LOCUS       NM_001165999            4642 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus leucine rich repeat and Ig domain containing 2
            (Lingo2), transcript variant 1, mRNA.
ACCESSION   NM_001165999
VERSION     NM_001165999.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4642)
  AUTHORS   Yoshida,F., Nagatomo,R., Utsunomiya,S., Kimura,M., Shun,S.,
            Kono,R., Kato,Y., Nao,Y., Maeda,K., Koyama,R., Ikegaya,Y.,
            Lichtenthaler,S.F., Takatori,S., Takemoto,H., Ogawa,K., Ito,G. and
            Tomita,T.
  TITLE     Soluble form of Lingo2, an autism spectrum disorder-associated
            molecule, functions as an excitatory synapse organizer in neurons
  JOURNAL   Transl Psychiatry 14 (1), 448 (2024)
   PUBMED   39443477
  REMARK    GeneRIF: Soluble form of Lingo2, an autism spectrum
            disorder-associated molecule, functions as an excitatory synapse
            organizer in neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4642)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4642)
  AUTHORS   Yang,H., Zhang,X., Zhang,M., Lu,Y., Xie,B., Sun,S., Yu,H., Cong,B.,
            Luo,Y., Ma,C. and Wen,D.
  TITLE     Roles of lncLingo2 and its derived miR-876-5p in the acquisition of
            opioid reinforcement
  JOURNAL   Addict Biol 29 (2), e13375 (2024)
   PUBMED   38380802
  REMARK    GeneRIF: Roles of lncLingo2 and its derived miR-876-5p in the
            acquisition of opioid reinforcement.
REFERENCE   4  (bases 1 to 4642)
  AUTHORS   Belle,N.M., Ji,Y., Herbine,K., Wei,Y., Park,J., Zullo,K.,
            Hung,L.Y., Srivatsa,S., Young,T., Oniskey,T., Pastore,C.,
            Nieves,W., Somsouk,M. and Herbert,D.R.
  TITLE     TFF3 interacts with LINGO2 to regulate EGFR activation for
            protection against colitis and gastrointestinal helminths
  JOURNAL   Nat Commun 10 (1), 4408 (2019)
   PUBMED   31562318
  REMARK    GeneRIF: Data show that trefoil factor 3 (TFF3) - leucine rich
            repeat receptor and nogo-interacting protein 2 (LINGO2)
            interactions disrupt EGFR-LINGO2 complexes resulting in enhanced
            epidermal growth factor receptor (EGFR) signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4642)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4642)
  AUTHORS   Um,J.W., Pramanik,G., Ko,J.S., Song,M.Y., Lee,D., Kim,H.,
            Park,K.S., Sudhof,T.C., Tabuchi,K. and Ko,J.
  TITLE     Calsyntenins function as synaptogenic adhesion molecules in concert
            with neurexins
  JOURNAL   Cell Rep 6 (6), 1096-1109 (2014)
   PUBMED   24613359
  REMARK    Erratum:[Cell Rep. 2024 Aug 27;43(8):114646. doi:
            10.1016/j.celrep.2024.114646.. PMID: 39110596]
REFERENCE   7  (bases 1 to 4642)
  AUTHORS   Garaffo,G., Provero,P., Molineris,I., Pinciroli,P., Peano,C.,
            Battaglia,C., Tomaiuolo,D., Etzion,T., Gothilf,Y., Santoro,M. and
            Merlo,G.R.
  TITLE     Profiling, Bioinformatic, and Functional Data on the Developing
            Olfactory/GnRH System Reveal Cellular and Molecular Pathways
            Essential for This Process and Potentially Relevant for the
            Kallmann Syndrome
  JOURNAL   Front Endocrinol (Lausanne) 4, 203 (2013)
   PUBMED   24427155
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4642)
  AUTHORS   Homma,S., Shimada,T., Hikake,T. and Yaginuma,H.
