LOCUS       NM_001103182            2968 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus lin-9 DREAM MuvB core complex component (Lin9),
            transcript variant 1, mRNA.
ACCESSION   NM_001103182
VERSION     NM_001103182.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2968)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2968)
  AUTHORS   Zhang,X., Li,M., Jiang,X., Ma,H., Fan,S., Li,Y., Yu,C., Xu,J.,
            Khan,R., Jiang,H. and Shi,Q.
  TITLE     Nuclear translocation of MTL5 from cytoplasm requires its direct
            interaction with LIN9 and is essential for male meiosis and
            fertility
  JOURNAL   PLoS Genet 17 (8), e1009753 (2021)
   PUBMED   34388164
  REMARK    GeneRIF: Nuclear translocation of MTL5 from cytoplasm requires its
            direct interaction with LIN9 and is essential for male meiosis and
            fertility.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2968)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   4  (bases 1 to 2968)
  AUTHORS   Grundl,M., Walz,S., Hauf,L., Schwab,M., Werner,K.M., Spahr,S.,
            Schulte,C., Maric,H.M., Ade,C.P. and Gaubatz,S.
  TITLE     Interaction of YAP with the Myb-MuvB (MMB) complex defines a
            transcriptional program to promote the proliferation of
            cardiomyocytes
  JOURNAL   PLoS Genet 16 (5), e1008818 (2020)
   PUBMED   32469866
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2968)
  AUTHORS   Iltzsche,F., Simon,K., Stopp,S., Pattschull,G., Francke,S.,
            Wolter,P., Hauser,S., Murphy,D.J., Garcia,P., Rosenwald,A. and
            Gaubatz,S.
  TITLE     An important role for Myb-MuvB and its target gene KIF23 in a mouse
            model of lung adenocarcinoma
  JOURNAL   Oncogene 36 (1), 110-121 (2017)
   PUBMED   27212033
REFERENCE   6  (bases 1 to 2968)
  AUTHORS   Knight,A.S., Notaridou,M. and Watson,R.J.
  TITLE     A Lin-9 complex is recruited by B-Myb to activate transcription of
            G2/M genes in undifferentiated embryonal carcinoma cells
  JOURNAL   Oncogene 28 (15), 1737-1747 (2009)
   PUBMED   19252525
  REMARK    GeneRIF: Lin-9 and B-Myb were both required for transcription of
            G(2)/M genes such as Cyclin B1 and Survivin.
REFERENCE   7  (bases 1 to 2968)
  AUTHORS   Pilkinton,M., Sandoval,R. and Colamonici,O.R.
  TITLE     Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4
            repressor complex or B-Myb in a cell cycle-phase-dependent context
            distinct from the Drosophila dREAM complex
  JOURNAL   Oncogene 26 (54), 7535-7543 (2007)
   PUBMED   17563750
  REMARK    GeneRIF: The repressor complex that Mip/LIN-9 forms with p107 takes
            functional precedence over the transcriptional activation linked to
            the Mip/LIN-9 and B-Myb interaction.
REFERENCE   8  (bases 1 to 2968)
  AUTHORS   Pilkinton,M., Sandoval,R., Song,J., Ness,S.A. and Colamonici,O.R.
  TITLE     Mip/LIN-9 regulates the expression of B-Myb and the induction of
            cyclin A, cyclin B, and CDK1
  JOURNAL   J Biol Chem 282 (1), 168-175 (2007)
   PUBMED   17098733
  REMARK    GeneRIF: Mip/LIN-9 is required for the expression of B-Myb, and
            both proteins collaborate in the control of the cell cycle
            progression via the regulation of S phase and cyclin A, cyclin B,
            and CDK1
REFERENCE   9  (bases 1 to 2968)
  AUTHORS   Sandoval,R., Xue,J., Tian,X., Barrett,K., Pilkinton,M., Ucker,D.S.,
            Raychaudhuri,P., Kineman,R.D., Luque,R.M., Baida,G., Zou,X.,
            Valli,V.E., Cook,J.L., Kiyokawa,H. and Colamonici,O.R.
  TITLE     A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by
            releasing the repression on E2F-regulated genes
  JOURNAL   Exp Cell Res 312 (13), 2465-2475 (2006)
   PUBMED   16730350
  REMARK    GeneRIF: Mutation of BARA/LIN-9 restores the expression of E2F
            target genes in CDK4 null Mouse Embryo Fibroblasts, indicating that
            the wild-type protein plays a role in the expression of genes
            required for the G1/S transition.
