LOCUS       NM_001361116            3603 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus leucine rich repeat and Ig domain containing 1
            (Lingo1), transcript variant 4, mRNA.
ACCESSION   NM_001361116 XM_017313336
VERSION     NM_001361116.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3603)
  AUTHORS   Xie,Y.H., Jiang,L., Zhang,Y., Deng,Y.H., Yang,H., He,Q., Zhou,Y.N.,
            Zhou,C.N., Luo,Y.M., Liang,X., Wang,J., Huang,D.J., Zhu,L., Tang,Y.
            and Chao,F.L.
  TITLE     Antagonizing LINGO-1 reduces activated microglia and alleviates
            dendritic spine loss in the hippocampus of APP/PS1 transgenic mice
  JOURNAL   Neurosci Lett 820, 137612 (2024)
   PUBMED   38142924
  REMARK    GeneRIF: Antagonizing LINGO-1 reduces activated microglia and
            alleviates dendritic spine loss in the hippocampus of APP/PS1
            transgenic mice.
REFERENCE   2  (bases 1 to 3603)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     LINGO-1 shRNA protects the brain against ischemia/reperfusion
            injury by inhibiting the activation of NF-kappaB and JAK2/STAT3
  JOURNAL   Hum Cell 34 (4), 1114-1122 (2021)
   PUBMED   33830473
  REMARK    GeneRIF: LINGO-1 shRNA protects the brain against
            ischemia/reperfusion injury by inhibiting the activation of
            NF-kappaB and JAK2/STAT3.
REFERENCE   3  (bases 1 to 3603)
  AUTHORS   Zhao,C.G., Qin,J., Li,J., Jiang,S., Ju,F., Sun,W., Ren,Z., Ji,Y.Q.,
            Wang,R., Sun,X.L., Mou,X. and Yuan,H.
  TITLE     LINGO-1 regulates Wnt5a signaling during neural stem and progenitor
            cell differentiation by modulating miR-15b-3p levels
  JOURNAL   Stem Cell Res Ther 12 (1), 372 (2021)
   PUBMED   34187584
  REMARK    GeneRIF: LINGO-1 regulates Wnt5a signaling during neural stem and
            progenitor cell differentiation by modulating miR-15b-3p levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3603)
  AUTHORS   Huang,L.J., Li,G., Ding,Y., Sun,J.H., Wu,T.T., Zhao,W. and
            Zeng,Y.S.
  TITLE     LINGO-1 deficiency promotes nerve regeneration through reduction of
            cell apoptosis, inflammation, and glial scar after spinal cord
            injury in mice
  JOURNAL   Exp Neurol 320, 112965 (2019)
   PUBMED   31132364
  REMARK    GeneRIF: results suggested that LINGO-1 plays a critical role in
            the injury microenvironment in processes such as cell death,
            inflammatory response, and glial scar formation after spinal cord
            injury
REFERENCE   5  (bases 1 to 3603)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   6  (bases 1 to 3603)
  AUTHORS   Inoue,H., Lin,L., Lee,X., Shao,Z., Mendes,S., Snodgrass-Belt,P.,
            Sweigard,H., Engber,T., Pepinsky,B., Yang,L., Beal,M.F., Mi,S. and
            Isacson,O.
  TITLE     Inhibition of the leucine-rich repeat protein LINGO-1 enhances
            survival, structure, and function of dopaminergic neurons in
            Parkinson's disease models
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14430-14435 (2007)
   PUBMED   17726113
  REMARK    GeneRIF: inhibitory agents of LINGO-1 activity can protect
            dopaminergic neurons against degeneration
REFERENCE   7  (bases 1 to 3603)
  AUTHORS   Mi,S., Miller,R.H., Lee,X., Scott,M.L., Shulag-Morskaya,S.,
            Shao,Z., Chang,J., Thill,G., Levesque,M., Zhang,M., Hession,C.,
            Sah,D., Trapp,B., He,Z., Jung,V., McCoy,J.M. and Pepinsky,R.B.
  TITLE     LINGO-1 negatively regulates myelination by oligodendrocytes
  JOURNAL   Nat Neurosci 8 (6), 745-751 (2005)
   PUBMED   15895088
REFERENCE   8  (bases 1 to 3603)
  AUTHORS   Aoki,K., Nakamura,T., Fujikawa,K. and Matsuda,M.
