LOCUS       NM_001039507            2785 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus lipase, hormone sensitive (Lipe), transcript variant
            2, mRNA.
ACCESSION   NM_001039507 XM_003084674 XM_003086575
VERSION     NM_001039507.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Adom,M.A., Hahn,W.N., McCaffery,T.D., Moors,T.E., Zhang,X.,
            Svenningsson,P., Selkoe,D.J., Fanning,S. and Nuber,S.
  TITLE     Reducing the lipase LIPE in mutant alpha-synuclein mice improves
            Parkinson-like deficits and reveals sex differences in fatty acid
            metabolism
  JOURNAL   Neurobiol Dis 199, 106593 (2024)
   PUBMED   38971480
  REMARK    GeneRIF: Reducing the lipase LIPE in mutant alpha-synuclein mice
            improves Parkinson-like deficits and reveals sex differences in
            fatty acid metabolism.
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Madsen,S., Delgado,A.C., Cadilhac,C., Maillard,V., Battiston,F.,
            Igelbuscher,C.M., De Neck,S., Magrinelli,E., Jabaudon,D.,
            Telley,L., Doetsch,F. and Knobloch,M.
  TITLE     A fluorescent perilipin 2 knock-in mouse model reveals a high
            abundance of lipid droplets in the developing and adult brain
  JOURNAL   Nat Commun 15 (1), 5489 (2024)
   PUBMED   38942786
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2785)
  AUTHORS   Skoug,C., Rogova,O., Spegel,P., Holm,C. and Duarte,J.M.N.
  TITLE     Genetic deletion of hormone-sensitive lipase in mice reduces
            cerebral blood flow but does not aggravate the impact of
            diet-induced obesity on memory
  JOURNAL   J Neurochem 168 (5), 781-800 (2024)
   PUBMED   38317494
  REMARK    GeneRIF: Genetic deletion of hormone-sensitive lipase in mice
            reduces cerebral blood flow but does not aggravate the impact of
            diet-induced obesity on memory.
REFERENCE   5  (bases 1 to 2785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 2785)
  AUTHORS   Purcell-Huynh,D.A., Weinreb,A., Castellani,L.W., Mehrabian,M.,
            Doolittle,M.H. and Lusis,A.J.
  TITLE     Genetic factors in lipoprotein metabolism. Analysis of a genetic
            cross between inbred mouse strains NZB/BINJ and SM/J using a
            complete linkage map approach
  JOURNAL   J Clin Invest 96 (4), 1845-1858 (1995)
   PUBMED   7560076
REFERENCE   7  (bases 1 to 2785)
  AUTHORS   Wang,S., Lapierre,P., Robert,M.F., Nadeau,J.H. and Mitchell,G.A.
  TITLE     Hormone-sensitive lipase maps to proximal chromosome 7 in mice and
            is genetically distinct from the Ad and Tub loci
  JOURNAL   Genomics 24 (2), 416-417 (1994)
   PUBMED   7698777
REFERENCE   8  (bases 1 to 2785)
  AUTHORS   Li,Z., Sumida,M., Birchbauer,A., Schotz,M.C. and Reue,K.
  TITLE     Isolation and characterization of the gene for mouse
            hormone-sensitive lipase
  JOURNAL   Genomics 24 (2), 259-265 (1994)
   PUBMED   7698747
REFERENCE   9  (bases 1 to 2785)
  AUTHORS   Warden,C.H., Davis,R.C., Yoon,M.Y., Hui,D.Y., Svenson,K., Xia,Y.R.,
            Diep,A., He,K.Y. and Lusis,A.J.
  TITLE     Chromosomal localization of lipolytic enzymes in the mouse:
            pancreatic lipase, colipase, hormone-sensitive lipase, hepatic
            lipase, and carboxyl ester lipase
  JOURNAL   J Lipid Res 34 (8), 1451-1455 (1993)
   PUBMED   8105016
REFERENCE   10 (bases 1 to 2785)
  AUTHORS   Clamp,P.A., Feltes,R., Shalhevet,D., Beever,J.E., Atac,E. and
            Schook,L.B.
  TITLE     Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on
            porcine chromosome 6
  JOURNAL   Genomics 17 (2), 324-329 (1993)
   PUBMED   8104872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC169209.2.
