LOCUS       NM_011699               4221 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus lin-7 homolog C, crumbs cell polarity complex
            component (Lin7c), mRNA.
ACCESSION   NM_011699 NM_133846 NM_173183
VERSION     NM_011699.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4221)
  AUTHORS   Hoekstra,E.J., von Oerthel,L., van der Linden,A.J.,
            Schellevis,R.D., Scheppink,G., Holstege,F.C., Groot-Koerkamp,M.J.,
            van der Heide,L.P. and Smidt,M.P.
  TITLE     Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the
            correct specification of rostral and medial mdDA neurons
  JOURNAL   Eur J Neurosci 37 (1), 23-32 (2013)
   PUBMED   23106268
REFERENCE   2  (bases 1 to 4221)
  AUTHORS   Crespi,A., Ferrari,I., Lonati,P., Disanza,A., Fornasari,D.,
            Scita,G., Padovano,V. and Pietrini,G.
  TITLE     LIN7 regulates the filopodium- and neurite-promoting activity of
            IRSp53
  JOURNAL   J Cell Sci 125 (Pt 19), 4543-4554 (2012)
   PUBMED   22767515
REFERENCE   3  (bases 1 to 4221)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   4  (bases 1 to 4221)
  AUTHORS   Varelas,X., Samavarchi-Tehrani,P., Narimatsu,M., Weiss,A.,
            Cockburn,K., Larsen,B.G., Rossant,J. and Wrana,J.L.
  TITLE     The Crumbs complex couples cell density sensing to Hippo-dependent
            control of the TGF-beta-SMAD pathway
  JOURNAL   Dev Cell 19 (6), 831-844 (2010)
   PUBMED   21145499
REFERENCE   5  (bases 1 to 4221)
  AUTHORS   Lozovatsky,L., Abayasekara,N., Piawah,S. and Walther,Z.
  TITLE     CASK deletion in intestinal epithelia causes mislocalization of
            LIN7C and the DLG1/Scrib polarity complex without affecting cell
            polarity
  JOURNAL   Mol Biol Cell 20 (21), 4489-4499 (2009)
   PUBMED   19726564
  REMARK    GeneRIF: Data show that CASK expression and the appropriate
            localization of DLG1 and LIN7c are not essential for either
            epithelial polarity or intestinal homeostasis in vivo.
REFERENCE   6  (bases 1 to 4221)
  AUTHORS   Setou,M., Nakagawa,T., Seog,D.H. and Hirokawa,N.
  TITLE     Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA
            receptor-containing vesicle transport
  JOURNAL   Science 288 (5472), 1796-1802 (2000)
   PUBMED   10846156
REFERENCE   7  (bases 1 to 4221)
  AUTHORS   Kamberov,E., Makarova,O., Roh,M., Liu,A., Karnak,D., Straight,S.
            and Margolis,B.
  TITLE     Molecular cloning and characterization of Pals, proteins associated
            with mLin-7
  JOURNAL   J Biol Chem 275 (15), 11425-11431 (2000)
   PUBMED   10753959
REFERENCE   8  (bases 1 to 4221)
  AUTHORS   Jo,K., Derin,R., Li,M. and Bredt,D.S.
  TITLE     Characterization of MALS/Velis-1, -2, and -3: a family of mammalian
            LIN-7 homologs enriched at brain synapses in association with the
            postsynaptic density-95/NMDA receptor postsynaptic complex
  JOURNAL   J Neurosci 19 (11), 4189-4199 (1999)
   PUBMED   10341223
REFERENCE   9  (bases 1 to 4221)
  AUTHORS   Borg,J.P., Straight,S.W., Kaech,S.M., de Taddeo-Borg,M.,
            Kroon,D.E., Karnak,D., Turner,R.S., Kim,S.K. and Margolis,B.
  TITLE     Identification of an evolutionarily conserved heterotrimeric
            protein complex involved in protein targeting
  JOURNAL   J Biol Chem 273 (48), 31633-31636 (1998)
   PUBMED   9822620
REFERENCE   10 (bases 1 to 4221)
  AUTHORS   Butz,S., Okamoto,M. and Sudhof,T.C.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845423.4.
