LOCUS       NM_001361115            3648 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus leucine rich repeat and Ig domain containing 1
            (Lingo1), transcript variant 3, mRNA.
ACCESSION   NM_001361115 XM_017313333
VERSION     NM_001361115.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3648)
  AUTHORS   Xie,Y.H., Jiang,L., Zhang,Y., Deng,Y.H., Yang,H., He,Q., Zhou,Y.N.,
            Zhou,C.N., Luo,Y.M., Liang,X., Wang,J., Huang,D.J., Zhu,L., Tang,Y.
            and Chao,F.L.
  TITLE     Antagonizing LINGO-1 reduces activated microglia and alleviates
            dendritic spine loss in the hippocampus of APP/PS1 transgenic mice
  JOURNAL   Neurosci Lett 820, 137612 (2024)
   PUBMED   38142924
  REMARK    GeneRIF: Antagonizing LINGO-1 reduces activated microglia and
            alleviates dendritic spine loss in the hippocampus of APP/PS1
            transgenic mice.
REFERENCE   2  (bases 1 to 3648)
  AUTHORS   Zhu,J., Zhu,Z., Ren,Y., Dong,Y., Li,Y. and Yang,X.
  TITLE     LINGO-1 shRNA protects the brain against ischemia/reperfusion
            injury by inhibiting the activation of NF-kappaB and JAK2/STAT3
  JOURNAL   Hum Cell 34 (4), 1114-1122 (2021)
   PUBMED   33830473
  REMARK    GeneRIF: LINGO-1 shRNA protects the brain against
            ischemia/reperfusion injury by inhibiting the activation of
            NF-kappaB and JAK2/STAT3.
REFERENCE   3  (bases 1 to 3648)
  AUTHORS   Zhao,C.G., Qin,J., Li,J., Jiang,S., Ju,F., Sun,W., Ren,Z., Ji,Y.Q.,
            Wang,R., Sun,X.L., Mou,X. and Yuan,H.
  TITLE     LINGO-1 regulates Wnt5a signaling during neural stem and progenitor
            cell differentiation by modulating miR-15b-3p levels
  JOURNAL   Stem Cell Res Ther 12 (1), 372 (2021)
   PUBMED   34187584
  REMARK    GeneRIF: LINGO-1 regulates Wnt5a signaling during neural stem and
            progenitor cell differentiation by modulating miR-15b-3p levels.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3648)
  AUTHORS   Huang,L.J., Li,G., Ding,Y., Sun,J.H., Wu,T.T., Zhao,W. and
            Zeng,Y.S.
  TITLE     LINGO-1 deficiency promotes nerve regeneration through reduction of
            cell apoptosis, inflammation, and glial scar after spinal cord
            injury in mice
  JOURNAL   Exp Neurol 320, 112965 (2019)
   PUBMED   31132364
  REMARK    GeneRIF: results suggested that LINGO-1 plays a critical role in
            the injury microenvironment in processes such as cell death,
            inflammatory response, and glial scar formation after spinal cord
            injury
REFERENCE   5  (bases 1 to 3648)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   6  (bases 1 to 3648)
  AUTHORS   Inoue,H., Lin,L., Lee,X., Shao,Z., Mendes,S., Snodgrass-Belt,P.,
            Sweigard,H., Engber,T., Pepinsky,B., Yang,L., Beal,M.F., Mi,S. and
            Isacson,O.
  TITLE     Inhibition of the leucine-rich repeat protein LINGO-1 enhances
            survival, structure, and function of dopaminergic neurons in
            Parkinson's disease models
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14430-14435 (2007)
   PUBMED   17726113
  REMARK    GeneRIF: inhibitory agents of LINGO-1 activity can protect
            dopaminergic neurons against degeneration
REFERENCE   7  (bases 1 to 3648)
  AUTHORS   Mi,S., Miller,R.H., Lee,X., Scott,M.L., Shulag-Morskaya,S.,
            Shao,Z., Chang,J., Thill,G., Levesque,M., Zhang,M., Hession,C.,
            Sah,D., Trapp,B., He,Z., Jung,V., McCoy,J.M. and Pepinsky,R.B.
  TITLE     LINGO-1 negatively regulates myelination by oligodendrocytes
  JOURNAL   Nat Neurosci 8 (6), 745-751 (2005)
   PUBMED   15895088
REFERENCE   8  (bases 1 to 3648)
  AUTHORS   Aoki,K., Nakamura,T., Fujikawa,K. and Matsuda,M.
