LOCUS       NM_001361119            3678 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus leucine rich repeat and Ig domain containing 1
            (Lingo1), transcript variant 7, mRNA.
ACCESSION   NM_001361119 XM_017313334
VERSION     NM_001361119.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3678)
  AUTHORS   Xie,Y.H., Jiang,L., Zhang,Y., Deng,Y.H., Yang,H., He,Q., Zhou,Y.N.,
            Zhou,C.N., Luo,Y.M., Liang,X., Wang,J., Huang,D.J., Zhu,L., Tang,Y.
            and Chao,F.L.
  TITLE     Antagonizing LINGO-1 reduces activated microglia and alleviates
            dendritic spine loss in the hippocampus of APP/PS1 transgenic mice
  JOURNAL   Neurosci Lett 820, 137612 (2024)
   PUBMED   38142924
  REMARK    GeneRIF: Antagonizing LINGO-1 reduces activated microglia and
            alleviates dendritic spine loss in the hippocampus of APP/PS1
            transgenic mice.
REFERENCE   2  (bases 1 to 3678)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     LINGO-1 shRNA protects the brain against ischemia/reperfusion
            injury by inhibiting the activation of NF-kappaB and JAK2/STAT3
  JOURNAL   Hum Cell 34 (4), 1114-1122 (2021)
   PUBMED   33830473
  REMARK    GeneRIF: LINGO-1 shRNA protects the brain against
            ischemia/reperfusion injury by inhibiting the activation of
            NF-kappaB and JAK2/STAT3.
REFERENCE   3  (bases 1 to 3678)
  AUTHORS   Zhao,C.G., Qin,J., Li,J., Jiang,S., Ju,F., Sun,W., Ren,Z., Ji,Y.Q.,
            Wang,R., Sun,X.L., Mou,X. and Yuan,H.
  TITLE     LINGO-1 regulates Wnt5a signaling during neural stem and progenitor
            cell differentiation by modulating miR-15b-3p levels
  JOURNAL   Stem Cell Res Ther 12 (1), 372 (2021)
   PUBMED   34187584
  REMARK    GeneRIF: LINGO-1 regulates Wnt5a signaling during neural stem and
            progenitor cell differentiation by modulating miR-15b-3p levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3678)
  AUTHORS   Huang,L.J., Li,G., Ding,Y., Sun,J.H., Wu,T.T., Zhao,W. and
            Zeng,Y.S.
  TITLE     LINGO-1 deficiency promotes nerve regeneration through reduction of
            cell apoptosis, inflammation, and glial scar after spinal cord
            injury in mice
  JOURNAL   Exp Neurol 320, 112965 (2019)
   PUBMED   31132364
  REMARK    GeneRIF: results suggested that LINGO-1 plays a critical role in
            the injury microenvironment in processes such as cell death,
            inflammatory response, and glial scar formation after spinal cord
            injury
REFERENCE   5  (bases 1 to 3678)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   6  (bases 1 to 3678)
  AUTHORS   Inoue,H., Lin,L., Lee,X., Shao,Z., Mendes,S., Snodgrass-Belt,P.,
            Sweigard,H., Engber,T., Pepinsky,B., Yang,L., Beal,M.F., Mi,S. and
            Isacson,O.
  TITLE     Inhibition of the leucine-rich repeat protein LINGO-1 enhances
            survival, structure, and function of dopaminergic neurons in
            Parkinson's disease models
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14430-14435 (2007)
   PUBMED   17726113
  REMARK    GeneRIF: inhibitory agents of LINGO-1 activity can protect
            dopaminergic neurons against degeneration
REFERENCE   7  (bases 1 to 3678)
  AUTHORS   Mi,S., Miller,R.H., Lee,X., Scott,M.L., Shulag-Morskaya,S.,
            Shao,Z., Chang,J., Thill,G., Levesque,M., Zhang,M., Hession,C.,
            Sah,D., Trapp,B., He,Z., Jung,V., McCoy,J.M. and Pepinsky,R.B.
  TITLE     LINGO-1 negatively regulates myelination by oligodendrocytes
  JOURNAL   Nat Neurosci 8 (6), 745-751 (2005)
   PUBMED   15895088
REFERENCE   8  (bases 1 to 3678)
  AUTHORS   Aoki,K., Nakamura,T., Fujikawa,K. and Matsuda,M.
  TITLE     Local phosphatidylinositol 3,4,5-trisphosphate accumulation
            recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite
            outgrowth in nerve growth factor-stimulated PC12 cells
  JOURNAL   Mol Biol Cell 16 (5), 2207-2217 (2005)
   PUBMED   15728722
REFERENCE   9  (bases 1 to 3678)
  AUTHORS   Nicholson,S.E., Metcalf,D., Sprigg,N.S., Columbus,R., Walker,F.,
            Silva,A., Cary,D., Willson,T.A., Zhang,J.G., Hilton,D.J.,
            Alexander,W.S. and Nicola,N.A.
