LOCUS       NM_172714               4472 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus lin-54 DREAM MuvB core complex component (Lin54),
            transcript variant 2, mRNA.
ACCESSION   NM_172714 NM_178895
VERSION     NM_172714.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4472)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4472)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   3  (bases 1 to 4472)
  AUTHORS   Hansen,G.M., Markesich,D.C., Burnett,M.B., Zhu,Q., Dionne,K.M.,
            Richter,L.J., Finnell,R.H., Sands,A.T., Zambrowicz,B.P. and
            Abuin,A.
  TITLE     Large-scale gene trapping in C57BL/6N mouse embryonic stem cells
  JOURNAL   Genome Res 18 (10), 1670-1679 (2008)
   PUBMED   18799693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            MG954270.1, AC109196.12 and AC107744.8.
            
            On Jul 30, 2020 this sequence version replaced NM_172714.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 5 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220225.1, AK134320.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               MG954270.1         236-382
            148-863             AC109196.12        171533-172248
            864-987             AC109196.12        177067-177190
            988-1130            AC109196.12        181557-181699
            1131-1347           AC107744.8         4982-5198
            1348-1421           AC107744.8         10276-10349
            1422-1619           AC107744.8         10647-10844
            1620-1711           AC107744.8         11692-11783
            1712-1783           AC107744.8         12441-12512
            1784-1886           AC107744.8         13776-13878
            1887-2024           AC107744.8         14027-14164
            2025-2227           AC107744.8         18058-18260
            2228-4472           AC107744.8         20507-22751
FEATURES             Location/Qualifiers
     source          1..4472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.48 cM"
     gene            1..4472
                     /gene="Lin54"
                     /note="lin-54 DREAM MuvB core complex component"
                     /db_xref="GeneID:231506"
                     /db_xref="MGI:MGI:2140902"
     exon            1..147
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            148..863
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2429
                     /gene="Lin54"
                     /note="isoform 1 is encoded by transcript variant 2;
                     protein lin-54 homolog"
                     /codon_start=1
                     /product="protein lin-54 homolog isoform 1"
                     /protein_id="NP_766302.2"
                     /db_xref="CCDS:CCDS19462.2"
                     /db_xref="GeneID:231506"
                     /db_xref="MGI:MGI:2140902"
                     /translation="MEVVPAEVNSLLPDDIMDTAITLVDEDSIEAVIVSSPIPMETEL
                     EEIVNINSTGDSTATPISTEPITVYSNHTNQVAVNTTVSKADSNTTVKPAFPSGLQKL
                     GAQTPVTISANQIILNKVSQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQ
                     LPQAQKVTAQAQPGDAKLPPQQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSV
                     LQTQQLKTVQIAKKPRTPTSGPVITKLIFAKPINSKAVTGQTTQASPPVVTGRVLSQS
                     TPGTPSKTITISESGVIGSTLNSTTQTPNKIAISPLKSPNKTVKSAVQTITVGGMSTS
                     QFKTIIPLATAPNVQQIQVPGSKFHYVRLVTATTASSSAQPVSQSPSVNTQPLQQAKP
                     VVVNTTPVRMSVPFVQAQAVKQVVPKPINSTSQIVTTSQPQQRLIMPATPLPQIQPNL
                     TNLPPGTVLAPAPGTGNVGYAVLPAQYVTQLQQSSYVSIASNSNFTGTSGIQTQARLP
