LOCUS       NM_152815               5243 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus lines homolog 1 (Lins1), transcript variant 1, mRNA.
ACCESSION   NM_152815 XM_976019
VERSION     NM_152815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5243)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5243)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of human WINS1 and mouse
            Wins2, homologous to Drosophila segment polarity gene Lines (Lin)
  JOURNAL   Int J Mol Med 10 (2), 155-159 (2002)
   PUBMED   12119551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120791.13.
            
            On Jul 17, 2010 this sequence version replaced NM_152815.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156066.1, SRR9219380.17381.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC120791.13        60109-60243
            136-266             AC120791.13        66396-66526
            267-780             AC120791.13        78260-78773
            781-885             AC120791.13        78859-78963
            886-1027            AC120791.13        79514-79655
            1028-1615           AC120791.13        80379-80966
            1616-1787           AC120791.13        82093-82264
            1788-5243           AC120791.13        84021-87476
FEATURES             Location/Qualifiers
     source          1..5243
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 36.08 cM"
     gene            1..5243
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /note="lines homolog 1"
                     /db_xref="GeneID:72635"
                     /db_xref="MGI:MGI:1919885"
     exon            1..135
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     exon            136..266
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..780
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2640
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein Lines homolog 1; Wins2 protein with Drosophila Lin
                     homologous domain; protein Lines homolog 2; wnt-signaling
                     molecule Lines homolog 1; wnt-signaling molecule Lines
                     homolog 2; lines homolog 2; protein with Drosophila Lines
                     homologous domain"
                     /codon_start=1
                     /product="protein Lines homolog 1 isoform 1"
                     /protein_id="NP_690028.2"
                     /db_xref="CCDS:CCDS21348.2"
                     /db_xref="GeneID:72635"
                     /db_xref="MGI:MGI:1919885"
                     /translation="MRYILDIKMEIVQEILDQLYRKVLLGTTLEDDVHGYIFYLNPDL
                     SEQDGCPAFPVAQSNASGVLDGMAGQHGPSSHEVATLPGAQECPKRQLQMDRTREMKL
                     LQLTVIDTMLSQVLSDETETHAKEGYRELTEVLLQSVELDSKLMRMLQNSDKLLSHMA
                     AKCLASLLYFQLREKVRSQHKMLSNSWVTFCQKHLSESSESGEAVRCLWILTAVIKEI
                     LKDTHSQRAESLKQLLTPFDITFEVFYNSLFSQHFGDFQSPSNLASSLMCFLELLELL
                     VASRIHLKLHFRSQRMLFLKPHALDILAWPIPAFIKRKLVILVKKCLLCKVGEDLCRE
                     PAPSLMSPDHLLDSDMLTLADTLLHAVHVGLWKALAVSGKPSCFGGDEVQPGCRLRTG
                     PDHVTLRAASLITVKSLEIKSQNCTSAAEMKVALQTFMSELLAFLKPHLQPSLQPHNP
                     CEWLSRVFIEQDDDMLEAAKASLSIYLQLTREWDASASLTQEKEAWIRSTHGHGCNPH
                     CVFLFFLKNVAFDSTVLLDFLISSETCFLEYFVKYLKLLQKDWAHFLSICKFFAAVES
                     QCGMLVHDPVPSPARGRSTSLTVPHAPASPVGENTCPWLPWASDASSESQSQVMMPKE
                     TLPVPANGPPSRTPQSLVDYDSSEASEEETTSEHLANSKQTSLCQERSEEIQGLPRTW
                     EEQKEHSLEPLLSAESSSPFSAKGRVAADGTVWQVGLFLRTVKCLEELQGAIYRLQEK
                     NLFPYNPAALLKLLKGVEAKCVNV"
