LOCUS       NP_690028                764 aa            linear   ROD 30-APR-2024
DEFINITION  protein Lines homolog 1 isoform 1 [Mus musculus].
ACCESSION   NP_690028 XP_981113
VERSION     NP_690028.2
DBSOURCE    REFSEQ: accession NM_152815.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 764)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 764)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of human WINS1 and mouse
            Wins2, homologous to Drosophila segment polarity gene Lines (Lin)
  JOURNAL   Int J Mol Med 10 (2), 155-159 (2002)
   PUBMED   12119551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120791.13.
            
            On Jul 17, 2010 this sequence version replaced NP_690028.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156066.1, SRR9219380.17381.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 36.08 cM"
     Protein         1..764
                     /product="protein Lines homolog 1 isoform 1"
                     /note="protein Lines homolog 1; Wins2 protein with
                     Drosophila Lin homologous domain; protein Lines homolog 2;
                     wnt-signaling molecule Lines homolog 1; wnt-signaling
                     molecule Lines homolog 2; lines homolog 2; protein with
                     Drosophila Lines homologous domain"
                     /calculated_mol_wt=85511
     Region          210..558
                     /region_name="LINES_N"
                     /note="Lines N-terminus; pfam14694"
                     /db_xref="CDD:464266"
     Region          723..759
                     /region_name="LINES_C"
                     /note="Lines C-terminus; pfam14695"
                     /db_xref="CDD:464267"
     CDS             1..764
                     /gene="Lins1"
                     /gene_synonym="2700083B01Rik; Lins; Lins2; Wins2"
                     /coded_by="NM_152815.2:346..2640"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS21348.2"
                     /db_xref="GeneID:72635"
                     /db_xref="MGI:MGI:1919885"
ORIGIN      
        1 mryildikme ivqeildqly rkvllgttle ddvhgyifyl npdlseqdgc pafpvaqsna
       61 sgvldgmagq hgpsshevat lpgaqecpkr qlqmdrtrem kllqltvidt mlsqvlsdet
      121 ethakegyre ltevllqsve ldsklmrmlq nsdkllshma akclasllyf qlrekvrsqh
      181 kmlsnswvtf cqkhlsesse sgeavrclwi ltavikeilk dthsqraesl kqlltpfdit
      241 fevfynslfs qhfgdfqsps nlasslmcfl ellellvasr ihlklhfrsq rmlflkphal
      301 dilawpipaf ikrklvilvk kcllckvged lcrepapslm spdhlldsdm ltladtllha
      361 vhvglwkala vsgkpscfgg devqpgcrlr tgpdhvtlra aslitvksle iksqnctsaa
      421 emkvalqtfm sellaflkph lqpslqphnp cewlsrvfie qdddmleaak aslsiylqlt
      481 rewdasaslt qekeawirst hghgcnphcv flfflknvaf dstvlldfli ssetcfleyf
      541 vkylkllqkd wahflsickf faavesqcgm lvhdpvpspa rgrstsltvp hapaspvgen
      601 tcpwlpwasd assesqsqvm mpketlpvpa ngppsrtpqs lvdydsseas eeettsehla
      661 nskqtslcqe rseeiqglpr tweeqkehsl epllsaesss pfsakgrvaa dgtvwqvglf
      721 lrtvkcleel qgaiyrlqek nlfpynpaal lkllkgveak cvnv
//
