LOCUS       NM_021460               2991 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus lysosomal acid lipase A (Lipa), transcript variant 1,
            mRNA.
ACCESSION   NM_021460
VERSION     NM_021460.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2991)
  AUTHORS   Buerger,M., Amor,M., Akhmetshina,A., Bianco,V., Perfler,B.,
            Zebisch,A., Weichhart,T. and Kratky,D.
  TITLE     Limited Alleviation of Lysosomal Acid Lipase Deficiency by Deletion
            of Matrix Metalloproteinase 12
  JOURNAL   Int J Mol Sci 25 (20), 11001 (2024)
   PUBMED   39456786
  REMARK    GeneRIF: Limited Alleviation of Lysosomal Acid Lipase Deficiency by
            Deletion of Matrix Metalloproteinase 12.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2991)
  AUTHORS   Bianco,V., Svecla,M., Vingiani,G.B., Kolb,D., Schwarz,B.,
            Buerger,M., Beretta,G., Norata,G.D. and Kratky,D.
  TITLE     Regional Differences in the Small Intestinal Proteome of Control
            Mice and of Mice Lacking Lysosomal Acid Lipase
  JOURNAL   J Proteome Res 23 (4), 1506-1518 (2024)
   PUBMED   38422518
  REMARK    GeneRIF: Regional Differences in the Small Intestinal Proteome of
            Control Mice and of Mice Lacking Lysosomal Acid Lipase.
REFERENCE   3  (bases 1 to 2991)
  AUTHORS   Akhmetshina,A., Bianco,V., Bradic,I., Korbelius,M., Pirchheim,A.,
            Kuentzel,K.B., Eichmann,T.O., Hinteregger,H., Kolb,D., Habisch,H.,
            Liesinger,L., Madl,T., Sattler,W., Radovic,B., Sedej,S.,
            Birner-Gruenberger,R., Vujic,N. and Kratky,D.
  TITLE     Loss of lysosomal acid lipase results in mitochondrial dysfunction
            and fiber switch in skeletal muscles of mice
  JOURNAL   Mol Metab 79, 101869 (2024)
   PUBMED   38160938
  REMARK    GeneRIF: Loss of lysosomal acid lipase results in mitochondrial
            dysfunction and fiber switch in skeletal muscles of mice.
REFERENCE   4  (bases 1 to 2991)
  AUTHORS   Bradic,I., Liesinger,L., Kuentzel,K.B., Vujic,N., Trauner,M.,
            Birner-Gruenberger,R. and Kratky,D.
  TITLE     Metabolic changes and propensity for inflammation, fibrosis, and
            cancer in livers of mice lacking lysosomal acid lipase
  JOURNAL   J Lipid Res 64 (9), 100427 (2023)
   PUBMED   37595802
REFERENCE   5  (bases 1 to 2991)
  AUTHORS   Kobayashi,K., Iwasa,K., Azuma-Suzuki,R., Kawauchi,T. and
            Nabeshima,Y.I.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2991)
  AUTHORS   Du,H., Heur,M., Duanmu,M., Grabowski,G.A., Hui,D.Y., Witte,D.P. and
            Mishra,J.
  TITLE     Lysosomal acid lipase-deficient mice: depletion of white and brown
            fat, severe hepatosplenomegaly, and shortened life span
  JOURNAL   J Lipid Res 42 (4), 489-500 (2001)
   PUBMED   11290820
REFERENCE   7  (bases 1 to 2991)
  AUTHORS   Du,H., Duanmu,M., Witte,D. and Grabowski,G.A.
  TITLE     Targeted disruption of the mouse lysosomal acid lipase gene:
            long-term survival with massive cholesteryl ester and triglyceride
            storage
  JOURNAL   Hum Mol Genet 7 (9), 1347-1354 (1998)
   PUBMED   9700186
REFERENCE   8  (bases 1 to 2991)
  AUTHORS   Du,H., Duanmu,M. and Rosa,L.R.