            
            On Oct 27, 2022 this sequence version replaced NM_011699.3.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128989.1, BC052471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL845423.4         61749-61810
            63-181              AL845423.4         65354-65472
            182-253             AL845423.4         65997-66068
            254-463             AL845423.4         67125-67334
            464-4221            AL845423.4         68135-71892
FEATURES             Location/Qualifiers
     source          1..4221
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.65 cM"
     gene            1..4221
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /note="lin-7 homolog C, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:22343"
                     /db_xref="MGI:MGI:1330839"
     exon            1..62
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..619
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /note="vertebrate lin-7 homolog 3; lin-7 homolog C;
                     mammalian lin-seven protein 3; vertebrate homolog of C.
                     elegans Lin-7 type 3; lin 7 homolog c"
                     /codon_start=1
                     /product="protein lin-7 homolog C"
                     /protein_id="NP_035829.1"
                     /db_xref="CCDS:CCDS16509.1"
                     /db_xref="GeneID:22343"
                     /db_xref="MGI:MGI:1330839"
                     /translation="MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQS
                     EFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEG
                     LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELL
                     KAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT"
     exon            63..181
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     exon            182..253
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     exon            254..463
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..4221
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4118..4123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /note="hexamer: AGTAAA"
     polyA_site      4155
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /note="major polyA site"
     regulatory      4190..4195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /note="hexamer: AATATA"
     polyA_site      4221
                     /gene="Lin7c"
                     /gene_synonym="9130007B12Rik; D2Ertd520e; LIN-7-C; LIN-7C;
                     MALS-3; Veli3"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtctgc acctccgaag agaagatggc ggcgctgggc gaacctgtcc ggctggaaag
       61 ggatatctgc agagcaattg aattgttgga gaaattacag aggagtggag aggtgccgcc
      121 acagaaactt caggctttgc aaagagtcct tcagagtgag ttctgcaatg ctgtaagaga
      181 ggtatacgaa catgtttatg agacggtgga catcagcagc agccctgaag tgagagccaa
      241 tgcaactgca aaggctactg ttgctgcatt tgctgccagt gaaggacact ctcatccccg
      301 agttgttgag ctacccaaaa cagaagaggg ccttggattc aatattatgg gaggcaaaga
      361 gcaaaactca ccaatctata tatcgcggat aattccaggt ggaattgctg acagacatgg
      421 gggcctcaaa cgaggagatc agctactttc tgttaatgga gtgagtgttg aaggggagca
      481 ccatgagaaa gcggtagagc tactgaaagc agcccaaggg aaggttaaat tagtcgtacg
      541 gtacacacca aaagtcttgg aagaaatgga gtcccgcttt gagaaaatga gatcagcaaa
      601 acgcagacaa cagacctaat catttaaaaa ctttgtgttc cttttgcttt tagctaggaa
      661 agttttactt gtgacctact gatggcctcc acgccagtga ttgtaaaaca ccagaaactt
      721 cggtgacctc ttcttgccat tttataaatg cctgttttag catcacttat ggttatagag
      781 aagcatacac tgtttttctc acgagaaaaa gtcagagttg gtgaggacag ttctgtcctg
      841 ctgtttttac aggccttttt caaacagatt ttgtcacaaa gttgttatag atttttaata
      901 atgctttttt aatattaaaa tgtactttta cattcttaat ctttttttaa aaagaggttc
      961 tctttatttg gcaacttatt tacagataac agctctccaa tatttccttt tgcttactgc
     1021 agtttctttg tgaaatttca tttttccaag aaatgaaaca tcgcagtctc gctcgtggca
