LOCUS       NM_173756               2184 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus lin-52 DREAM MuvB core complex component (Lin52),
            transcript variant 1, mRNA.
ACCESSION   NM_173756
VERSION     NM_173756.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Alvarez-Dominguez,J.R., Hu,W., Yuan,B., Shi,J., Park,S.S.,
            Gromatzky,A.A., van Oudenaarden,A. and Lodish,H.F.
  TITLE     Global discovery of erythroid long noncoding RNAs reveals novel
            regulators of red cell maturation
  JOURNAL   Blood 123 (4), 570-581 (2014)
   PUBMED   24200680
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   5  (bases 1 to 2184)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120402.10 and AC110564.7.
            
            On Apr 10, 2021 this sequence version replaced NM_173756.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189679.74719.1, AK030923.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC120402.10        121995-122032
            39-113              AC110564.7         44329-44403
            114-151             AC110564.7         46037-46074
            152-218             AC110564.7         47707-47773
            219-302             AC110564.7         50457-50540
            303-2184            AC110564.7         117778-119659
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.22 cM"
     gene            1..2184
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /note="lin-52 DREAM MuvB core complex component"
                     /db_xref="GeneID:217708"
                     /db_xref="MGI:MGI:3045391"
     exon            1..38
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..358
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein lin-52 homolog"
                     /codon_start=1
                     /product="protein lin-52 homolog isoform 1"
                     /protein_id="NP_776117.2"
                     /db_xref="CCDS:CCDS49110.1"
                     /db_xref="GeneID:217708"
                     /db_xref="MGI:MGI:3045391"
                     /translation="MASPTDGTDLEASLLSFEKLDRASPDLWPEQLPGVAEFAASFKS
                     PITSSPPKWMAEIERDDIDMLKELGSLTTANLMEKVRGLQNLAYQLGLDESREMTRGK
                     FLNILEKPKK"
     exon            39..113
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            114..151
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            152..218
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            219..302
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            303..2184
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2184
                     /gene="Lin52"
                     /gene_synonym="5830457H20Rik"
                     /note="major polyA site"
ORIGIN      
        1 acgtgacatg ggctggaaga tggcgtctcc cacagacggg acggatttgg aagcatcttt
       61 gctaagtttt gagaaacttg accgtgcctc accagatctc tggccagaac agctaccagg
      121 tgtcgctgaa tttgcagctt ctttcaaaag tcccatcaca agctctccac cgaaatggat
      181 ggctgagata gagcgtgatg acattgatat gttgaaagaa ctggggagcc tcaccacagc
      241 taacctgatg gagaaggtac gaggcctaca gaacctggcc taccagctgg ggctggatga
      301 gtccagagag atgacaaggg gaaaattctt gaacattcta gaaaagccca agaagtagca
      361 actgctcatg gactggtgtc ctgaagactg taaccaagct tccttctaaa tacgaccctg
      421 atgcccacca cgtgctctct tgggaaaagc ctggaggctg agcttcagga ctgccctcct
      481 cccctgcccc ggcaccctgc gcctctgagg atattcggta tcaagaggag agattgttgt
      541 aaccaaggag cattgctgtt tactgagtcg gcttcgtagc tctggctatt ggtaacacag
      601 aggtcctgtc attctgaaag gtattttcca ggagccccag gatggtagag ttcctttgat
      661 tctgtaatgg caaagtcagt agtgacttgt tggttgaatg ggttctgttg cgttgtactt
      721 gatctcttaa gcattcatga tgaggacgtc agagaccaac tatgttctgg accagactct
      781 gcatcctgac ctgtgaactc tgcaagacct attgattcta tgacttccat tctagaggaa
      841 acattagaat cttgttgaaa tgcacatctg cttttttaag tctatacctc caacgacact
      901 cctgctctca ggactgtccc gtccccacct ccagtcccac tcgcaggtct gagtccagac
      961 aagaggacct cttgcagtga ctttcctggg attagctgta gagtgaacgg cccatgctgt
     1021 gccactttga atcctagacc tccagaccag gaagaaggta acagaaggaa ctctgggtag
     1081 tctgttatat ttgtaagtaa aaaagtgggc aggcacggtt gtgagagtcc ccacatgact
     1141 gaagacaagg aagcctgatt gactggtgtg ctagccagtg gtagtggcat ttgtcccctc
     1201 cttcctcctc tcagccgctt atcagatgct ttgcttatgt gataagaaca caccccatga
     1261 aagtgtcttg gcttaactac aactctcgcc tatttttttt ttttttccaa attgcatatg
     1321 tctgctaaat tctgaaaatc ttgcccctgg gtaaaatcga ttagacctag tctctcacat
     1381 tttgaagagt acagcaggtt ccttgaacat tgtagaaaga aaagctctgt ggccatcgtc
     1441 cactgggagt gtggacacag gaaaagtgtg gtcaagtttg tggtcttgtc tctgttaggg
     1501 cacagtactc ttggggtcca cagcaggtcc cttgactgtt tttgacattt gtgtttaatg
     1561 ctagaattga tgttggattt tccccctcat taatggttct gatcaacaca attttacttt
     1621 ttgaaaggaa aaggcagtga aatatatacc ataaaatatg aatatgagaa gaaatatatt
     1681 ctgctggggt actccctaca agggccaatt ggttttaaat ttaattctat aattgacatt
     1741 ttttaatctc actgaatgca gttaaagtga gtgtgtactc atggtgggaa caatgccata
     1801 atgtcagttg tccttcttca ctctgttttt gagagttgat gacatcaggc acttttcaga
     1861 gtttggggaa attgaaaagt ctgtggagaa tactgagcta gctcccccaa actaaagcaa
     1921 gtctataata ggaagccagg agttggtgtt ttgatctgct acacctcctc ctcctatcat
     1981 cctattcacc agcacttaat taatgtaagt agatgtttta gacttgtgct atttattgtt
     2041 tttgtattgt catccttaga aatgttaata gtgtattttt atattgataa tataaactaa
     2101 tgtatagtat gtatatgtat tttataatgt tagagaatac tttgtgtata atgttgtgtc
     2161 tctataataa atatgtccct tgta
//
