LOCUS       NM_011698                746 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lin-7 homolog B, crumbs cell polarity complex
            component (Lin7b), mRNA.
ACCESSION   NM_011698 XM_001002360
VERSION     NM_011698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 746)
  AUTHORS   Karataeva,A.R., Klaassen,R.V., Stroder,J., Ruiperez-Alonso,M.,
            Hjorth,J.J., van Nierop,P., Spijker,S., Mansvelder,H.D. and
            Smit,A.B.
  TITLE     C-terminal interactors of the AMPA receptor auxiliary subunit
            Shisa9
  JOURNAL   PLoS One 9 (2), e87360 (2014)
   PUBMED   24498314
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 746)
  AUTHORS   Zhang,J., Yang,X., Wang,Z., Zhou,H., Xie,X., Shen,Y. and Long,J.
  TITLE     Structure of an L27 domain heterotrimer from cell polarity complex
            Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly
            mode
  JOURNAL   J Biol Chem 287 (14), 11132-11140 (2012)
   PUBMED   22337881
  REMARK    GeneRIF: the crystal structure of a 4-L27 domain-containing
            heterotrimer derived from the tripartite complex Patj/Pals1/Mals2
REFERENCE   3  (bases 1 to 746)
  AUTHORS   Zhang,J., Yang,X., Shen,Y. and Long,J.
  TITLE     Crystallization and preliminary X-ray data collection of the
            L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) tripartite complex
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 67 (Pt 11),
            1443-1447 (2011)
   PUBMED   22102253
  REMARK    GeneRIF: Crystals of tripartite complex 1 of
            L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) diffracted to 2.05 A
            resolution
REFERENCE   4  (bases 1 to 746)
  AUTHORS   Zucker,B., Kama,J.A., Kuhn,A., Thu,D., Orlando,L.R., Dunah,A.W.,
            Gokce,O., Taylor,D.M., Lambeck,J., Friedrich,B., Lindenberg,K.S.,
            Faull,R.L., Weiller,C., Young,A.B. and Luthi-Carter,R.
  TITLE     Decreased Lin7b expression in layer 5 pyramidal neurons may
            contribute to impaired corticostriatal connectivity in huntington
            disease
  JOURNAL   J Neuropathol Exp Neurol 69 (9), 880-895 (2010)
   PUBMED   20720508
  REMARK    GeneRIF: Data suggest that decreased cortical LIN7b expression may
            contribute to abnormal corticostriatal connectivity in Huntington
            disease.
REFERENCE   5  (bases 1 to 746)
  AUTHORS   Lozovatsky,L., Abayasekara,N., Piawah,S. and Walther,Z.
  TITLE     CASK deletion in intestinal epithelia causes mislocalization of
            LIN7C and the DLG1/Scrib polarity complex without affecting cell
            polarity
  JOURNAL   Mol Biol Cell 20 (21), 4489-4499 (2009)
   PUBMED   19726564
REFERENCE   6  (bases 1 to 746)
  AUTHORS   Feng,W., Long,J.F. and Zhang,M.
  TITLE     A unified assembly mode revealed by the structures of tetrameric
            L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1
            scaffold proteins
  JOURNAL   Proc Natl Acad Sci U S A 102 (19), 6861-6866 (2005)
   PUBMED   15863617
  REMARK    GeneRIF: analysis of structures of tetrameric L27 domain complexes
            formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins
REFERENCE   7  (bases 1 to 746)
  AUTHORS   Misawa,H., Kawasaki,Y., Mellor,J., Sweeney,N., Jo,K., Nicoll,R.A.
            and Bredt,D.S.
  TITLE     Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and
            molecular compensation in knockout mice
  JOURNAL   J Biol Chem 276 (12), 9264-9272 (2001)
   PUBMED   11104771
REFERENCE   8  (bases 1 to 746)
  AUTHORS   Setou,M., Nakagawa,T., Seog,D.H. and Hirokawa,N.
  TITLE     Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA
            receptor-containing vesicle transport
  JOURNAL   Science 288 (5472), 1796-1802 (2000)
   PUBMED   10846156
REFERENCE   9  (bases 1 to 746)
  AUTHORS   Jo,K., Derin,R., Li,M. and Bredt,D.S.
  TITLE     Characterization of MALS/Velis-1, -2, and -3: a family of mammalian
            LIN-7 homologs enriched at brain synapses in association with the
            postsynaptic density-95/NMDA receptor postsynaptic complex
  JOURNAL   J Neurosci 19 (11), 4189-4199 (1999)
   PUBMED   10341223
REFERENCE   10 (bases 1 to 746)
  AUTHORS   Butz,S., Okamoto,M. and Sudhof,T.C.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF173082.1.
            
            [WARNING] On Jun 17, 2024 this sequence was replaced by
            NM_011698.2.
            
            On May 4, 2006 this sequence version replaced XM_001002360.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF173082.1, BC031780.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.28 cM"
     gene            1..746
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /note="lin-7 homolog B, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:22342"
                     /db_xref="MGI:MGI:1330858"
     exon            1..43
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..630
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /note="veli-2; vertebrate lin-7 homolog 2; mammalian
                     lin-seven protein 2; vertebrate homolog of C. elegans
                     Lin-7 type 2; lin 7 homolog b; lin-7 homolog B"
                     /codon_start=1
                     /product="protein lin-7 homolog B"
                     /protein_id="NP_035828.1"
                     /db_xref="CCDS:CCDS21239.1"
                     /db_xref="GeneID:22342"
                     /db_xref="MGI:MGI:1330858"
                     /translation="MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQS
                     RFCSAIREVYEQLYDTLDITGSAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDEG
                     LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELL
                     KAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHHSYTSLESRG"
     exon            44..162
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            163..234
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            235..444
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            445..608
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            609..716
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      716
                     /gene="Lin7b"
                     /gene_synonym="LIN-7B; MALS-2; Veli2"
                     /note="major polyA site"
ORIGIN      
        1 ggcgatatgg ctgcactggt ggagccgctg gggctggagc gggacgtgtc ccgggctgtg
       61 gagctgctgg agcggctgca gcgcagcgga gagctgcccc cgcagaagct gcaggccctg
      121 cagcgggtcc tgcagagtcg cttctgctcc gccatccgcg aggtgtatga acagctctat
      181 gacacgctgg acatcactgg cagcgccgag gtgcgggctc atgccacagc taaggccaca
      241 gtggctgctt tcacggccag tgagggccac gcacatccca gggtcgtgga actaccgaag
      301 actgatgagg gtttgggctt caacatcatg ggtggcaagg agcagaactc acccatctat
      361 atctctcgag tcatccctgg gggcgtggct gatcgccatg gtggcctcaa gaggggagac
      421 cagctgctgt ctgtgaatgg tgtgagtgtg gaaggcgaac accatgaaaa ggcggtggaa
      481 ctcctgaagg ctgcacaggg ctcagtgaaa ctggtggtgc gctacactcc tcgggtgctg
      541 gaggagatgg aagcccgctt cgagaagatg cgatctgccc gtcggcgcca gcagcaccac
      601 agctacacgt ccttggagtc tcgaggctga aatcacagac caggaccctc cttctcctcc
      661 cctgtacagt attatttatt gtcactggct ccttatttaa agatctttaa ccctcaaaaa
      721 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