REFERENCE   10 (bases 1 to 2968)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167020.3.
            
            On Dec 22, 2021 this sequence version replaced NM_001103182.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089989.1, AF190325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC167020.3         78792-78847
            57-89               AC167020.3         85751-85783
            90-184              AC167020.3         88192-88286
            185-289             AC167020.3         89312-89416
            290-423             AC167020.3         96513-96646
            424-549             AC167020.3         98927-99052
            550-707             AC167020.3         103233-103390
            708-841             AC167020.3         104775-104908
            842-961             AC167020.3         106214-106333
            962-1063            AC167020.3         106582-106683
            1064-1144           AC167020.3         111514-111594
            1145-1270           AC167020.3         118550-118675
            1271-1450           AC167020.3         125410-125589
            1451-1548           AC167020.3         125713-125810
            1549-2968           AC167020.3         126718-128137
FEATURES             Location/Qualifiers
     source          1..2968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.46 cM"
     gene            1..2968
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /note="lin-9 DREAM MuvB core complex component"
                     /db_xref="GeneID:72568"
                     /db_xref="MGI:MGI:1919818"
     exon            1..56
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1654
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /note="lin-9 homolog; TUDOR gene similar 1 protein; type I
                     interferon receptor beta chain-associated protein"
                     /codon_start=1
                     /product="protein lin-9 homolog"
                     /protein_id="NP_001096652.3"
                     /db_xref="CCDS:CCDS48468.2"
                     /db_xref="GeneID:72568"
                     /db_xref="MGI:MGI:1919818"
                     /translation="MAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKG
                     RNAGPAVEMPFRNSKRSRLFSDEDDRQINTKSPKRNQRVAMIPQKFTATMSTPDKKAS
                     QKIGFRLRNLLKLPKAHKWCIYEWFYSNIDKPLFEGDNDFCVCLKESFPNLKTRKLTR
                     VEWGKIRRLMGKPRRCSSAFFEEERSALKQKRQKIRLLQQRKVADVSQFKDLPDEIPL
                     PLVIGTKVTARLRGIHDGLFTGQIDAVDTLNATYRVTFDRTGLGTHTIPDYEVLSNEP
                     HETMPISAFGQKQRPSRFFMTPPRLHYTPPLQSPITDGDPLLGQSPWRSKVSGSDTET
                     LGGFPVEFLIQVTKLSKILMIKKEHIKKLREMNTEAEKLKSYSMPIGIEFQRRYATIV
                     LELEQLNKDLNKVLHKVQQYCYELAPDQGLQPADQPTDMRRRCEEEAQEIVRQANSAS
                     GQPCVENENLTDLISRLTAILLQIKCLAEGGDLNSFEFKSLTDSLNDIKNTIDASNIS
                     CFQNNVEIHVAHIQSGLSQMGNLHAFAANNTNRD"
     exon            57..89
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..184
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            185..289
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            290..423
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            424..549
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            550..707
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..841
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..961
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1063
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1144
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1270
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1450
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1548
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..2968
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2945..2950
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /note="hexamer: AATAAA"
     polyA_site      2968