     exon            781..885
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1027
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1615
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1787
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..5243
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2716..2721
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /note="hexamer: AACAAG"
     polyA_site      2734
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /note="major polyA site"
ORIGIN      
        1 actacgaatg gggcttctac gcctgctgag ggaggggccg gcaaggcctt ccgtggagta
       61 cggtggcctg gagtaggcag ctgtgggcac gagtggccgg gcgatggctg cgtggcccgg
      121 cgggatggca gccagttttc agaagtgact ttcttttggg aacgggacag tccagggatg
      181 tgggaggaac acagtgctct tcggtaggag atgtctcctg atgcagatgt gctaaagagg
      241 cttctacatc cttggctgtg ttaccggctt cactgaggaa acatcttaga gatccattgt
      301 atttctaagt cttcaatatt tactcctgtg gctgttgact ctcttatgag atacattttg
      361 gatatcaaaa tggaaatagt ccaagaaatt ttggatcaat tatacaggaa agtacttctt
      421 ggaaccactc ttgaagatga cgtccatggt tacatcttct atctcaaccc agatctctca
      481 gaacaagatg gctgtccagc cttccctgta gctcagtcta atgccagtgg tgtgcttgat
      541 ggcatggcag gccagcatgg gccatcctcc cacgaggtgg ccacccttcc tggagcacag
      601 gagtgtccca agagacagct tcagatggac agaacccggg agatgaagct ccttcagtta
      661 acagtgattg acacgatgct gagccaggta ctgtctgatg aaacggagac ccacgcaaag
      721 gaggggtaca gagagctaac tgaagtcctt ttgcagtctg ttgaactcga ttccaaattg
      781 atgcgcatgc tccagaattc tgacaagttg ttgtcccaca tggctgcgaa gtgcctcgcc
      841 tcgctactgt atttccagct gagagagaag gtcagaagcc agcacaaaat gttaagtaat
      901 tcctgggtca ctttctgcca gaagcatctc tcggagtcct ctgagagtgg tgaagcagtg
      961 cgttgcctct ggatccttac agctgtgata aaagagatcc ttaaagacac acattcacag
     1021 agagcagaaa gtctaaagca gctcttgact ccttttgaca ttacttttga agtgttctac
     1081 aattccttat tttcccagca ttttggagac ttccagagcc cctctaactt agccagcagc
     1141 ctgatgtgct ttctggagct gcttgagctt ctcgtagcct ccagaatcca cctgaaactg
     1201 cacttcagga gccagaggat gctatttttg aaaccccatg ctctagatat tcttgcctgg
     1261 cctattccag cttttataaa aaggaagttg gttatactcg tcaaaaagtg ccttctctgt
     1321 aaagtgggcg aagacctctg ccgggaacct gcgccctccc tgatgtcacc agatcacctt
     1381 ctggacagtg acatgctcac tttagctgac acacttctgc acgctgtaca tgtggggttg
     1441 tggaaggcac tggctgtttc tggaaagcct tcctgctttg gaggggatga agttcaacct
     1501 ggatgcagac tcaggactgg tcctgatcac gtgaccctga gagcagcaag cttaattaca
     1561 gtgaagtcct tagaaatcaa gtcccagaat tgcacctcag cagctgagat gaaagttgcc
     1621 ttgcagacgt tcatgtccga gctactggcc ttcttaaagc ctcacctcca gccctctcta
     1681 cagccacaca acccatgcga gtggctgtcc agggtcttca tagagcagga cgatgacatg
     1741 ctggaggctg ccaaagcctc cctgagcatc tacctccagc tgaccagaga gtgggatgct
     1801 tcggcaagtc tgacccaaga aaaggaagca tggatccgct ccacacatgg acatggctgt
     1861 aaccctcact gtgttttctt attcttcttg aagaatgtag cattcgattc tactgttctt
     1921 ctcgacttct tgatatcctc agagacctgt ttccttgaat attttgttaa atatttaaaa
     1981 ctgctgcaga aagactgggc ccactttctg tccatctgca agttctttgc tgcagtggaa
     2041 tcacaatgtg gaatgcttgt tcatgatcct gtcccctcac ctgcccgtgg cagaagcacc
     2101 agcctcacag tgcctcatgc tccggcttct ccagttggag agaacacttg cccctggctc
     2161 ccctgggctt ctgatgcctc ctccgaatcc cagagccagg tcatgatgcc caaggaaact
     2221 ctcccagtgc cagctaatgg cccaccttcc cggacaccgc agagtctggt agattatgac
     2281 agctccgaag cttctgagga ggaaaccaca agtgagcatt tagcaaacag caaacagaca
     2341 tctttatgtc aagaaaggtc tgaggagatc cagggcctgc ctaggacatg ggaggagcaa