  TITLE     Suppressor of cytokine signaling (SOCS)-5 is a potential negative
            regulator of epidermal growth factor signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (7), 2328-2333 (2005)
   PUBMED   15695332
REFERENCE   10 (bases 1 to 3678)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene
            with enriched expression in limbic system and neocortex
  JOURNAL   Eur J Neurosci 18 (12), 3167-3182 (2003)
   PUBMED   14686891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126257.4 and AC134578.5.
            
            On Mar 1, 2018 this sequence version replaced XM_017313334.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.22645.1,
                                           SRR10662774.1780088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC126257.4         11551-11871         c
            322-431             AC134578.5         187754-187863       c
            432-593             AC134578.5         97335-97496         c
            594-826             AC134578.5         65815-66047         c
            827-3678            AC134578.5         30679-33530         c
FEATURES             Location/Qualifiers
     source          1..3678
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.28 cM"
     gene            1..3678
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="leucine rich repeat and Ig domain containing 1"
                     /db_xref="GeneID:235402"
                     /db_xref="MGI:MGI:1915522"
     exon            1..321
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            322..431
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            432..593
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            594..826
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            827..3678
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     CDS             839..2683
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 7; leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1;
                     leucine-rich repeat neuronal protein 1; leucine-rich
                     repeat neuronal protein 6A"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     isoform 2 precursor"
                     /protein_id="NP_001348048.1"
                     /db_xref="CCDS:CCDS23209.1"
                     /db_xref="GeneID:235402"
                     /db_xref="MGI:MGI:1915522"
                     /translation="MLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSA
                     QDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVS
                     AVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDL
                     YNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRH
                     LNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA
                     VRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVL
                     NVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCAT
                     PEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAI
                     LWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV
                     RSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVV
                     LFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="hexamer: AATAAA"
     polyA_site      3031
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
     polyA_site      3453
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
     polyA_site      3678
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
ORIGIN      
        1 gttagggatt ctgctggcat cgcagcgtgg agagcaggag gcaggagccg ggcgcgcagg
       61 ggagcgcggg ggctctgccg cgcacacgtc gtgcgcgctc tcttgtgcac atacactctt
      121 ttgcacacac acacacacac acacacacac acacacacac acacacacac acgccttttc
      181 tgcttcgttg gttgctgctg ccaccatctc ggagctgagc cctgcggagc gagaacccaa
      241 gctggagctg ggatcggagg cgagcccagc ctggtgatgc cggcccagag cagagccccg
      301 cgcggacgac tagctctgat gcctcctgta tccataggcc ctgagattct ggtacctatg
      361 ggcaaaaggg ccaactgaac caggcctagg ctgattccag cccagctgca cccagcacta