                     FNGIIPSESTSRPRKPCNCTKSLCLKLYCDCFANGEFCNNCNCTNCYNNLEHENERQK
                     AIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCNCKRSGCLKNYCECYEAKIMCSSIC
                     KCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQISDLLTRPTPALNSAGG
                     KLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRCLMSVINSAGKA
                     KSDPCAMHC"
     exon            864..987
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1130
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1347
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1421
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1619
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1711
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1783
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1886
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2024
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2227
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..4472
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2735..2740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin54"
                     /note="hexamer: ATTATA"
     polyA_site      2756
                     /gene="Lin54"
                     /note="major polyA site"
     polyA_site      4156
                     /gene="Lin54"
                     /note="major polyA site"
     regulatory      4281..4286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin54"
                     /note="hexamer: ATTAAA"
     polyA_site      4306
                     /gene="Lin54"
                     /note="major polyA site"
ORIGIN      
        1 gtattatggg atgcggcggt ggaatggcgc tgggcgcgtg attttgaaca aacccgggtc
       61 tgtgtttcgg aggcgccgcc gccgccgcgg ctgctgggag cccggggagc gcggcgcgag
      121 aaggaggcgg cggcgccgcc ggctcggcac ctgggcatct ctctagaagc ggtgcgatca
      181 tggaggtggt gccggccgag gtgaatagtt tgcttccaga cgacataatg gacactgcta
      241 taacgttagt ggatgaggat agtattgagg ctgtaattgt gtcatcccca attcccatgg
      301 agacagagct ggaagaaatt gtcaacataa attctaccgg tgactctaca gccacgccca
      361 tttccacgga accaatcaca gtgtacagta accacactaa ccaagttgca gtgaatacca
      421 cagtttctaa agcagattct aataccacag tgaaaccagc atttccaagt ggccttcaaa
      481 aacttggtgc tcagactcct gtgactatat cagccaatca gattatttta aacaaagtat
      541 cacagacatc tgatcttaaa cttggcaatc agacccttaa accagatgga cagaagttaa
      601 tattaacaac tttgggcaag tctggttcac caattgtttt agcactaccc catagccaac
      661 taccccaggc tcagaaagtt acagctcagg cccagccagg agatgctaag ttaccaccgc
      721 agcaaattaa agtagttacc attggaggga ggccagaggt gaaacctgtc attggtgtct
      781 cagcactgac cccaggaagc caactgatta atactacaac tcagccctct gtgttacaga
      841 cccaacagtt aaaaacagta cagattgcta agaagcctcg gacaccaacc tcgggtccag
      901 tgatcacgaa gctgattttt gcaaaaccaa ttaatagcaa agcagttaca ggacagacaa
      961 ctcaagcatc tccacccgtc gtcacaggta gggttctttc acagtctact cctggaactc
     1021 catcaaagac tataacaata tcagaaagtg gtgtgattgg atcaacttta aattcgacaa
     1081 cacagacacc aaataagata gccatctcac ctttgaagtc gccaaataag acagtgaaat
     1141 cggctgtgca gaccatcact gtgggaggaa tgagcacctc acagtttaag accatcatcc
     1201 ctctggccac tgctcccaat gtccagcaga ttcaagtgcc tggaagcaag tttcattatg
     1261 tccgacttgt tactgccaca acagccagta gctcagccca gccagtcagt cagagcccca
     1321 gtgtaaacac acagcctctc cagcaagcaa aaccagtggt tgttaatacc acccctgtac
     1381 ggatgtcagt tccatttgtc caagctcagg ccgttaagca agttgttcca aaaccaatca
     1441 attcaacttc acaaattgta actaccagcc agccacagca gcggctcatc atgcctgcca
     1501 caccactgcc tcagatccag cccaacctca ctaacctgcc accaggtact gtgctggcac
     1561 cagctccagg aacagggaat gtgggctatg cagtgcttcc agctcagtat gttactcagt