  TITLE     Local phosphatidylinositol 3,4,5-trisphosphate accumulation
            recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite
            outgrowth in nerve growth factor-stimulated PC12 cells
  JOURNAL   Mol Biol Cell 16 (5), 2207-2217 (2005)
   PUBMED   15728722
REFERENCE   9  (bases 1 to 3603)
  AUTHORS   Nicholson,S.E., Metcalf,D., Sprigg,N.S., Columbus,R., Walker,F.,
            Silva,A., Cary,D., Willson,T.A., Zhang,J.G., Hilton,D.J.,
            Alexander,W.S. and Nicola,N.A.
  TITLE     Suppressor of cytokine signaling (SOCS)-5 is a potential negative
            regulator of epidermal growth factor signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (7), 2328-2333 (2005)
   PUBMED   15695332
REFERENCE   10 (bases 1 to 3603)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene
            with enriched expression in limbic system and neocortex
  JOURNAL   Eur J Neurosci 18 (12), 3167-3182 (2003)
   PUBMED   14686891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126257.4 and AC134578.5.
            
            On Mar 1, 2018 this sequence version replaced XM_017313336.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.193084.1,
                                           SRR10662772.2038586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC126257.4         11551-11871         c
            322-431             AC134578.5         187754-187863       c
            432-518             AC134578.5         86638-86724         c
            519-751             AC134578.5         65815-66047         c
            752-3603            AC134578.5         30679-33530         c
FEATURES             Location/Qualifiers
     source          1..3603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.28 cM"
     gene            1..3603
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="leucine rich repeat and Ig domain containing 1"
                     /db_xref="GeneID:235402"
                     /db_xref="MGI:MGI:1915522"
     exon            1..321
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            322..431
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            432..518
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            519..751
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            752..3603
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     CDS             764..2608
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4; leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1;
                     leucine-rich repeat neuronal protein 1; leucine-rich
                     repeat neuronal protein 6A"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     isoform 2 precursor"
                     /protein_id="NP_001348045.1"
                     /db_xref="CCDS:CCDS23209.1"
                     /db_xref="GeneID:235402"
                     /db_xref="MGI:MGI:1915522"
                     /translation="MLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSA
                     QDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVS
                     AVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDL
                     YNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRH
                     LNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLA
                     VRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVL
                     NVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCAT
                     PEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAI
                     LWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHV
                     RSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVV
                     LFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="hexamer: AATAAA"
     polyA_site      2956
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
     polyA_site      3378
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
     polyA_site      3603
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
ORIGIN      
        1 gttagggatt ctgctggcat cgcagcgtgg agagcaggag gcaggagccg ggcgcgcagg
       61 ggagcgcggg ggctctgccg cgcacacgtc gtgcgcgctc tcttgtgcac atacactctt
      121 ttgcacacac acacacacac acacacacac acacacacac acacacacac acgccttttc