     1081 gttcatcacg ttatgagtat tggcgtctct gctgcctttt gtacttggaa cataacatat
     1141 ctataatcag tggtaaatca tagctatcat ggaacctttt tatttttatt taaacaatgt
     1201 ataatgtatt catttatact gatttataaa agtttttaaa cactgaagca atcattgcta
     1261 aaatatgttt ttcataatat ttaagcagtg aggctggagg atgtaatctg attattagca
     1321 ttaccaatta aatctttatt tatatataac agtatgtcat aaattataca tgcaaacaag
     1381 ctcagatttc aacttttcaa gttttttatg ctgttcattt gaatttaaat atatttctca
     1441 taatttggtt ctttcatgcc tagagatgag tcagtgctgg ggagaatgga agtaagacaa
     1501 ggtggtgact tctaactctg gagcctgaag agccatgcat gcattcttac tatcctagcc
     1561 tcagcaccgg ctggaggtgg caagggcagg agggatgtgt ctaagataca gagacaggtg
     1621 gcttcataag tctcaccgtg ggtggggctc gggacgattt ctgtcttgat gattcaaata
     1681 gtaatgggag tttggaacaa tactttttac catttgtcca ctggatgtca ccggtttcct
     1741 aaaaggcagc tattgataaa tgattgggac tatggtctac taaaagctga aatcaaagtg
     1801 attaattttc agtcacagat tataggaaca tttgtaaagg gtgtaagtga tggtgttaaa
     1861 aagaaaccgt tgggttgaaa atggaggaat ttgtcataat tatgactatt acctttattt
     1921 ttaaaaaatg ggcattttgt aacattcctt caggaagaat ggaagtgtgt atgtttttct
     1981 gcatggtgtg agcattgtga gtcttacaag attactgcag ttttcagagt aaaagtcaat
     2041 caacatgtta tttatcactt aggaattgaa cactggattg tgcatggttg aatgtcttta
     2101 gtccactgca aatgtgcttg acattgataa gatcatgctg aactgtatat tttcagaatt
     2161 agctcatgtg tttttaaaat gttgagacca aagtagtata gaagagtatg acgtatttta
     2221 atttaattgt aaaattatta gaggtaattg ttttaaaact atattaaaga aaagcgttgg
     2281 tgcatataga acagtaccgt tattgttatg ctcgtatttc tgcatcccag ggttaggaaa
     2341 ccctgaggaa cccttgtctt agtgtagcta ctgtggctgc agttgctcca gaggtcgcat
     2401 cagcattccg tgatggttac agcttcctgg ttttatgttt cagctgttgc agaatttcag
     2461 ccaagttact tttttttttt cttaagttat gttgaaaaag cttttttttt tctttttctt
     2521 cagtaaccca cagtctgttc tttgtgtggg ccggcaccta tttataactc ttaaaataaa
     2581 aacaacttaa aggagccaaa tacatagctg ttcttggtac tgttgcgcat gagtagcaat
     2641 actttgcttt catcgatgcg attctcctat ctcagaattt taaatactga ccataggaaa
     2701 gtcagtgaca agtgtacagt agtctgcttg tgtacttagg aaggggatga attctaatta
     2761 atatatggat gatttgtgaa taaagctagg cagtaaatat ataaagggtg ttcgtttgac
     2821 ttgtagctta caaatgtaaa tttcccttag ccccagtttt ccatctattt tcttatacag
     2881 ttcacagtga gttgaggcga cttggcgatt cttggcctta gccgttgtta gatgccctgc
     2941 agatgtacaa ctcacccagg tcccttcccg tgcagctgat ttgtgacgcg tttatccatt
     3001 gtctgtagag gctcgtctgc acacccaggc ttcaggggta ccagctcatg gactttctgg
     3061 ttatgctgga ctctgtttgc aagtactttt agtctgatgt gattctattt ctcagtacct
     3121 ctttatggac ttaagaggta tttggcattc cttattaaca aaataattac aatctacttt
     3181 ttttttaagc tctggctgtc ctggaacact ctgtaaacca tgctagcttc cttttgtttt
     3241 cccatttttg ttttccaaaa taaaacctac tagtaattca attgtaaaat cttagtgttt
     3301 tctccttctg tcccctttac ctttaaaaaa acctataaag gttcttattt gaagagcatg
     3361 tttaagtgtt gccgatgtga gcgcactgtg agggtgagtc tggcttgtta gatggggctc
     3421 ctttgccttt actgtactgc tatactacat ggatgtagtc ctgttcttta gggtctcgct
     3481 ttttaagatc atcttcctgt tgtaaaagtt taaggcattt tgctcaagta ctttgtttac
     3541 agttaaaatg aatagaattt aatagaaaat acggttatgg cttacctgga aagcgtcagc
     3601 atgacttggc atagacgtaa aagagtacat gtgattatac tgtggaatga tactgataag
     3661 gactctcgta attgtacctc ctgaataagt ctgtgcattt tctaacttac agttcattgt
     3721 ctgttctagc aacaatctca ttttgtagtt tttattctcc aaaacttatg agtaatgttt
     3781 cctcaaaggt tgttgaaata ataatagtta cataatgggg gaaagtcatt tgattattaa
     3841 ttttcaagaa gttttaaact aatttgtaac tggacatggt ttttaaaaat attggcaaag
     3901 atttgataca cttgtactct ttagtttgag aaaattattt ggaatgtgaa acagtgcttt
     3961 ttcaaataga tgaatcattt agcaattaaa ttctgattct aaggcttatt taaaatgtat
     4021 ttgtatgagt cgtgcttgtc ctttgcattt gacaaaattg atacaattac aaatcgatgt
     4081 atttctgaac gccgtgtgta aaacaacctt tacatagagt aaaaaccaaa atccgtggtg
     4141 gttcctgaca tgaaacttca gatgtctgta ttttgtttgc ctttcgtaaa atataagtaa
     4201 agaaaacttt ctcttctgtt a
//
