LOCUS       NM_001013758            3456 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus leucine rich repeat and Ig domain containing 3
            (Lingo3), transcript variant 1, mRNA.
ACCESSION   NM_001013758 XM_137156 XM_910978
VERSION     NM_001013758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3456)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3456)
  AUTHORS   Wang,X.W., Yang,S.G., Hu,M.W., Wang,R.Y., Zhang,C., Kosanam,A.R.,
            Ochuba,A.J., Jiang,J.J., Luo,X., Guan,Y., Qian,J., Liu,C.M. and
            Zhou,F.Q.
  TITLE     Histone methyltransferase Ezh2 coordinates mammalian axon
            regeneration via regulation of key regenerative pathways
  JOURNAL   J Clin Invest 134 (3), e163145 (2023)
   PUBMED   38015636
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3456)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   4  (bases 1 to 3456)
  AUTHORS   Haines,B.P. and Rigby,P.W.
  TITLE     Expression of the Lingo/LERN gene family during mouse embryogenesis
  JOURNAL   Gene Expr Patterns 8 (2), 79-86 (2008)
   PUBMED   18297755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ131945.1 and BC072620.1.
            
            On Nov 28, 2009 this sequence version replaced NM_001013758.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072620.1, CA320240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               CJ131945.1         1-508
            509-3456            BC072620.1         500-3447
FEATURES             Location/Qualifiers
     source          1..3456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3456
                     /gene="Lingo3"
                     /gene_synonym="LERN2"
                     /note="leucine rich repeat and Ig domain containing 3"
                     /db_xref="GeneID:237403"
                     /db_xref="MGI:MGI:3609246"
     exon            1..98
                     /gene="Lingo3"
                     /gene_synonym="LERN2"
                     /inference="alignment:Splign:2.1.0"
     exon            99..3439
                     /gene="Lingo3"
                     /gene_synonym="LERN2"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..1915
                     /gene="Lingo3"
                     /gene_synonym="LERN2"
                     /note="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 3;
                     leucine-rich repeat neuronal protein 6B"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 3
                     precursor"
                     /protein_id="NP_001013780.2"
                     /db_xref="CCDS:CCDS24035.1"
                     /db_xref="GeneID:237403"
                     /db_xref="MGI:MGI:3609246"
                     /translation="MTCWLHMLGLHLLLLPTAPLAAGCPARCECSASTRTVACGRRRL
                     TAIPEGIPAETRMLELSRNRIRCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPR
                     LRVLRLRGNQLKLIPPGVFTHLDSLTLLDLSENKLVILLDFSFQDLRSLQRLEVGDND
                     LVFISRRAFAGLLGLAELTLERCNLTSLSPESLGHLRGLGALRLRHLAIAALEDQNFQ
                     KLPGLSHLEIDNWPLLEEVAPGSLRGLNLTSLSITHTNITAVPAAALRQQAHLTCLNL
                     SHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLSDNLLSTLEE
                     NTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPACATPAEVRGDALHNL
                     PDSVLFEYFVCRKPKIRERRLQHVTATEGDDVRFLCRAEGEPAPTVAWVTPQHHSVTA
                     ASRGRARVLPGGTLTIADTRPQDSGTYTCVASNAGGNDTYFATLTVQPAANRTQGDGH
                     NETQVGVRFPLDLTTILVSTAMGCITFLGVVLFCFLLLFVWSRGRGQHKNNFSVEYSF
                     RKVDGPAAAAGQGGARKFNMKMI"
     regulatory      3418..3423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lingo3"
                     /gene_synonym="LERN2"
                     /note="hexamer: AACAAG"
     polyA_site      3439
                     /gene="Lingo3"
                     /gene_synonym="LERN2"
                     /note="major polyA site"
ORIGIN      
        1 gaggtggcgg tggcggcggc ggtggcagtg gcggccgtgg cggcggctgg tggcggctcc
       61 gagcagcccc tcgcgccgtc cgaggaggag ccgcccagct gtcctggact atgctggcgt
      121 ggccctaggc cccacacctt gcaccatgac ctgctggctg cacatgctgg gcctgcactt
