LOCUS       NM_001039354            5878 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus lin-7 homolog A, crumbs cell polarity complex
            component (Lin7a), transcript variant 1, mRNA.
ACCESSION   NM_001039354
VERSION     NM_001039354.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5878)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5878)
  AUTHORS   Singh,S., Howell,D., Trivedi,N., Kessler,K., Ong,T., Rosmaninho,P.,
            Raposo,A.A., Robinson,G., Roussel,M.F., Castro,D.S. and
            Solecki,D.J.
  TITLE     Zeb1 controls neuron differentiation and germinal zone exit by a
            mesenchymal-epithelial-like transition
  JOURNAL   Elife 5, e12717 (2016)
   PUBMED   27178982
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5878)
  AUTHORS   Rowton,M., Ramos,P., Anderson,D.M., Rhee,J.M., Cunliffe,H.E. and
            Rawls,A.
  TITLE     Regulation of mesenchymal-to-epithelial transition by PARAXIS
            during somitogenesis
  JOURNAL   Dev Dyn 242 (11), 1332-1344 (2013)
   PUBMED   24038871
REFERENCE   4  (bases 1 to 5878)
  AUTHORS   Crespi,A., Ferrari,I., Lonati,P., Disanza,A., Fornasari,D.,
            Scita,G., Padovano,V. and Pietrini,G.
  TITLE     LIN7 regulates the filopodium- and neurite-promoting activity of
            IRSp53
  JOURNAL   J Cell Sci 125 (Pt 19), 4543-4554 (2012)
   PUBMED   22767515
  REMARK    GeneRIF: LIN7 is a novel regulator of IRSp53.
REFERENCE   5  (bases 1 to 5878)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   6  (bases 1 to 5878)
  AUTHORS   Karnak,D., Lee,S. and Margolis,B.
  TITLE     Identification of multiple binding partners for the amino-terminal
            domain of synapse-associated protein 97
  JOURNAL   J Biol Chem 277 (48), 46730-46735 (2002)
   PUBMED   12351654
REFERENCE   7  (bases 1 to 5878)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   8  (bases 1 to 5878)
  AUTHORS   Misawa,H., Kawasaki,Y., Mellor,J., Sweeney,N., Jo,K., Nicoll,R.A.
            and Bredt,D.S.
  TITLE     Contrasting localizations of MALS/LIN-7 PDZ proteins in brain and
            molecular compensation in knockout mice
  JOURNAL   J Biol Chem 276 (12), 9264-9272 (2001)
   PUBMED   11104771
REFERENCE   9  (bases 1 to 5878)
  AUTHORS   Setou,M., Nakagawa,T., Seog,D.H. and Hirokawa,N.
  TITLE     Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA
            receptor-containing vesicle transport
  JOURNAL   Science 288 (5472), 1796-1802 (2000)
   PUBMED   10846156
REFERENCE   10 (bases 1 to 5878)
  AUTHORS   Perego,C., Vanoni,C., Villa,A., Longhi,R., Kaech,S.M., Frohli,E.,
            Hajnal,A., Kim,S.K. and Pietrini,G.
  TITLE     PDZ-mediated interactions retain the epithelial GABA transporter on
            the basolateral surface of polarized epithelial cells
  JOURNAL   EMBO J 18 (9), 2384-2393 (1999)
   PUBMED   10228153
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140338.3, AC116325.5 and AC155168.3.