  TITLE     Local phosphatidylinositol 3,4,5-trisphosphate accumulation
            recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite
            outgrowth in nerve growth factor-stimulated PC12 cells
  JOURNAL   Mol Biol Cell 16 (5), 2207-2217 (2005)
   PUBMED   15728722
REFERENCE   9  (bases 1 to 3648)
  AUTHORS   Nicholson,S.E., Metcalf,D., Sprigg,N.S., Columbus,R., Walker,F.,
            Silva,A., Cary,D., Willson,T.A., Zhang,J.G., Hilton,D.J.,
            Alexander,W.S. and Nicola,N.A.
  TITLE     Suppressor of cytokine signaling (SOCS)-5 is a potential negative
            regulator of epidermal growth factor signaling
  JOURNAL   Proc Natl Acad Sci U S A 102 (7), 2328-2333 (2005)
   PUBMED   15695332
REFERENCE   10 (bases 1 to 3648)
  AUTHORS   Carim-Todd,L., Escarceller,M., Estivill,X. and Sumoy,L.
  TITLE     LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene
            with enriched expression in limbic system and neocortex
  JOURNAL   Eur J Neurosci 18 (12), 3167-3182 (2003)
   PUBMED   14686891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126257.4 and AC134578.5.
            
            On Mar 1, 2018 this sequence version replaced XM_017313333.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.156374.1,
                                           SRR7974084.22654.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC126257.4         11551-11871         c
            322-431             AC134578.5         187754-187863       c
            432-476             AC134578.5         136516-136560       c
            477-563             AC134578.5         86638-86724         c
            564-796             AC134578.5         65815-66047         c
            797-3648            AC134578.5         30679-33530         c
FEATURES             Location/Qualifiers
     source          1..3648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 30.28 cM"
     gene            1..3648
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="leucine rich repeat and Ig domain containing 1"
                     /db_xref="GeneID:235402"
                     /db_xref="MGI:MGI:1915522"
     exon            1..321
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            322..431
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            432..476
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            477..563
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            564..796
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     exon            797..3648
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2983..2988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="hexamer: AATAAA"
     polyA_site      3001
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
     polyA_site      3423
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
     polyA_site      3648
                     /gene="Lingo1"
                     /gene_synonym="4930471K13Rik; LERN1; LINGO-1; Lrrn6a;
                     UNQ201"
                     /note="major polyA site"
ORIGIN      
        1 gttagggatt ctgctggcat cgcagcgtgg agagcaggag gcaggagccg ggcgcgcagg
       61 ggagcgcggg ggctctgccg cgcacacgtc gtgcgcgctc tcttgtgcac atacactctt
      121 ttgcacacac acacacacac acacacacac acacacacac acacacacac acgccttttc
      181 tgcttcgttg gttgctgctg ccaccatctc ggagctgagc cctgcggagc gagaacccaa
      241 gctggagctg ggatcggagg cgagcccagc ctggtgatgc cggcccagag cagagccccg
      301 cgcggacgac tagctctgat gcctcctgta tccataggcc ctgagattct ggtacctatg
      361 ggcaaaaggg ccaactgaac caggcctagg ctgattccag cccagctgca cccagcacta
      421 cccagtcaca ggagtcctgc tggcgagctg tgagcctgga gtgaggcccc agagagtgca
      481 tgctgagact gagccccgaa ggctgctgtg tcctcaggcc tttggcagcc cctctgcttg
      541 gctccctgtg ccatctgacc caggagtcac gtgagcctcc ctctgggatc tggcatgaag