  TITLE     Expression pattern of LRR and Ig domain-containing protein (LRRIG
            protein) in the early mouse embryo
  JOURNAL   Gene Expr Patterns 9 (1), 1-26 (2009)
   PUBMED   18848646
REFERENCE   9  (bases 1 to 4642)
  AUTHORS   Haines,B.P. and Rigby,P.W.
  TITLE     Expression of the Lingo/LERN gene family during mouse embryogenesis
  JOURNAL   Gene Expr Patterns 8 (2), 79-86 (2008)
   PUBMED   18297755
REFERENCE   10 (bases 1 to 4642)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139458.1, AK141568.1, AL844208.5 and BY651810.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All variants (1-4) encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK035778.1, BB587007.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-518               AK139458.1         2-519
            519-3580            AK141568.1         2-3063
            3581-4621           AL844208.5         155542-156582       c
            4622-4642           BY651810.1         395-415
FEATURES             Location/Qualifiers
     source          1..4642
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 17.74 cM"
     gene            1..4642
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /note="leucine rich repeat and Ig domain containing 2"
                     /db_xref="GeneID:242384"
                     /db_xref="MGI:MGI:2442298"
     exon            1..664
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     exon            665..761
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     exon            762..841
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     exon            842..921
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     exon            922..954
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1117
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1275
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..4642
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /inference="alignment:Splign:2.1.0"
     CDS             1311..3131
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /note="leucine rich repeat neuronal 6C; leucine-rich
                     repeat and immunoglobulin-like domain-containing nogo
                     receptor-interacting protein 2; leucine-rich repeat
                     neuronal protein 6C"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 2
                     precursor"
                     /protein_id="NP_001159471.1"
                     /db_xref="CCDS:CCDS18040.1"
                     /db_xref="GeneID:242384"
                     /db_xref="MGI:MGI:2442298"
                     /translation="MLHTAIPCWQPFLGLAVVLLLMGSTIGCPARCECSAQNKSVSCH
                     RRRLLAIPEGIPIETKILDLSKNRLKSINPEEFISYPLLEEIDLSDNIIANVEPGAFN
                     NLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEV
                     GDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLIALHLKHLNINNMPV
                     YAFKRLFHLKNLEIDYWPLLDLMPANSLYGLNLTSLSITNTNLSTVPFLAFKHLVYLT
                     HLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLE
                     TLEENVFSSPRALEVLSINNNPLACDCRLLWLLQRQPNLQFGGQQPMCAGPDTIRERS
                     FKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECNADGDPQPVISWVTPRRR
                     FITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTVKGFTSDRF
                     LYANRTPMYMTDSNDTVSNGTNANTFSLDLKTILVSTAMGCFTFLGVVLFCFLLLFVW
                     SRGKGKHKNSIDLEYVPRKNNGAVVEGEVAGPRRFNMKMI"
     regulatory      3860..3865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /note="hexamer: AATAAA"
     polyA_site      3888
                     /gene="Lingo2"
                     /gene_synonym="B230217C06Rik; Lern3; Lrrn6c"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgtgcgc gcagtccgcg cgctgagtgt ggccgccggg acccagcagc ccgccgcccg
       61 cccggtgtct ctccttccca gctcctcagc cacctcacag ggccttccac cacccatccc
      121 ttggctttcc ggcctccgct caaagtttcc ttggcgcaga cgcttgggcg caagggctgt
      181 agccaagacg ccttggtggt ggagcgcgat cctcggcgtg gctctgctgc cagcacctgc
      241 tctgcaccga acctgcctga gcgcaggttt tcttcccact tggcgggagc agggggaggg
      301 gtgcggtggc gagaatcaga gaggagcccc ggctcctgac ggcgtaccca gcttggctat
      361 ccgacgcatc tgtggggtca cggaagaaaa ctggatccgc agccaagttg cctgagcagg
      421 gacagggaag gtttccacgg ccatccaagg ttgtccctgt atcagtcgcc acaggcgtga
      481 gggtttggag acacctagac tgtcagggct ttagaaccga cattcccttc ctgacccctt
      541 tgaaaggaaa agctgacaga gctgaggcag gaggacgcct aaagaagccc ggagactcct
      601 gtgagcttca tcctccttgg ctttggattt taaggacacg aaggggcatg aacaacatgt
      661 caaggaaaac tgatgatgat ggtttcaaga tgtagaatcc ttatacatga agtatcccaa
      721 atgaagttga ggaatctgga ttgaaagtgc ttcatattgt gggattggag agtgacacag
      781 gaagacagca tcatgagctc tggggatttc taagctactc tgtggatttt taacatatga
      841 gcatagtgaa agaatcataa aaagaggttc taagaccaag agtgcaggtg gccaccagca
      901 tgaggaaccc agttcacgtt gatgaaatga aagaagcaaa atgcagtgtt caaggcatgt
      961 ttcaagcagt tggctggtgg gactttgaga gatgctgccg cccgtgatgt ggtggagtta
     1021 tcatgatcaa ccactccgtt cggatttcaa ccagttgcca tgagctttgt ctgatagacc
     1081 acagcaggag ttggattttt aaaaaggagc aaaccaggta aatgaaaatc atcaaatctg
     1141 caacctgggg atggttcaat ggataagaaa gcttgcagtg ggaacaagag gacctggatt
     1201 caaattgcca gcacccacta taccactccc actattcctt ctacacagtt cttttaagag
     1261 acaagcaaaa cacaggcccg taaccaaggt gtagacaaag aagtggagtc atgcttcaca
     1321 cggctatacc atgctggcag ccattcctgg gtctggctgt ggtgttactc ttaatgggat
     1381 ccaccattgg ctgtcctgct cgctgtgagt gctccgccca gaacaaatct gttagctgcc
     1441 acagaagacg attgctcgcg atcccagaag gcattcccat tgagaccaaa atcttggacc
     1501 tgagcaaaaa tcgactaaag agcataaacc ctgaagagtt catctcatat cctctgttgg
     1561 aggagataga cttgagcgac aacattattg ccaatgtgga gcctggggca tttaacaatc
     1621 tctttaacct gcgttccctc cgcctaaaag gcaatcgcct taagttggtc cctttaggag
     1681 tattcacagg actgtccaac ctcaccaagc ttgacattag tgagaataag attgtcattt
     1741 tgctggacta catgttccag gatctgcata acctgaagtc tctagaagtg ggggacaatg
     1801 atttagtgta tatctcacac agggccttca gcggactact tagcttggag cagctcaccc
     1861 tggagaagtg caacttgaca gcagtaccaa cagaagccct ttcccatctc cgcagcctca
     1921 tcgccctgca tctgaagcat ctcaatatca acaatatgcc tgtgtatgcc tttaaaagat
     1981 tgttccacct gaaaaaccta gagatcgact attggccttt gttggatttg atgccagcca
     2041 acagcctcta tggtctcaac ctcacgtccc tttcaatcac caacaccaac ctgtccactg