            
            On Jul 1, 2022 this sequence version replaced NM_001039354.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.234496.1,
                                           SRR9219379.12274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               AC140338.3         95563-95662         c
            101-219             AC140338.3         43476-43594         c
            220-291             AC116325.5         153418-153489
            292-501             AC116325.5         155842-156051
            502-720             AC116325.5         185291-185509
            721-3659            AC116325.5         193327-196265
            3660-5878           AC155168.3         77524-79742
FEATURES             Location/Qualifiers
     source          1..5878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 55.83 cM"
     gene            1..5878
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /note="lin-7 homolog A, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:108030"
                     /db_xref="MGI:MGI:2135609"
     exon            1..100
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..720
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein lin-7 homolog A; vertebrate lin-7 homolog 1;
                     mammalian lin-seven protein 1; mammalian LIN-7 1;
                     vertebrate homolog of C. elegans Lin-7 type 1; lin 7
                     homolog a"
                     /codon_start=1
                     /product="protein lin-7 homolog A isoform 1"
                     /protein_id="NP_001034443.1"
                     /db_xref="CCDS:CCDS24160.1"
                     /db_xref="GeneID:108030"
                     /db_xref="MGI:MGI:2135609"
                     /translation="MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGE
                     VPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEG
                     HSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNG
                     VSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQ
                     QQQQQQQQPQQNHMS"
     exon            101..219
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..291
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..501
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..720
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..5878
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1021..1026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /note="hexamer: AATAAA"
     polyA_site      1046
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /note="major polyA site"
     regulatory      5857..5862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
                     /note="hexamer: AGTAAA"
     polyA_site      5878
                     /gene="Lin7a"
                     /gene_synonym="LIN-7A; MALS-1; TIP-33; Veli; Veli1"
ORIGIN      
        1 cactacaagc ggttgctgat gctgaagccg agcgtcactt cggctcccac ggcagacatg
       61 gcgacattga cagtggtcca gccgcttact ctggacagag atgttgcaag agcaatcgaa
      121 ctactggaaa agctacaaga atctggagaa gtaccagtgc acaagctcca gtctctcaaa
      181 aaggtgcttc agagtgagtt ttgtacagca atccgagagg tgtatcaata catgcatgaa
      241 acgattactg ttaatggctg ccctgaattc cgtgcgaggg ccacagcaaa ggcaacagtt
      301 gcagcttttg cagccagcga aggccactcc caccctcggg tagttgaact gccaaagact
      361 gatgaaggcc tgggttttaa tgtgatggga gggaaggaac agaattcccc gatttacatc
