LOCUS       NM_010720               3787 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus lipase, endothelial (Lipg), mRNA.
ACCESSION   NM_010720
VERSION     NM_010720.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3787)
  AUTHORS   Shirasaki,T., Murai,K., Ishida,A., Kuroki,K., Kawaguchi,K.,
            Wang,Y., Yamanaka,S., Yasukawa,R., Kawasaki,N., Li,Y.Y.,
            Shimakami,T., Sumiyadorj,A., Nio,K., Sugimoto,S., Orita,N.,
            Takayama,H., Okada,H., Thi Bich,P.D., Iwabuchi,S., Hashimoto,S.,
            Ide,M., Tabata,N., Ito,S., Matsushima,K., Yanagawa,H.,
            Yamashita,T., Kaneko,S. and Honda,M.
  TITLE     Functional involvement of endothelial lipase in hepatitis B virus
            infection
  JOURNAL   Hepatol Commun 7 (9), e0206 (2023)
   PUBMED   37655967
  REMARK    GeneRIF: Functional involvement of endothelial lipase in hepatitis
            B virus infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3787)
  AUTHORS   Sugasini,D., Yang,P., Ng,D., Khetarpal,S.A., Vitali,C., Rader,D.J.
            and Subbaiah,P.V.
  TITLE     Potential role of hepatic lipase in the accretion of
            docosahexaenoic acid (DHA) by the brain
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (10), 159002 (2021)
   PUBMED   34197964
  REMARK    GeneRIF: Potential role of hepatic lipase in the accretion of
            docosahexaenoic acid (DHA) by the brain.
REFERENCE   3  (bases 1 to 3787)
  AUTHORS   Khetarpal,S.A., Vitali,C., Levin,M.G., Klarin,D., Park,J.,
            Pampana,A., Millar,J.S., Kuwano,T., Sugasini,D., Subbaiah,P.V.,
            Billheimer,J.T., Natarajan,P. and Rader,D.J.
  TITLE     Endothelial lipase mediates efficient lipolysis of
            triglyceride-rich lipoproteins
  JOURNAL   PLoS Genet 17 (9), e1009802 (2021)
   PUBMED   34543263
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3787)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3787)
  AUTHORS   Burke,T.P., Engstrom,P., Chavez,R.A., Fonbuena,J.A., Vance,R.E. and
            Welch,M.D.
  TITLE     Inflammasome-mediated antagonism of type I interferon enhances
            Rickettsia pathogenesis
  JOURNAL   Nat Microbiol 5 (5), 688-696 (2020)
   PUBMED   32123346
REFERENCE   6  (bases 1 to 3787)
  AUTHORS   Jin,W., Millar,J.S., Broedl,U., Glick,J.M. and Rader,D.J.
  TITLE     Inhibition of endothelial lipase causes increased HDL cholesterol
            levels in vivo
  JOURNAL   J Clin Invest 111 (3), 357-362 (2003)
   PUBMED   12569161
  REMARK    GeneRIF: endothelial lipase has a role in regulating HDL
            cholesterol levels
REFERENCE   7  (bases 1 to 3787)
  AUTHORS   Ishida,T., Choi,S., Kundu,R.K., Hirata,K., Rubin,E.M., Cooper,A.D.
            and Quertermous,T.
  TITLE     Endothelial lipase is a major determinant of HDL level
  JOURNAL   J Clin Invest 111 (3), 347-355 (2003)
   PUBMED   12569160
  REMARK    GeneRIF: endothelial lipase has a role in regulating HDL levels
REFERENCE   8  (bases 1 to 3787)
  AUTHORS   Cohen,J.C.
  TITLE     Endothelial lipase: direct evidence for a role in HDL metabolism
  JOURNAL   J Clin Invest 111 (3), 318-321 (2003)
   PUBMED   12569156
  REMARK    GeneRIF: Endothelial lipase has a role in HDL metabolism [review]
            Review article
REFERENCE   9  (bases 1 to 3787)
  AUTHORS   Bonne,A.C., Den Bieman,M.G., Van Lith,H.A. and Van Zutphen,B.F.
  TITLE     Sequencing and chromosomal assignment of the rat
            endothelial-derived lipase gene (Lipg)
  JOURNAL   DNA Seq 12 (4), 285-287 (2001)
   PUBMED   11924532
REFERENCE   10 (bases 1 to 3787)
  AUTHORS   Hirata,K., Dichek,H.L., Cioffi,J.A., Choi,S.Y., Leeper,N.J.,
            Quintana,L., Kronmal,G.S., Cooper,A.D. and Quertermous,T.