            
            On Jul 18, 2012 this sequence version replaced NM_001039507.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream in-frame
            start codon, compared to variant 1. The encoded isoform (2) is
            shorter at the N-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169858.1, BC021642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC169209.2         35814-35864         c
            52-587              AC169209.2         33870-34405         c
            588-678             AC169209.2         31189-31279         c
            679-824             AC169209.2         30932-31077         c
            825-1010            AC169209.2         30532-30717         c
            1011-1302           AC169209.2         30125-30416         c
            1303-1530           AC169209.2         29205-29432         c
            1531-1707           AC169209.2         28903-29079         c
            1708-2138           AC169209.2         26278-26708         c
            2139-2785           AC169209.2         25279-25925         c
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.78 cM"
     gene            1..2785
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /note="lipase, hormone sensitive"
                     /db_xref="GeneID:16890"
                     /db_xref="MGI:MGI:96790"
     exon            1..51
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            52..587
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2351
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /EC_number="3.1.1.79"
                     /EC_number="3.1.1.23"
                     /note="isoform 2 is encoded by transcript variant 2;
                     hormone-sensitive lipase; retinyl ester hydrolase;
                     monoacylglycerol lipase LIPE"
                     /codon_start=1
                     /product="hormone-sensitive lipase isoform 2"
                     /protein_id="NP_001034596.1"
                     /db_xref="CCDS:CCDS20982.1"
                     /db_xref="GeneID:16890"
                     /db_xref="MGI:MGI:96790"
                     /translation="MDLRTMTQSLVTLAEDNMAFFSSQGPGETARRLSNVFAGVREQA
                     LGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRKSIFF
                     RASHNLAELEAYLAALTQLRAMAYYAQRLLTINRPGVLFFEGDEGLTADFLQEYVTLH
                     KGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAID
                     PELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEM
                     PLTSDPRLTVTISPPLAHTGPAPVLARLISYDLREGQDSKVLNSLAKSEGPRLELRPR
                     PHQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIFSIDYSLAPEAPFPRA
                     LEECFFAYCWAVKHCDLLGSTGERICLAGDSAGGNLCITVSLRAAAYGVRVPDGIMAA
                     YPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTEAEDHFDSDQKALGVMGLVQ
                     RDTSLFLRDLRLGASSWLNSFLELSGRKPQKTTSPTAESVRPTESMRRSVSEAALAQP
                     EGLLGTDTLKKLTIKDLSNSEPSDSPEMSQSMETLGPSTPSDVNFFLRPGNSQEEAEA
                     KDEVRPMDGVPRVRAAFPEGFHPRRSSQGVLHMPLYTSPIVKNPFMSPLLAPDSMLKT
                     LPPVHLVACALDPMLDDSVMFARRLRDLGQPVTLKVVEDLPHGFLSLAALCRETRQAT
                     EFCVQRIRLILTPPAAPLN"
     exon            588..678
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            679..824
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1010
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1302
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1530
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1707
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..2138
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2785
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2374..2379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /note="hexamer: ACTAAA"
     polyA_site      2395