      421 tcccgcatca tccctggagg ggtggctgaa agacatggag gcctcaaaag aggggaccag
      481 ctgctatcag tgaacggagt gagtgtggaa ggggagcacc atgagaaagc tgtggaactt
      541 ctcaaggctg ctaaggacag tgtgaagctg gtggtcagat acaccccaaa agtcctggaa
      601 gagatggagg ctcgtttcga gaagctgcgg acagctcggc gtcgacagca gcagcagttg
      661 ctcattcagc agcagcaaca gcagcagcaa caacaaccac aacaaaacca catgtcatag
      721 gcgctcgaag gaaagctagc aggtcaatca tccgccagtc acaaatttgg aacccgtgct
      781 ccggaatccc agcacacaga aaaagggaaa gaaaacacca gtaatgacac ccgtcacaaa
      841 gctgtgaaca catggtgtat ccattcgtta ccaaggcaat tcagtatctt cctcctctgg
      901 gcaccagccc cccattcatt gcttttttac ctactcagac cttttccatc catgtcagtg
      961 gaaactcgca gtgtattgag ggagtgaagt attccagtct gcagactgaa acagtgtaag
     1021 aataaagtcc gtgacttttg aacaaatcac ctgggctagg attaagtgaa tctttggtct
     1081 aaggctcctc cggagattag caaacccttc attaggctat cgttcaaact gcatcagttc
     1141 aaggttgtgg ccacgtgaaa ggaacctaca cattgacctc tgccctcacc ccttccacag
     1201 tctatgttgc agagctgtct gaattggaat ttgatttagc tacaacctcc attcttctga
     1261 aaatgccgag ttcttatcct acttaatctg ttctgaactt ggaaacagtt ggctttttaa
     1321 tttttttcat ttctaccaat gtccaaacac atcagctgaa ggttttttgt tttttgtttt
     1381 ttttatttta ggatgtttta ggcaaacttt taatttatta gcagtgaagg ttggaacttg
     1441 atgctatcct tttttaaaag tcaggtattg cctgtattga atattagttc agacagaata
     1501 taatgtgtat ttgttccaca aaatatataa gaccggagta cacgtgttat aacttggctc
     1561 tttgtttatc aagggtcact actctggtaa gcgactctct tggttttatg aattcctcct
     1621 cacttgatat atgtaacctg ccctcaatac tttcttgtta aattttattt actcatttcc
     1681 attgatgaac tttggagaag tctaagccca ttctgcacac actaatgtgc tttcatagaa
     1741 atcaagttga tattttaaat cttggagatt tataaaactg aattataata tgtgcacata
     1801 gatattctcc aaagggatat atcacacaaa gtttagatgg gcaaccgtaa ataccaattt
     1861 tatatttttg acagtctaag atcaaaggta ctggccctct tccgttgagg tatgtagtac
     1921 ccactgatac cagtattgta aatgacagac actgctttct ctgaggggaa gtctgtttca
     1981 tttttgcaca ttcccatttg taaataaaca gtcagacttt tttagctatc acaaagatct
     2041 attagaacct cctgtacaca caatattttt ttttatttag ggtacatcta gacatctaat
     2101 ttggttttcc ataatgcaat gaatagacat ttaaacacca taagcacaaa aatgtacaca
     2161 cacacacaca tacacacaca cacacacaca cacacataca cacaccaaaa aaaacaaaaa
     2221 acaaacaaac aaaaaaaacg aaaaacaaaa aatgcaagca gatggatgga tcatcaaaac
     2281 agagtccaat attttaatat gtccattttt tttcaaaagc agaaaatggt tcccacaaga
     2341 tacaaagaat ttgatatttc agataatcct ctagcataga aatttgtgaa gctcagctca
     2401 caagccatcc tcctgaaact aaacaaaacc aattagatgt acccagcatg ttctgtctca
     2461 caccatcggg tggtactctt gtcaatagcc atttcttact gctttagata gtgcatcgcc
     2521 cgccgggtga caaacagcca gaaaaccaag agctacacca atttatttca acactatctt
     2581 attgtggtaa cagagtccca tcctcaaaaa catatcattg gttttttttt ttcctagaga
     2641 gagattgggg gaggggtcag cgaggaccca gaatgttata taaaataggt caataaaagg
     2701 gacaagcatg acaaaaaaaa ttaagtgcag actatatgag tattattcag tttgaaagat
     2761 agttctcatt tttataaaaa aaattgtaat aaacctatat tttagttatc attcaacaaa
     2821 gatattaaag ctattcagga gatgccacca aactctcata aaaggaaacc atctcaccct
     2881 tacaatgaga aaatggtcat ttcaatgagt ttcagtacat tgtatacatt tggagtttaa
     2941 gatgaatata tttttccctt agctgttaag tgtttagtta ataccaaact taatatatga
     3001 tttcacatca gtacaagtgt tgtcagaagc aaccatgaaa taatcagata cttcatgctg
     3061 gtgtttttta gaagtctttg aattttttgc ttcatttgta caacatgtac tgctgatgaa
     3121 tgtttgccag gttgtttgtc aaaatgaagc aatccatcat acgcacagaa gccaagggat