  TITLE     Mouse lysosomal acid lipase: characterization of the gene and
            analysis of promoter activity
  JOURNAL   Gene 208 (2), 285-295 (1998)
   PUBMED   9524282
REFERENCE   9  (bases 1 to 2991)
  AUTHORS   Du,H., Witte,D.P. and Grabowski,G.A.
  TITLE     Tissue and cellular specific expression of murine lysosomal acid
            lipase mRNA and protein
  JOURNAL   J Lipid Res 37 (5), 937-949 (1996)
   PUBMED   8725147
REFERENCE   10 (bases 1 to 2991)
  AUTHORS   Koch,G., Lalley,P.A., McAvoy,M. and Shows,T.B.
  TITLE     Assignment of LIPA, associated with human acid lipase deficiency,
            to human chromosome 10 and comparative assignment to mouse
            chromosome 19
  JOURNAL   Somatic Cell Genet 7 (3), 345-358 (1981)
   PUBMED   7292252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164007.1, AK149791.1, AK169567.1, BE449010.1, BE198807.1 and
            AA881350.1.
            
            On Dec 5, 2007 this sequence version replaced NM_021460.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058564.1, AK154804.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AK164007.1         1-108
            109-1512            AK149791.1         69-1472
            1513-2348           AK169567.1         1479-2314
            2349-2800           BE449010.1         8-459
            2801-2961           BE198807.1         230-390
            2962-2991           AA881350.1         412-441
FEATURES             Location/Qualifiers
     source          1..2991
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.7 cM"
     gene            1..2991
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /note="lysosomal acid lipase A"
                     /db_xref="GeneID:16889"
                     /db_xref="MGI:MGI:96789"
     exon            1..109
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            110..218
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            219..336
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            337..535
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..645
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..782
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            783..929
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1001
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1073
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..2971
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /note="hexamer: AATAAA"
     polyA_site      2971
                     /gene="Lipa"
                     /gene_synonym="Lal; Lip-1; Lip1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgacggct ccgccctccc accaagtagg tgtaggcacc aggttggcca agctcgcctg
       61 cttgtagtgg gcactgcttc tggaggctga ggttggagga ccactcccgg aagatgcaac
      121 tccagggcct ggtgttcgtt ttcaccattg ggatcctgct ttctcgggtg cccacgggaa
      181 ctgtatcagc tgtggatcct gaagtcaaca tgaatgtgac cgagataatc atgcgctggg
      241 gatatcctgg tgaggaacac tcggtcctga caggagatgg ctatattctg agtattcacc
      301 gaatccctcg tgggcggaag aaccattttg gcaaaggtcc cagaccagtt gtgtatcttc
      361 agcacggctt gctggcagat tctagtaact gggtcacaaa cattgacaac agcagcttgg
      421 gcttcctcct ggcggatgct ggctttgatg tgtggatggg aaacagcaga ggaaacacct