                     /gene="Lin9"
                     /gene_synonym="2700022J23Rik; Bara; Lin-9; mLin-9; TGS;
                     TGS1"
                     /note="major polyA site"
ORIGIN      
        1 gaaaaagcgg cgcggctcgt tcaagatggc ggagctcgac cagttgcctg acgagagctc
       61 ttcagcaaaa gcccttgtca gtttaaaaga gggaagttta tctaacacat ggaatgaaaa
      121 gtacagttct ttacagaaaa ctcctgtttg gaaaggcagg aatgcgggcc ctgctgtaga
      181 aatgcctttc agaaattcaa aaagaagtcg actcttttct gatgaagatg acagacaaat
      241 aaatacaaag tcacctaaaa gaaaccagag agtggcaatg atcccacaga aatttacagc
      301 aacgatgtca acaccagata agaaagcatc acagaagatt ggttttcgat tacggaacct
      361 actcaagctt cccaaagcac ataagtggtg catatatgag tggttctact caaacataga
      421 caagccactt tttgaaggag ataatgactt ttgtgtatgc ctaaaggaat cctttcctaa
      481 tttgaaaaca agaaaattaa caagagtaga atggggaaaa atcaggagac tgatgggaaa
      541 acctcggaga tgttcttctg cattttttga ggaagagaga tcagccttaa aacagaagcg
      601 gcagaaaatc aggctgttac aacaaaggaa agttgcagat gtttcacagt tcaaagatct
      661 ccccgatgaa atccctctac ccctggttat tggaaccaaa gttacagcgc ggttacgtgg
      721 cattcacgat ggcctgttta ctggtcagat agatgcagtg gacactctta atgctactta
      781 cagagtaact ttcgatagga caggccttgg gactcacacc attcctgact atgaagttct
      841 tagtaatgag cctcatgaga caatgccaat ctctgccttt ggacaaaaac agcggccttc
      901 tcggtttttt atgacccccc cacggttaca ttatacccct cctctccagt caccaattac
      961 agatggcgat cctttactgg ggcagtcacc ttggagaagt aaagtttctg gctctgacac
     1021 ggagacgtta ggaggctttc cagtggaatt ccttatccag gtgactaagt tatcaaaaat
     1081 tctcatgatt aaaaaagagc atataaagaa attaagggag atgaacacag aagcagaaaa
     1141 gctgaaatcc tattccatgc ccattggcat tgagtttcag cggagatacg caacgatcgt
     1201 cctggagctt gagcagctga acaaggacct gaacaaagtt ctgcataaag ttcagcagta
     1261 ttgctatgag cttgcaccag accagggact ccagcctgcc gatcagccaa cagacatgag
     1321 acggaggtgt gaggaagaag cccaggaaat cgtccggcaa gccaactctg cttccggaca
     1381 gccctgtgta gaaaacgaaa atctgacgga cttgatctcc aggctcactg cgattttatt
     1441 acaaattaag tgtctggcag agggaggaga cctgaattcc tttgaattca aatctctcac
     1501 agattcatta aatgacataa aaaacacaat agatgcttct aatatcagtt gttttcagaa
     1561 taacgtagaa atccatgttg cacatatcca gagtggcctg agtcagatgg gaaacttaca
     1621 cgcctttgca gccaacaaca cgaacagaga ctgagcacag gattctggta cccagctgca
     1681 cacagccatg gtctgaggag tcctggtcct taacccatgc ttccaacacc agataaccta
     1741 gctgctggaa aaccggagaa ctgtacatct ccagatacgg ctttttaata cactctactg
     1801 cttcttcaac cagcattgtg ctgaccagca tttatttatt gttcttttat tatccagatg
     1861 cagtagtgtt gcttatattt cctgtttatc agcaaacatt tttaaccgga aactctctga
     1921 acgtactatc ccatggagga taaaccactg ttttatgcat gcatgaattc tgctcagcac
     1981 atgcagacga ctcctgtgac agacagagaa catgaagaag cacggtcttt ccatgcatga
     2041 tggtgggaat cccatccgag agtcaccggt ccagtggagt tagttggcat tatatcttgg
     2101 gctgcaaaat agacgtcatg agtgtgagag tccgagtcgt aaggaacccg ctggggtaca
     2161 gatgggaaac acggacttaa gtgtatgttt catatactga cagtgggaca tggttctata
     2221 gatcaattat aataataaat attttaattt atcataattt ataaaagctt tgttgtttat
     2281 cagcagagga aatgaaggag ccggaggaac tgtactgtgc cccgctggat cccagcgggt
     2341 ggacttggca tgccttccat gattcagggc aaaagtgtta agtgttgaga cttattttaa
     2401 aaaagactga tgacacacta ttttcgtatt tttttgttta tttgcacaac tttaaaccag
     2461 atgactggtt aaaattgaac agtacacaat ttataaagtg aaaatctttt ataaggaaag
     2521 catatgacat gtgaatacac agggaggttt ggctttggtt gttttgtttg gttttgtttt
     2581 ttctttttaa gaaaaaccct gcctaaaata atcttgtaaa aagtatgtat tttaaaattt
     2641 ttgttttaat atagaatatt ataaagccaa aatataattg ttttcagatt tggagtttaa
     2701 aatagagcta tagaggtggt tctgattctt tgacgtctca taaaatgaga cttttgtata
     2761 ttaatgtata ataaaactga aataagatta ttttccttga aatttttgta tagtttaaaa
     2821 atgcttctgt gttctttgtt ggtattgggc cactgcagat cttagtgcag agtttatatt
     2881 tagctagact gttatgttaa ttaagaaatg cataaatctt ttattcttaa tatttgtaat
     2941 tctaaataaa tcaatctatg aaatttaa
//