     3181 aggttatatg tctccatggt cttacataca aatggctggt tctctttagt gaaatttagc
     3241 tcattgaaat gtaagtattt ctctagaatt ttaatcaaaa gggacacaca cacacccctc
     3301 caaagactta cagaaacccc cagcgcatct ctgacatttc cctgaagcaa gatggaaagg
     3361 gaagaacaaa ttcaaccatg atttttactg aacttctcta ttcccaagag tcacatacag
     3421 agtctccgac atgtctgatg tcattcattt aaagaaaaga ctgtgcttcc atgcagttca
     3481 acatagatac gataagtggg gtgttaaaag ttagggaaaa gtggttgtaa tttttcaaca
     3541 aggacccaat gaagtaaatt tcagtttctt cctttgatca aggtaataga cagtgcaagc
     3601 agactctgtt ccttgtccca gctgtgattc taaggcaagc acaaaaggta aaagaattcc
     3661 tgagtctttt cactggagca tttacatttc gattctgtag ccattcgcaa cagaacatct
     3721 gcaggaagat aatgagctta aattacaatt gactttggaa gaataacaga ctctcctgtt
     3781 cctcaatcat gtaatcaata gggaattctc cagcaatgag agccacagcc atctttcaag
     3841 acaatgttaa gatctaaata aaaaaaaaaa ttctagcatt cagggccttg ttaagaagga
     3901 agtttttctc taaagaactt ggctagagac aaatcacacc catttacaaa tgcggttctc
     3961 aaacgtgaca tcaagccaat cttgtttcct tttacagggc tgtacattca ggattccaaa
     4021 gatggcacac ctctttcaac atctagtact atttgtgggt gtgtgaataa gtccccaggt
     4081 ttctcacctt tcagctgggt tttgcttgta agcacttcta acccagactt aagcttcaaa
     4141 caagatggag atacagatac cgagcattct ctggggattc agggaccccc ttgagtaaga
     4201 ctttccatag catcctatcc ttcctcagac cccagactcc atcagaccaa gtcatgtgac
     4261 tgtggtcctg caaatgtgct ggtgcactct gggcactcaa tgaggatttg ttgaatgggt
     4321 gaattattga agaggaggct aaattaatta tttttgactt ctgactaaca tatattaatg
     4381 ggcattataa ttttgcatgc catagccaaa gccagaattt cttccaagat acatcctgga
     4441 atcaaattaa acatctcaaa ggttcaagga cctttaagtc agaagcaatg attgagaatt
     4501 catatatata tatgaaatct ctctagttct ttacaaaaat acatggataa tttggcatgg
     4561 aggcttcaaa agtagaactt tatttgtaaa gtttacagaa cacaatgcat taggtttttt
     4621 ttaagctgtg acatcatatt agattacctt acaatacaaa ggacccacaa gtcattgaaa
     4681 gcaccatttc taaacgtcgg ctttcaaatg cctcttcttt catctttgac tcctagaata
     4741 tacccgagat aaaaattact cacacgacat ctccctcccg aacatctaca tgtatttatt
     4801 tatttaacag atatgtctgt tttcccggta cgtgctagat tctagaaatg caatgggaaa
     4861 caagttaact gcaatcccat cctaaggttt gctatgaggg actcttattc tggctaacta
     4921 gtttatcatc ccctgggtcc tcctcataca tgctagagta acaacagcaa caagagctag
     4981 ccttccctgc atggcaacca gtcaatactt cctgcataga tttatgtgag ctcgcctttc
     5041 tgaacacaaa cactcatact tgccccatag tttagccata aagcagagtt acaacccagg
     5101 gaggttggca attttaaggg tcttaaaatt tcatcagtct cgaccagatt acagcttcaa
     5161 agctcctccc tccaaaactg tgttcactgg gctccattca cacacaggaa aactgaagca
     5221 ctgatgcatg cctttgccaa ggttacctga ttagctggta gagttggggg tttgaaccca
     5281 caaagtccaa cacagtggtc catgtgccta agcactatct gtaggctttg ggggtggggg
     5341 gacactccta cattaaaatg aatgaatcat tgtatataga aatatcttga gtttgtaagg
     5401 tagtaactaa aagatattag tacattataa ctcattgtag cctacaaatt acatcagaaa
     5461 caagaacagg attagaactg catcttatgt gatagcatac tctcatgaac tacaatacat
     5521 caagccaggg acaggcatac aagttcagat ccagaaaatt tctacttggg aaaatgtttc
     5581 aatgacttca gaattattca ttgtcagcca ctgtgtctat ttggtgctac aaaaaaaaat
     5641 ggaaagaaca aatacccctg attgaagggc ttataaatac acagtgtgga gatgaaccaa
     5701 gggcatttca tatttataga aaggattggc caattgtacc gtttctcacc attgcatgta
     5761 cattgtctct ccaattgttt ttgcattgtt tttatgaaag aactgcaaaa ttgtgcagtg
     5821 gttcaacctg accaaagtgg tattacgctg ctgggaagta aatgtattag ataccaga
//