      181 tgcttcgttg gttgctgctg ccaccatctc ggagctgagc cctgcggagc gagaacccaa
      241 gctggagctg ggatcggagg cgagcccagc ctggtgatgc cggcccagag cagagccccg
      301 cgcggacgac tagctctgat gcctcctgta tccataggcc ctgagattct ggtacctatg
      361 ggcaaaaggg ccaactgaac caggcctagg ctgattccag cccagctgca cccagcacta
      421 cccagtcaca gtgcatgctg agactgagcc ccgaaggctg ctgtgtcctc aggcctttgg
      481 cagcccctct gcttggctcc ctgtgccatc tgacccagga gtcacgtgag cctccctctg
      541 ggatctggca tgaaggagaa atggattctg gctttcccgc tctggctttc cctgacttct
      601 ccagaatcta agaagtgtcc tgaggcatct cttgctctac ctcagcccag aatccctgag
      661 gatccatcca gaaatccaac gacttcaaga cctaaaaaca tcaggcccct ctccctggac
      721 acagacttga cagaagtggc cagttcatca ggtgagcgag aggatgctgg cagggggtat
      781 gagaagcatg cccagccccc tcctggcctg ctggcagccc atcctcctgc tggtactggg
      841 ctcagtgctg tcaggctctg ctacaggctg cccgccccgc tgcgagtgct cagcgcagga
      901 ccgagccgtg ctctgccacc gcaaacgctt tgtggcggtg cccgagggca tccccaccga
      961 gactcgcctg ctggacctgg gcaaaaaccg catcaagaca ctcaaccagg acgagtttgc
     1021 cagcttccca cacctggagg agctagaact caatgaaaac atcgtgagcg ccgtggagcc
     1081 aggcgccttc aacaacctct tcaacctgag gactctgggg ctgcgcagca accgcctgaa
     1141 gcttatcccg ctgggcgtct tcaccggcct cagcaacttg accaagctgg acatcagtga
     1201 gaacaagatc gtcatcctgc tagactacat gttccaagac ctatacaacc tcaagtcgct
     1261 ggaggtcggc gacaacgacc tcgtctacat ctcccatcga gccttcagcg gcctcaacag
     1321 cctggaacag ctgacgctgg agaaatgcaa tctgacctcc atccccacgg aggcgctctc
     1381 ccacctgcac ggcctcatcg tcctgcggct acgacatctc aacatcaatg ccatcaggga
     1441 ctactccttc aagaggctgt accgacttaa ggtcttagag atctcccact ggccctacct
     1501 ggacaccatg acccccaact gcctctacgg cctcaacctg acatccctat ccatcacgca
     1561 ctgcaacctg acagccgtgc cctatctggc agtgcgtcac ctggtctatc tccgtttcct
     1621 caacctttcc tacaacccaa tcggtacaat cgagggctcc atgctgcatg agctgctgcg
     1681 gttgcaggag atccagctgg tgggcgggca gctggccgtg gtggagccct atgcctttcg
     1741 tgggctcaac tacctgcgtg tgctcaatgt ctctggcaac cagctgacca ccctggagga
     1801 gtcagccttc cattcggtgg gcaacctgga gacgctcatc ctggactcca acccactggc
     1861 ctgtgactgc cggctgctgt gggtgttccg gcgccgctgg cggctcaact tcaacaggca
     1921 gcagcccacc tgcgccacac ctgagttcgt ccagggcaaa gagttcaagg actttccgga
     1981 tgtactccta cccaactact tcacctgccg ccgggcccac atccgggacc gcaaggcaca
     2041 gcaggtgttt gtagatgagg gccacacggt gcagtttgta tgccgggcag atggcgaccc
     2101 tccaccagct atcctttggc tctcaccccg caagcacttg gtctcggcca agagcaatgg
     2161 gcggctcaca gtcttccctg atggcacgct ggaggtgcgc tacgcccagg tacaggacaa
     2221 cggcacgtac ctgtgcatcg cagccaatgc tggcggcaac gactccatgc ccgcccactt
     2281 gcatgtgcgc agctactcgc ctgactggcc ccatcaaccc aacaagacct tcgccttcat
     2341 ctccaaccag ccaggcgagg gagaggccaa cagcacccgc gccactgtgc ctttcccctt
     2401 cgacatcaag acgctcatta tcgccaccac catgggcttc atctccttcc tgggcgttgt
     2461 cctattctgc ctggtgctgc tgtttctatg gagccggggc aaaggcaaca caaagcacaa
     2521 catcgaaatt gagtatgtgc cccggaaatc ggacgcaggc atcagctcag ctgatgcacc
     2581 ccgcaagttc aacatgaaga tgatatgagg acggggcagg gtgggggcac agggaccccc
     2641 caccctcagt ggaaacactg ggcagggaag gtgcctggct gctgccttcc cacctcctcc
     2701 ctgccctcct cacacactct ccccctcccc acactcgcct cgccctcacc gcctgccctc
     2761 cttctaccag gatttcagaa ggccaggcct gaggacccca cctgcacagg ggccagagtt
     2821 gacaaagccg acgaaccaac acgcggcaga gtcaataatt caattaaaaa aaaagttaca
     2881 aacttcctct gtaacttggg tttcaataat taatggattt ttatgaaaac ttgaaataat
     2941 aaaaagaaaa aaactatttc ctatagctag tcggaatgca aacttttgac gtcctgatgg
     3001 ctccagggcc ttcttccaac tcagtttctt gtttttctct tcctcctcct cctcttcctc
     3061 ctctctcttc tcttcccctg tggggaggga tcactcagga aaacagggaa ggagattcca
     3121 gccccaccct ctggcccact ctgctgggcg ccatttggag ccatgggtgc cagctcagct
     3181 ccaggcccag ctccagctgt ttttttggca ggaagtaggg gaggggatag gactgcccag
     3241 gggggatggg gtttgtctgc tggatgtcag gcagcactac caaggagagg tgggggtcag
     3301 gctcgggtgt ggctgaaact gggatgggct ggggtcctcc tggggaacag cacggtcagt
     3361 ggaaagagtc aggagccaga ggcaggccga ttcctctcct ctggtcccag ctctgctgct
     3421 cactgttgtg tgacctcctt gcaggtcgct ggcccctctt gggcctcagt ctccacatct
     3481 gtacaaatgg gaacatttat ccctgccctg cctacctcac agggctgttg tgaggaactg
     3541 atgagatgat gtatgtgaaa cactttgtaa tctgtaaagc gctgtgcaca tgtgtgtggg
     3601 tga
//
