LOCUS       NM_001115010            4596 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus lin-54 DREAM MuvB core complex component (Lin54),
            transcript variant 1, mRNA.
ACCESSION   NM_001115010
VERSION     NM_001115010.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4596)
  AUTHORS   Rousseau,V., Einig,E., Jin,C., Horn,J., Riebold,M., Poth,T.,
            Jarboui,M.A., Flentje,M. and Popov,N.
  TITLE     Trim33 masks a non-transcriptional function of E2f4 in replication
            fork progression
  JOURNAL   Nat Commun 14 (1), 5143 (2023)
   PUBMED   37612308
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4596)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   3  (bases 1 to 4596)
  AUTHORS   Hansen,G.M., Markesich,D.C., Burnett,M.B., Zhu,Q., Dionne,K.M.,
            Richter,L.J., Finnell,R.H., Sands,A.T., Zambrowicz,B.P. and
            Abuin,A.
  TITLE     Large-scale gene trapping in C57BL/6N mouse embryonic stem cells
  JOURNAL   Genome Res 18 (10), 1670-1679 (2008)
   PUBMED   18799693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030894.1, AK134320.1, AK220225.1 and AC107744.8.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1, 2 and 5
            encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030894.1, SRR17253012.1521112.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1627              AK030894.1         3-1629
            1628-1670           AK134320.1         1494-1536
            1671-4588           AK220225.1         1534-4451
            4589-4596           AC107744.8         22744-22751
FEATURES             Location/Qualifiers
     source          1..4596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 48.48 cM"
     gene            1..4596
                     /gene="Lin54"
                     /note="lin-54 DREAM MuvB core complex component"
                     /db_xref="GeneID:231506"
                     /db_xref="MGI:MGI:2140902"
     exon            1..271
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            272..987
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..2553
                     /gene="Lin54"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein lin-54 homolog"
                     /codon_start=1
                     /product="protein lin-54 homolog isoform 1"
                     /protein_id="NP_001108482.1"
                     /db_xref="CCDS:CCDS19462.2"
                     /db_xref="GeneID:231506"
                     /db_xref="MGI:MGI:2140902"
                     /translation="MEVVPAEVNSLLPDDIMDTAITLVDEDSIEAVIVSSPIPMETEL
                     EEIVNINSTGDSTATPISTEPITVYSNHTNQVAVNTTVSKADSNTTVKPAFPSGLQKL
                     GAQTPVTISANQIILNKVSQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQ
                     LPQAQKVTAQAQPGDAKLPPQQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSV
                     LQTQQLKTVQIAKKPRTPTSGPVITKLIFAKPINSKAVTGQTTQASPPVVTGRVLSQS
                     TPGTPSKTITISESGVIGSTLNSTTQTPNKIAISPLKSPNKTVKSAVQTITVGGMSTS
                     QFKTIIPLATAPNVQQIQVPGSKFHYVRLVTATTASSSAQPVSQSPSVNTQPLQQAKP
                     VVVNTTPVRMSVPFVQAQAVKQVVPKPINSTSQIVTTSQPQQRLIMPATPLPQIQPNL
                     TNLPPGTVLAPAPGTGNVGYAVLPAQYVTQLQQSSYVSIASNSNFTGTSGIQTQARLP
                     FNGIIPSESTSRPRKPCNCTKSLCLKLYCDCFANGEFCNNCNCTNCYNNLEHENERQK
                     AIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCNCKRSGCLKNYCECYEAKIMCSSIC
                     KCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQISDLLTRPTPALNSAGG
                     KLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRCLMSVINSAGKA
                     KSDPCAMHC"
     exon            988..1111
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1254
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1471
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1545
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1743
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1835
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1907
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2010
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2148
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2351
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..4596
                     /gene="Lin54"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2859..2864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin54"
                     /note="hexamer: ATTATA"
     polyA_site      2880
                     /gene="Lin54"
                     /note="major polyA site"
     polyA_site      4280
                     /gene="Lin54"
                     /note="major polyA site"
     regulatory      4405..4410
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin54"
                     /note="hexamer: ATTAAA"
     polyA_site      4430
                     /gene="Lin54"
                     /note="major polyA site"
ORIGIN      
        1 ggtgatgacg aggtgaaaat ggcggatctt tcgaaataca atcccggcct ctgacatacc
       61 agaggcggcg gccgcggcga catcgccacc ccggctccct cctgggtccc cgggtaccct
      121 atagcgctcc atttcgtgca aactgggaaa ggaagcagct ggacagagct acggtgcaca
      181 ggcaaaacaa gcactgcccg ggctcgaaat tgcccgggac ctctggagcc cgctcggagc
      241 cggagggtgg agaaagcggc agcctctgga gcacctgggc atctctctag aagcggtgcg
      301 atcatggagg tggtgccggc cgaggtgaat agtttgcttc cagacgacat aatggacact
      361 gctataacgt tagtggatga ggatagtatt gaggctgtaa ttgtgtcatc cccaattccc
      421 atggagacag agctggaaga aattgtcaac ataaattcta ccggtgactc tacagccacg
      481 cccatttcca cggaaccaat cacagtgtac agtaaccaca ctaaccaagt tgcagtgaat
      541 accacagttt ctaaagcaga ttctaatacc acagtgaaac cagcatttcc aagtggcctt
      601 caaaaacttg gtgctcagac tcctgtgact atatcagcca atcagattat tttaaacaaa
      661 gtatcacaga catctgatct taaacttggc aatcagaccc ttaaaccaga tggacagaag
      721 ttaatattaa caactttggg caagtctggt tcaccaattg ttttagcact accccatagc
      781 caactacccc aggctcagaa agttacagct caggcccagc caggagatgc taagttacca
      841 ccgcagcaaa ttaaagtagt taccattgga gggaggccag aggtgaaacc tgtcattggt
      901 gtctcagcac tgaccccagg aagccaactg attaatacta caactcagcc ctctgtgtta
      961 cagacccaac agttaaaaac agtacagatt gctaagaagc ctcggacacc aacctcgggt
     1021 ccagtgatca cgaagctgat ttttgcaaaa ccaattaata gcaaagcagt tacaggacag
     1081 acaactcaag catctccacc cgtcgtcaca ggtagggttc tttcacagtc tactcctgga
     1141 actccatcaa agactataac aatatcagaa agtggtgtga ttggatcaac tttaaattcg
     1201 acaacacaga caccaaataa gatagccatc tcacctttga agtcgccaaa taagacagtg
     1261 aaatcggctg tgcagaccat cactgtggga ggaatgagca cctcacagtt taagaccatc
     1321 atccctctgg ccactgctcc caatgtccag cagattcaag tgcctggaag caagtttcat
     1381 tatgtccgac ttgttactgc cacaacagcc agtagctcag cccagccagt cagtcagagc
     1441 cccagtgtaa acacacagcc tctccagcaa gcaaaaccag tggttgttaa taccacccct
     1501 gtacggatgt cagttccatt tgtccaagct caggccgtta agcaagttgt tccaaaacca
     1561 atcaattcaa cttcacaaat tgtaactacc agccagccac agcagcggct catcatgcct
     1621 gccacaccac tgcctcagat ccagcccaac ctcactaacc tgccaccagg tactgtgctg
     1681 gcaccagctc caggaacagg gaatgtgggc tatgcagtgc ttccagctca gtatgttact