     2401 aaggaacata gcctggagcc tttgctctct gcagagtcca gttctccctt ctctgccaag
     2461 ggtagagttg ctgcagacgg gactgtctgg caagtgggat tgtttcttcg tacagtgaaa
     2521 tgccttgagg agctacaggg agcaatttac cgtttgcagg agaaaaatct ctttccatat
     2581 aacccagcgg cacttctgaa gttgttgaaa ggtgtggagg ccaagtgtgt taacgtctga
     2641 gccctgggta acacagcagc atctgtcctc ggctttgttc tccttgatag aaagcgtcta
     2701 cctaagataa ataaaaacaa gcaagaactg caaacatgcg tgtctgggtc tttgccttat
     2761 ggagcatagt agtgtttgag aaaggaccat cccatgacag gtcaactggc ccagcttgct
     2821 acagctgaga gtttatgcta gttcagacta cacggaattc gccatgacaa atgactgcat
     2881 attctgtagc ccaaactaag taagatttat cttctgagct caagaggcca gaagcttaaa
     2941 atcaagatgt gcagtgtaat gtcctgggac gctgcacatc ttatccatga tgcatctcca
     3001 tctctgcacg ctctgcatcg tttgctacca tggttatttt ctcttctgtt ttgagcatag
     3061 ctttccagct ggagtaacat tgtctcgttg tagctttgat ttgccctgcc ctgatcggag
     3121 acatccacta ctcctccttg tccaaagatc cagtttcaag ttgaggaaga aaccctgtct
     3181 taaggcagaa aagcctagtc aaatagaagt gtggatgtca aaacggttag ggagacatgt
     3241 tggtgaggct gtgtgttgtc agtgtgtact tgaattttta accttgattt gtcttagtca
     3301 caggccttgc aatgttgagg aaagctttgg actgcagggc ttggtagccg ttcctgcttc
     3361 ctttctcttt gccgttggct tgttctcaaa ctcctgtgtg cagccctctt gcctcagctt
     3421 ccccttggca gctcactact gtctgtaatg cctcagggga gttgacacct ttacacagat
     3481 attcatgcag ataaaacacc aatgtactga gatagaagta aataaaaatg taaaactagg
     3541 attgtacgtt gtaaaagaca agactaggca tttcattgga atattacaga cctgtaaaga
     3601 agaatgcatt gtgttcatgc tgtggatatg aaacttctcc actcaaaact gaaaagaata
     3661 tactgggctt ccatttgttt aagaaaagta ttgggcagga gcagagacat ttacatcctc
     3721 gtgtacttat atatataatt accttttggt atccagaggc atggcttcca ggacccatcg
     3781 ctacccctat catgaaacca aaatctactg acagtctctt tataaaacag catgcgatct
     3841 tcatacagcc tacatacatc cacctagatt cacttacact cacacaagat aagttctggt
     3901 tgcactgtaa catttaattt ttttattcac tttacatccc aatcacagcc cctcccttct
     3961 ctcccctcag tcacaccctt acaagtccct ccccagcgcc ccttacgttc tcctcagaga
     4021 aggggagccc ccctggctac cacctaccct gggacacctg gtcccagcag gactaggcac
     4081 aacctctcac tgagacctaa ccaggcagtc cagttagagg aagggaaacc agtaagaaag
     4141 aggagacagt ccctgcccca gttgttaggg gacccacatg aaaaccaagc tgcacatttg
     4201 ctacaagtgt gtagggggcc taggtccagc ctctgaaagc tccctggttg tggcccaggc
     4261 tccataacat ccatggtccc aggttagttg actgtaggtc tcatggtgtc cttgacccct
     4321 ccaacttgct cacttctatc tccaactttt ccacaagagt cccagatctc tgcctggtga
     4381 ttggctatgg gtctctgcat ctgcctccct ccgatgctgg atgaagctct caggagacag
     4441 tcgtgctagg ttcctgtctg caagcatagc aggatattaa tagtgttagg ggttgactct
     4501 ttcccatgga atgaatgggt ctcagccaat gaggcagttg ctggtggctg ttccctctgt
     4561 ctctcctcca tctttatccc tgcacgtctt gtaagcagga cagattttgt gttgacgact
     4621 ttgtgggtgg attgatgtcc ccctccctcc tctggaagtc ctgcctggct acaggaggtg
     4681 gcctcttcag tctctttatc cccgtctggt aggaatctca gttagggtca cccccataga
     4741 ctcccagtat catctcctgt cccaggccca gctaatcact agtgaccccc ccatttccat
     4801 tctcactccc agccttctgc agccccccac ctcttgccac acctgattga catgattgct
     4861 tccctcctca cgccgtcttc tctcttcatc cacctccagt ggctatctat ttcccccttc
     4921 tgagtgagat ttacacatca ttccttggga cctactttat tacccagtat ctttgggtct
     4981 gtgaattgaa gcatggttat ccttcacttt atggcgaatg tctacttata aatgagtata
     5041 tatcatctgt cttgctggct ccggggtacc tcactcagga tgatattctc aagttccatc
     5101 catttgcctc aaaattttat gatgtttttg tttttaatag ttgaatagta ttccactgtg
     5161 tagatgtaac aaattttctt tattctttat ttctgttgtt tgtagtttct gactattatg
     5221 aataaagctg ctatgagcat aga
//