      481 ggtctctgaa gcacaagact ctttcagttt ctcaggatga gttctgggcc ttcagttttg
      541 atgagatggc aaaatatgac ctacctgctt caattaacta cattttgaat aaaactggcc
      601 aagaacaaat ctattatgtg ggtcattctc aaggctgcac cataggtttc atagcttttt
      661 cacagatgcc tgagttggca aagaagatta aaatgttttt agtcttggct cccgtgttgt
      721 ctctcaattt tgcttcaggc ccgctacttc aattgggacg cttgccagac cctcttctca
      781 aggacatgtt tggacagaag caatttctcc ctcagagtgc gatgctgaag tggctgagca
      841 ttcacgtttg cacccacgtc atcatgaagg agctttgcgc aaacgtcttc ttcctgctat
      901 gtggcttcaa tgagaagaat ttaaatatgt ctagagtgga tgtgtataca acacactgcc
      961 ctgcgggaac ttctgtgcaa aacatgttac actggggtca ggtttttaaa taccgtaagc
     1021 ttcaagcttt tgactgggga agcagtgaaa agaattattt tcattacaac cagagttttc
     1081 ctccctcgta caacataaaa aacatgcgtc tacccactgc tttgtggagc gggggccggg
     1141 actggctggc agacatcaat gacatcacta tcttactgac tcaaatcccc aagttggtgt
     1201 atcacaagaa cattcctgag tgggaccatc tggattttat ctggggtttg gatgccccct
     1261 ggaaactgta tgatgaaata atcagtctaa tgaagaaata ccagtgaatg ctggacttga
     1321 atacttcccc ttcaatagag gggggaaaaa aaaaaacagg tgtttgctta atttctgtaa
     1381 aatccttgtg ttttccttgc ctaggtcatt tgtatttttt atgtgcaaga aaatgatgac
     1441 gtcgaaggtg tacattgctc tctggttaat aagaagcacg ctagctgtct tatgcttcat
     1501 tgtgactgac tagcaagcgt ccacaaccag tgatgccttt taagtgtctc tgtgatcctt
     1561 ttgtttacct tttacagttg ttttcggtgc atatgtgctg tgcatatatg tgcctaagtg
     1621 tgtgtgggct gtgttctggc ccttgtgtgg aggtaatggc tcacatcaag gtgtcttcct
     1681 cagttacttc ccatcttact ttttgaaaca gggtctcttg ctgaacaggg agcctgctat
     1741 ttcagttaca ctggttggcc catgagcctc caggatctgc ctgtctctac cttccccctc
     1801 accaatgcgg tggaatgggg tgtctgtccc agccggcatt tttaccctga ttctagggac
     1861 aggaactcag gttctcatgc ttgtgtagca agcccttcac tcaccgaatc attgcctcaa
     1921 accttctgca gtagaccaag ctactcagtt gcttttatat tcctgcccaa cacaagtgag
     1981 cacacacagg acatttcaag ctgttgtttg ctagcaaaaa taagtctgcc agtgacctga
     2041 acacacgatg aaaagctcct tgctctgagc ttcatgtggc agtgcaaacc tacaatccta
     2101 gttctccaga ggttgagaca ggaaggctgc tgtaggactt agggttcatc tagaaagcga
     2161 gactttgtct ctagaaaacc aaagacaaag gaggaaaaaa aaaacccaaa gtactcagtt
     2221 ctcatccctt tgccttagag gactgtctag cccagagttc ctgtgtttac ctatccaaac
     2281 aacattttca tgttttaatg cattagcttc ctagtgaaat ccagtgtaat cccagcttct
     2341 ccaggaataa atatcctctc ttcagtttca tcagacctca ataacaaaat ttttcaggcc
     2401 aagccccccc ccccccccca aataagcgta gactcttgaa aagcagtttg cactgattaa
     2461 aaaaattaaa aaaaaaaaac ttgaagatta atacaatgag ctctgttggt tccgaatgtg
     2521 tagtctggtc acttttctgt ggagaaacat tctgtggagg gacaaaccac tgatttgcca
     2581 gaagcgaata tggctgccgt gacggtgcct gcatgaagct aaagctggtt gtggtggcaa
     2641 gtggtccgat tccctttcac acaaatgatg ttttcagaca gagctcggct caggaatttc
     2701 gctttgagaa tcagtgttgt atgcacaatg ttttactgag cctgctttgc tcctgcgtac
     2761 aggaagccca catctgttca cttggcttgc tggcgatggc tgtcaccact agacagttga
     2821 taagttttct gatattctga tattaggtac cacggatgca ggaatattac ttgatattgg
     2881 ctcatacaga caggcagaat gatacaactt tgtaacaatt taaaggtttg tatttaaact
     2941 tttcaataaa tctcagcctc ataggcctga aaaaaaaaaa aaaaaaaaaa a
//
