LOCUS       NP_001034596             759 aa            linear   ROD 05-DEC-2024
DEFINITION  hormone-sensitive lipase isoform 2 [Mus musculus].
ACCESSION   NP_001034596 XP_003084722 XP_003086623
VERSION     NP_001034596.1
DBSOURCE    REFSEQ: accession NM_001039507.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 759)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (residues 1 to 759)
  AUTHORS   Adom,M.A., Hahn,W.N., McCaffery,T.D., Moors,T.E., Zhang,X.,
            Svenningsson,P., Selkoe,D.J., Fanning,S. and Nuber,S.
  TITLE     Reducing the lipase LIPE in mutant alpha-synuclein mice improves
            Parkinson-like deficits and reveals sex differences in fatty acid
            metabolism
  JOURNAL   Neurobiol Dis 199, 106593 (2024)
   PUBMED   38971480
  REMARK    GeneRIF: Reducing the lipase LIPE in mutant alpha-synuclein mice
            improves Parkinson-like deficits and reveals sex differences in
            fatty acid metabolism.
REFERENCE   3  (residues 1 to 759)
  AUTHORS   Madsen,S., Delgado,A.C., Cadilhac,C., Maillard,V., Battiston,F.,
            Igelbuscher,C.M., De Neck,S., Magrinelli,E., Jabaudon,D.,
            Telley,L., Doetsch,F. and Knobloch,M.
  TITLE     A fluorescent perilipin 2 knock-in mouse model reveals a high
            abundance of lipid droplets in the developing and adult brain
  JOURNAL   Nat Commun 15 (1), 5489 (2024)
   PUBMED   38942786
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 759)
  AUTHORS   Skoug,C., Rogova,O., Spegel,P., Holm,C. and Duarte,J.M.N.
  TITLE     Genetic deletion of hormone-sensitive lipase in mice reduces
            cerebral blood flow but does not aggravate the impact of
            diet-induced obesity on memory
  JOURNAL   J Neurochem 168 (5), 781-800 (2024)
   PUBMED   38317494
  REMARK    GeneRIF: Genetic deletion of hormone-sensitive lipase in mice
            reduces cerebral blood flow but does not aggravate the impact of
            diet-induced obesity on memory.
REFERENCE   5  (residues 1 to 759)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (residues 1 to 759)
  AUTHORS   Purcell-Huynh,D.A., Weinreb,A., Castellani,L.W., Mehrabian,M.,
            Doolittle,M.H. and Lusis,A.J.
  TITLE     Genetic factors in lipoprotein metabolism. Analysis of a genetic
            cross between inbred mouse strains NZB/BINJ and SM/J using a
            complete linkage map approach
  JOURNAL   J Clin Invest 96 (4), 1845-1858 (1995)
   PUBMED   7560076
REFERENCE   7  (residues 1 to 759)
  AUTHORS   Wang,S., Lapierre,P., Robert,M.F., Nadeau,J.H. and Mitchell,G.A.
  TITLE     Hormone-sensitive lipase maps to proximal chromosome 7 in mice and
            is genetically distinct from the Ad and Tub loci
  JOURNAL   Genomics 24 (2), 416-417 (1994)
   PUBMED   7698777
REFERENCE   8  (residues 1 to 759)
  AUTHORS   Li,Z., Sumida,M., Birchbauer,A., Schotz,M.C. and Reue,K.
  TITLE     Isolation and characterization of the gene for mouse
            hormone-sensitive lipase
  JOURNAL   Genomics 24 (2), 259-265 (1994)
   PUBMED   7698747
REFERENCE   9  (residues 1 to 759)
  AUTHORS   Warden,C.H., Davis,R.C., Yoon,M.Y., Hui,D.Y., Svenson,K., Xia,Y.R.,
            Diep,A., He,K.Y. and Lusis,A.J.
  TITLE     Chromosomal localization of lipolytic enzymes in the mouse:
            pancreatic lipase, colipase, hormone-sensitive lipase, hepatic
            lipase, and carboxyl ester lipase
  JOURNAL   J Lipid Res 34 (8), 1451-1455 (1993)
   PUBMED   8105016
REFERENCE   10 (residues 1 to 759)
  AUTHORS   Clamp,P.A., Feltes,R., Shalhevet,D., Beever,J.E., Atac,E. and
            Schook,L.B.