      421 cccagtcaca gggatcctaa ggcaatgtcc tggttctttt gagtctgtgg gctgcaaaac
      481 tctcagggct ctgaccggtc caggcctgac cagtcttgag cggattcctg cccccacctg
      541 gttacagaat ctccttgtgc ttcaggattc ggtcaagcat tggaccaatc acggagtcac
      601 gtgagcctcc ctctgggatc tggcatgaag gagaaatgga ttctggcttt cccgctctgg
      661 ctttccctga cttctccaga atctaagaag tgtcctgagg catctcttgc tctacctcag
      721 cccagaatcc ctgaggatcc atccagaaat ccaacgactt caagacctaa aaacatcagg
      781 cccctctccc tggacacaga cttgacagaa gtggccagtt catcaggtga gcgagaggat
      841 gctggcaggg ggtatgagaa gcatgcccag ccccctcctg gcctgctggc agcccatcct
      901 cctgctggta ctgggctcag tgctgtcagg ctctgctaca ggctgcccgc cccgctgcga
      961 gtgctcagcg caggaccgag ccgtgctctg ccaccgcaaa cgctttgtgg cggtgcccga
     1021 gggcatcccc accgagactc gcctgctgga cctgggcaaa aaccgcatca agacactcaa
     1081 ccaggacgag tttgccagct tcccacacct ggaggagcta gaactcaatg aaaacatcgt
     1141 gagcgccgtg gagccaggcg ccttcaacaa cctcttcaac ctgaggactc tggggctgcg
     1201 cagcaaccgc ctgaagctta tcccgctggg cgtcttcacc ggcctcagca acttgaccaa
     1261 gctggacatc agtgagaaca agatcgtcat cctgctagac tacatgttcc aagacctata
     1321 caacctcaag tcgctggagg tcggcgacaa cgacctcgtc tacatctccc atcgagcctt
     1381 cagcggcctc aacagcctgg aacagctgac gctggagaaa tgcaatctga cctccatccc
     1441 cacggaggcg ctctcccacc tgcacggcct catcgtcctg cggctacgac atctcaacat
     1501 caatgccatc agggactact ccttcaagag gctgtaccga cttaaggtct tagagatctc
     1561 ccactggccc tacctggaca ccatgacccc caactgcctc tacggcctca acctgacatc
     1621 cctatccatc acgcactgca acctgacagc cgtgccctat ctggcagtgc gtcacctggt
     1681 ctatctccgt ttcctcaacc tttcctacaa cccaatcggt acaatcgagg gctccatgct
     1741 gcatgagctg ctgcggttgc aggagatcca gctggtgggc gggcagctgg ccgtggtgga
     1801 gccctatgcc tttcgtgggc tcaactacct gcgtgtgctc aatgtctctg gcaaccagct
     1861 gaccaccctg gaggagtcag ccttccattc ggtgggcaac ctggagacgc tcatcctgga
     1921 ctccaaccca ctggcctgtg actgccggct gctgtgggtg ttccggcgcc gctggcggct
     1981 caacttcaac aggcagcagc ccacctgcgc cacacctgag ttcgtccagg gcaaagagtt
     2041 caaggacttt ccggatgtac tcctacccaa ctacttcacc tgccgccggg cccacatccg
     2101 ggaccgcaag gcacagcagg tgtttgtaga tgagggccac acggtgcagt ttgtatgccg
     2161 ggcagatggc gaccctccac cagctatcct ttggctctca ccccgcaagc acttggtctc
     2221 ggccaagagc aatgggcggc tcacagtctt ccctgatggc acgctggagg tgcgctacgc
     2281 ccaggtacag gacaacggca cgtacctgtg catcgcagcc aatgctggcg gcaacgactc
     2341 catgcccgcc cacttgcatg tgcgcagcta ctcgcctgac tggccccatc aacccaacaa
     2401 gaccttcgcc ttcatctcca accagccagg cgagggagag gccaacagca cccgcgccac
     2461 tgtgcctttc cccttcgaca tcaagacgct cattatcgcc accaccatgg gcttcatctc
     2521 cttcctgggc gttgtcctat tctgcctggt gctgctgttt ctatggagcc ggggcaaagg
     2581 caacacaaag cacaacatcg aaattgagta tgtgccccgg aaatcggacg caggcatcag
     2641 ctcagctgat gcaccccgca agttcaacat gaagatgata tgaggacggg gcagggtggg
     2701 ggcacaggga ccccccaccc tcagtggaaa cactgggcag ggaaggtgcc tggctgctgc
     2761 cttcccacct cctccctgcc ctcctcacac actctccccc tccccacact cgcctcgccc
     2821 tcaccgcctg ccctccttct accaggattt cagaaggcca ggcctgagga ccccacctgc
     2881 acaggggcca gagttgacaa agccgacgaa ccaacacgcg gcagagtcaa taattcaatt
     2941 aaaaaaaaag ttacaaactt cctctgtaac ttgggtttca ataattaatg gatttttatg
     3001 aaaacttgaa ataataaaaa gaaaaaaact atttcctata gctagtcgga atgcaaactt
     3061 ttgacgtcct gatggctcca gggccttctt ccaactcagt ttcttgtttt tctcttcctc
     3121 ctcctcctct tcctcctctc tcttctcttc ccctgtgggg agggatcact caggaaaaca
     3181 gggaaggaga ttccagcccc accctctggc ccactctgct gggcgccatt tggagccatg
     3241 ggtgccagct cagctccagg cccagctcca gctgtttttt tggcaggaag taggggaggg
     3301 gataggactg cccagggggg atggggtttg tctgctggat gtcaggcagc actaccaagg
     3361 agaggtgggg gtcaggctcg ggtgtggctg aaactgggat gggctggggt cctcctgggg
     3421 aacagcacgg tcagtggaaa gagtcaggag ccagaggcag gccgattcct ctcctctggt
     3481 cccagctctg ctgctcactg ttgtgtgacc tccttgcagg tcgctggccc ctcttgggcc
     3541 tcagtctcca catctgtaca aatgggaaca tttatccctg ccctgcctac ctcacagggc
     3601 tgttgtgagg aactgatgag atgatgtatg tgaaacactt tgtaatctgt aaagcgctgt
     3661 gcacatgtgt gtgggtga
//
