggaacgc caggctctgt
      121 gcggagtgcg acacgtcctc gtgtttgggg cacatgatct cttgaggttc cctatgctga
      181 ggctatgttt tttcatcagt ttcatgtgct tggtgaaatc agacacggat gaaacatgcc
      241 cgtccttcac cagactgagc ttccacagcg cggtggttgg tacaggactc tccgtgagac
      301 tgatgctcta cacacagaga gaccagacct gtgcacagat catcaactcc acagctctgg
      361 ggagcttaaa tgtgaccaag aaaaccactt ttataatcca cggtttccgg ccaacaggct
      421 cccctccggt ttggatagag gagctggtac agagtttgat cagtgtacaa gagatgaatg
      481 tagtggttgt tgattggaat cgaggagcga caactgtgat atacccccat gcgtctagca
      541 agaccagaca agtagcttct attttgaagg aatttattga ccagatgttg gtcaaaggag
      601 cttctctgga caacatttac atgattggag taagtctagg agcccacata gctggatttg
      661 ttggcgagtc gtatgagggg aagctgggga gagtcacagg tcttgaccct gcaggccctt
      721 tattcaacgg gagacctcct gaggagagat tagaccccag cgacgcactg ttcgtggacg
      781 tcatccactc tgacactgac gcactaggct acaaggaagc cctaggacac atagacttct
      841 acccgaatgg aggactagat caacccggtt gccccaagac aatatttgga ggtataaagt
      901 acttcaagtg tgaccaccag atgtccgtct acctgtacct tgcatccctg caaaataact
      961 gctccatcac ggcctatccc tgcgactcct atcgggatta taggaatggc aagtgtgtca
     1021 gctgtggcgc tggacaaatt gtgccatgtc cccgtgtagg ctactatgct gacagctgga
     1081 aagagtactt atgggacaga gatcctccga tgacgaaggc gttcttcgac acagctgaga
     1141 caaagccata ctgcatgtat cattattttg tggacattgt atcttggaac aagagcgtaa
     1201 gaagagggtt tattacaatc aaactgagag gcgaagatgg caatatcaca gaatccaaaa
     1261 tcgatcatga gccatctgca tttgagaaat accatcaagt gagtctcctc gcaagattta
     1321 atcgagatct ggataaggtg gcagagattt ccttgttgtt ctccacaggg tctgtagtgg
     1381 gcccaaagta caagctcagg gtcctgcaga tgaagctgag gtctctggcc catccagaca
     1441 ggcctcactt gtgtcgatat gatctcgtcc ttatggagaa tgttgagaca tccttccaac
     1501 ctatcctgtg ctctcagcag cagatgtagc tgctgttaag acctgtgggc agtgatgaca
     1561 tcaagatctc tacagctata ggctttcagt gcctcaccct atagcgtcct gaaggcttcc
     1621 aaagcatggg gaagaaaacc aaggttattt tcggctgtgt tccaaggatg tcgcgtcaca
     1681 aaaatgtcaa aggacctgcg attatgaaac accactggga gggggggggc gccctaacta
     1741 gggcaagaca gaaatagccc agctccctac agcaaagcac tttgtctggc tgcgtcccga
     1801 ggccccactt gttccccact gtcgaatctg ctgcctgtca taccacaccc tcagggccgt
     1861 ggggcaagca tctaaatggt ccctgtgccc aatcctctgc catctcggcg ggaaccgaat
     1921 ggagaatgaa ccagactacc tcacagggac tgtgggtggg gagggccagg ctgtgaaggg
     1981 tttggaaatc ccttgggtcc cttgggtgga ctactgtgaa catgcttttc ttttgatagg
     2041 gtttggctct tacgtaaaga cacacaatct ctctttttca acaccagctt tcctcctgga
     2101 ctgtttgcct cggggcgaca agaaggctct ggcttagtcc agactcttct gaagtgatgc
     2161 tgatggccag aggtattggg ctgggctcat agccctgagg cctgtgcagc taagtggaag
     2221 aaagagaaaa aacaaaaaaa aaacaaaaac aaacagggct agcattgcag catgtggact
     2281 gggcagagaa aaggctggaa ggaaactggc ctgctttcac tcaagttgcg aaagtgttaa
     2341 ttacaaggtt gtttttctgc tctgggattg agtatgctaa gtgcactgag ccctgctctc
     2401 agcttcagac attttttaaa agtagtcctt aagactgttt tcttaaaaaa caaaaacaaa
     2461 agctgggcag tggtggagca caactttaac cccagcactt gagaggagag gcaggcagat
     2521 ctctgtgagt ttgaggacag cctggtctat agagcaagtt ccgggacaac cagggctaca
     2581 cggagaaacc ctgtcttcaa aacaaaaaca aacaaatgaa agttttcttt ccttcctatt
     2641 ggtgcaatcc atacttattc caggaaattc cttaagatgt atagatgtaa aatacaaaac
     2701 tgtgcacagt cctgcctgtt agaggaatta atgttaatat ttagacttgt ttctcaaact
     2761 tgtggggctc agattcagag catggccggc tcttggggca tggaaactct gagaagtctt
     2821 cccaggcctc cctggaggca gatgtgactt caaacatttc tgaataacag tggcaaacag
     2881 attaaggggt cacagggggc cagggacaga gggcaaaatg aaagtagaac aggtagaggg
     2941 tccagacgcc tggtgtggag gtgagtgccc cccacccctc atctgtgacc actgggggaa
     3001 ggtgtcacag gcccagggcc cttctcttca ttgaattgcc ccagctattg taaagaaatg
     3061 gatactgtga gcaaatgtgt tgaaatccac actgtcttag tttcttttcc cgttgctatg
     3121 ataaaatgct ctgatgaaaa caacgtgaag gagaaagggt ttattttagc tcgcagttca
     3181 gggtatacag tccactgtga cagggagtcg gggtagcagc atcgtaaaag cagctggtcc
     3241 tatcgctgcc acagtcagga agcagggcga tgaacacatg cttgcgagta tttagctcag
     3301 tttcctgaca catttaaaaa ttgttaaact ttgttaattt atagcgtgtg tttgtatttg
     3361 tacacacatg tacacatgtc acacacagtg cacatgtgga gttcagaagg aaatttgtgg
     3421 gagtcagttc tctccttcca atgtgtgggt cccaggtatc tgggcattag gcttagaggc
     3481 aagtatgttt accacctgag ccatctcact ggactagttt cccagctctt acacaattca
     3541 gattccctga ctagggaatg gtgccaccta caatgggcag gtgtccataa atataatcaa
     3601 gatcatttct cgggctgtac agaaggctca gtggttaaga gcactgactg ttcttccaga
     3661 ggtcctgagt tcaatatcca acaactacct ggtggctcac aaccatctgt aataggatct
     3721 gatgctctct tctggtgtgt gtgaagacag ctacagtgga ctcataaata taaaaataaa
     3781 taaataagtc tttaaaaaga aaaaaaaaaa a
//