  TITLE     Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on
            porcine chromosome 6
  JOURNAL   Genomics 17 (2), 324-329 (1993)
   PUBMED   8104872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC169209.2.
            
            On or before Oct 18, 2011 this sequence version replaced
            XP_003086623.1, XP_003084722.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and uses a downstream in-frame
            start codon, compared to variant 1. The encoded isoform (2) is
            shorter at the N-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK169858.1, BC021642.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.78 cM"
     Protein         1..759
                     /product="hormone-sensitive lipase isoform 2"
                     /EC_number="3.1.1.79"
                     /EC_number="3.1.1.23"
                     /note="hormone-sensitive lipase; retinyl ester hydrolase;
                     monoacylglycerol lipase LIPE"
                     /calculated_mol_wt=83217
     Region          6..314
                     /region_name="HSL_N"
                     /note="Hormone-sensitive lipase (HSL) N-terminus;
                     pfam06350"
                     /db_xref="CDD:461882"
     Region          334..>464
                     /region_name="Aes"
                     /note="Acetyl esterase/lipase [Lipid transport and
                     metabolism]; COG0657"
                     /db_xref="CDD:440422"
     Region          349..351
                     /region_name="Involved in the stabilization of the
                     negatively charged intermediate by the formation of the
                     oxyanion hole. /evidence=ECO:0000250|UniProtKB:Q5NUF3"
                     /note="propagated from UniProtKB/Swiss-Prot (P54310.2)"
     Region          534..553
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54310.2)"
     Site            557
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P16386; propagated from
                     UniProtKB/Swiss-Prot (P54310.2)"
     Site            559
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AMPK.
                     /evidence=ECO:0000305|PubMed:19921680,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54310.2)"
     Site            574
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54310.2)"
     Region          583..604
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54310.2)"
     Site            597
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15304; propagated from
                     UniProtKB/Swiss-Prot (P54310.2)"
     Site            618
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15304; propagated from
                     UniProtKB/Swiss-Prot (P54310.2)"
     Site            650
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P15304; propagated from
                     UniProtKB/Swiss-Prot (P54310.2)"
     Site            651
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54310.2)"
     CDS             1..759
                     /gene="Lipe"
                     /gene_synonym="4933403G17Rik; HSL; REH"
                     /coded_by="NM_001039507.2:72..2351"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS20982.1"
                     /db_xref="GeneID:16890"
                     /db_xref="MGI:MGI:96790"
ORIGIN      
        1 mdlrtmtqsl vtlaednmaf fssqgpgeta rrlsnvfagv reqalglept lgqllgvahh
       61 fdldtetpan gyrslvhtar cclahllhks ryvasnrksi ffrashnlae leaylaaltq
      121 lramayyaqr lltinrpgvl ffegdeglta dflqeyvtlh kgcfygrclg fqftpairpf
      181 lqtlsiglvs fgehykrnet glsvtasslf tggrfaidpe lrgaeferii qnldvhfwka
      241 fwniteievl sslanmastt vrvsrllslp peafemplts dprltvtisp plahtgpapv
      301 larlisydlr egqdskvlns laksegprle lrprphqapr sralvvhihg ggfvaqtsks
      361 hepylknwaq elgvpifsid yslapeapfp raleecffay cwavkhcdll gstgericla
      421 gdsaggnlci tvslraaayg vrvpdgimaa ypvttlqssa spsrllslmd pllplsvlsk
      481 cvsaysgtea edhfdsdqka lgvmglvqrd tslflrdlrl gasswlnsfl elsgrkpqkt
      541 tsptaesvrp tesmrrsvse aalaqpegll gtdtlkklti kdlsnsepsd spemsqsmet
      601 lgpstpsdvn fflrpgnsqe eaeakdevrp mdgvprvraa fpegfhprrs sqgvlhmply
      661 tspivknpfm spllapdsml ktlppvhlva caldpmldds vmfarrlrdl gqpvtlkvve
      721 dlphgflsla alcretrqat efcvqrirli ltppaapln
//