      181 gctgctgctg cccacagcgc ccctggccgc aggctgcccc gcacgctgcg agtgctccgc
      241 atccacccgc actgtggcct gtgggcgccg ccggctgaca gccatccccg agggcatccc
      301 ggccgaaact cgcatgctgg agctgagccg caaccgcatc cgctgtctga accctgggga
      361 cctggcctcg ttgcccaccc tggaggagct ggacctcaac cataatgtga ttgcccacgt
      421 ggaacctggg gccttcgcca acctgccccg cctgcgcgtc ctgcgtctcc gtggcaacca
      481 gctgaagctc atcccgccag gcgtgttcac gcatctggac agcctcacgc tgctggacct
      541 gagcgagaac aagctggtca tcctgctgga tttcagcttc caggacctgc gcagcctgca
      601 gcggctggag gtgggcgaca atgacctggt gttcatctcc cgcagggcct ttgcggggct
      661 gttggggctg gctgagctca cgctggagcg ctgcaatctc acatcactgt ccccggagtc
      721 gctgggtcac ctgcggggct tgggcgctct gcgcctgcgc cacctggcca tcgccgccct
      781 ggaggaccag aatttccaga agcttccagg actctcgcat ctggagatcg acaactggcc
      841 gctgctggag gaggtggccc cgggcagcct gcgtgggctg aacctcacgt cgttgtccat
      901 cacacacacc aacatcacgg ctgtaccggc cgctgcgctg cgacagcagg cccacctcac
      961 gtgcctcaac ctgtcgcaca accccatcag catggtgcca cgcggctcct tcagagacct
     1021 ggtgcgcctg cgtgagctgc acctagcagg agccctgctg gctgtcatcg agccgcaggc
     1081 cttcgtgggg ctgcgacaga tccgcctgct caacctttcg gacaacctgc tgtccacact
     1141 ggaggagaac acattccact cggtgaacac gctcgagacg ctgcgcgtgg acggcaaccc
     1201 gctggcctgc gactgtcgcc tgctgtggat cgtgcagagg cggaagaccc tgaacttcga
     1261 cggcaggctc cccgcctgcg ccacccccgc cgaggtgcgc ggcgacgccc tgcacaatct
     1321 ccccgactct gtgctcttcg agtacttcgt gtgccgcaag cccaagatcc gggagaggcg
     1381 gctgcagcat gtgaccgcca ccgagggcga cgacgtgcgc tttctgtgcc gcgctgaggg
     1441 tgagcccgcg cccacggtag cctgggtgac gccccagcac cactcggtta cggctgccag
     1501 ccggggccgg gcacgcgtgc tgcctggggg caccctgacc atcgcggaca cgcggcccca
     1561 ggacagtggc acctacacat gtgtggccag caacgccggg ggtaacgaca cttatttcgc
     1621 caccttgacc gtccagccgg ccgccaaccg gacccagggc gatgggcaca acgagacgca
     1681 ggtgggcgtc cggttcccgc tggacctcac caccattctt gtgtccaccg ccatggggtg
     1741 catcaccttc ctgggcgtgg tcctcttctg ttttctgctg ctttttgtgt ggagccgtgg
     1801 ccgcggacag cacaagaata acttctctgt ggaatattcc ttccgtaagg tggacggtcc
     1861 ggcggctgcg gctggccagg gtggtgcgcg caagttcaac atgaagatga tctgagctga
     1921 tcccacggtg ggttgtgtga gccggaccgt tcaaacctct gtccagtccc agataatttc
     1981 cacctatgca tatttttccc agggggtagg catggaggtg actgcaagtc agctcacaag
     2041 caaaactttc tcatttttgt agacatctgc aggactgttt ttgagcagat cacatctttt
     2101 gcagttcctg aagtgttttc taagggtttc aacgtgtctt tcccaccctt tgctgtggct
     2161 gctgtgctaa gacacaaagt ggctggggac actcagggtc catggtttct tatgcaggtg
     2221 caggctgtgg ccccaaagtc cagggtcctc cctgtgccct tactcagaag tcacgtcccc
     2281 agatgcctgg ggacacagga cacaccgtgc ttgcagtggc tgtctcctcc gctcattgtg
     2341 acctgtgtct catacagggc ccaggactgc agtagggacc tgggaatgca ccagcccagc
     2401 tcctgtccac cgctgctcgg gtacccaggg ctaccccaga ccctgcagag aggctcacag
     2461 tcatctcggg agccctgttc ccgccacttt ccatcccacc aggaacttca ggcccaggag
     2521 gccacctgcc aggagaagcc atgtccccat gtcccctaga ggtccctcca ccctgccttg
     2581 ccatactgga catctgcttg caggagggct ggctgccctg ggtcctagga gtgcctctca
     2641 ggccaccaca tccactctgc tgctctacag ggaaagtgga ctgctgtagg ggtgagcagg
     2701 cagggccagt tgattgtgac aaggccaagt catgatccac tagcctaccc catctaagtt
     2761 cctccccagt gtcacctctg cctggtcaca gttaggacac cgttgaaaga agggacagag
     2821 ggcattttgt gggacttggc caactgaccc cctggacata tggtaagaca ggctgcagct
     2881 cttttcccac ctgtccagct gtaatgtctg tggtccactg ggaccctgtg tcttccttta
     2941 cagaacaagt ctgagcctgt agcctttgcc ctgtgtgccc tcatgtttgt gtccagacag
     3001 gaaggaggca aacctaatgc aatgagagac ccagatcaag cttggctagt ctgaactgga
     3061 ctgggaacac ggggaccctt tggtcttgcg cccccccccc cgactttccc atcacataca
     3121 aactgattga caggacacga atgactgggt tgactggcat tttcagactc tatccctgag
     3181 tctgacaaga tggacctctt tgtcctggac tgtcctctta gcccctgttg ctatggcaac
     3241 cccagggccc tcaaaacaac aaccaacgaa atccaagtgc ctttagagtt attaaaagac
     3301 agaaggggtg cactcccggc agggttagag ttcacaaagt gtcagaacat tacatcgggg
     3361 ttccccagtc ccaacaacct ctatcctcac ctgctgtgtt tgactgaaat ccaattaaac
     3421 aagctgattt aatacaaaaa aaaaaaaaaa aaaaaa
//
