LOCUS       NM_029377                998 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lin-37 DREAM MuvB core complex component (Lin37),
            transcript variant 1, mRNA.
ACCESSION   NM_029377 XM_994246
VERSION     NM_029377.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 998)
  AUTHORS   Mages,C.F., Wintsche,A., Bernhart,S.H. and Muller,G.A.
  TITLE     The DREAM complex through its subunit Lin37 cooperates with Rb to
            initiate quiescence
  JOURNAL   Elife 6, e26876 (2017)
   PUBMED   28920576
  REMARK    GeneRIF: Thus, Lin37 is an essential component of DREAM complex
            that cooperates with Rb to induce quiescence.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007858.1.
            
            On Apr 6, 2007 this sequence version replaced NM_029377.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007858.1, CB209044.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-998               AK007858.1         2-999
FEATURES             Location/Qualifiers
     source          1..998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.58 cM"
     gene            1..998
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /note="lin-37 DREAM MuvB core complex component"
                     /db_xref="GeneID:75660"
                     /db_xref="MGI:MGI:1922910"
     exon            1..205
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..912
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein lin-37 homolog; antolefinine"
                     /codon_start=1
                     /product="protein lin-37 homolog isoform 1"
                     /protein_id="NP_083653.1"
                     /db_xref="CCDS:CCDS21098.1"
                     /db_xref="GeneID:75660"
                     /db_xref="MGI:MGI:1922910"
                     /translation="MFPVKVKVEKSEMEMAKARNQLDAVLQCLLEKSHMDRERLDEEA
                     GKTPLDTHNKDCSIAATGKRPSARFPHQRRKKRREMDDGLAEGGPQRSNTYVIKLFDR
                     SVDLAQFSENTPLYPICRAWMRNSPTVRERERSPGSPLPPLPEDGEGSEVINSKNRDV
                     YKLPPPTAPGPLGDACRSRIPSPLQPETEGTPDDEPSEPEPSPSTLIYRNMQRWKRIR
                     QRWKEASHRNQLRYSESMKILREMYDRQ"
     exon            206..281
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            282..332
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            333..362
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            363..448
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            449..615
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            616..756
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            757..830
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            831..998
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      934..939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      955
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
                     /note="major polyA site"
     polyA_site      994
                     /gene="Lin37"
                     /gene_synonym="1810054G18Rik"
ORIGIN      
        1 ggaagaaggg aagtggccgc caaggcagtc gcggctggac agtgctcagg cccgaggacc
       61 agtggtgccc agacttacct ttgacctttc cctgcccgcc ttccgcctag cttttgaacc
      121 acacctcctc caagtttttc tgatccagcg cattagacct gcacccaaat catgttcccg
      181 gtaaaggtga aagtggagaa atcagagatg gagatggcca aagcccggaa ccagctggat
      241 gccgttcttc agtgtctgct ggagaagagt cacatggaca gggaacgcct ggatgaagaa
      301 gctgggaaaa cccccttgga tacgcacaac aaggattgtt ccattgctgc cacaggcaaa
      361 aggccatctg cccgcttccc ccaccagcgg aggaagaaga ggagggagat ggacgatggg
      421 ctcgctgagg ggggtcctca gagatccaat acgtatgtga tcaagctatt tgaccggagt
      481 gtggacttgg cccagttcag tgagaacaca ccactgtacc ccatctgccg cgcctggatg
      541 cgcaacagcc ccacagtgcg agagcgcgag cgctcacccg gctcaccgct gcctcctctg
      601 cccgaggatg gagagggttc agaggtcatc aacagcaaaa accgtgatgt gtacaagctg
      661 cctccaccca cagctcctgg accacttgga gatgcctgta gatccagaat tccatcccca
      721 ctgcagcctg agaccgaggg tacccccgat gatgaacctt ccgagcctga accttctcct
      781 tccacactta tctatcgcaa catgcaacgt tggaaacgca tacgccagag gtggaaggag
      841 gcatctcatc ggaaccagct tcgctactca gaaagtatga agatcctacg ggagatgtat
      901 gaccggcagt gaccttccca ggaaccccac cccaataaat gtgcccccca acccacactg
      961 gccaggccat cgttcctggc ccagacataa ggcagttg
//