      601 gagaaatgga ttctggcttt cccgctctgg ctttccctga cttctccaga atctaagaag
      661 tgtcctgagg catctcttgc tctacctcag cccagaatcc ctgaggatcc atccagaaat
      721 ccaacgactt caagacctaa aaacatcagg cccctctccc tggacacaga cttgacagaa
      781 gtggccagtt catcaggtga gcgagaggat gctggcaggg ggtatgagaa gcatgcccag
      841 ccccctcctg gcctgctggc agcccatcct cctgctggta ctgggctcag tgctgtcagg
      901 ctctgctaca ggctgcccgc cccgctgcga gtgctcagcg caggaccgag ccgtgctctg
      961 ccaccgcaaa cgctttgtgg cggtgcccga gggcatcccc accgagactc gcctgctgga
     1021 cctgggcaaa aaccgcatca agacactcaa ccaggacgag tttgccagct tcccacacct
     1081 ggaggagcta gaactcaatg aaaacatcgt gagcgccgtg gagccaggcg ccttcaacaa
     1141 cctcttcaac ctgaggactc tggggctgcg cagcaaccgc ctgaagctta tcccgctggg
     1201 cgtcttcacc ggcctcagca acttgaccaa gctggacatc agtgagaaca agatcgtcat
     1261 cctgctagac tacatgttcc aagacctata caacctcaag tcgctggagg tcggcgacaa
     1321 cgacctcgtc tacatctccc atcgagcctt cagcggcctc aacagcctgg aacagctgac
     1381 gctggagaaa tgcaatctga cctccatccc cacggaggcg ctctcccacc tgcacggcct
     1441 catcgtcctg cggctacgac atctcaacat caatgccatc agggactact ccttcaagag
     1501 gctgtaccga cttaaggtct tagagatctc ccactggccc tacctggaca ccatgacccc
     1561 caactgcctc tacggcctca acctgacatc cctatccatc acgcactgca acctgacagc
     1621 cgtgccctat ctggcagtgc gtcacctggt ctatctccgt ttcctcaacc tttcctacaa
     1681 cccaatcggt acaatcgagg gctccatgct gcatgagctg ctgcggttgc aggagatcca
     1741 gctggtgggc gggcagctgg ccgtggtgga gccctatgcc tttcgtgggc tcaactacct
     1801 gcgtgtgctc aatgtctctg gcaaccagct gaccaccctg gaggagtcag ccttccattc
     1861 ggtgggcaac ctggagacgc tcatcctgga ctccaaccca ctggcctgtg actgccggct
     1921 gctgtgggtg ttccggcgcc gctggcggct caacttcaac aggcagcagc ccacctgcgc
     1981 cacacctgag ttcgtccagg gcaaagagtt caaggacttt ccggatgtac tcctacccaa
     2041 ctacttcacc tgccgccggg cccacatccg ggaccgcaag gcacagcagg tgtttgtaga
     2101 tgagggccac acggtgcagt ttgtatgccg ggcagatggc gaccctccac cagctatcct
     2161 ttggctctca ccccgcaagc acttggtctc ggccaagagc aatgggcggc tcacagtctt
     2221 ccctgatggc acgctggagg tgcgctacgc ccaggtacag gacaacggca cgtacctgtg
     2281 catcgcagcc aatgctggcg gcaacgactc catgcccgcc cacttgcatg tgcgcagcta
     2341 ctcgcctgac tggccccatc aacccaacaa gaccttcgcc ttcatctcca accagccagg
     2401 cgagggagag gccaacagca cccgcgccac tgtgcctttc cccttcgaca tcaagacgct
     2461 cattatcgcc accaccatgg gcttcatctc cttcctgggc gttgtcctat tctgcctggt
     2521 gctgctgttt ctatggagcc ggggcaaagg caacacaaag cacaacatcg aaattgagta
     2581 tgtgccccgg aaatcggacg caggcatcag ctcagctgat gcaccccgca agttcaacat
     2641 gaagatgata tgaggacggg gcagggtggg ggcacaggga ccccccaccc tcagtggaaa
     2701 cactgggcag ggaaggtgcc tggctgctgc cttcccacct cctccctgcc ctcctcacac
     2761 actctccccc tccccacact cgcctcgccc tcaccgcctg ccctccttct accaggattt
     2821 cagaaggcca ggcctgagga ccccacctgc acaggggcca gagttgacaa agccgacgaa
     2881 ccaacacgcg gcagagtcaa taattcaatt aaaaaaaaag ttacaaactt cctctgtaac
     2941 ttgggtttca ataattaatg gatttttatg aaaacttgaa ataataaaaa gaaaaaaact
     3001 atttcctata gctagtcgga atgcaaactt ttgacgtcct gatggctcca gggccttctt
     3061 ccaactcagt ttcttgtttt tctcttcctc ctcctcctct tcctcctctc tcttctcttc
     3121 ccctgtgggg agggatcact caggaaaaca gggaaggaga ttccagcccc accctctggc
     3181 ccactctgct gggcgccatt tggagccatg ggtgccagct cagctccagg cccagctcca
     3241 gctgtttttt tggcaggaag taggggaggg gataggactg cccagggggg atggggtttg
     3301 tctgctggat gtcaggcagc actaccaagg agaggtgggg gtcaggctcg ggtgtggctg
     3361 aaactgggat gggctggggt cctcctgggg aacagcacgg tcagtggaaa gagtcaggag
     3421 ccagaggcag gccgattcct ctcctctggt cccagctctg ctgctcactg ttgtgtgacc
     3481 tccttgcagg tcgctggccc ctcttgggcc tcagtctcca catctgtaca aatgggaaca
     3541 tttatccctg ccctgcctac ctcacagggc tgttgtgagg aactgatgag atgatgtatg
     3601 tgaaacactt tgtaatctgt aaagcgctgt gcacatgtgt gtgggtga
//