     2101 tccccttcct cgcctttaaa caccttgtat acctgaccca ccttaacctc tcctacaatc
     2161 ccatcagcac tattgaagct ggcatgttct ctgacctgat ccgcctacag gagcttcata
     2221 tagtgggggc ccagctccgc actattgagc ctcactcctt ccaagggctc cgcttcctcc
     2281 gtgtgctcaa tgtatctcag aacctgctgg aaacattgga agagaacgtc ttctcctccc
     2341 ctagggcttt ggaggtcctg agcattaaca acaacccact agcctgtgac tgccgactcc
     2401 tctggctcct gcagcgacaa cccaacctgc agtttggggg ccagcagccc atgtgtgctg
     2461 ggccagacac catccgtgag agatcattta aggatttcca tagcactgct ctttcttttt
     2521 attttacctg caaaaaaccc aaaatccgtg aaaagaagtt acagcatctc ctcgtggatg
     2581 aagggcaaac ggtccagctg gagtgcaacg ctgatggaga cccgcagccc gtgatttcct
     2641 gggtgacacc tcgaaggcgt tttatcacca ccaagtccaa cggaagggcc actgtgttgg
     2701 gtgatggcac cttggaaatc cgttttgccc aggatcaaga cagtgggatg tatgtttgca
     2761 tcgcgagcaa cgctgctggg aacgatacct tcacagcatc tctcactgtg aagggattca
     2821 cgtcagaccg cttcctttac gcaaacagga cccctatgta catgactgac tccaacgaca
     2881 ccgtttccaa cggcactaat gccaatactt tctccctgga ccttaaaaca atactggtat
     2941 ctacagccat gggctgtttc acattcctgg gagtggtttt attttgtttt ctccttcttt
     3001 ttgtgtggag ccgagggaaa ggcaagcaca aaaacagcat tgaccttgag tatgtgcccc
     3061 gaaaaaacaa tggtgctgtt gtggaagggg aggtggctgg ccccaggagg ttcaacatga
     3121 aaatgatcta agggcccacc acacactact gtctctctgt tactgttggt cgtgagtaag
     3181 acgtctgata gagtgactcg atcacaaggt tatcgggcag ctttgcgcag ctgcccctgt
     3241 gtcaaagcag ggtccatgga agcaggaaga cttctcatgg agactggctg attagaggca
     3301 ggcaggcatg tgtcagagcc cttcacacag tgggatacta attgtttgca ttgcaaatat
     3361 tggcattctg gggatctcag caatgaacct gaacctttgg ctcatgctga tggacaataa
     3421 ttcaacattt tctaccactg caaaactaaa aggaaaaaaa attaaaaaga acaacctaca
     3481 gtgtaggatt tacatattaa aaagacacat ttgtctaaaa catactctac agtcaaattt
     3541 gtatttatta tcatttgtta aaaccttgca tcatacaata ctgttggttc agcaccaaaa
     3601 agagatcaat atattctttt ttttgaaaca tatatgctgt atatgtttta aagcaatatg
     3661 aatgagaggt tgtgctttta gttactcacc agtatagatc caagtgtggt ttcaccttcc
     3721 ttttacctgc agataaacct gagaatagat ccctggaata ctaggcagag atgtgttgag
     3781 atgtgtatgt ctgatgtagg atgccaagaa acaagaccca agtcaaaact gctcaactct
     3841 gttaacttct gttactataa ataaaggcat gtgcctagtt ttgatacaga atggaatatt
     3901 ttttatacat acactaccaa cctggaccag tttactgtaa cagaagccct tggtttctcc
     3961 agaaggcggt acatcgctag gggtacctat agaatacaag gtaggtgtca ctcttaaaag
     4021 taatccatgt agctactgct tagttttact ttcgccagtc actgctaatg ggttaatgac
     4081 caatggaaaa gagaatattg attatataga attatttggc aatattcacc aatagctaat
     4141 atcaataatt ctgttgtccg aaagccctct gaataaggag gtttcagaag tcaataggaa
     4201 gcagggagag acaagagcat cacagcagcg attcagccaa tgatctcttt caaatgtggc
     4261 agctgcctgc cggatggcta caaatcaaag ggaatacgct gcacatgcca gcccaacttc
     4321 tatccaagta ctatacacag agtaggacca cagttaggca acttcaggat attcctctgc
     4381 ttcctgatca agatctttag tttcatattg aaaaccatat tacacagcta cgaggaatat
     4441 gttttgtgtg aaagaagtaa aagtagtgaa agaaaaacca atatagatct aaaaaacaat
     4501 gttttgttcc ttcactgggg aagagctaag cttatagttc tacaaatatg taatgctgtg
     4561 ccaattcttt taccttcttg acctgagcat atttgcccaa ttaagttgat attaatgtta
     4621 ctaatgcaaa cataaccaga aa
//