  TITLE     Cloning of a unique lipase from endothelial cells extends the
            lipase gene family
  JOURNAL   J Biol Chem 274 (20), 14170-14175 (1999)
   PUBMED   10318835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK152872.1, AK152430.1, AK152161.1, AK014047.1 and AK150054.1.
            
            On May 15, 2008 this sequence version replaced NM_010720.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172101.1, AK090224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK152872.1         1-3
            4-652               AK152430.1         2-650
            653-1665            AK152161.1         655-1667
            1666-3188           AK152430.1         1664-3186
            3189-3691           AK014047.1         418-920
            3692-3725           AK152430.1         3690-3723
            3726-3787           AK150054.1         2107-2168
FEATURES             Location/Qualifiers
     source          1..3787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 50.94 cM"
     gene            1..3787
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /note="lipase, endothelial"
                     /db_xref="GeneID:16891"
                     /db_xref="MGI:MGI:1341803"
     exon            1..386
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1792
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.32"
                     /note="lipose, endothelial; EDL; endothelial cell-derived
                     lipase; endothelial lipase; phospholipase A1"
                     /codon_start=1
                     /product="endothelial lipase precursor"
                     /protein_id="NP_034850.3"
                     /db_xref="CCDS:CCDS29343.1"
                     /db_xref="GeneID:16891"
                     /db_xref="MGI:MGI:1341803"
                     /translation="MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPAT
                     ARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWL
                     HKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSL
                     GNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDV
                     LHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHER
                     AVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKM
                     YLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIEL
                     NATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIR
                     VKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA"
     exon            387..568
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            569..748
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            749..860
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1082
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1325
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1446
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1665
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1770
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..3787
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /note="hexamer: AATAAA"
     polyA_site      3787
                     /gene="Lipg"
                     /gene_synonym="3110013K01Rik; EL; lipase; mEDL"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtgacag cggcgagtcc cgacttcgca gcggctctgg gagaggacag gtcgggctgg
       61 gcagcgtgtc cctccacacg ctcgctttcc cggtcaccgc tcgcagcgct accaaccttc
      121 caggttctgc cagctgtcca ccccatcacc ttctggccga cacccggcct gtccacttct
      181 agtctctgga ggttttagtg gtttcaaacc aaaccaaccc aaaccaaccc aacaacaaaa
      241 aagcccaaac caaaaacctg cttgagagga gggggcgtgg cggggaagga tgcgaaacac
      301 ggttttcctg ctcggctttt ggagcgtcta ttgttacttc ccggcgggaa gtatcacaac
      361 cttgcgtccc caggggtcgc tgcgagatga gcatcataaa cccactggag taccagctac
      421 cgccagaccc tctgtggctt ttaacatccg cacttctaag gacccagagc aggaagggtg
      481 taatctctcc cttggtgaca gcaaactctt agaaaactgt ggcttcaaca tgacagccaa
      541 aaccttcttc atcattcatg gatggacgat gagtggcatg tttgagagct ggctgcataa