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /note="major polyA site"
     regulatory      2636..2641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /note="hexamer: AATAAA"
     polyA_site      2667
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /note="major polyA site"
ORIGIN      
        1 agacctgctg tgccagcttg gggagctcca gtcggaagag gccagggagg gcctcagcgt
       61 tctcacacag catggattta cgcacgatga cacagtcgct ggtgacactc gcagaagaca
      121 atatggcctt cttctcaagc cagggcccag gagagacagc acggcggctg tctaatgtct
      181 ttgcaggtgt tcgggaacag gcactggggc tggaaccaac cctaggccaa ctgttgggtg
      241 tggcacacca ttttgacctg gacacagaga caccagccaa cggataccgt agtttggtgc
      301 acacagcccg atgctgcctg gcacacctac tacacaaatc ccgctatgtg gcttctaacc
      361 gcaaaagtat cttcttccgt gccagccaca acctagcaga gctggaggcc tacctggccg
      421 ccctcaccca gctccgtgct atggcctact atgcccagcg cctgctgacc atcaaccgac
      481 caggagtgct cttcttcgag ggtgatgaag gactcaccgc tgacttcctg caagagtatg
      541 tcacgctaca caaaggctgc ttctacggcc gctgcctggg cttccagttc acacctgcca
      601 tccggccgtt cctgcagact ctctccatcg ggctggtgtc cttcggggag cactacaaac
      661 gcaacgagac aggcctcagt gtgaccgcca gttccctctt taccggtggc cgattcgcca
      721 tagacccaga gttgcgtggg gctgaatttg aacgcatcat acagaacctg gatgtgcact
      781 tctggaaagc cttctggaac atcactgaga ttgaggtgct gtcgtctctg gccaacatgg
      841 catcaaccac tgtgagggta agccgcctgc tcagcttgcc acctgaggcc tttgagatgc
      901 cactcacctc tgatcccagg ctcacagtta ccatctcacc tcccttggca cacacgggac
      961 cagctcctgt gctagccagg ctcatctcct atgacctacg ggaaggacag gacagcaagg
     1021 tactcaacag cctggcaaaa tctgagggcc cacgcctgga gctgcgccca cggcctcacc
     1081 aagcaccccg ttcacgggcc ctggttgttc acatccacgg aggcggcttt gtggcacaga
     1141 cctctaaatc ccacgagccc tacctcaaga actgggccca ggagctagga gtccctatct
     1201 tctccatcga ctactccctg gcccccgagg ctccctttcc ccgagcgctg gaggagtgtt
     1261 tttttgccta ctgctgggct gtcaagcact gtgacctgct tggttcaact ggagagcgga
     1321 tatgccttgc aggggacagt gcaggtggga atctctgcat cactgtgtcc cttcgggcag
     1381 cagcctatgg agtgagggtg ccagatggca tcatggcagc ctacccagtt accaccctgc
     1441 agtcctctgc ttctccctct cgtctgctga gcctcatgga ccctcttcta ccactgagcg
     1501 tactctctaa gtgtgtcagt gcctattcag ggacagaggc agaggaccat tttgactcag
     1561 accagaaggc actaggcgtg atggggctgg tgcagagaga cacttcgctg ttcctcagag
     1621 acctccgact gggtgcctcc tcatggctca actccttcct ggaactaagt ggacgcaagc
     1681 cccaaaagac cacatcgccc acagcagagt ctgtgcgccc cacggagtct atgcgcagga
     1741 gtgtgtctga ggcagccctg gcccagcctg agggcttact gggcacagat accttgaaga
     1801 agctgacaat aaaggacttg agcaactcag agccttcaga cagccccgag atgtcacagt
     1861 caatggagac acttggcccc tccacaccct ctgatgtcaa cttttttctg cggcctggga
     1921 attcccagga agaggctgaa gccaaagatg aagtgagacc catggacgga gtcccccgcg
     1981 tgcgcgctgc tttccctgag gggtttcacc cccggcgctc aagccaaggt gtcctccaca
     2041 tgcccctcta cacgtcaccc atagtcaaga accccttcat gtctcctctg ctggcccctg
     2101 acagcatgct gaagaccttg ccgcctgtgc accttgtggc ttgcgctctg gaccccatgc
     2161 tagatgactc ggtcatgttc gcgcggcgac tgcgcgacct gggccagccg gtgacgctga
     2221 aagtggtaga agatctgccg catggcttcc tgagcctggc ggcactgtgt cgcgagaccc
     2281 ggcaggccac ggagttctgc gtgcagcgca tccggctgat cctcaccccg cctgctgcac
     2341 cactgaactg agctggggac ggcggggggc ggcactaaaa gacctcttgc tcccatctgc
     2401 gcgggcttcc gttatgagtg cgctccgaga tgggctccag gccccctcag tcgggctggg
     2461 cgggcgggag tgggctgtgc cttaacttga gacagtaagt ggggcgggac aggggccaaa
     2521 agctgaacct gggggaggga cacacacaca cctgtcactg agacagctgg atctgcactc
     2581 taccactgcc ttctgctgct gtgaccgacc cggctagtcg gttttgcctt ttgtaaataa
     2641 aagttattta actaggcctt ttaaaaatag ggagtgtgtt ttcccagcag atggcagcac
     2701 tgaactaaag ttgctgcgaa agggaaaatt agaatatgtg gaccccgact ctagctttgc
     2761 tcacaaacaa aaccacctaa tatgc
//