     1741 cagttacagc agtcttcata tgtgtctata gcaagcaact ctaattttac tggaacatct
     1801 ggcatccaga cacaggcaag gcttccattc aatggcataa ttccatcaga gtctaccagt
     1861 cggcccagaa aaccctgtaa ctgtacaaaa tcactgtgtt tgaaattata ctgtgattgc
     1921 tttgcaaatg gtgaattctg caacaactgc aactgtacca attgttacaa caatttagag
     1981 cacgagaatg agagacaaaa ggcaatcaag gcatgccttg atagaaatcc ggaagccttc
     2041 aagccaaaga taggaaaagg aaaagagggg gagtcggatc ggcggcacag caaaggctgc
     2101 aactgcaaac gctcggggtg tcttaaaaac tactgcgagt gctatgaggc aaaaataatg
     2161 tgttcttcta tatgcaaatg catcggctgt aagaattttg aagaaagccc agaacggaag
     2221 acattgatgc acttagcaga tgcggctgaa gtaagggtcc agcagcagac agcagcgaag
     2281 accaagctgt cctctcagat ctcagacctc cttacaaggc caaccccagc tctcaacagt
     2341 gcaggaggga aattgccgtt tacatttgta actaaagaag tagctgaagc cacgtgtaat
     2401 tgccttcttg cccaggcaga gcaggcagac aagaagggga aatcaaaggc ggcagcagag
     2461 cggatgatac ttgaggaatt tggacgatgt ttgatgagcg tcatcaactc tgcaggaaaa
     2521 gccaaaagtg acccctgtgc catgcactgc taactcttgc acaaaagact gaatggaact
     2581 gtacagaaaa tttaaggtgc cgggacactt gattttctag aagatagctt aacaattact
     2641 gtattttaat tcagcctttg ttttaagaga tctgaaacta taatattgaa agagaagaaa
     2701 ttagtacatt taaaatctta gttaattctg cctatgcccc ttctaaattt ttttctttaa
     2761 aaatttttct tttatgtatt atatattttt ttaatttgct tgggtttctt aagaattaga
     2821 tgttctgtcc tgattctatt gacaaagaac attcataaat tatagtgata tcatttataa
     2881 tgtatggtgt tgtatgactt tgttcagtag aaaaggccaa agtagcatgg gtattaccca
     2941 ttctttggtt acagatccag agtattcaca ggtagaatgt ccgcataacc agattctaaa
     3001 tgaaatatat ttaggagaca ttttgtttag agaaacacca tccttaaaaa aaaaaaatca
     3061 gatttttaga gtggattctg gaatgctgtc tgctgtctcg ttgggagtat cagaagggga
     3121 aacaatcccc accacacttt tcagtataat acaaacatta tgctttcttt aaagaaagca
     3181 aaatattaag gggcagtaat tttcagagga caggctgtgt ctctgatgag gaatggctaa
     3241 catggtctgg ggcgtcttca ttttctctga aggaggtggt atgttttata ataattgtca
     3301 aagtgattat ggctaattac taaaatatga gaatgaatta cattaaacat tttgtgtcat
     3361 gatgacagaa ctcatacgca gtaagtctga agtctggctc gctggagacg cgaggactca
     3421 gagctgggag gttatgtgtg gtggcgcttt atgcacacac ttctctgcag accttctgga
     3481 ctgagttcag tcagtgtgtg actcctacct ggtttactga gataaacgcg cctcctagca
     3541 gcttctagaa ctgcagccag ctttttataa aagaagtttt aatacaacat tgtttaaaac
     3601 agtgatttgg taagctgaag tatgtgtgct cttagactcg caaaaacaac ctctatattc
     3661 ttcagtaatt agaaaccgtg tgaactcggg agcctactat aataggactt gagtttatga
     3721 caagcagaaa actaggttgg aattgaaaca ttttgtaagg taccttaatc cttggtaatt
     3781 attagcatat gattattgcc cttcctacaa ggactctagc attgtaagta gtaagtatgt
     3841 atatatgttc atatgaacat gaaagatata gacaatagaa attaacccca agaggattcc
     3901 gttactcatt taagtatcct ccatttaaaa tggttttata agatgacagt gcagtaactt
     3961 taaatgtaga taatgcaggc atccttagca cctcggtcta gagtttttaa gtaaactttg
     4021 tacaaatgta aattagtcta agaggacaaa ataatatcta atcaagttat ttttcaaaag
     4081 actgcaataa gtttttggtc taaacctaaa ctttgttcat tttgtatata ttatgtgtta
     4141 attctaatag caccattgtg atgtgtattt atatacagtg tgcacaaaat gtttgtgaat
     4201 tttttattat aattgtagat tatgtatgat ggcattgctt aagattgttt tgcttgtaag
     4261 aatttgaagg tgcaatcaaa gctacgagtt tggattttta agaagccttt aacctatcag
     4321 cccctttcct tctgtgtggt tccaactgaa caactttttg tattaggcat ttgcatcaaa
     4381 ttgctgaaca aagttaatag ccacattaaa tcaccaattt caaaagatta tttggggagg
     4441 gtttggtcta taatttttaa gccctattta catcctaagg tagaaagatt atatttacta
     4501 gagctattca aaaagtacac ttttctatat tgtaaaagca gggcagaaga ataaatcata
     4561 cagaaaataa acatttatac tattctgtaa aaaaaa
//