     1621 tacagcagtc ttcatatgtg tctatagcaa gcaactctaa ttttactgga acatctggca
     1681 tccagacaca ggcaaggctt ccattcaatg gcataattcc atcagagtct accagtcggc
     1741 ccagaaaacc ctgtaactgt acaaaatcac tgtgtttgaa attatactgt gattgctttg
     1801 caaatggtga attctgcaac aactgcaact gtaccaattg ttacaacaat ttagagcacg
     1861 agaatgagag acaaaaggca atcaaggcat gccttgatag aaatccggaa gccttcaagc
     1921 caaagatagg aaaaggaaaa gagggggagt cggatcggcg gcacagcaaa ggctgcaact
     1981 gcaaacgctc ggggtgtctt aaaaactact gcgagtgcta tgaggcaaaa ataatgtgtt
     2041 cttctatatg caaatgcatc ggctgtaaga attttgaaga aagcccagaa cggaagacat
     2101 tgatgcactt agcagatgcg gctgaagtaa gggtccagca gcagacagca gcgaagacca
     2161 agctgtcctc tcagatctca gacctcctta caaggccaac cccagctctc aacagtgcag
     2221 gagggaaatt gccgtttaca tttgtaacta aagaagtagc tgaagccacg tgtaattgcc
     2281 ttcttgccca ggcagagcag gcagacaaga aggggaaatc aaaggcggca gcagagcgga
     2341 tgatacttga ggaatttgga cgatgtttga tgagcgtcat caactctgca ggaaaagcca
     2401 aaagtgaccc ctgtgccatg cactgctaac tcttgcacaa aagactgaat ggaactgtac
     2461 agaaaattta aggtgccggg acacttgatt ttctagaaga tagcttaaca attactgtat
     2521 tttaattcag cctttgtttt aagagatctg aaactataat attgaaagag aagaaattag
     2581 tacatttaaa atcttagtta attctgccta tgccccttct aaattttttt ctttaaaaat
     2641 ttttctttta tgtattatat atttttttaa tttgcttggg tttcttaaga attagatgtt
     2701 ctgtcctgat tctattgaca aagaacattc ataaattata gtgatatcat ttataatgta
     2761 tggtgttgta tgactttgtt cagtagaaaa ggccaaagta gcatgggtat tacccattct
     2821 ttggttacag atccagagta ttcacaggta gaatgtccgc ataaccagat tctaaatgaa
     2881 atatatttag gagacatttt gtttagagaa acaccatcct taaaaaaaaa aaatcagatt
     2941 tttagagtgg attctggaat gctgtctgct gtctcgttgg gagtatcaga aggggaaaca
     3001 atccccacca cacttttcag tataatacaa acattatgct ttctttaaag aaagcaaaat
     3061 attaaggggc agtaattttc agaggacagg ctgtgtctct gatgaggaat ggctaacatg
     3121 gtctggggcg tcttcatttt ctctgaagga ggtggtatgt tttataataa ttgtcaaagt
     3181 gattatggct aattactaaa atatgagaat gaattacatt aaacattttg tgtcatgatg
     3241 acagaactca tacgcagtaa gtctgaagtc tggctcgctg gagacgcgag gactcagagc
     3301 tgggaggtta tgtgtggtgg cgctttatgc acacacttct ctgcagacct tctggactga
     3361 gttcagtcag tgtgtgactc ctacctggtt tactgagata aacgcgcctc ctagcagctt
     3421 ctagaactgc agccagcttt ttataaaaga agttttaata caacattgtt taaaacagtg
     3481 atttggtaag ctgaagtatg tgtgctctta gactcgcaaa aacaacctct atattcttca
     3541 gtaattagaa accgtgtgaa ctcgggagcc tactataata ggacttgagt ttatgacaag
     3601 cagaaaacta ggttggaatt gaaacatttt gtaaggtacc ttaatccttg gtaattatta
     3661 gcatatgatt attgcccttc ctacaaggac tctagcattg taagtagtaa gtatgtatat
     3721 atgttcatat gaacatgaaa gatatagaca atagaaatta accccaagag gattccgtta
     3781 ctcatttaag tatcctccat ttaaaatggt tttataagat gacagtgcag taactttaaa
     3841 tgtagataat gcaggcatcc ttagcacctc ggtctagagt ttttaagtaa actttgtaca
     3901 aatgtaaatt agtctaagag gacaaaataa tatctaatca agttattttt caaaagactg
     3961 caataagttt ttggtctaaa cctaaacttt gttcattttg tatatattat gtgttaattc
     4021 taatagcacc attgtgatgt gtatttatat acagtgtgca caaaatgttt gtgaattttt
     4081 tattataatt gtagattatg tatgatggca ttgcttaaga ttgttttgct tgtaagaatt
     4141 tgaaggtgca atcaaagcta cgagtttgga tttttaagaa gcctttaacc tatcagcccc
     4201 tttccttctg tgtggttcca actgaacaac tttttgtatt aggcatttgc atcaaattgc
     4261 tgaacaaagt taatagccac attaaatcac caatttcaaa agattatttg gggagggttt
     4321 ggtctataat ttttaagccc tatttacatc ctaaggtaga aagattatat ttactagagc
     4381 tattcaaaaa gtacactttt ctatattgta aaagcagggc agaagaataa atcatacaga
     4441 aaataaacat ttatactatt ctgtaaaaaa aa
//