      601 acttgtatca gccctgcaga tgagagagaa agatgctaac gtcgtggtgg ttgactggct
      661 gcccctggct catcagctgt acacggatgc agtcaataac accagggtgg tgggacagag
      721 agtagctggg atgcttgact ggctgcagga gaaggaagag ttctctcttg ggaacgttca
      781 cttgattggc tacagccttg gagcacacgt ggctggatac gctggcaact ttgtgaaagg
      841 aacagtgggc aggatcactg gtctggatcc cgcgggtccc atgtttgaag gggtggacat
      901 caacagaagg ctgtccccgg acgatgcaga ctttgtggat gtcctgcata cctacacgct
      961 gtcctttggc ttgagcattg ggattcggat gcctgtgggt cacattgaca tctatcccaa
     1021 tggcggtgac ttccagccag gctgtggatt caatgatgtc atcggatctt ttgcatatgg
     1081 aacaatctca gagatggtga aatgcgagca cgagcgagcc gtacacctct ttgtcgactc
     1141 tctggtgaat caggacaagc ccagctttgc cttccagtgc acagactcca gccgcttcaa
     1201 aaggggaatc tgcctcagct gccggaagaa ccgttgtaat aacattggct acaacgccaa
     1261 gaaaatgaga aagaagagga atagcaaaat gtatttaaaa acccgggctg gcatgccttt
     1321 caaagtttac cattaccagc tgaaagttca catgttctct tacaataaca gtggggacac
     1381 ccagcccacc ctctacatta ccctgtatgg tagcaacgca gactcccaga acctgccctt
     1441 ggaaatagtg gagaagattg agctgaatgc cacaaacacc ttccttgtct acactgagga
     1501 ggacttgggc gatctcttga agatgcgact tacctgggag ggggtagccc attcctggta
     1561 caacctgtgg aatgagtttc gcaactacct gtctcaaccc agcaacccct cgagggagct
     1621 gtacatccgg cgaattcgtg tcaaatctgg ggaaacccag cgcaaagtga cattttgcac
     1681 tcaagaccca acgaagagta gcatctcccc tggccaggag ctgtggtttc acaagtgtca
     1741 ggatggctgg aaaatgaaaa acaaaaccag tccctttgtg aacttggcct gagggcccaa
     1801 gaagtcctgg cgtccacacc cacaccccac tgtccacgca catggaggaa aagttactgc
     1861 tgaagaccca ctcgatggac gatctcagcc ttgagcccca cgaggagctt gcttgctggg
     1921 ctcatcctgt ctcccctgac aactgtgact tctcctggag aggcctgtgc actgctgaag
     1981 ttcttgctga tgattctagc tgtaaacctt tgttgccgcc gcaggaagct gaggccagct
     2041 tgtgtgtgag cactggagtg tccagagccc tgcacactcg gggtgggggg cggggtactc
     2101 tccctgtcgc taggtgagca ctggctttgt ccaacatcag ggaacacaag gctctgaagt
     2161 ggccctgtgt ggaaggttgg cagctgcctg gcctcactga accttagtga caagtctttg
     2221 cctcaggagc tgactcatgc catagagagg ggactgtaga ccaggctggg gctgctgccc
     2281 tcccacacga ggtactgatg gatcctggtt ctattctggg tatttcatcc tgccttccag
     2341 agcaccttct gaagttcaca tcgttggcat ttccttttta tgttatgcat actttggctg
     2401 aacaaacatt tattgggcac ttcagctcat tagcaccagg catgtataga cacatgactc
     2461 aacttcagca tttggagcca gcgagaccag gatccctgga atctctcaag ttcactggcc
     2521 cctgagaatg cctgtgttag ttaaagacag atgggatcaa ggcgagggct acaggctgag
     2581 agagcttgag ctcagaggct tttatgaacc gtttcctctg agggccaccc ttgatctcta
     2641 gcagaacagc aagcagaaca ccgtgcatgc tggccacagc agtggagcca agtctctgct
     2701 ggttacggag ctatacggta ctgcaggagt tctacatacc tgctgcgcag agaccagccc
     2761 cgtggacaga gctggcatga tggttgctac agtgctcttt ctcccatgaa gtctttgctt
     2821 ttatatcagt gccttatctg ttaagctcct ggaggaaagc cccctattct agatctttat
     2881 gtgaatggat aaatgtgaca cccgagacac cctttagtag tttgacagct tgcgtgtgtg
     2941 ccgcctaatt agagcacagg gagcagggca gctgttattc ctgttttacc aagtcaaggc
     3001 ttagggaagt tcagccacct gcttagatga tatatcaagg tggcagtgga agggggtgag
     3061 ctaaggaccc agcaaggttt cctggaggca aagtttatga aatcctttct gtaactccat
     3121 aaagatgtct gcagctattt cctacccaga tgttcctgat gtgataagca ggggactttt
     3181 tttttttttc cttcagatgc tatccataaa atccaagccc tttcttaaga tacaagcaga
     3241 agaacggttg cgtttttgtg ggtgtgctgt cagcctgggg ggtggggggt ggggggtggg
     3301 agagcgatta ctctgtgttt aggtttgtca cgcacattct ttgcatctgt attgtaccag
     3361 ctttatagca ctgtttcatg ccaaagttct gatgacgtaa ccagttgacc cttcacacag
     3421 agtgcccttt ccccccctcc cccctcccca tgcttctgtg attgctctgt agccatgtga
     3481 agcttgctag ccgcggctgt acatcctgtg acttccacct tgggtttagt aatgggagct
     3541 tgagattgga gagctgagtc ctctgtgggt tctgtattta tccatttggc ttgaagcttt
     3601 gtttatatat cggctgcttt ttttttttta aatgctcaga ccattattta tttcttgagt
     3661 gtatataagt ataaagacaa atctatggtt agtttttact ttaagattaa ccgatttcaa
     3721 gatttacaaa aaaaaacaac aaaaaacaaa aaacaaattt aatagtaaaa taaaaaagta
     3781 tacagct
//
